RBCC

Full text data of APMAP

APMAP (C20orf3) [Confidence: high (present in two of the MS resources)]
Adipocyte plasma membrane-associated protein (Protein BSCv)

hRBCD IPI00031131
IPI00031131 Adipocyte plasma membrane-associated protein, Low molecular weight phosphotyrosine protein phosphatase Adipocyte plasma membrane-associated protein, Low molecular weight phosphotyrosine protein phosphatase membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a n/a 12 n/a n/a membrane bound n/a found at its expected molecular weight found at molecular weight

UniProt Q9HDC9
ID APMAP_HUMAN Reviewed; 416 AA.
AC Q9HDC9; A8K514; B4DXG1; Q6UVZ8; Q9GZS8; Q9NUB2;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 19-OCT-2002, sequence version 2.
DT 22-JAN-2014, entry version 105.
DE RecName: Full=Adipocyte plasma membrane-associated protein;
DE AltName: Full=Protein BSCv;
GN Name=APMAP; Synonyms=C20orf3; ORFNames=UNQ1869/PRO4305;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10945474; DOI=10.1006/geno.2000.6237;
RA Morita M., Hara Y., Tamai Y., Arakawa H., Nishimura S.;
RT "Genomic construct and mapping of the gene for CMAP
RT (leukocystatin/cystatin F, CST7) and identification of a proximal
RT novel gene, BSCv (C20orf3).";
RL Genomics 67:87-91(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Adipose tissue, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-416 (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [6]
RP GLYCOSYLATION AT ASN-160 AND ASN-196.
RX PubMed=12754519; DOI=10.1038/nbt827;
RA Zhang H., Li X.-J., Martin D.B., Aebersold R.;
RT "Identification and quantification of N-linked glycoproteins using
RT hydrazide chemistry, stable isotope labeling and mass spectrometry.";
RL Nat. Biotechnol. 21:660-666(2003).
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-196, AND MASS
RP SPECTROMETRY.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA Moore R.J., Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND VARIANTS
RP GLN-282 AND TRP-374.
RX PubMed=18513186; DOI=10.1042/BJ20080503;
RA Ilhan A., Gartner W., Nabokikh A., Daneva T., Majdic O., Cohen G.,
RA Boehmig G.A., Base W., Hoerl W.H., Wagner L.;
RT "Localization and characterization of the novel protein encoded by
RT C20orf3.";
RL Biochem. J. 414:485-495(2008).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-196, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Exhibits strong arylesterase activity with beta-naphthyl
CC acetate and phenyl acetate. May play a role in adipocyte
CC differentiation.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
CC protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9HDC9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HDC9-2; Sequence=VSP_036992, VSP_036993;
CC -!- TISSUE SPECIFICITY: Liver, glomerular and tubular structures of
CC the kidney, endothelial cells, arterial wall and pancreatic islets
CC of Langerhans (at protein level). Found ubiquitously in adult as
CC well as in embryonic tissues. In adult tissue, the highest
CC expression is found in the liver, placenta and heart. Found on the
CC cell surface of monocytes. In embryonic tissue, the highest
CC expression levels is found in the liver and the kidney.
CC -!- SIMILARITY: Belongs to the strictosidine synthase family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ89435.1; Type=Erroneous initiation;
CC Sequence=BAB11885.1; Type=Erroneous initiation;
CC Sequence=BAB15253.1; Type=Erroneous initiation;
CC Sequence=BAB15578.1; Type=Erroneous initiation;
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DR EMBL; AB033767; BAB11885.1; ALT_INIT; mRNA.
DR EMBL; AK291129; BAF83818.1; -; mRNA.
DR EMBL; AK301959; BAG63373.1; -; mRNA.
DR EMBL; AL035661; CAB75499.1; -; Genomic_DNA.
DR EMBL; BC003501; AAH03501.1; -; mRNA.
DR EMBL; AY359076; AAQ89435.1; ALT_INIT; mRNA.
DR EMBL; AK025834; BAB15253.1; ALT_INIT; mRNA.
DR EMBL; AK026866; BAB15578.1; ALT_INIT; mRNA.
DR RefSeq; NP_065392.1; NM_020531.2.
DR RefSeq; XP_005260820.1; XM_005260763.1.
DR UniGene; Hs.472330; -.
DR ProteinModelPortal; Q9HDC9; -.
DR SMR; Q9HDC9; 113-403.
DR IntAct; Q9HDC9; 7.
DR MINT; MINT-1427236; -.
DR STRING; 9606.ENSP00000217456; -.
DR PhosphoSite; Q9HDC9; -.
DR DMDM; 24211474; -.
DR PaxDb; Q9HDC9; -.
DR PRIDE; Q9HDC9; -.
DR DNASU; 57136; -.
DR Ensembl; ENST00000217456; ENSP00000217456; ENSG00000101474.
DR Ensembl; ENST00000447138; ENSP00000415373; ENSG00000101474.
DR GeneID; 57136; -.
DR KEGG; hsa:57136; -.
DR UCSC; uc002wty.3; human.
DR CTD; 57136; -.
DR GeneCards; GC20M024945; -.
DR H-InvDB; HIX0174724; -.
DR HGNC; HGNC:13238; APMAP.
DR HPA; HPA012863; -.
DR neXtProt; NX_Q9HDC9; -.
DR PharmGKB; PA25745; -.
DR eggNOG; COG3386; -.
DR HOGENOM; HOG000223914; -.
DR HOVERGEN; HBG050543; -.
DR InParanoid; Q9HDC9; -.
DR OMA; CKTRDDE; -.
DR PhylomeDB; Q9HDC9; -.
DR ChiTaRS; C20orf3; human.
DR GeneWiki; C20orf3; -.
DR GenomeRNAi; 57136; -.
DR NextBio; 63063; -.
DR PRO; PR:Q9HDC9; -.
DR Bgee; Q9HDC9; -.
DR CleanEx; HS_C20orf3; -.
DR Genevestigator; Q9HDC9; -.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0004064; F:arylesterase activity; IDA:UniProtKB.
DR GO; GO:0016844; F:strictosidine synthase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR018119; Strictosidine_synth_cons-reg.
DR Pfam; PF03088; Str_synth; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Glycoprotein;
KW Membrane; Polymorphism; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 416 Adipocyte plasma membrane-associated
FT protein.
FT /FTId=PRO_0000205945.
FT TOPO_DOM 2 40 Cytoplasmic (Potential).
FT TRANSMEM 41 61 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 62 416 Extracellular (Potential).
FT MOD_RES 2 2 N-acetylserine.
FT CARBOHYD 160 160 N-linked (GlcNAc...).
FT CARBOHYD 196 196 N-linked (GlcNAc...).
FT VAR_SEQ 283 289 RVYVSGL -> SSLVKRR (in isoform 2).
FT /FTId=VSP_036992.
FT VAR_SEQ 290 416 Missing (in isoform 2).
FT /FTId=VSP_036993.
FT VARIANT 65 65 I -> V (in dbSNP:rs17298715).
FT /FTId=VAR_014128.
FT VARIANT 282 282 R -> Q (in dbSNP:rs35097515).
FT /FTId=VAR_055039.
FT VARIANT 374 374 R -> W (in dbSNP:rs28364786).
FT /FTId=VAR_055040.
FT CONFLICT 12 12 P -> A (in Ref. 2; BAG63373).
FT CONFLICT 74 74 E -> G (in Ref. 2; BAF83818).
FT CONFLICT 295 295 D -> G (in Ref. 2; BAF83818).
FT CONFLICT 416 416 V -> A (in Ref. 2; BAF83818).
SQ SEQUENCE 416 AA; 46480 MW; C88E2DF2DF6093C4 CRC64;
MSEADGLRQR RPLRPQVVTD DDGQAPEAKD GSSFSGRVFR VTFLMLAVSL TVPLLGAMML
LESPIDPQPL SFKEPPLLLG VLHPNTKLRQ AERLFENQLV GPESIAHIGD VMFTGTADGR
VVKLENGEIE TIARFGSGPC KTRDDEPVCG RPLGIRAGPN GTLFVADAYK GLFEVNPWKR
EVKLLLSSET PIEGKNMSFV NDLTVTQDGR KIYFTDSSSK WQRRDYLLLV MEGTDDGRLL
EYDTVTREVK VLLDQLRFPN GVQLSPAEDF VLVAETTMAR IRRVYVSGLM KGGADLFVEN
MPGFPDNIRP SSSGGYWVGM STIRPNPGFS MLDFLSERPW IKRMIFKLFS QETVMKFVPR
YSLVLELSDS GAFRRSLHDP DGLVATYISE VHEHDGHLYL GSFRSPFLCR LSLQAV
//

RBCC Red Blood Cell Collection

Full text data of APMAP