Full text data of ABTB2
ABTB2
[Confidence: low (only semi-automatic identification from reviews)]
Ankyrin repeat and BTB/POZ domain-containing protein 2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Ankyrin repeat and BTB/POZ domain-containing protein 2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8N961
ID ABTB2_HUMAN Reviewed; 1025 AA.
AC Q8N961; A8K6S9; E9PRW7; Q52LD6; Q6MZW4; Q8NB44;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2013, sequence version 2.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 2;
GN Name=ABTB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP GLN-250.
RC TISSUE=Fetal brain, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2).
RC TISSUE=Rectum tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in the initiation of hepatocyte growth
CC (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N961-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N961-2; Sequence=VSP_046439;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 4 ANK repeats.
CC -!- SIMILARITY: Contains 1 BTB (POZ) domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH93968.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAC03697.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAF84433.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAF84433.1; Type=Erroneous termination; Positions=101; Note=Translated as Glu;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK091560; BAC03697.1; ALT_INIT; mRNA.
DR EMBL; AK095632; BAC04595.1; -; mRNA.
DR EMBL; AK291744; BAF84433.1; ALT_SEQ; mRNA.
DR EMBL; AC090469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093968; AAH93968.1; ALT_INIT; mRNA.
DR EMBL; BX640841; CAE45913.3; -; mRNA.
DR RefSeq; NP_665803.2; NM_145804.2.
DR UniGene; Hs.23361; -.
DR ProteinModelPortal; Q8N961; -.
DR SMR; Q8N961; 521-738, 841-944.
DR STRING; 9606.ENSP00000298992; -.
DR PhosphoSite; Q8N961; -.
DR DMDM; 61218305; -.
DR PaxDb; Q8N961; -.
DR PRIDE; Q8N961; -.
DR Ensembl; ENST00000298992; ENSP00000298992; ENSG00000166016.
DR Ensembl; ENST00000435224; ENSP00000410157; ENSG00000166016.
DR GeneID; 25841; -.
DR KEGG; hsa:25841; -.
DR UCSC; uc001mvl.2; human.
DR CTD; 25841; -.
DR GeneCards; GC11M034129; -.
DR H-InvDB; HIX0009548; -.
DR HGNC; HGNC:23842; ABTB2.
DR HPA; HPA020065; -.
DR neXtProt; NX_Q8N961; -.
DR PharmGKB; PA134937734; -.
DR eggNOG; NOG81568; -.
DR HOGENOM; HOG000033776; -.
DR HOVERGEN; HBG050447; -.
DR InParanoid; Q8N961; -.
DR KO; K10521; -.
DR OMA; FPWTEGD; -.
DR OrthoDB; EOG773XF8; -.
DR ChiTaRS; ABTB2; human.
DR GenomeRNAi; 25841; -.
DR NextBio; 13640301; -.
DR PRO; PR:Q8N961; -.
DR Bgee; Q8N961; -.
DR CleanEx; HS_ABTB2; -.
DR Genevestigator; Q8N961; -.
DR GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
DR Gene3D; 1.10.20.10; -; 2.
DR Gene3D; 1.25.40.20; -; 3.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR InterPro; IPR000210; BTB/POZ-like.
DR InterPro; IPR011333; BTB/POZ_fold.
DR InterPro; IPR013069; BTB_POZ.
DR InterPro; IPR009072; Histone-fold.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF47113; SSF47113; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Complete proteome; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 1025 Ankyrin repeat and BTB/POZ domain-
FT containing protein 2.
FT /FTId=PRO_0000066887.
FT REPEAT 521 550 ANK 1.
FT REPEAT 567 596 ANK 2.
FT REPEAT 606 635 ANK 3.
FT REPEAT 649 678 ANK 4.
FT DOMAIN 845 914 BTB.
FT VAR_SEQ 1 186 Missing (in isoform 2).
FT /FTId=VSP_046439.
FT VARIANT 250 250 H -> Q (in dbSNP:rs1925368).
FT /FTId=VAR_022087.
FT VARIANT 918 918 T -> A (in dbSNP:rs2473928).
FT /FTId=VAR_024171.
FT CONFLICT 189 189 A -> D (in Ref. 1; BAF84433).
SQ SEQUENCE 1025 AA; 113656 MW; E0DBA1B9BC0AFB82 CRC64;
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF
SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
EIRARVMASH SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR
AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH
GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA
MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIREEEYN
EELVTEGLQL MFDILKTSKN DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN
NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM
MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME SAVNTYKYAK
IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY
ITSRV
//
ID ABTB2_HUMAN Reviewed; 1025 AA.
AC Q8N961; A8K6S9; E9PRW7; Q52LD6; Q6MZW4; Q8NB44;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2013, sequence version 2.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 2;
GN Name=ABTB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP GLN-250.
RC TISSUE=Fetal brain, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2).
RC TISSUE=Rectum tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in the initiation of hepatocyte growth
CC (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N961-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N961-2; Sequence=VSP_046439;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 4 ANK repeats.
CC -!- SIMILARITY: Contains 1 BTB (POZ) domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH93968.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAC03697.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAF84433.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAF84433.1; Type=Erroneous termination; Positions=101; Note=Translated as Glu;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK091560; BAC03697.1; ALT_INIT; mRNA.
DR EMBL; AK095632; BAC04595.1; -; mRNA.
DR EMBL; AK291744; BAF84433.1; ALT_SEQ; mRNA.
DR EMBL; AC090469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093968; AAH93968.1; ALT_INIT; mRNA.
DR EMBL; BX640841; CAE45913.3; -; mRNA.
DR RefSeq; NP_665803.2; NM_145804.2.
DR UniGene; Hs.23361; -.
DR ProteinModelPortal; Q8N961; -.
DR SMR; Q8N961; 521-738, 841-944.
DR STRING; 9606.ENSP00000298992; -.
DR PhosphoSite; Q8N961; -.
DR DMDM; 61218305; -.
DR PaxDb; Q8N961; -.
DR PRIDE; Q8N961; -.
DR Ensembl; ENST00000298992; ENSP00000298992; ENSG00000166016.
DR Ensembl; ENST00000435224; ENSP00000410157; ENSG00000166016.
DR GeneID; 25841; -.
DR KEGG; hsa:25841; -.
DR UCSC; uc001mvl.2; human.
DR CTD; 25841; -.
DR GeneCards; GC11M034129; -.
DR H-InvDB; HIX0009548; -.
DR HGNC; HGNC:23842; ABTB2.
DR HPA; HPA020065; -.
DR neXtProt; NX_Q8N961; -.
DR PharmGKB; PA134937734; -.
DR eggNOG; NOG81568; -.
DR HOGENOM; HOG000033776; -.
DR HOVERGEN; HBG050447; -.
DR InParanoid; Q8N961; -.
DR KO; K10521; -.
DR OMA; FPWTEGD; -.
DR OrthoDB; EOG773XF8; -.
DR ChiTaRS; ABTB2; human.
DR GenomeRNAi; 25841; -.
DR NextBio; 13640301; -.
DR PRO; PR:Q8N961; -.
DR Bgee; Q8N961; -.
DR CleanEx; HS_ABTB2; -.
DR Genevestigator; Q8N961; -.
DR GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
DR Gene3D; 1.10.20.10; -; 2.
DR Gene3D; 1.25.40.20; -; 3.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR InterPro; IPR000210; BTB/POZ-like.
DR InterPro; IPR011333; BTB/POZ_fold.
DR InterPro; IPR013069; BTB_POZ.
DR InterPro; IPR009072; Histone-fold.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF47113; SSF47113; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Complete proteome; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 1025 Ankyrin repeat and BTB/POZ domain-
FT containing protein 2.
FT /FTId=PRO_0000066887.
FT REPEAT 521 550 ANK 1.
FT REPEAT 567 596 ANK 2.
FT REPEAT 606 635 ANK 3.
FT REPEAT 649 678 ANK 4.
FT DOMAIN 845 914 BTB.
FT VAR_SEQ 1 186 Missing (in isoform 2).
FT /FTId=VSP_046439.
FT VARIANT 250 250 H -> Q (in dbSNP:rs1925368).
FT /FTId=VAR_022087.
FT VARIANT 918 918 T -> A (in dbSNP:rs2473928).
FT /FTId=VAR_024171.
FT CONFLICT 189 189 A -> D (in Ref. 1; BAF84433).
SQ SEQUENCE 1025 AA; 113656 MW; E0DBA1B9BC0AFB82 CRC64;
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF
SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
EIRARVMASH SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR
AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH
GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA
MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIREEEYN
EELVTEGLQL MFDILKTSKN DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN
NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM
MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME SAVNTYKYAK
IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY
ITSRV
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