Full text data of PPP2R5D
PPP2R5D
[Confidence: low (only semi-automatic identification from reviews)]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q14738
ID 2A5D_HUMAN Reviewed; 602 AA.
AC Q14738; A8K3I9; B5BUA6; O00494; O00696; Q15171; Q5TC39;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1996, sequence version 1.
DT 22-JAN-2014, entry version 148.
DE RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;
DE AltName: Full=PP2A B subunit isoform B'-delta;
DE AltName: Full=PP2A B subunit isoform B56-delta;
DE AltName: Full=PP2A B subunit isoform PR61-delta;
DE AltName: Full=PP2A B subunit isoform R5-delta;
GN Name=PPP2R5D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA-1).
RC TISSUE=Fetal brain;
RX PubMed=8703017; DOI=10.1074/jbc.271.36.22081;
RA McCright B., Rivers A.M., Audlin S., Virshup D.M.;
RT "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
RT encodes differentiation-induced phosphoproteins that target PP2A to
RT both nucleus and cytoplasm.";
RL J. Biol. Chem. 271:22081-22089(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DELTA-1 AND DELTA-3).
RC TISSUE=Brain cortex;
RX PubMed=9180267; DOI=10.1016/S0014-5793(97)00392-X;
RA Tanabe O., Gomez G.A., Nishito Y., Usui H., Takeda M.;
RT "Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory
RT subunit (B'' or delta) of human protein phosphatase 2A.";
RL FEBS Lett. 408:52-56(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA-2), AND PROTEIN SEQUENCE OF
RP 501-508; 550-559; 573-580 AND 584-601 (DELTA-1).
RC TISSUE=Bone marrow, and Brain cortex;
RX PubMed=8566219; DOI=10.1016/0014-5793(95)01500-0;
RA Tanabe O., Nagase T., Murakami T., Nozaki H., Usui H., Nishito Y.,
RA Hayashi H., Kagamiyama H., Takeda M.;
RT "Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of
RT human protein phosphatase 2A.";
RL FEBS Lett. 379:107-111(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA-2).
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA-1).
RX PubMed=19054851; DOI=10.1038/nmeth.1273;
RA Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H.,
RA Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M.,
RA Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T.,
RA Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A.,
RA Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K.,
RA Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S.,
RA Isogai T., Imai J., Watanabe S., Nomura N.;
RT "Human protein factory for converting the transcriptome into an in
RT vitro-expressed proteome.";
RL Nat. Methods 5:1011-1017(2008).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS DELTA-1 AND DELTA-2).
RC TISSUE=Colon, Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP INTERACTION WITH SGOL1.
RX PubMed=16541025; DOI=10.1038/nature04663;
RA Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T.,
RA Kawashima S.A., Watanabe Y.;
RT "Shugoshin collaborates with protein phosphatase 2A to protect
RT cohesin.";
RL Nature 441:46-52(2006).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-598, AND MASS
RP SPECTROMETRY.
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
RA Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
RA Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [14]
RP VARIANT SER-53.
RX PubMed=23033978; DOI=10.1056/NEJMoa1206524;
RA de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G.,
RA Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P.,
RA Gilissen C., del Rosario M., Hoischen A., Scheffer H., de Vries B.B.,
RA Brunner H.G., Veltman J.A., Vissers L.E.;
RT "Diagnostic exome sequencing in persons with severe intellectual
RT disability.";
RL N. Engl. J. Med. 367:1921-1929(2012).
CC -!- FUNCTION: The B regulatory subunit might modulate substrate
CC selectivity and catalytic activity, and also might direct the
CC localization of the catalytic enzyme to a particular subcellular
CC compartment.
CC -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme,
CC composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa
CC constant regulatory subunit (PR65 or subunit A), that associates
CC with a variety of regulatory subunits. Proteins that associate
CC with the core dimer include three families of regulatory subunits
CC B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56
CC families), the 48 kDa variable regulatory subunit, viral proteins,
CC and cell signaling molecules. Interacts with SGOL1.
CC -!- INTERACTION:
CC O08785:Clock (xeno); NbExp=2; IntAct=EBI-396563, EBI-79859;
CC Q13136:PPFIA1; NbExp=2; IntAct=EBI-396563, EBI-745426;
CC P30153:PPP2R1A; NbExp=4; IntAct=EBI-396563, EBI-302388;
CC P30154:PPP2R1B; NbExp=2; IntAct=EBI-396563, EBI-357094;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in
CC interphase, nuclear during mitosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=Delta-1;
CC IsoId=Q14738-1; Sequence=Displayed;
CC Name=Delta-2;
CC IsoId=Q14738-2; Sequence=VSP_005111;
CC Name=Delta-3;
CC IsoId=Q14738-3; Sequence=VSP_005110;
CC -!- TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform
CC Delta-1 is highly expressed in brain.
CC -!- INDUCTION: By retinoic acid; in neuroblastoma cell lines.
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56
CC family.
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DR EMBL; L76702; AAB69751.1; -; mRNA.
DR EMBL; AB000634; BAA20381.1; -; mRNA.
DR EMBL; AB000635; BAA20382.1; -; mRNA.
DR EMBL; D78360; BAA11372.1; -; mRNA.
DR EMBL; AK290604; BAF83293.1; -; mRNA.
DR EMBL; AB451342; BAG70156.1; -; mRNA.
DR EMBL; AB451357; BAG70171.1; -; mRNA.
DR EMBL; AL136304; CAI19791.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX04133.1; -; Genomic_DNA.
DR EMBL; BC010692; AAH10692.1; -; mRNA.
DR EMBL; BC001095; AAH01095.1; -; mRNA.
DR EMBL; BC001175; AAH01175.1; -; mRNA.
DR PIR; S68686; S68686.
DR RefSeq; NP_001257405.1; NM_001270476.1.
DR RefSeq; NP_006236.1; NM_006245.3.
DR RefSeq; NP_851307.1; NM_180976.2.
DR RefSeq; NP_851308.1; NM_180977.2.
DR UniGene; Hs.533308; -.
DR ProteinModelPortal; Q14738; -.
DR SMR; Q14738; 110-512.
DR DIP; DIP-29961N; -.
DR IntAct; Q14738; 27.
DR MINT; MINT-5006095; -.
DR STRING; 9606.ENSP00000417963; -.
DR PhosphoSite; Q14738; -.
DR DMDM; 7387495; -.
DR PaxDb; Q14738; -.
DR PRIDE; Q14738; -.
DR DNASU; 5528; -.
DR Ensembl; ENST00000394110; ENSP00000377669; ENSG00000112640.
DR Ensembl; ENST00000461010; ENSP00000420674; ENSG00000112640.
DR Ensembl; ENST00000485511; ENSP00000417963; ENSG00000112640.
DR GeneID; 5528; -.
DR KEGG; hsa:5528; -.
DR UCSC; uc003oth.4; human.
DR CTD; 5528; -.
DR GeneCards; GC06P042952; -.
DR HGNC; HGNC:9312; PPP2R5D.
DR HPA; HPA029045; -.
DR HPA; HPA029046; -.
DR MIM; 601646; gene.
DR neXtProt; NX_Q14738; -.
DR PharmGKB; PA33676; -.
DR eggNOG; NOG264925; -.
DR HOVERGEN; HBG000009; -.
DR InParanoid; Q14738; -.
DR KO; K11584; -.
DR OMA; GSGRAEM; -.
DR OrthoDB; EOG7C2R2S; -.
DR PhylomeDB; Q14738; -.
DR Reactome; REACT_111102; Signal Transduction.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_115566; Cell Cycle.
DR Reactome; REACT_21300; Mitotic M-M/G1 phases.
DR Reactome; REACT_604; Hemostasis.
DR Reactome; REACT_6782; TRAF6 Mediated Induction of proinflammatory cytokines.
DR Reactome; REACT_6900; Immune System.
DR SignaLink; Q14738; -.
DR GeneWiki; PPP2R5D; -.
DR GenomeRNAi; 5528; -.
DR NextBio; 21410; -.
DR PRO; PR:Q14738; -.
DR ArrayExpress; Q14738; -.
DR Bgee; Q14738; -.
DR CleanEx; HS_PPP2R5D; -.
DR Genevestigator; Q14738; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
DR GO; GO:0008601; F:protein phosphatase type 2A regulator activity; TAS:ProtInc.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; TAS:Reactome.
DR GO; GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
DR GO; GO:0006096; P:glycolysis; TAS:Reactome.
DR GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
DR GO; GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
DR GO; GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002554; PP2A_B56.
DR PANTHER; PTHR10257; PTHR10257; 1.
DR Pfam; PF01603; B56; 1.
DR PIRSF; PIRSF028043; PP2A_B56; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 602 Serine/threonine-protein phosphatase 2A
FT 56 kDa regulatory subunit delta isoform.
FT /FTId=PRO_0000071452.
FT REPEAT 37 38 1.
FT REPEAT 39 40 2.
FT REPEAT 41 42 3.
FT REPEAT 43 44 4.
FT REPEAT 45 46 5.
FT REPEAT 47 48 6; approximate.
FT REPEAT 49 50 7; approximate.
FT REPEAT 51 52 8.
FT REGION 37 52 8 X 2 AA approximate tandem repeats of Q-
FT P.
FT MOTIF 523 530 SH3-binding; class I (Potential).
FT MOTIF 548 565 Nuclear localization signal (Potential).
FT MOD_RES 573 573 Phosphoserine.
FT MOD_RES 598 598 Phosphoserine.
FT VAR_SEQ 11 116 Missing (in isoform Delta-3).
FT /FTId=VSP_005110.
FT VAR_SEQ 85 116 Missing (in isoform Delta-2).
FT /FTId=VSP_005111.
FT VARIANT 53 53 P -> S (found in a patient with delayed
FT psychomotor development, no speech and
FT cataracts).
FT /FTId=VAR_069414.
SQ SEQUENCE 602 AA; 69992 MW; F15F71AF4E565387 CRC64;
MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS QPPSSNKRPS
NSTPPPTQLS KIKYSGGPQI VKKERRQSSS RFNLSKNREL QKLPALKDSP TQEREELFIQ
KLRQCCVLFD FVSDPLSDLK FKEVKRAGLN EMVEYITHSR DVVTEAIYPE AVTMFSVNLF
RTLPPSSNPT GAEFDPEEDE PTLEAAWPHL QLVYEFFLRF LESPDFQPNI AKKYIDQKFV
LALLDLFDSE DPRERDFLKT ILHRIYGKFL GLRAYIRRQI NHIFYRFIYE TEHHNGIAEL
LEILGSIING FALPLKEEHK MFLIRVLLPL HKVKSLSVYH PQLAYCVVQF LEKESSLTEP
VIVGLLKFWP KTHSPKEVMF LNELEEILDV IEPSEFSKVM EPLFRQLAKC VSSPHFQVAE
RALYYWNNEY IMSLISDNAA RVLPIMFPAL YRNSKSHWNK TIHGLIYNAL KLFMEMNQKL
FDDCTQQYKA EKQKGRFRMK EREEMWQKIE ELARLNPQYP MFRAPPPLPP VYSMETETPT
AEDIQLLKRT VETEAVQMLK DIKKEKVLLR RKSELPQDVY TIKALEAHKR AEEFLTASQE
AL
//
ID 2A5D_HUMAN Reviewed; 602 AA.
AC Q14738; A8K3I9; B5BUA6; O00494; O00696; Q15171; Q5TC39;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1996, sequence version 1.
DT 22-JAN-2014, entry version 148.
DE RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;
DE AltName: Full=PP2A B subunit isoform B'-delta;
DE AltName: Full=PP2A B subunit isoform B56-delta;
DE AltName: Full=PP2A B subunit isoform PR61-delta;
DE AltName: Full=PP2A B subunit isoform R5-delta;
GN Name=PPP2R5D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA-1).
RC TISSUE=Fetal brain;
RX PubMed=8703017; DOI=10.1074/jbc.271.36.22081;
RA McCright B., Rivers A.M., Audlin S., Virshup D.M.;
RT "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
RT encodes differentiation-induced phosphoproteins that target PP2A to
RT both nucleus and cytoplasm.";
RL J. Biol. Chem. 271:22081-22089(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DELTA-1 AND DELTA-3).
RC TISSUE=Brain cortex;
RX PubMed=9180267; DOI=10.1016/S0014-5793(97)00392-X;
RA Tanabe O., Gomez G.A., Nishito Y., Usui H., Takeda M.;
RT "Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory
RT subunit (B'' or delta) of human protein phosphatase 2A.";
RL FEBS Lett. 408:52-56(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA-2), AND PROTEIN SEQUENCE OF
RP 501-508; 550-559; 573-580 AND 584-601 (DELTA-1).
RC TISSUE=Bone marrow, and Brain cortex;
RX PubMed=8566219; DOI=10.1016/0014-5793(95)01500-0;
RA Tanabe O., Nagase T., Murakami T., Nozaki H., Usui H., Nishito Y.,
RA Hayashi H., Kagamiyama H., Takeda M.;
RT "Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of
RT human protein phosphatase 2A.";
RL FEBS Lett. 379:107-111(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA-2).
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA-1).
RX PubMed=19054851; DOI=10.1038/nmeth.1273;
RA Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H.,
RA Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M.,
RA Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T.,
RA Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A.,
RA Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K.,
RA Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S.,
RA Isogai T., Imai J., Watanabe S., Nomura N.;
RT "Human protein factory for converting the transcriptome into an in
RT vitro-expressed proteome.";
RL Nat. Methods 5:1011-1017(2008).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS DELTA-1 AND DELTA-2).
RC TISSUE=Colon, Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP INTERACTION WITH SGOL1.
RX PubMed=16541025; DOI=10.1038/nature04663;
RA Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T.,
RA Kawashima S.A., Watanabe Y.;
RT "Shugoshin collaborates with protein phosphatase 2A to protect
RT cohesin.";
RL Nature 441:46-52(2006).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-598, AND MASS
RP SPECTROMETRY.
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
RA Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
RA Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [14]
RP VARIANT SER-53.
RX PubMed=23033978; DOI=10.1056/NEJMoa1206524;
RA de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G.,
RA Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P.,
RA Gilissen C., del Rosario M., Hoischen A., Scheffer H., de Vries B.B.,
RA Brunner H.G., Veltman J.A., Vissers L.E.;
RT "Diagnostic exome sequencing in persons with severe intellectual
RT disability.";
RL N. Engl. J. Med. 367:1921-1929(2012).
CC -!- FUNCTION: The B regulatory subunit might modulate substrate
CC selectivity and catalytic activity, and also might direct the
CC localization of the catalytic enzyme to a particular subcellular
CC compartment.
CC -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme,
CC composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa
CC constant regulatory subunit (PR65 or subunit A), that associates
CC with a variety of regulatory subunits. Proteins that associate
CC with the core dimer include three families of regulatory subunits
CC B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56
CC families), the 48 kDa variable regulatory subunit, viral proteins,
CC and cell signaling molecules. Interacts with SGOL1.
CC -!- INTERACTION:
CC O08785:Clock (xeno); NbExp=2; IntAct=EBI-396563, EBI-79859;
CC Q13136:PPFIA1; NbExp=2; IntAct=EBI-396563, EBI-745426;
CC P30153:PPP2R1A; NbExp=4; IntAct=EBI-396563, EBI-302388;
CC P30154:PPP2R1B; NbExp=2; IntAct=EBI-396563, EBI-357094;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in
CC interphase, nuclear during mitosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=Delta-1;
CC IsoId=Q14738-1; Sequence=Displayed;
CC Name=Delta-2;
CC IsoId=Q14738-2; Sequence=VSP_005111;
CC Name=Delta-3;
CC IsoId=Q14738-3; Sequence=VSP_005110;
CC -!- TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform
CC Delta-1 is highly expressed in brain.
CC -!- INDUCTION: By retinoic acid; in neuroblastoma cell lines.
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56
CC family.
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DR EMBL; L76702; AAB69751.1; -; mRNA.
DR EMBL; AB000634; BAA20381.1; -; mRNA.
DR EMBL; AB000635; BAA20382.1; -; mRNA.
DR EMBL; D78360; BAA11372.1; -; mRNA.
DR EMBL; AK290604; BAF83293.1; -; mRNA.
DR EMBL; AB451342; BAG70156.1; -; mRNA.
DR EMBL; AB451357; BAG70171.1; -; mRNA.
DR EMBL; AL136304; CAI19791.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX04133.1; -; Genomic_DNA.
DR EMBL; BC010692; AAH10692.1; -; mRNA.
DR EMBL; BC001095; AAH01095.1; -; mRNA.
DR EMBL; BC001175; AAH01175.1; -; mRNA.
DR PIR; S68686; S68686.
DR RefSeq; NP_001257405.1; NM_001270476.1.
DR RefSeq; NP_006236.1; NM_006245.3.
DR RefSeq; NP_851307.1; NM_180976.2.
DR RefSeq; NP_851308.1; NM_180977.2.
DR UniGene; Hs.533308; -.
DR ProteinModelPortal; Q14738; -.
DR SMR; Q14738; 110-512.
DR DIP; DIP-29961N; -.
DR IntAct; Q14738; 27.
DR MINT; MINT-5006095; -.
DR STRING; 9606.ENSP00000417963; -.
DR PhosphoSite; Q14738; -.
DR DMDM; 7387495; -.
DR PaxDb; Q14738; -.
DR PRIDE; Q14738; -.
DR DNASU; 5528; -.
DR Ensembl; ENST00000394110; ENSP00000377669; ENSG00000112640.
DR Ensembl; ENST00000461010; ENSP00000420674; ENSG00000112640.
DR Ensembl; ENST00000485511; ENSP00000417963; ENSG00000112640.
DR GeneID; 5528; -.
DR KEGG; hsa:5528; -.
DR UCSC; uc003oth.4; human.
DR CTD; 5528; -.
DR GeneCards; GC06P042952; -.
DR HGNC; HGNC:9312; PPP2R5D.
DR HPA; HPA029045; -.
DR HPA; HPA029046; -.
DR MIM; 601646; gene.
DR neXtProt; NX_Q14738; -.
DR PharmGKB; PA33676; -.
DR eggNOG; NOG264925; -.
DR HOVERGEN; HBG000009; -.
DR InParanoid; Q14738; -.
DR KO; K11584; -.
DR OMA; GSGRAEM; -.
DR OrthoDB; EOG7C2R2S; -.
DR PhylomeDB; Q14738; -.
DR Reactome; REACT_111102; Signal Transduction.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_115566; Cell Cycle.
DR Reactome; REACT_21300; Mitotic M-M/G1 phases.
DR Reactome; REACT_604; Hemostasis.
DR Reactome; REACT_6782; TRAF6 Mediated Induction of proinflammatory cytokines.
DR Reactome; REACT_6900; Immune System.
DR SignaLink; Q14738; -.
DR GeneWiki; PPP2R5D; -.
DR GenomeRNAi; 5528; -.
DR NextBio; 21410; -.
DR PRO; PR:Q14738; -.
DR ArrayExpress; Q14738; -.
DR Bgee; Q14738; -.
DR CleanEx; HS_PPP2R5D; -.
DR Genevestigator; Q14738; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
DR GO; GO:0008601; F:protein phosphatase type 2A regulator activity; TAS:ProtInc.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; TAS:Reactome.
DR GO; GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
DR GO; GO:0006096; P:glycolysis; TAS:Reactome.
DR GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
DR GO; GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
DR GO; GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002554; PP2A_B56.
DR PANTHER; PTHR10257; PTHR10257; 1.
DR Pfam; PF01603; B56; 1.
DR PIRSF; PIRSF028043; PP2A_B56; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 602 Serine/threonine-protein phosphatase 2A
FT 56 kDa regulatory subunit delta isoform.
FT /FTId=PRO_0000071452.
FT REPEAT 37 38 1.
FT REPEAT 39 40 2.
FT REPEAT 41 42 3.
FT REPEAT 43 44 4.
FT REPEAT 45 46 5.
FT REPEAT 47 48 6; approximate.
FT REPEAT 49 50 7; approximate.
FT REPEAT 51 52 8.
FT REGION 37 52 8 X 2 AA approximate tandem repeats of Q-
FT P.
FT MOTIF 523 530 SH3-binding; class I (Potential).
FT MOTIF 548 565 Nuclear localization signal (Potential).
FT MOD_RES 573 573 Phosphoserine.
FT MOD_RES 598 598 Phosphoserine.
FT VAR_SEQ 11 116 Missing (in isoform Delta-3).
FT /FTId=VSP_005110.
FT VAR_SEQ 85 116 Missing (in isoform Delta-2).
FT /FTId=VSP_005111.
FT VARIANT 53 53 P -> S (found in a patient with delayed
FT psychomotor development, no speech and
FT cataracts).
FT /FTId=VAR_069414.
SQ SEQUENCE 602 AA; 69992 MW; F15F71AF4E565387 CRC64;
MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS QPPSSNKRPS
NSTPPPTQLS KIKYSGGPQI VKKERRQSSS RFNLSKNREL QKLPALKDSP TQEREELFIQ
KLRQCCVLFD FVSDPLSDLK FKEVKRAGLN EMVEYITHSR DVVTEAIYPE AVTMFSVNLF
RTLPPSSNPT GAEFDPEEDE PTLEAAWPHL QLVYEFFLRF LESPDFQPNI AKKYIDQKFV
LALLDLFDSE DPRERDFLKT ILHRIYGKFL GLRAYIRRQI NHIFYRFIYE TEHHNGIAEL
LEILGSIING FALPLKEEHK MFLIRVLLPL HKVKSLSVYH PQLAYCVVQF LEKESSLTEP
VIVGLLKFWP KTHSPKEVMF LNELEEILDV IEPSEFSKVM EPLFRQLAKC VSSPHFQVAE
RALYYWNNEY IMSLISDNAA RVLPIMFPAL YRNSKSHWNK TIHGLIYNAL KLFMEMNQKL
FDDCTQQYKA EKQKGRFRMK EREEMWQKIE ELARLNPQYP MFRAPPPLPP VYSMETETPT
AEDIQLLKRT VETEAVQMLK DIKKEKVLLR RKSELPQDVY TIKALEAHKR AEEFLTASQE
AL
//
MIM
601646
*RECORD*
*FIELD* NO
601646
*FIELD* TI
*601646 PROTEIN PHOSPHATASE 2, REGULATORY SUBUNIT B (B56), DELTA; PPP2R5D
*FIELD* TX
read moreFor background information on protein phosphatase 2A (PP2A) and its
subunits, see 601643.
CLONING
McCright et al. (1996) cloned the B56-delta gene from a human fetal
brain cDNA library using a partial cDNA sequence. They found that
B56-delta encoded a 602-amino acid protein with a predicted molecular
mass of 69,947 Da. This subunit is able to form a functional trimeric
PP2A phosphatase when combined with an A and a C subunit.
GENE FUNCTION
McCright et al. (1996) observed that the location of B56-delta varies
with the cell cycle, being present in both cytoplasm and nucleus in
interphase cells but concentrated in the nucleus of mitotic and recently
divided cells. Both B56-beta (601644) and B56-delta are highly expressed
in the adult brain, and mRNA for these isoforms increases 3- to 5-fold
when neuroblastoma cell lines are induced to differentiate by retinoic
acid treatment.
MAPPING
McCright et al. (1996) mapped the gene for the delta subunit, designated
PPP2R5D, to 6p21.1 by fluorescence in situ hybridization.
*FIELD* RF
1. McCright, B.; Brothman, A. R.; Virshup, D. M.: Assignment of human
protein phosphatase 2A regulatory subunit genes B56-alpha, B56-beta,
B56-gamma, B56-delta, and B56-epsilon (PPP2R5A--PPP2R5E), highly expressed
in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1,
and 7p11.2-to-p12. Genomics 36: 168-170, 1996.
2. McCright, B.; Rivers, A. M.; Audlin, S.; Virshup, D. M.: The B56
family of protein phosphatase 2A (PP2A) regulatory subunits encodes
differentiation-induced phosphoproteins that target PP2A to both nucleus
and cytoplasm. J. Biol. Chem. 271: 22081-22089, 1996.
*FIELD* CN
Jennifer P. Macke - updated: 5/5/1997
*FIELD* CD
Alan F. Scott: 1/23/1997
*FIELD* ED
alopez: 04/27/2010
alopez: 4/27/2010
mgross: 2/4/2009
alopez: 12/1/1999
alopez: 5/5/1997
alopez: 4/8/1997
mark: 2/10/1997
jenny: 1/28/1997
mark: 1/23/1997
*RECORD*
*FIELD* NO
601646
*FIELD* TI
*601646 PROTEIN PHOSPHATASE 2, REGULATORY SUBUNIT B (B56), DELTA; PPP2R5D
*FIELD* TX
read moreFor background information on protein phosphatase 2A (PP2A) and its
subunits, see 601643.
CLONING
McCright et al. (1996) cloned the B56-delta gene from a human fetal
brain cDNA library using a partial cDNA sequence. They found that
B56-delta encoded a 602-amino acid protein with a predicted molecular
mass of 69,947 Da. This subunit is able to form a functional trimeric
PP2A phosphatase when combined with an A and a C subunit.
GENE FUNCTION
McCright et al. (1996) observed that the location of B56-delta varies
with the cell cycle, being present in both cytoplasm and nucleus in
interphase cells but concentrated in the nucleus of mitotic and recently
divided cells. Both B56-beta (601644) and B56-delta are highly expressed
in the adult brain, and mRNA for these isoforms increases 3- to 5-fold
when neuroblastoma cell lines are induced to differentiate by retinoic
acid treatment.
MAPPING
McCright et al. (1996) mapped the gene for the delta subunit, designated
PPP2R5D, to 6p21.1 by fluorescence in situ hybridization.
*FIELD* RF
1. McCright, B.; Brothman, A. R.; Virshup, D. M.: Assignment of human
protein phosphatase 2A regulatory subunit genes B56-alpha, B56-beta,
B56-gamma, B56-delta, and B56-epsilon (PPP2R5A--PPP2R5E), highly expressed
in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1,
and 7p11.2-to-p12. Genomics 36: 168-170, 1996.
2. McCright, B.; Rivers, A. M.; Audlin, S.; Virshup, D. M.: The B56
family of protein phosphatase 2A (PP2A) regulatory subunits encodes
differentiation-induced phosphoproteins that target PP2A to both nucleus
and cytoplasm. J. Biol. Chem. 271: 22081-22089, 1996.
*FIELD* CN
Jennifer P. Macke - updated: 5/5/1997
*FIELD* CD
Alan F. Scott: 1/23/1997
*FIELD* ED
alopez: 04/27/2010
alopez: 4/27/2010
mgross: 2/4/2009
alopez: 12/1/1999
alopez: 5/5/1997
alopez: 4/8/1997
mark: 2/10/1997
jenny: 1/28/1997
mark: 1/23/1997