Full text data of ANP32E
ANP32E
[Confidence: low (only semi-automatic identification from reviews)]
Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein; LANP-L)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein; LANP-L)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9BTT0
ID AN32E_HUMAN Reviewed; 268 AA.
AC Q9BTT0; B4E0I6; E9PEA6; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member E;
DE AltName: Full=LANP-like protein;
DE Short=LANP-L;
GN Name=ANP32E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=12438741; DOI=10.1159/000064058;
RA Jiang M., Ma Y., Ni X., Cao G., Ji C., Cheng H., Tang R., Xie Y.,
RA Mao Y.;
RT "Molecular cloning and characterization of a novel human gene (ANP32E
RT alias LANPL) from human fetal brain.";
RL Cytogenet. Genome Res. 97:68-71(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Pulmonary artery, Thymus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adipose tissue;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Inhibits activity of protein phosphatase 2A (PP2A). Does
CC not inhibit protein phosphatase 1. May play a role in cerebellar
CC development and synaptogenesis process by modulating PP2A activity
CC (By similarity).
CC -!- SUBUNIT: Interacts with the importin alpha KPNA1 and KPNA2 (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BTT0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BTT0-2; Sequence=VSP_045618;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q9BTT0-3; Sequence=VSP_047262;
CC Note=Gene prediction based on EST data;
CC -!- TISSUE SPECIFICITY: Expressed in peripheral blood leukocytes,
CC colon, small intestine, prostate, thymus, spleen, skeletal muscle,
CC liver and kidney.
CC -!- PTM: Phosphorylated. The phosphorylation is nuclear localization
CC signal (NLS)-dependent (By similarity).
CC -!- SIMILARITY: Belongs to the ANP32 family.
CC -!- SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 LRRCT domain.
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DR EMBL; AY057381; AAL25814.1; -; mRNA.
DR EMBL; AK095228; BAC04505.1; -; mRNA.
DR EMBL; AK092672; BAC03942.1; -; mRNA.
DR EMBL; AK303392; BAG64448.1; -; mRNA.
DR EMBL; AL832674; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL138795; CAI22806.1; -; Genomic_DNA.
DR EMBL; AL138795; CAI22808.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53575.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53577.1; -; Genomic_DNA.
DR EMBL; BC003380; AAH03380.1; -; mRNA.
DR RefSeq; NP_001129950.1; NM_001136478.3.
DR RefSeq; NP_001129951.1; NM_001136479.2.
DR RefSeq; NP_001267488.1; NM_001280559.1.
DR RefSeq; NP_001267489.1; NM_001280560.1.
DR RefSeq; NP_112182.1; NM_030920.4.
DR UniGene; Hs.656466; -.
DR ProteinModelPortal; Q9BTT0; -.
DR SMR; Q9BTT0; 1-149.
DR IntAct; Q9BTT0; 4.
DR MINT; MINT-3061467; -.
DR STRING; 9606.ENSP00000324074; -.
DR PhosphoSite; Q9BTT0; -.
DR DMDM; 30580363; -.
DR PaxDb; Q9BTT0; -.
DR PRIDE; Q9BTT0; -.
DR DNASU; 81611; -.
DR Ensembl; ENST00000314136; ENSP00000324074; ENSG00000143401.
DR Ensembl; ENST00000369119; ENSP00000358115; ENSG00000143401.
DR Ensembl; ENST00000436748; ENSP00000393718; ENSG00000143401.
DR GeneID; 81611; -.
DR KEGG; hsa:81611; -.
DR UCSC; uc010pbv.2; human.
DR CTD; 81611; -.
DR GeneCards; GC01M150190; -.
DR HGNC; HGNC:16673; ANP32E.
DR HPA; CAB021114; -.
DR MIM; 609611; gene.
DR neXtProt; NX_Q9BTT0; -.
DR PharmGKB; PA134880751; -.
DR eggNOG; NOG322008; -.
DR HOGENOM; HOG000007361; -.
DR HOVERGEN; HBG053102; -.
DR InParanoid; Q9BTT0; -.
DR OMA; NCHSVNG; -.
DR OrthoDB; EOG7TJ3KH; -.
DR PhylomeDB; Q9BTT0; -.
DR ChiTaRS; ANP32E; human.
DR GeneWiki; ANP32E; -.
DR GenomeRNAi; 81611; -.
DR NextBio; 71940; -.
DR PRO; PR:Q9BTT0; -.
DR ArrayExpress; Q9BTT0; -.
DR Bgee; Q9BTT0; -.
DR CleanEx; HS_ANP32E; -.
DR Genevestigator; Q9BTT0; -.
DR GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00446; LRRcap; 1.
DR PROSITE; PS51450; LRR; 4.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
KW Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1 268 Acidic leucine-rich nuclear
FT phosphoprotein 32 family member E.
FT /FTId=PRO_0000137599.
FT REPEAT 18 38 LRR 1.
FT REPEAT 43 64 LRR 2.
FT REPEAT 65 87 LRR 3.
FT REPEAT 89 110 LRR 4.
FT DOMAIN 123 161 LRRCT.
FT COMPBIAS 151 266 Asp/Glu-rich (highly acidic).
FT MOD_RES 1 1 N-acetylmethionine.
FT VAR_SEQ 1 48 Missing (in isoform 3).
FT /FTId=VSP_047262.
FT VAR_SEQ 69 109 Missing (in isoform 2).
FT /FTId=VSP_045618.
FT CONFLICT 185 186 Missing (in Ref. 1; AAL25814 and 2;
FT BAC04505/BAG64448).
SQ SEQUENCE 268 AA; 30692 MW; 99D74AF4B59BF971 CRC64;
MEMKKKINLE LRNRSPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA NVELSSLARL
PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI KDLSTVEALQ NLKNLKSLDL
FNCEITNLED YRESIFELLQ QITYLDGFDQ EDNEAPDSEE EDDEDGDEDD EEEEENEAGP
PEGYEEEEEE EEEEDEDEDE DEDEAGSELG EGEEEVGLSY LMKEEIQDEE DDDDYVEEGE
EEEEEEEGGL RGEKRKRDAE DDGEEEDD
//
ID AN32E_HUMAN Reviewed; 268 AA.
AC Q9BTT0; B4E0I6; E9PEA6; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member E;
DE AltName: Full=LANP-like protein;
DE Short=LANP-L;
GN Name=ANP32E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=12438741; DOI=10.1159/000064058;
RA Jiang M., Ma Y., Ni X., Cao G., Ji C., Cheng H., Tang R., Xie Y.,
RA Mao Y.;
RT "Molecular cloning and characterization of a novel human gene (ANP32E
RT alias LANPL) from human fetal brain.";
RL Cytogenet. Genome Res. 97:68-71(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Pulmonary artery, Thymus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adipose tissue;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Inhibits activity of protein phosphatase 2A (PP2A). Does
CC not inhibit protein phosphatase 1. May play a role in cerebellar
CC development and synaptogenesis process by modulating PP2A activity
CC (By similarity).
CC -!- SUBUNIT: Interacts with the importin alpha KPNA1 and KPNA2 (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BTT0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BTT0-2; Sequence=VSP_045618;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q9BTT0-3; Sequence=VSP_047262;
CC Note=Gene prediction based on EST data;
CC -!- TISSUE SPECIFICITY: Expressed in peripheral blood leukocytes,
CC colon, small intestine, prostate, thymus, spleen, skeletal muscle,
CC liver and kidney.
CC -!- PTM: Phosphorylated. The phosphorylation is nuclear localization
CC signal (NLS)-dependent (By similarity).
CC -!- SIMILARITY: Belongs to the ANP32 family.
CC -!- SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 LRRCT domain.
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DR EMBL; AY057381; AAL25814.1; -; mRNA.
DR EMBL; AK095228; BAC04505.1; -; mRNA.
DR EMBL; AK092672; BAC03942.1; -; mRNA.
DR EMBL; AK303392; BAG64448.1; -; mRNA.
DR EMBL; AL832674; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL138795; CAI22806.1; -; Genomic_DNA.
DR EMBL; AL138795; CAI22808.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53575.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53577.1; -; Genomic_DNA.
DR EMBL; BC003380; AAH03380.1; -; mRNA.
DR RefSeq; NP_001129950.1; NM_001136478.3.
DR RefSeq; NP_001129951.1; NM_001136479.2.
DR RefSeq; NP_001267488.1; NM_001280559.1.
DR RefSeq; NP_001267489.1; NM_001280560.1.
DR RefSeq; NP_112182.1; NM_030920.4.
DR UniGene; Hs.656466; -.
DR ProteinModelPortal; Q9BTT0; -.
DR SMR; Q9BTT0; 1-149.
DR IntAct; Q9BTT0; 4.
DR MINT; MINT-3061467; -.
DR STRING; 9606.ENSP00000324074; -.
DR PhosphoSite; Q9BTT0; -.
DR DMDM; 30580363; -.
DR PaxDb; Q9BTT0; -.
DR PRIDE; Q9BTT0; -.
DR DNASU; 81611; -.
DR Ensembl; ENST00000314136; ENSP00000324074; ENSG00000143401.
DR Ensembl; ENST00000369119; ENSP00000358115; ENSG00000143401.
DR Ensembl; ENST00000436748; ENSP00000393718; ENSG00000143401.
DR GeneID; 81611; -.
DR KEGG; hsa:81611; -.
DR UCSC; uc010pbv.2; human.
DR CTD; 81611; -.
DR GeneCards; GC01M150190; -.
DR HGNC; HGNC:16673; ANP32E.
DR HPA; CAB021114; -.
DR MIM; 609611; gene.
DR neXtProt; NX_Q9BTT0; -.
DR PharmGKB; PA134880751; -.
DR eggNOG; NOG322008; -.
DR HOGENOM; HOG000007361; -.
DR HOVERGEN; HBG053102; -.
DR InParanoid; Q9BTT0; -.
DR OMA; NCHSVNG; -.
DR OrthoDB; EOG7TJ3KH; -.
DR PhylomeDB; Q9BTT0; -.
DR ChiTaRS; ANP32E; human.
DR GeneWiki; ANP32E; -.
DR GenomeRNAi; 81611; -.
DR NextBio; 71940; -.
DR PRO; PR:Q9BTT0; -.
DR ArrayExpress; Q9BTT0; -.
DR Bgee; Q9BTT0; -.
DR CleanEx; HS_ANP32E; -.
DR Genevestigator; Q9BTT0; -.
DR GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00446; LRRcap; 1.
DR PROSITE; PS51450; LRR; 4.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
KW Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1 268 Acidic leucine-rich nuclear
FT phosphoprotein 32 family member E.
FT /FTId=PRO_0000137599.
FT REPEAT 18 38 LRR 1.
FT REPEAT 43 64 LRR 2.
FT REPEAT 65 87 LRR 3.
FT REPEAT 89 110 LRR 4.
FT DOMAIN 123 161 LRRCT.
FT COMPBIAS 151 266 Asp/Glu-rich (highly acidic).
FT MOD_RES 1 1 N-acetylmethionine.
FT VAR_SEQ 1 48 Missing (in isoform 3).
FT /FTId=VSP_047262.
FT VAR_SEQ 69 109 Missing (in isoform 2).
FT /FTId=VSP_045618.
FT CONFLICT 185 186 Missing (in Ref. 1; AAL25814 and 2;
FT BAC04505/BAG64448).
SQ SEQUENCE 268 AA; 30692 MW; 99D74AF4B59BF971 CRC64;
MEMKKKINLE LRNRSPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA NVELSSLARL
PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI KDLSTVEALQ NLKNLKSLDL
FNCEITNLED YRESIFELLQ QITYLDGFDQ EDNEAPDSEE EDDEDGDEDD EEEEENEAGP
PEGYEEEEEE EEEEDEDEDE DEDEAGSELG EGEEEVGLSY LMKEEIQDEE DDDDYVEEGE
EEEEEEEGGL RGEKRKRDAE DDGEEEDD
//
MIM
609611
*RECORD*
*FIELD* NO
609611
*FIELD* TI
*609611 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY, MEMBER E; ANP32E
;;LEUCINE-RICH ACIDIC NUCLEAR PROTEIN-LIKE; LANPL
read more*FIELD* TX
CLONING
By searching a fetal brain cDNA library, Jiang et al. (2002) identified
ANP32E. The deduced 266-amino acid protein has a predicted molecular
mass of 30.4 kD and contains 4 tandem repeats of a 21- to 24-residue
leucine-rich region. ANP32E shares 98% amino acid identity with mouse
Anp32e and 71% identity with human ANP32A (600832). RT-PCR analysis of
16 adult tissues showed expression in peripheral blood leukocytes,
colon, small intestine, prostate, thymus, spleen, skeletal muscle,
liver, and kidney.
GENE STRUCTURE
Jiang et al. (2002) determined that the ANP32E gene contains 7 exons and
spans 15.7 kb.
MAPPING
By genomic sequence analysis, Jiang et al. (2002) mapped the ANP32E gene
to chromosome 1q22.
*FIELD* RF
1. Jiang, M.; Ma, Y.; Ni, X.; Cao, G.; Ji, C.; Cheng, H.; Tang, R.;
Xie, Y.; Mao, Y.: Molecular cloning and characterization of a novel
human gene (ANP32E alias LANPL) from human fetal brain. Cytogenet.
Genome Res. 97: 68-71, 2002.
*FIELD* CD
Laura L. Baxter: 9/27/2005
*FIELD* ED
wwang: 09/19/2006
wwang: 9/28/2005
*RECORD*
*FIELD* NO
609611
*FIELD* TI
*609611 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY, MEMBER E; ANP32E
;;LEUCINE-RICH ACIDIC NUCLEAR PROTEIN-LIKE; LANPL
read more*FIELD* TX
CLONING
By searching a fetal brain cDNA library, Jiang et al. (2002) identified
ANP32E. The deduced 266-amino acid protein has a predicted molecular
mass of 30.4 kD and contains 4 tandem repeats of a 21- to 24-residue
leucine-rich region. ANP32E shares 98% amino acid identity with mouse
Anp32e and 71% identity with human ANP32A (600832). RT-PCR analysis of
16 adult tissues showed expression in peripheral blood leukocytes,
colon, small intestine, prostate, thymus, spleen, skeletal muscle,
liver, and kidney.
GENE STRUCTURE
Jiang et al. (2002) determined that the ANP32E gene contains 7 exons and
spans 15.7 kb.
MAPPING
By genomic sequence analysis, Jiang et al. (2002) mapped the ANP32E gene
to chromosome 1q22.
*FIELD* RF
1. Jiang, M.; Ma, Y.; Ni, X.; Cao, G.; Ji, C.; Cheng, H.; Tang, R.;
Xie, Y.; Mao, Y.: Molecular cloning and characterization of a novel
human gene (ANP32E alias LANPL) from human fetal brain. Cytogenet.
Genome Res. 97: 68-71, 2002.
*FIELD* CD
Laura L. Baxter: 9/27/2005
*FIELD* ED
wwang: 09/19/2006
wwang: 9/28/2005