Full text data of SLC25A6
SLC25A6
(ANT3)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
ADP/ATP translocase 3 (ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6)
ADP/ATP translocase 3 (ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6)
UniProt
P12236
ID ADT3_HUMAN Reviewed; 298 AA.
AC P12236; Q96C49;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 4.
DT 22-JAN-2014, entry version 162.
DE RecName: Full=ADP/ATP translocase 3;
DE AltName: Full=ADP,ATP carrier protein 3;
DE AltName: Full=ADP,ATP carrier protein, isoform T2;
DE Short=ANT 2;
DE AltName: Full=Adenine nucleotide translocator 3;
DE Short=ANT 3;
DE AltName: Full=Solute carrier family 25 member 6;
GN Name=SLC25A6; Synonyms=ANT3; ORFNames=CDABP0051;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2541251; DOI=10.1016/0022-2836(89)90477-4;
RA Cozens A.L., Runswick M.J., Walker J.E.;
RT "DNA sequences of two expressed nuclear genes for human mitochondrial
RT ADP/ATP translocase.";
RL J. Mol. Biol. 206:261-280(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-242.
RC TISSUE=Leukemia;
RA Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A.,
RA Margolin J.F.;
RT "Pediatric leukemia cDNA sequencing project.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Cervix, Eye, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 2-10, ACETYLATION AT THR-2, AND MASS SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUL-2004) to UniProtKB.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 36-298.
RC TISSUE=Liver;
RX PubMed=2829183; DOI=10.1073/pnas.85.2.377;
RA Houldsworth J., Attardi G.;
RT "Two distinct genes for ADP/ATP translocase are expressed at the mRNA
RT level in adult human liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1988).
RN [6]
RP FUNCTION IN APOPTOSIS.
RX PubMed=15033708; DOI=10.1196/annals.1299.022;
RA Verrier F., Mignotte B., Jan G., Brenner C.;
RT "Study of PTPC composition during apoptosis for identification of
RT viral protein target.";
RL Ann. N. Y. Acad. Sci. 1010:126-142(2003).
RN [7]
RP INTERACTION WITH HIV-1 VPR.
RX PubMed=16120388; DOI=10.1016/j.mito.2004.06.012;
RA Deniaud A., Brenner C., Kroemer G.;
RT "Mitochondrial membrane permeabilization by HIV-1 Vpr.";
RL Mitochondrion 4:223-233(2004).
RN [8]
RP INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
RX PubMed=16201016; DOI=10.1371/journal.ppat.0010004;
RA Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.;
RT "Influenza virus PB1-F2 protein induces cell death through
RT mitochondrial ANT3 and VDAC1.";
RL PLoS Pathog. 1:40-54(2005).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105 AND LYS-268, AND MASS
RP SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Catalyzes the exchange of cytoplasmic ADP with
CC mitochondrial ATP across the mitochondrial inner membrane. May
CC participate in the formation of the permeability transition pore
CC complex (PTPC) responsible for the release of mitochondrial
CC products that triggers apoptosis.
CC -!- SUBUNIT: Found in a complex with ARL2, ARL2BP and SLC25A6 (By
CC similarity). Homodimer. Interacts with influenza A virus PB1-F2
CC protein and HIV-1 Vpr.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein. Note=The complex formed with ARL2BP, ARL2 and
CC SLC25A6 is expressed in mitochondria (By similarity).
CC -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to
CC the plane of the membrane, but cross the membrane at an angle.
CC Odd-numbered transmembrane helices exhibit a sharp kink, due to
CC the presence of a conserved proline residue (By similarity).
CC -!- MISCELLANEOUS: The gene coding for this protein is located in the
CC pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
CC family.
CC -!- SIMILARITY: Contains 3 Solcar repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY007135; AAG01998.1; -; mRNA.
DR EMBL; BC007295; AAH07295.1; -; mRNA.
DR EMBL; BC007850; AAH07850.1; -; mRNA.
DR EMBL; BC008737; AAH08737.1; -; mRNA.
DR EMBL; BC008935; AAH08935.1; -; mRNA.
DR EMBL; BC014775; AAH14775.1; -; mRNA.
DR EMBL; BC031912; AAH31912.1; -; mRNA.
DR EMBL; J03592; AAA36750.1; -; mRNA.
DR PIR; S03894; S03894.
DR RefSeq; NP_001627.2; NM_001636.3.
DR UniGene; Hs.350927; -.
DR ProteinModelPortal; P12236; -.
DR SMR; P12236; 2-294.
DR IntAct; P12236; 42.
DR MINT; MINT-1154461; -.
DR STRING; 9606.ENSP00000370808; -.
DR DrugBank; DB00720; Clodronate.
DR TCDB; 2.A.29.1.10; the mitochondrial carrier (mc) family.
DR PhosphoSite; P12236; -.
DR DMDM; 113463; -.
DR PaxDb; P12236; -.
DR PeptideAtlas; P12236; -.
DR PRIDE; P12236; -.
DR DNASU; 293; -.
DR Ensembl; ENST00000381401; ENSP00000370808; ENSG00000169100.
DR GeneID; 293; -.
DR KEGG; hsa:293; -.
DR UCSC; uc004cpt.3; human.
DR CTD; 293; -.
DR GeneCards; GC0XM001505; -.
DR H-InvDB; HIX0034763; -.
DR HGNC; HGNC:10992; SLC25A6.
DR MIM; 300151; gene.
DR MIM; 403000; gene.
DR neXtProt; NX_P12236; -.
DR PharmGKB; PA35868; -.
DR eggNOG; NOG238123; -.
DR HOVERGEN; HBG108348; -.
DR InParanoid; P12236; -.
DR KO; K05863; -.
DR OMA; CWRKIFK; -.
DR OrthoDB; EOG7T1RBR; -.
DR PhylomeDB; P12236; -.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR GeneWiki; SLC25A6; -.
DR GenomeRNAi; 293; -.
DR NextBio; 1195; -.
DR PRO; PR:P12236; -.
DR ArrayExpress; P12236; -.
DR Bgee; P12236; -.
DR CleanEx; HS_SLC25A6; -.
DR Genevestigator; P12236; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005744; C:mitochondrial inner membrane presequence translocase complex; TAS:UniProtKB.
DR GO; GO:0005471; F:ATP:ADP antiporter activity; NAS:UniProtKB.
DR GO; GO:0046732; P:active induction of host immune response by virus; TAS:Reactome.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
DR GO; GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
DR GO; GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome.
DR GO; GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0019058; P:viral life cycle; TAS:Reactome.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002113; Aden_trnslctor.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00927; ADPTRNSLCASE.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Acetylation; Apoptosis; Complete proteome; Direct protein sequencing;
KW Host-virus interaction; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Polymorphism; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 298 ADP/ATP translocase 3.
FT /FTId=PRO_0000090584.
FT TRANSMEM 5 39 Helical; Name=1; (By similarity).
FT TRANSMEM 75 100 Helical; Name=2; (By similarity).
FT TRANSMEM 109 143 Helical; Name=3; (By similarity).
FT TRANSMEM 176 202 Helical; Name=4; (By similarity).
FT TRANSMEM 207 241 Helical; Name=5; (By similarity).
FT TRANSMEM 273 298 Helical; Name=6; (By similarity).
FT REPEAT 6 98 Solcar 1.
FT REPEAT 111 201 Solcar 2.
FT REPEAT 212 297 Solcar 3.
FT MOTIF 235 240 Substrate recognition (By similarity).
FT BINDING 80 80 Nucleotide (By similarity).
FT MOD_RES 2 2 N-acetylthreonine.
FT MOD_RES 105 105 N6-acetyllysine.
FT MOD_RES 268 268 N6-acetyllysine.
FT VARIANT 242 242 S -> F (in dbSNP:rs17851235).
FT /FTId=VAR_054819.
FT CONFLICT 105 108 KHTQ -> RHA (in Ref. 5; AAA36750).
SQ SEQUENCE 298 AA; 32866 MW; 18534E9F0E49672F CRC64;
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR
IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG
GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS
VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM
QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
//
ID ADT3_HUMAN Reviewed; 298 AA.
AC P12236; Q96C49;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 4.
DT 22-JAN-2014, entry version 162.
DE RecName: Full=ADP/ATP translocase 3;
DE AltName: Full=ADP,ATP carrier protein 3;
DE AltName: Full=ADP,ATP carrier protein, isoform T2;
DE Short=ANT 2;
DE AltName: Full=Adenine nucleotide translocator 3;
DE Short=ANT 3;
DE AltName: Full=Solute carrier family 25 member 6;
GN Name=SLC25A6; Synonyms=ANT3; ORFNames=CDABP0051;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2541251; DOI=10.1016/0022-2836(89)90477-4;
RA Cozens A.L., Runswick M.J., Walker J.E.;
RT "DNA sequences of two expressed nuclear genes for human mitochondrial
RT ADP/ATP translocase.";
RL J. Mol. Biol. 206:261-280(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-242.
RC TISSUE=Leukemia;
RA Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A.,
RA Margolin J.F.;
RT "Pediatric leukemia cDNA sequencing project.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Cervix, Eye, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 2-10, ACETYLATION AT THR-2, AND MASS SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUL-2004) to UniProtKB.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 36-298.
RC TISSUE=Liver;
RX PubMed=2829183; DOI=10.1073/pnas.85.2.377;
RA Houldsworth J., Attardi G.;
RT "Two distinct genes for ADP/ATP translocase are expressed at the mRNA
RT level in adult human liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1988).
RN [6]
RP FUNCTION IN APOPTOSIS.
RX PubMed=15033708; DOI=10.1196/annals.1299.022;
RA Verrier F., Mignotte B., Jan G., Brenner C.;
RT "Study of PTPC composition during apoptosis for identification of
RT viral protein target.";
RL Ann. N. Y. Acad. Sci. 1010:126-142(2003).
RN [7]
RP INTERACTION WITH HIV-1 VPR.
RX PubMed=16120388; DOI=10.1016/j.mito.2004.06.012;
RA Deniaud A., Brenner C., Kroemer G.;
RT "Mitochondrial membrane permeabilization by HIV-1 Vpr.";
RL Mitochondrion 4:223-233(2004).
RN [8]
RP INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
RX PubMed=16201016; DOI=10.1371/journal.ppat.0010004;
RA Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.;
RT "Influenza virus PB1-F2 protein induces cell death through
RT mitochondrial ANT3 and VDAC1.";
RL PLoS Pathog. 1:40-54(2005).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105 AND LYS-268, AND MASS
RP SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Catalyzes the exchange of cytoplasmic ADP with
CC mitochondrial ATP across the mitochondrial inner membrane. May
CC participate in the formation of the permeability transition pore
CC complex (PTPC) responsible for the release of mitochondrial
CC products that triggers apoptosis.
CC -!- SUBUNIT: Found in a complex with ARL2, ARL2BP and SLC25A6 (By
CC similarity). Homodimer. Interacts with influenza A virus PB1-F2
CC protein and HIV-1 Vpr.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein. Note=The complex formed with ARL2BP, ARL2 and
CC SLC25A6 is expressed in mitochondria (By similarity).
CC -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to
CC the plane of the membrane, but cross the membrane at an angle.
CC Odd-numbered transmembrane helices exhibit a sharp kink, due to
CC the presence of a conserved proline residue (By similarity).
CC -!- MISCELLANEOUS: The gene coding for this protein is located in the
CC pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
CC family.
CC -!- SIMILARITY: Contains 3 Solcar repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY007135; AAG01998.1; -; mRNA.
DR EMBL; BC007295; AAH07295.1; -; mRNA.
DR EMBL; BC007850; AAH07850.1; -; mRNA.
DR EMBL; BC008737; AAH08737.1; -; mRNA.
DR EMBL; BC008935; AAH08935.1; -; mRNA.
DR EMBL; BC014775; AAH14775.1; -; mRNA.
DR EMBL; BC031912; AAH31912.1; -; mRNA.
DR EMBL; J03592; AAA36750.1; -; mRNA.
DR PIR; S03894; S03894.
DR RefSeq; NP_001627.2; NM_001636.3.
DR UniGene; Hs.350927; -.
DR ProteinModelPortal; P12236; -.
DR SMR; P12236; 2-294.
DR IntAct; P12236; 42.
DR MINT; MINT-1154461; -.
DR STRING; 9606.ENSP00000370808; -.
DR DrugBank; DB00720; Clodronate.
DR TCDB; 2.A.29.1.10; the mitochondrial carrier (mc) family.
DR PhosphoSite; P12236; -.
DR DMDM; 113463; -.
DR PaxDb; P12236; -.
DR PeptideAtlas; P12236; -.
DR PRIDE; P12236; -.
DR DNASU; 293; -.
DR Ensembl; ENST00000381401; ENSP00000370808; ENSG00000169100.
DR GeneID; 293; -.
DR KEGG; hsa:293; -.
DR UCSC; uc004cpt.3; human.
DR CTD; 293; -.
DR GeneCards; GC0XM001505; -.
DR H-InvDB; HIX0034763; -.
DR HGNC; HGNC:10992; SLC25A6.
DR MIM; 300151; gene.
DR MIM; 403000; gene.
DR neXtProt; NX_P12236; -.
DR PharmGKB; PA35868; -.
DR eggNOG; NOG238123; -.
DR HOVERGEN; HBG108348; -.
DR InParanoid; P12236; -.
DR KO; K05863; -.
DR OMA; CWRKIFK; -.
DR OrthoDB; EOG7T1RBR; -.
DR PhylomeDB; P12236; -.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR GeneWiki; SLC25A6; -.
DR GenomeRNAi; 293; -.
DR NextBio; 1195; -.
DR PRO; PR:P12236; -.
DR ArrayExpress; P12236; -.
DR Bgee; P12236; -.
DR CleanEx; HS_SLC25A6; -.
DR Genevestigator; P12236; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005744; C:mitochondrial inner membrane presequence translocase complex; TAS:UniProtKB.
DR GO; GO:0005471; F:ATP:ADP antiporter activity; NAS:UniProtKB.
DR GO; GO:0046732; P:active induction of host immune response by virus; TAS:Reactome.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
DR GO; GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
DR GO; GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome.
DR GO; GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0019058; P:viral life cycle; TAS:Reactome.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002113; Aden_trnslctor.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00927; ADPTRNSLCASE.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Acetylation; Apoptosis; Complete proteome; Direct protein sequencing;
KW Host-virus interaction; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Polymorphism; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 298 ADP/ATP translocase 3.
FT /FTId=PRO_0000090584.
FT TRANSMEM 5 39 Helical; Name=1; (By similarity).
FT TRANSMEM 75 100 Helical; Name=2; (By similarity).
FT TRANSMEM 109 143 Helical; Name=3; (By similarity).
FT TRANSMEM 176 202 Helical; Name=4; (By similarity).
FT TRANSMEM 207 241 Helical; Name=5; (By similarity).
FT TRANSMEM 273 298 Helical; Name=6; (By similarity).
FT REPEAT 6 98 Solcar 1.
FT REPEAT 111 201 Solcar 2.
FT REPEAT 212 297 Solcar 3.
FT MOTIF 235 240 Substrate recognition (By similarity).
FT BINDING 80 80 Nucleotide (By similarity).
FT MOD_RES 2 2 N-acetylthreonine.
FT MOD_RES 105 105 N6-acetyllysine.
FT MOD_RES 268 268 N6-acetyllysine.
FT VARIANT 242 242 S -> F (in dbSNP:rs17851235).
FT /FTId=VAR_054819.
FT CONFLICT 105 108 KHTQ -> RHA (in Ref. 5; AAA36750).
SQ SEQUENCE 298 AA; 32866 MW; 18534E9F0E49672F CRC64;
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR
IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG
GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS
VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM
QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
//
MIM
300151
*RECORD*
*FIELD* NO
300151
*FIELD* TI
*300151 SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, ADENINE NUCLEOTIDE
TRANSLOCATOR), MEMBER A6; SLC25A6
read more;;ADENINE NUCLEOTIDE TRANSLOCATOR 3; ANT3;;
ADP/ATP TRANSLOCATOR OF LIVER;;
ADP/ATP TRANSLOCASE 3;;
ADP/ATP CARRIER 3; AAC3
*FIELD* TX
The gene encoding adenine nucleotide translocator-3 is located in the
pseudoautosomal region (PAR) at the end of the short arm of the X and Y
chromosomes. See also 403000.
Schiebel et al. (1993) cloned a highly conserved pseudoautosomal gene by
selecting a cDNA clone with a microdissected clone from chromosomal
subregion Xp22.3. They found that it encodes a previously characterized
member of the ADP/ATP translocase family and plays a fundamental role in
cellular energy metabolism. Designated ANT3, the gene is located
approximately 1,300 kb from the telomere, proximal to the
pseudoautosomal gene CSF2RA (306250), and escapes X-inactivation. A
homolog of ANT3, ANT2 (300150), maps to Xq13-q26 and is subject to X
inactivation. The physical location of the ANT3 gene was determined by
pulsed field mapping. From the location of a CpG island, they determined
the orientation of the gene to be from centromere toward the telomere.
It is probably directly adjacent to CSF2RA. All pseudogenes of the ANT
gene family seem to lack introns. Schiebel et al. (1993) identified an
intronless ANT3 pseudogene on chromosome 9. The ANT3 gene had previously
been characterized by Houldsworth and Attardi (1988) and by Cozens et
al. (1989). Slim et al. (1993) identified the ANT3 gene in a clone
microdissected from Xp22.3. It contained in its first intron a CpG
island mapped 13,000 kb from the telomere. They showed that the gene is
transcribed from the Y chromosome and from both the active and inactive
X chromosomes.
Comparative in situ hybridization in various primate species revealed a
pseudoautosomal location for the ANT3 gene and an X-specific location
for the steroid sulfatase gene (STS; 300747) throughout the higher
primate species up to the New World monkeys. However, Toder et al.
(1995) found that ANT3 and STS map together on an autosome of 2
prosimian species of the genera Lemur and Eulemur. These results
suggested an autosomal-to-X/Y translocation after the simians radiated
from the prosimians, resulting in a pseudoautosomal location of genes
such as ANT3 and STS. In simian primates, STS then became X-specific by
a pericentric inversion in the Y chromosome followed by mutational
inactivation of the Y allele.
*FIELD* RF
1. Cozens, A. L.; Runswick, M. J.; Walker, J. E.: DNA sequences of
two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J.
Molec. Biol. 206: 261-280, 1989.
2. Houldsworth, J.; Attardi, G.: Two distinct genes for ADP/ATP translocase
are expressed at the mRNA level in adult human liver. Proc. Nat.
Acad. Sci. 85: 377-381, 1988.
3. Schiebel, K.; Weiss, B.; Wohrle, D.; Rappold, G.: A human pseudoautosomal
gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue
on Xq is subject to X-inactivation. Nature Genet. 3: 82-87, 1993.
4. Slim, R.; Levilliers, J.; Ludecke, H.-J.; Claussen, U.; Nguyen,
V. C.; Gough, N. M.; Horsthemke, B.; Petit, C.: A human pseudoautosomal
gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. Genomics 16:
26-33, 1993.
5. Toder, R.; Rappold, G. A.; Schiebel, K.; Schempp, W.: ANT3 and
STS are autosomal in prosimian lemurs: implications for the evolution
of the pseudoautosomal region. Hum. Genet. 95: 22-28, 1995.
*FIELD* CD
Victor A. McKusick: 1/26/1993
*FIELD* ED
carol: 10/31/2008
mgross: 2/22/2007
terry: 3/28/2002
carol: 3/7/2000
mark: 7/7/1997
carol: 2/1/1995
terry: 4/21/1994
mimadm: 2/27/1994
carol: 5/4/1993
carol: 1/26/1993
*RECORD*
*FIELD* NO
300151
*FIELD* TI
*300151 SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, ADENINE NUCLEOTIDE
TRANSLOCATOR), MEMBER A6; SLC25A6
read more;;ADENINE NUCLEOTIDE TRANSLOCATOR 3; ANT3;;
ADP/ATP TRANSLOCATOR OF LIVER;;
ADP/ATP TRANSLOCASE 3;;
ADP/ATP CARRIER 3; AAC3
*FIELD* TX
The gene encoding adenine nucleotide translocator-3 is located in the
pseudoautosomal region (PAR) at the end of the short arm of the X and Y
chromosomes. See also 403000.
Schiebel et al. (1993) cloned a highly conserved pseudoautosomal gene by
selecting a cDNA clone with a microdissected clone from chromosomal
subregion Xp22.3. They found that it encodes a previously characterized
member of the ADP/ATP translocase family and plays a fundamental role in
cellular energy metabolism. Designated ANT3, the gene is located
approximately 1,300 kb from the telomere, proximal to the
pseudoautosomal gene CSF2RA (306250), and escapes X-inactivation. A
homolog of ANT3, ANT2 (300150), maps to Xq13-q26 and is subject to X
inactivation. The physical location of the ANT3 gene was determined by
pulsed field mapping. From the location of a CpG island, they determined
the orientation of the gene to be from centromere toward the telomere.
It is probably directly adjacent to CSF2RA. All pseudogenes of the ANT
gene family seem to lack introns. Schiebel et al. (1993) identified an
intronless ANT3 pseudogene on chromosome 9. The ANT3 gene had previously
been characterized by Houldsworth and Attardi (1988) and by Cozens et
al. (1989). Slim et al. (1993) identified the ANT3 gene in a clone
microdissected from Xp22.3. It contained in its first intron a CpG
island mapped 13,000 kb from the telomere. They showed that the gene is
transcribed from the Y chromosome and from both the active and inactive
X chromosomes.
Comparative in situ hybridization in various primate species revealed a
pseudoautosomal location for the ANT3 gene and an X-specific location
for the steroid sulfatase gene (STS; 300747) throughout the higher
primate species up to the New World monkeys. However, Toder et al.
(1995) found that ANT3 and STS map together on an autosome of 2
prosimian species of the genera Lemur and Eulemur. These results
suggested an autosomal-to-X/Y translocation after the simians radiated
from the prosimians, resulting in a pseudoautosomal location of genes
such as ANT3 and STS. In simian primates, STS then became X-specific by
a pericentric inversion in the Y chromosome followed by mutational
inactivation of the Y allele.
*FIELD* RF
1. Cozens, A. L.; Runswick, M. J.; Walker, J. E.: DNA sequences of
two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J.
Molec. Biol. 206: 261-280, 1989.
2. Houldsworth, J.; Attardi, G.: Two distinct genes for ADP/ATP translocase
are expressed at the mRNA level in adult human liver. Proc. Nat.
Acad. Sci. 85: 377-381, 1988.
3. Schiebel, K.; Weiss, B.; Wohrle, D.; Rappold, G.: A human pseudoautosomal
gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue
on Xq is subject to X-inactivation. Nature Genet. 3: 82-87, 1993.
4. Slim, R.; Levilliers, J.; Ludecke, H.-J.; Claussen, U.; Nguyen,
V. C.; Gough, N. M.; Horsthemke, B.; Petit, C.: A human pseudoautosomal
gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. Genomics 16:
26-33, 1993.
5. Toder, R.; Rappold, G. A.; Schiebel, K.; Schempp, W.: ANT3 and
STS are autosomal in prosimian lemurs: implications for the evolution
of the pseudoautosomal region. Hum. Genet. 95: 22-28, 1995.
*FIELD* CD
Victor A. McKusick: 1/26/1993
*FIELD* ED
carol: 10/31/2008
mgross: 2/22/2007
terry: 3/28/2002
carol: 3/7/2000
mark: 7/7/1997
carol: 2/1/1995
terry: 4/21/1994
mimadm: 2/27/1994
carol: 5/4/1993
carol: 1/26/1993
MIM
403000
*RECORD*
*FIELD* NO
403000
*FIELD* TI
*403000 ADENINE NUCLEOTIDE TRANSLOCATOR 3, Y-CHROMOSOMAL; ANT3Y
*FIELD* TX
The ADP/ATP translocase gene (ANT3) is located on the pseudoautosomal
read moreregion of the X and Y chromosomes, escapes X inactivation, and is
transcribed from the Y chromosome and from both the active and the
inactive X chromosome. See 300151 and Slim et al. (1993).
*FIELD* RF
1. Slim, R.; Levilliers, J.; Ludecke, H.-J.; Claussen, U.; Nguyen,
V. C.; Gough, N. M.; Horsthemke, B.; Petit, C.: A human pseudoautosomal
gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. Genomics 16:
26-33, 1993.
*FIELD* CD
Victor A. McKusick: 5/4/1993
*FIELD* ED
mark: 07/07/1997
mimadm: 3/11/1994
carol: 5/4/1993
*RECORD*
*FIELD* NO
403000
*FIELD* TI
*403000 ADENINE NUCLEOTIDE TRANSLOCATOR 3, Y-CHROMOSOMAL; ANT3Y
*FIELD* TX
The ADP/ATP translocase gene (ANT3) is located on the pseudoautosomal
read moreregion of the X and Y chromosomes, escapes X inactivation, and is
transcribed from the Y chromosome and from both the active and the
inactive X chromosome. See 300151 and Slim et al. (1993).
*FIELD* RF
1. Slim, R.; Levilliers, J.; Ludecke, H.-J.; Claussen, U.; Nguyen,
V. C.; Gough, N. M.; Horsthemke, B.; Petit, C.: A human pseudoautosomal
gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. Genomics 16:
26-33, 1993.
*FIELD* CD
Victor A. McKusick: 5/4/1993
*FIELD* ED
mark: 07/07/1997
mimadm: 3/11/1994
carol: 5/4/1993