Full text data of AAMDC
AAMDC
(C11orf67)
[Confidence: low (only semi-automatic identification from reviews)]
Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9H7C9
ID AAMDC_HUMAN Reviewed; 122 AA.
AC Q9H7C9; Q96AQ4; Q9Y6B1;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Mth938 domain-containing protein;
DE AltName: Full=Adipogenesis associated Mth938 domain-containing protein;
GN Name=AAMDC; Synonyms=C11orf67; ORFNames=PTD015;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Pituitary tumor;
RA Mao M., Peng Y., Dai M., Song H., Mao Y., Zhang Q., Huang Q., Fu G.,
RA Luo M., Chen J., Hu R.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS).
RG Center for eukaryotic structural genomics (CESG);
RT "X-ray structure of gene product from Homo sapiens HS.95870.";
RL Submitted (JUL-2005) to the PDB data bank.
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS).
RX PubMed=17850744; DOI=10.1016/j.str.2007.06.019;
RA Levin E.J., Kondrashov D.A., Wesenberg G.E., Phillips G.N. Jr.;
RT "Ensemble refinement of protein crystal structures: validation and
RT application.";
RL Structure 15:1040-1052(2007).
CC -!- FUNCTION: May play a role in preadipocyte differentiation and
CC adipogenesis (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Diffuse
CC distribution with some highly concentrated spots around the
CC nucleus (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H7C9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H7C9-2; Sequence=VSP_019267, VSP_019269;
CC Name=3;
CC IsoId=Q9H7C9-3; Sequence=VSP_019266, VSP_019268;
CC -!- SIMILARITY: Belongs to the AAMDC family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF092136; AAD40378.1; -; mRNA.
DR EMBL; AK024688; BAB14963.1; -; mRNA.
DR EMBL; CR457332; CAG33613.1; -; mRNA.
DR EMBL; AP000580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002752; AAH02752.1; -; mRNA.
DR EMBL; BC016854; AAH16854.1; -; mRNA.
DR RefSeq; NP_078960.1; NM_024684.2.
DR RefSeq; XP_005273995.1; XM_005273938.1.
DR UniGene; Hs.745040; -.
DR PDB; 2AB1; X-ray; 2.59 A; A/B=2-122.
DR PDB; 2Q4Q; X-ray; 2.59 A; A/B=2-122.
DR PDBsum; 2AB1; -.
DR PDBsum; 2Q4Q; -.
DR ProteinModelPortal; Q9H7C9; -.
DR SMR; Q9H7C9; 2-122.
DR STRING; 9606.ENSP00000263301; -.
DR PhosphoSite; Q9H7C9; -.
DR DMDM; 74733628; -.
DR PaxDb; Q9H7C9; -.
DR PRIDE; Q9H7C9; -.
DR DNASU; 28971; -.
DR Ensembl; ENST00000393427; ENSP00000377078; ENSG00000087884.
DR Ensembl; ENST00000526415; ENSP00000431808; ENSG00000087884.
DR Ensembl; ENST00000532481; ENSP00000433293; ENSG00000087884.
DR GeneID; 28971; -.
DR KEGG; hsa:28971; -.
DR UCSC; uc001oyq.3; human.
DR CTD; 28971; -.
DR GeneCards; GC11P077533; -.
DR H-InvDB; HIX0009970; -.
DR HGNC; HGNC:30205; AAMDC.
DR neXtProt; NX_Q9H7C9; -.
DR PharmGKB; PA144596486; -.
DR eggNOG; NOG46285; -.
DR HOGENOM; HOG000223243; -.
DR HOVERGEN; HBG081222; -.
DR InParanoid; Q9H7C9; -.
DR KO; K09008; -.
DR OrthoDB; EOG71RXMQ; -.
DR PhylomeDB; Q9H7C9; -.
DR ChiTaRS; C11orf67; human.
DR EvolutionaryTrace; Q9H7C9; -.
DR GenomeRNAi; 28971; -.
DR NextBio; 51835; -.
DR ArrayExpress; Q9H7C9; -.
DR Bgee; Q9H7C9; -.
DR CleanEx; HS_C11orf67; -.
DR Genevestigator; Q9H7C9; -.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:RefGenome.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IBA:RefGenome.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
DR Gene3D; 3.40.1230.10; -; 1.
DR InterPro; IPR007523; NADH_Ub_cplx-1_asu_assmbl-fac3.
DR Pfam; PF04430; DUF498; 1.
DR SUPFAM; SSF64076; SSF64076; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; Cytoplasm;
KW Polymorphism; Reference proteome.
FT CHAIN 1 122 Mth938 domain-containing protein.
FT /FTId=PRO_0000239814.
FT REGION 6 122 MTH138-like domain (By similarity).
FT VAR_SEQ 77 118 VPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGV
FT F -> APTQQLPSGVHVRAGVQFHLLQLHGTSFERCKTGAG
FT LTSNML (in isoform 2).
FT /FTId=VSP_019267.
FT VAR_SEQ 77 88 VPSSTVEYLKKH -> DGIQGAQLDLNC (in isoform
FT 3).
FT /FTId=VSP_019266.
FT VAR_SEQ 89 122 Missing (in isoform 3).
FT /FTId=VSP_019268.
FT VAR_SEQ 119 122 Missing (in isoform 2).
FT /FTId=VSP_019269.
FT VARIANT 92 92 V -> M (in dbSNP:rs2186564).
FT /FTId=VAR_052696.
FT STRAND 6 10
FT STRAND 13 16
FT STRAND 22 29
FT STRAND 32 36
FT HELIX 38 41
FT STRAND 45 47
FT HELIX 51 58
FT STRAND 63 69
FT HELIX 79 87
FT STRAND 91 95
FT HELIX 97 109
FT STRAND 114 119
SQ SEQUENCE 122 AA; 13332 MW; A0C88AD311E62C78 CRC64;
MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ PADVKEVVEK
GVQTLVIGRG MSEALKVPSS TVEYLKKHGI DVRVLQTEQA VKEYNALVAQ GVRVGGVFHS
TC
//
ID AAMDC_HUMAN Reviewed; 122 AA.
AC Q9H7C9; Q96AQ4; Q9Y6B1;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Mth938 domain-containing protein;
DE AltName: Full=Adipogenesis associated Mth938 domain-containing protein;
GN Name=AAMDC; Synonyms=C11orf67; ORFNames=PTD015;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Pituitary tumor;
RA Mao M., Peng Y., Dai M., Song H., Mao Y., Zhang Q., Huang Q., Fu G.,
RA Luo M., Chen J., Hu R.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS).
RG Center for eukaryotic structural genomics (CESG);
RT "X-ray structure of gene product from Homo sapiens HS.95870.";
RL Submitted (JUL-2005) to the PDB data bank.
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS).
RX PubMed=17850744; DOI=10.1016/j.str.2007.06.019;
RA Levin E.J., Kondrashov D.A., Wesenberg G.E., Phillips G.N. Jr.;
RT "Ensemble refinement of protein crystal structures: validation and
RT application.";
RL Structure 15:1040-1052(2007).
CC -!- FUNCTION: May play a role in preadipocyte differentiation and
CC adipogenesis (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Diffuse
CC distribution with some highly concentrated spots around the
CC nucleus (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H7C9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H7C9-2; Sequence=VSP_019267, VSP_019269;
CC Name=3;
CC IsoId=Q9H7C9-3; Sequence=VSP_019266, VSP_019268;
CC -!- SIMILARITY: Belongs to the AAMDC family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF092136; AAD40378.1; -; mRNA.
DR EMBL; AK024688; BAB14963.1; -; mRNA.
DR EMBL; CR457332; CAG33613.1; -; mRNA.
DR EMBL; AP000580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002752; AAH02752.1; -; mRNA.
DR EMBL; BC016854; AAH16854.1; -; mRNA.
DR RefSeq; NP_078960.1; NM_024684.2.
DR RefSeq; XP_005273995.1; XM_005273938.1.
DR UniGene; Hs.745040; -.
DR PDB; 2AB1; X-ray; 2.59 A; A/B=2-122.
DR PDB; 2Q4Q; X-ray; 2.59 A; A/B=2-122.
DR PDBsum; 2AB1; -.
DR PDBsum; 2Q4Q; -.
DR ProteinModelPortal; Q9H7C9; -.
DR SMR; Q9H7C9; 2-122.
DR STRING; 9606.ENSP00000263301; -.
DR PhosphoSite; Q9H7C9; -.
DR DMDM; 74733628; -.
DR PaxDb; Q9H7C9; -.
DR PRIDE; Q9H7C9; -.
DR DNASU; 28971; -.
DR Ensembl; ENST00000393427; ENSP00000377078; ENSG00000087884.
DR Ensembl; ENST00000526415; ENSP00000431808; ENSG00000087884.
DR Ensembl; ENST00000532481; ENSP00000433293; ENSG00000087884.
DR GeneID; 28971; -.
DR KEGG; hsa:28971; -.
DR UCSC; uc001oyq.3; human.
DR CTD; 28971; -.
DR GeneCards; GC11P077533; -.
DR H-InvDB; HIX0009970; -.
DR HGNC; HGNC:30205; AAMDC.
DR neXtProt; NX_Q9H7C9; -.
DR PharmGKB; PA144596486; -.
DR eggNOG; NOG46285; -.
DR HOGENOM; HOG000223243; -.
DR HOVERGEN; HBG081222; -.
DR InParanoid; Q9H7C9; -.
DR KO; K09008; -.
DR OrthoDB; EOG71RXMQ; -.
DR PhylomeDB; Q9H7C9; -.
DR ChiTaRS; C11orf67; human.
DR EvolutionaryTrace; Q9H7C9; -.
DR GenomeRNAi; 28971; -.
DR NextBio; 51835; -.
DR ArrayExpress; Q9H7C9; -.
DR Bgee; Q9H7C9; -.
DR CleanEx; HS_C11orf67; -.
DR Genevestigator; Q9H7C9; -.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:RefGenome.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IBA:RefGenome.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
DR Gene3D; 3.40.1230.10; -; 1.
DR InterPro; IPR007523; NADH_Ub_cplx-1_asu_assmbl-fac3.
DR Pfam; PF04430; DUF498; 1.
DR SUPFAM; SSF64076; SSF64076; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; Cytoplasm;
KW Polymorphism; Reference proteome.
FT CHAIN 1 122 Mth938 domain-containing protein.
FT /FTId=PRO_0000239814.
FT REGION 6 122 MTH138-like domain (By similarity).
FT VAR_SEQ 77 118 VPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGV
FT F -> APTQQLPSGVHVRAGVQFHLLQLHGTSFERCKTGAG
FT LTSNML (in isoform 2).
FT /FTId=VSP_019267.
FT VAR_SEQ 77 88 VPSSTVEYLKKH -> DGIQGAQLDLNC (in isoform
FT 3).
FT /FTId=VSP_019266.
FT VAR_SEQ 89 122 Missing (in isoform 3).
FT /FTId=VSP_019268.
FT VAR_SEQ 119 122 Missing (in isoform 2).
FT /FTId=VSP_019269.
FT VARIANT 92 92 V -> M (in dbSNP:rs2186564).
FT /FTId=VAR_052696.
FT STRAND 6 10
FT STRAND 13 16
FT STRAND 22 29
FT STRAND 32 36
FT HELIX 38 41
FT STRAND 45 47
FT HELIX 51 58
FT STRAND 63 69
FT HELIX 79 87
FT STRAND 91 95
FT HELIX 97 109
FT STRAND 114 119
SQ SEQUENCE 122 AA; 13332 MW; A0C88AD311E62C78 CRC64;
MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ PADVKEVVEK
GVQTLVIGRG MSEALKVPSS TVEYLKKHGI DVRVLQTEQA VKEYNALVAQ GVRVGGVFHS
TC
//