Full text data of ANKRD49
ANKRD49
(FGIF)
[Confidence: low (only semi-automatic identification from reviews)]
Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8WVL7
ID ANR49_HUMAN Reviewed; 239 AA.
AC Q8WVL7; Q8NDF2; Q96JE5; Q9NXK7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 94.
DE RecName: Full=Ankyrin repeat domain-containing protein 49;
DE AltName: Full=Fetal globin-inducing factor;
GN Name=ANKRD49; Synonyms=FGIF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RC TISSUE=Fetal liver;
RX PubMed=11162141; DOI=10.1006/bcmd.2000.0344;
RA Yang Y., Duan Z., Skarpidi E., Li Q., Papayannopoulou T.,
RA Stamatoyannopoulos G.;
RT "Cloning and characterization of a potential transcriptional activator
RT of human gamma-globin genes.";
RL Blood Cells Mol. Dis. 27:1-15(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- TISSUE SPECIFICITY: Widely expressed in fetus, at a high level in
CC fetal liver, brain and lung.
CC -!- SIMILARITY: Contains 4 ANK repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF025354; AAK60412.1; -; mRNA.
DR EMBL; AK000196; BAA91003.1; -; mRNA.
DR EMBL; AL833977; CAD38821.2; -; mRNA.
DR EMBL; BC017798; AAH17798.1; -; mRNA.
DR RefSeq; NP_060174.2; NM_017704.2.
DR UniGene; Hs.29052; -.
DR ProteinModelPortal; Q8WVL7; -.
DR SMR; Q8WVL7; 44-216.
DR STRING; 9606.ENSP00000303518; -.
DR PhosphoSite; Q8WVL7; -.
DR DMDM; 74751554; -.
DR PaxDb; Q8WVL7; -.
DR PRIDE; Q8WVL7; -.
DR DNASU; 54851; -.
DR Ensembl; ENST00000302755; ENSP00000303518; ENSG00000168876.
DR Ensembl; ENST00000544612; ENSP00000440396; ENSG00000168876.
DR GeneID; 54851; -.
DR KEGG; hsa:54851; -.
DR UCSC; uc001pew.3; human.
DR CTD; 54851; -.
DR GeneCards; GC11P094227; -.
DR HGNC; HGNC:25970; ANKRD49.
DR HPA; HPA040273; -.
DR neXtProt; NX_Q8WVL7; -.
DR PharmGKB; PA142672615; -.
DR eggNOG; COG0666; -.
DR HOGENOM; HOG000021411; -.
DR HOVERGEN; HBG054416; -.
DR InParanoid; Q8WVL7; -.
DR OMA; LHSACRW; -.
DR OrthoDB; EOG7R832G; -.
DR PhylomeDB; Q8WVL7; -.
DR GenomeRNAi; 54851; -.
DR NextBio; 57700; -.
DR PRO; PR:Q8WVL7; -.
DR ArrayExpress; Q8WVL7; -.
DR Bgee; Q8WVL7; -.
DR CleanEx; HS_ANKRD49; -.
DR Genevestigator; Q8WVL7; -.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Complete proteome; Reference proteome; Repeat.
FT CHAIN 1 239 Ankyrin repeat domain-containing protein
FT 49.
FT /FTId=PRO_0000244585.
FT REPEAT 73 103 ANK 1.
FT REPEAT 107 136 ANK 2.
FT REPEAT 140 169 ANK 3.
FT REPEAT 173 206 ANK 4.
FT CONFLICT 25 25 N -> S (in Ref. 1; AAK60412).
FT CONFLICT 201 201 K -> R (in Ref. 2; BAA91003).
SQ SEQUENCE 239 AA; 27290 MW; 97103467E8F1EA50 CRC64;
MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE
EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH
LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL
AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS
//
ID ANR49_HUMAN Reviewed; 239 AA.
AC Q8WVL7; Q8NDF2; Q96JE5; Q9NXK7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 94.
DE RecName: Full=Ankyrin repeat domain-containing protein 49;
DE AltName: Full=Fetal globin-inducing factor;
GN Name=ANKRD49; Synonyms=FGIF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RC TISSUE=Fetal liver;
RX PubMed=11162141; DOI=10.1006/bcmd.2000.0344;
RA Yang Y., Duan Z., Skarpidi E., Li Q., Papayannopoulou T.,
RA Stamatoyannopoulos G.;
RT "Cloning and characterization of a potential transcriptional activator
RT of human gamma-globin genes.";
RL Blood Cells Mol. Dis. 27:1-15(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- TISSUE SPECIFICITY: Widely expressed in fetus, at a high level in
CC fetal liver, brain and lung.
CC -!- SIMILARITY: Contains 4 ANK repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF025354; AAK60412.1; -; mRNA.
DR EMBL; AK000196; BAA91003.1; -; mRNA.
DR EMBL; AL833977; CAD38821.2; -; mRNA.
DR EMBL; BC017798; AAH17798.1; -; mRNA.
DR RefSeq; NP_060174.2; NM_017704.2.
DR UniGene; Hs.29052; -.
DR ProteinModelPortal; Q8WVL7; -.
DR SMR; Q8WVL7; 44-216.
DR STRING; 9606.ENSP00000303518; -.
DR PhosphoSite; Q8WVL7; -.
DR DMDM; 74751554; -.
DR PaxDb; Q8WVL7; -.
DR PRIDE; Q8WVL7; -.
DR DNASU; 54851; -.
DR Ensembl; ENST00000302755; ENSP00000303518; ENSG00000168876.
DR Ensembl; ENST00000544612; ENSP00000440396; ENSG00000168876.
DR GeneID; 54851; -.
DR KEGG; hsa:54851; -.
DR UCSC; uc001pew.3; human.
DR CTD; 54851; -.
DR GeneCards; GC11P094227; -.
DR HGNC; HGNC:25970; ANKRD49.
DR HPA; HPA040273; -.
DR neXtProt; NX_Q8WVL7; -.
DR PharmGKB; PA142672615; -.
DR eggNOG; COG0666; -.
DR HOGENOM; HOG000021411; -.
DR HOVERGEN; HBG054416; -.
DR InParanoid; Q8WVL7; -.
DR OMA; LHSACRW; -.
DR OrthoDB; EOG7R832G; -.
DR PhylomeDB; Q8WVL7; -.
DR GenomeRNAi; 54851; -.
DR NextBio; 57700; -.
DR PRO; PR:Q8WVL7; -.
DR ArrayExpress; Q8WVL7; -.
DR Bgee; Q8WVL7; -.
DR CleanEx; HS_ANKRD49; -.
DR Genevestigator; Q8WVL7; -.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Complete proteome; Reference proteome; Repeat.
FT CHAIN 1 239 Ankyrin repeat domain-containing protein
FT 49.
FT /FTId=PRO_0000244585.
FT REPEAT 73 103 ANK 1.
FT REPEAT 107 136 ANK 2.
FT REPEAT 140 169 ANK 3.
FT REPEAT 173 206 ANK 4.
FT CONFLICT 25 25 N -> S (in Ref. 1; AAK60412).
FT CONFLICT 201 201 K -> R (in Ref. 2; BAA91003).
SQ SEQUENCE 239 AA; 27290 MW; 97103467E8F1EA50 CRC64;
MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE
EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH
LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL
AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS
//