Full text data of ACRC
ACRC
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Acidic repeat-containing protein
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Acidic repeat-containing protein
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00289929
IPI00289929 Hypothetical protein Hypothetical protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a nucleus n/a expected molecular weight found in band > 188 kDa together with ubiquitin
IPI00289929 Hypothetical protein Hypothetical protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a nucleus n/a expected molecular weight found in band > 188 kDa together with ubiquitin
UniProt
Q96QF7
ID ACRC_HUMAN Reviewed; 691 AA.
AC Q96QF7; B9EG62;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=Acidic repeat-containing protein;
GN Name=ACRC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=11714101;
RA Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U.;
RT "ACRC codes for a novel nuclear protein with unusual acidic repeat
RT tract and maps to DYT3 (dystonia parkinsonism) critical interval in
RT xq13.1.";
RL Neurogenetics 3:207-213(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- TISSUE SPECIFICITY: Detected in skeletal muscle, liver, kidney,
CC pancreas, heart, lung and brain.
CC -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing
CC protein (SDr) family.
CC -!- SIMILARITY: Contains 1 SprT-like domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ311392; CAC60255.1; -; mRNA.
DR EMBL; AK097433; BAC05051.1; -; mRNA.
DR EMBL; BC136259; AAI36260.1; -; mRNA.
DR RefSeq; NP_443189.1; NM_052957.4.
DR UniGene; Hs.135167; -.
DR ProteinModelPortal; Q96QF7; -.
DR IntAct; Q96QF7; 1.
DR PhosphoSite; Q96QF7; -.
DR DMDM; 74732669; -.
DR PaxDb; Q96QF7; -.
DR PRIDE; Q96QF7; -.
DR Ensembl; ENST00000373695; ENSP00000362799; ENSG00000147174.
DR Ensembl; ENST00000373696; ENSP00000362800; ENSG00000147174.
DR GeneID; 93953; -.
DR KEGG; hsa:93953; -.
DR UCSC; uc004eae.2; human.
DR CTD; 93953; -.
DR GeneCards; GC0XP070797; -.
DR HGNC; HGNC:15805; ACRC.
DR HPA; HPA023476; -.
DR MIM; 300369; gene.
DR neXtProt; NX_Q96QF7; -.
DR PharmGKB; PA24453; -.
DR eggNOG; NOG302054; -.
DR HOGENOM; HOG000033791; -.
DR HOVERGEN; HBG102033; -.
DR InParanoid; Q96QF7; -.
DR OMA; TISNWAQ; -.
DR OrthoDB; EOG75J0M8; -.
DR GeneWiki; Acidic_repeat-containing_protein; -.
DR GenomeRNAi; 93953; -.
DR NextBio; 78222; -.
DR PRO; PR:Q96QF7; -.
DR Bgee; Q96QF7; -.
DR CleanEx; HS_ACRC; -.
DR Genevestigator; Q96QF7; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR006640; SprT-like_domain.
DR Pfam; PF10263; SprT-like; 1.
DR SMART; SM00731; SprT; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Nucleus; Polymorphism; Reference proteome.
FT CHAIN 1 691 Acidic repeat-containing protein.
FT /FTId=PRO_0000317387.
FT DOMAIN 522 677 SprT-like.
FT COMPBIAS 125 331 Asp/Ser-rich.
FT COMPBIAS 412 518 Arg/Lys/Pro-rich.
FT VARIANT 471 471 R -> H (in dbSNP:rs10217999).
FT /FTId=VAR_050634.
FT VARIANT 662 662 T -> I (in dbSNP:rs2280962).
FT /FTId=VAR_038520.
SQ SEQUENCE 691 AA; 76112 MW; F6B63CBF9A7CE1EA CRC64;
MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL NVQSRSGDTS
GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI NSDDESPECC HVKPAIQEPP
IVISDDDNDD DNGNDLEVPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD
DNSDDSDVPD DNSDDSSDDN SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD
DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD
DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD EEELVEAAAA
VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE EEPAPVVEQS GKRKSKTKTI
VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA
AKVEKRKTRT PKCKVPGCFL QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE
KLRIGWNNKM VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW
LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK TRIGCYTKSL
DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V
//
ID ACRC_HUMAN Reviewed; 691 AA.
AC Q96QF7; B9EG62;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=Acidic repeat-containing protein;
GN Name=ACRC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=11714101;
RA Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U.;
RT "ACRC codes for a novel nuclear protein with unusual acidic repeat
RT tract and maps to DYT3 (dystonia parkinsonism) critical interval in
RT xq13.1.";
RL Neurogenetics 3:207-213(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- TISSUE SPECIFICITY: Detected in skeletal muscle, liver, kidney,
CC pancreas, heart, lung and brain.
CC -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing
CC protein (SDr) family.
CC -!- SIMILARITY: Contains 1 SprT-like domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ311392; CAC60255.1; -; mRNA.
DR EMBL; AK097433; BAC05051.1; -; mRNA.
DR EMBL; BC136259; AAI36260.1; -; mRNA.
DR RefSeq; NP_443189.1; NM_052957.4.
DR UniGene; Hs.135167; -.
DR ProteinModelPortal; Q96QF7; -.
DR IntAct; Q96QF7; 1.
DR PhosphoSite; Q96QF7; -.
DR DMDM; 74732669; -.
DR PaxDb; Q96QF7; -.
DR PRIDE; Q96QF7; -.
DR Ensembl; ENST00000373695; ENSP00000362799; ENSG00000147174.
DR Ensembl; ENST00000373696; ENSP00000362800; ENSG00000147174.
DR GeneID; 93953; -.
DR KEGG; hsa:93953; -.
DR UCSC; uc004eae.2; human.
DR CTD; 93953; -.
DR GeneCards; GC0XP070797; -.
DR HGNC; HGNC:15805; ACRC.
DR HPA; HPA023476; -.
DR MIM; 300369; gene.
DR neXtProt; NX_Q96QF7; -.
DR PharmGKB; PA24453; -.
DR eggNOG; NOG302054; -.
DR HOGENOM; HOG000033791; -.
DR HOVERGEN; HBG102033; -.
DR InParanoid; Q96QF7; -.
DR OMA; TISNWAQ; -.
DR OrthoDB; EOG75J0M8; -.
DR GeneWiki; Acidic_repeat-containing_protein; -.
DR GenomeRNAi; 93953; -.
DR NextBio; 78222; -.
DR PRO; PR:Q96QF7; -.
DR Bgee; Q96QF7; -.
DR CleanEx; HS_ACRC; -.
DR Genevestigator; Q96QF7; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR006640; SprT-like_domain.
DR Pfam; PF10263; SprT-like; 1.
DR SMART; SM00731; SprT; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Nucleus; Polymorphism; Reference proteome.
FT CHAIN 1 691 Acidic repeat-containing protein.
FT /FTId=PRO_0000317387.
FT DOMAIN 522 677 SprT-like.
FT COMPBIAS 125 331 Asp/Ser-rich.
FT COMPBIAS 412 518 Arg/Lys/Pro-rich.
FT VARIANT 471 471 R -> H (in dbSNP:rs10217999).
FT /FTId=VAR_050634.
FT VARIANT 662 662 T -> I (in dbSNP:rs2280962).
FT /FTId=VAR_038520.
SQ SEQUENCE 691 AA; 76112 MW; F6B63CBF9A7CE1EA CRC64;
MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL NVQSRSGDTS
GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI NSDDESPECC HVKPAIQEPP
IVISDDDNDD DNGNDLEVPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD
DNSDDSDVPD DNSDDSSDDN SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD
DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD
DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD EEELVEAAAA
VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE EEPAPVVEQS GKRKSKTKTI
VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA
AKVEKRKTRT PKCKVPGCFL QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE
KLRIGWNNKM VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW
LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK TRIGCYTKSL
DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V
//
MIM
300369
*RECORD*
*FIELD* NO
300369
*FIELD* TI
*300369 ACIDIC REPEAT-CONTAINING GENE; ACRC
*FIELD* TX
CLONING
By a combination of in silico and 'wet' experiments, Nolte et al. (2001)
read moreidentified a novel gene, designated ACRC, within the DYT3 (314250)
critical region on Xq13.1. They cloned an ACRC cDNA from a fetal brain
cDNA library. ACRC encodes a predicted acidic nuclear protein of 691
amino acids with a characteristic repeat of 21 units of 8 to 10 amino
acids. The protein contains several potential nuclear localization
signals in the C terminus as well as putative N-glycosylation and
phosphorylation sites. Northern blot analysis detected expression of a
3.2-kb ACRC transcript in all tissues tested, with highest expression in
skeletal muscle.
GENE FUNCTION
Based on its deduced nuclear localization and the deduced nature of the
polypeptide, Nolte et al. (2001) suggested that the ACRC gene may play a
role in chromatin structure.
Nolte et al. (2001) found no mutations in the transcribed portion of the
ACRC gene in patients with X-linked dystonia-parkinsonism (314250).
GENE STRUCTURE
Nolte et al. (2001) determined that the ACRC gene contains at least 12
exons and spans 35.5 kb.
MAPPING
By sequence analysis, Nolte et al. (2001) identified the ACRC gene on
chromosome Xq13.1 within the DYT3 critical region.
*FIELD* RF
1. Nolte, D.; Ramser, J.; Niemann, S.; Lehrach, H.; Sudbrak, R.; Muller,
U.: ACRC codes for a novel nuclear protein with unusual acidic repeat
tract and maps to DYT3 (dystonia parkinsonism) critical interval in
Xq13.1. Neurogenetics 3: 207-213, 2001.
*FIELD* CD
Victor A. McKusick: 12/27/2001
*FIELD* ED
carol: 12/27/2001
*RECORD*
*FIELD* NO
300369
*FIELD* TI
*300369 ACIDIC REPEAT-CONTAINING GENE; ACRC
*FIELD* TX
CLONING
By a combination of in silico and 'wet' experiments, Nolte et al. (2001)
read moreidentified a novel gene, designated ACRC, within the DYT3 (314250)
critical region on Xq13.1. They cloned an ACRC cDNA from a fetal brain
cDNA library. ACRC encodes a predicted acidic nuclear protein of 691
amino acids with a characteristic repeat of 21 units of 8 to 10 amino
acids. The protein contains several potential nuclear localization
signals in the C terminus as well as putative N-glycosylation and
phosphorylation sites. Northern blot analysis detected expression of a
3.2-kb ACRC transcript in all tissues tested, with highest expression in
skeletal muscle.
GENE FUNCTION
Based on its deduced nuclear localization and the deduced nature of the
polypeptide, Nolte et al. (2001) suggested that the ACRC gene may play a
role in chromatin structure.
Nolte et al. (2001) found no mutations in the transcribed portion of the
ACRC gene in patients with X-linked dystonia-parkinsonism (314250).
GENE STRUCTURE
Nolte et al. (2001) determined that the ACRC gene contains at least 12
exons and spans 35.5 kb.
MAPPING
By sequence analysis, Nolte et al. (2001) identified the ACRC gene on
chromosome Xq13.1 within the DYT3 critical region.
*FIELD* RF
1. Nolte, D.; Ramser, J.; Niemann, S.; Lehrach, H.; Sudbrak, R.; Muller,
U.: ACRC codes for a novel nuclear protein with unusual acidic repeat
tract and maps to DYT3 (dystonia parkinsonism) critical interval in
Xq13.1. Neurogenetics 3: 207-213, 2001.
*FIELD* CD
Victor A. McKusick: 12/27/2001
*FIELD* ED
carol: 12/27/2001