Full text data of ARF3
ARF3
[Confidence: high (present in two of the MS resources)]
ADP-ribosylation factor 3
Note: presumably soluble (membrane word is not in UniProt keywords or features)
ADP-ribosylation factor 3
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00215917
IPI00215917 ADP-ribosylation factor 3 Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cytoplasmic n/a found at its expected molecular weight found at molecular weight
IPI00215917 ADP-ribosylation factor 3 Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cytoplasmic n/a found at its expected molecular weight found at molecular weight
UniProt
P61204
ID ARF3_HUMAN Reviewed; 181 AA.
AC P61204; A8K6G8; P16587;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 96.
DE RecName: Full=ADP-ribosylation factor 3;
GN Name=ARF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cerebellum;
RX PubMed=2474826; DOI=10.1073/pnas.86.16.6101;
RA Bobak D.A., Nightingale M.S., Murtagh J.J. Jr., Price S.R., Moss J.,
RA Vaughan M.;
RT "Molecular cloning, characterization, and expression of human ADP-
RT ribosylation factors: two guanine nucleotide-dependent activators of
RT cholera toxin.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:6101-6105(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1744102;
RA Tsai S.C., Haun R.S., Tsuchiya M., Moss J., Vaughan M.;
RT "Isolation and characterization of the human gene for ADP-ribosylation
RT factor 3, a 20-kDa guanine nucleotide-binding protein activator of
RT cholera toxin.";
RL J. Biol. Chem. 266:23053-23059(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction
RT sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH PRKCABP.
RX PubMed=10623590; DOI=10.1006/bbrc.1999.1932;
RA Takeya R., Takeshige K., Sumimoto H.;
RT "Interaction of the PDZ domain of human PICK1 with class I ADP-
RT ribosylation factors.";
RL Biochem. Biophys. Res. Commun. 267:149-155(2000).
RN [9]
RP INTERACTION WITH PI4KB AND NCS1, AND SUBCELLULAR LOCATION.
RX PubMed=17555535; DOI=10.1111/j.1600-0854.2007.00594.x;
RA Haynes L.P., Sherwood M.W., Dolman N.J., Burgoyne R.D.;
RT "Specificity, promiscuity and localization of ARF protein interactions
RT with NCS-1 and phosphatidylinositol-4 kinase-III beta.";
RL Traffic 8:1080-1092(2007).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: GTP-binding protein that functions as an allosteric
CC activator of the cholera toxin catalytic subunit, an ADP-
CC ribosyltransferase. Involved in protein trafficking; may modulate
CC vesicle budding and uncoating within the Golgi apparatus.
CC -!- SUBUNIT: Interacts with PRKCABP. Interacts with PI4KB and
CC NCS1/FREQ at the Golgi complex.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, perinuclear
CC region.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M74493; AAA58359.1; -; Genomic_DNA.
DR EMBL; M33384; AAA83931.1; -; mRNA.
DR EMBL; M74491; AAB59425.1; -; mRNA.
DR EMBL; AF493882; AAM12596.1; -; mRNA.
DR EMBL; BT006670; AAP35316.1; -; mRNA.
DR EMBL; AK291633; BAF84322.1; -; mRNA.
DR EMBL; CH471111; EAW58026.1; -; Genomic_DNA.
DR EMBL; BC007647; AAH07647.1; -; mRNA.
DR EMBL; BC007762; AAH07762.1; -; mRNA.
DR EMBL; BC017565; AAH17565.1; -; mRNA.
DR EMBL; BC028402; AAH28402.1; -; mRNA.
DR PIR; A41570; A41570.
DR RefSeq; NP_001650.1; NM_001659.2.
DR RefSeq; XP_005268913.1; XM_005268856.1.
DR UniGene; Hs.119177; -.
DR ProteinModelPortal; P61204; -.
DR SMR; P61204; 18-177.
DR IntAct; P61204; 7.
DR STRING; 9606.ENSP00000256682; -.
DR PhosphoSite; P61204; -.
DR DMDM; 47117657; -.
DR OGP; P16587; -.
DR PaxDb; P61204; -.
DR PeptideAtlas; P61204; -.
DR PRIDE; P61204; -.
DR DNASU; 377; -.
DR Ensembl; ENST00000256682; ENSP00000256682; ENSG00000134287.
DR Ensembl; ENST00000541959; ENSP00000438510; ENSG00000134287.
DR GeneID; 377; -.
DR KEGG; hsa:377; -.
DR UCSC; uc001rsr.2; human.
DR CTD; 377; -.
DR GeneCards; GC12M049299; -.
DR HGNC; HGNC:654; ARF3.
DR MIM; 103190; gene.
DR neXtProt; NX_P61204; -.
DR PharmGKB; PA24936; -.
DR eggNOG; COG1100; -.
DR HOGENOM; HOG000163691; -.
DR HOVERGEN; HBG002073; -.
DR InParanoid; P61204; -.
DR KO; K07938; -.
DR OMA; NDNERVS; -.
DR PhylomeDB; P61204; -.
DR Reactome; REACT_111217; Metabolism.
DR ChiTaRS; ARF3; human.
DR GeneWiki; ARF3; -.
DR GenomeRNAi; 377; -.
DR NextBio; 1579; -.
DR PRO; PR:P61204; -.
DR ArrayExpress; P61204; -.
DR Bgee; P61204; -.
DR CleanEx; HS_ARF3; -.
DR Genevestigator; P61204; -.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; TAS:ProtInc.
DR GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus;
KW GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW Protein transport; Reference proteome; Transport.
FT INIT_MET 1 1 Removed (Potential).
FT CHAIN 2 181 ADP-ribosylation factor 3.
FT /FTId=PRO_0000207386.
FT NP_BIND 24 31 GTP (By similarity).
FT NP_BIND 67 71 GTP (By similarity).
FT NP_BIND 126 129 GTP (By similarity).
FT LIPID 2 2 N-myristoyl glycine (Potential).
SQ SEQUENCE 181 AA; 20601 MW; D6FA234DFAED3E5F CRC64;
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK
K
//
ID ARF3_HUMAN Reviewed; 181 AA.
AC P61204; A8K6G8; P16587;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 96.
DE RecName: Full=ADP-ribosylation factor 3;
GN Name=ARF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cerebellum;
RX PubMed=2474826; DOI=10.1073/pnas.86.16.6101;
RA Bobak D.A., Nightingale M.S., Murtagh J.J. Jr., Price S.R., Moss J.,
RA Vaughan M.;
RT "Molecular cloning, characterization, and expression of human ADP-
RT ribosylation factors: two guanine nucleotide-dependent activators of
RT cholera toxin.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:6101-6105(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1744102;
RA Tsai S.C., Haun R.S., Tsuchiya M., Moss J., Vaughan M.;
RT "Isolation and characterization of the human gene for ADP-ribosylation
RT factor 3, a 20-kDa guanine nucleotide-binding protein activator of
RT cholera toxin.";
RL J. Biol. Chem. 266:23053-23059(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction
RT sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH PRKCABP.
RX PubMed=10623590; DOI=10.1006/bbrc.1999.1932;
RA Takeya R., Takeshige K., Sumimoto H.;
RT "Interaction of the PDZ domain of human PICK1 with class I ADP-
RT ribosylation factors.";
RL Biochem. Biophys. Res. Commun. 267:149-155(2000).
RN [9]
RP INTERACTION WITH PI4KB AND NCS1, AND SUBCELLULAR LOCATION.
RX PubMed=17555535; DOI=10.1111/j.1600-0854.2007.00594.x;
RA Haynes L.P., Sherwood M.W., Dolman N.J., Burgoyne R.D.;
RT "Specificity, promiscuity and localization of ARF protein interactions
RT with NCS-1 and phosphatidylinositol-4 kinase-III beta.";
RL Traffic 8:1080-1092(2007).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: GTP-binding protein that functions as an allosteric
CC activator of the cholera toxin catalytic subunit, an ADP-
CC ribosyltransferase. Involved in protein trafficking; may modulate
CC vesicle budding and uncoating within the Golgi apparatus.
CC -!- SUBUNIT: Interacts with PRKCABP. Interacts with PI4KB and
CC NCS1/FREQ at the Golgi complex.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, perinuclear
CC region.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M74493; AAA58359.1; -; Genomic_DNA.
DR EMBL; M33384; AAA83931.1; -; mRNA.
DR EMBL; M74491; AAB59425.1; -; mRNA.
DR EMBL; AF493882; AAM12596.1; -; mRNA.
DR EMBL; BT006670; AAP35316.1; -; mRNA.
DR EMBL; AK291633; BAF84322.1; -; mRNA.
DR EMBL; CH471111; EAW58026.1; -; Genomic_DNA.
DR EMBL; BC007647; AAH07647.1; -; mRNA.
DR EMBL; BC007762; AAH07762.1; -; mRNA.
DR EMBL; BC017565; AAH17565.1; -; mRNA.
DR EMBL; BC028402; AAH28402.1; -; mRNA.
DR PIR; A41570; A41570.
DR RefSeq; NP_001650.1; NM_001659.2.
DR RefSeq; XP_005268913.1; XM_005268856.1.
DR UniGene; Hs.119177; -.
DR ProteinModelPortal; P61204; -.
DR SMR; P61204; 18-177.
DR IntAct; P61204; 7.
DR STRING; 9606.ENSP00000256682; -.
DR PhosphoSite; P61204; -.
DR DMDM; 47117657; -.
DR OGP; P16587; -.
DR PaxDb; P61204; -.
DR PeptideAtlas; P61204; -.
DR PRIDE; P61204; -.
DR DNASU; 377; -.
DR Ensembl; ENST00000256682; ENSP00000256682; ENSG00000134287.
DR Ensembl; ENST00000541959; ENSP00000438510; ENSG00000134287.
DR GeneID; 377; -.
DR KEGG; hsa:377; -.
DR UCSC; uc001rsr.2; human.
DR CTD; 377; -.
DR GeneCards; GC12M049299; -.
DR HGNC; HGNC:654; ARF3.
DR MIM; 103190; gene.
DR neXtProt; NX_P61204; -.
DR PharmGKB; PA24936; -.
DR eggNOG; COG1100; -.
DR HOGENOM; HOG000163691; -.
DR HOVERGEN; HBG002073; -.
DR InParanoid; P61204; -.
DR KO; K07938; -.
DR OMA; NDNERVS; -.
DR PhylomeDB; P61204; -.
DR Reactome; REACT_111217; Metabolism.
DR ChiTaRS; ARF3; human.
DR GeneWiki; ARF3; -.
DR GenomeRNAi; 377; -.
DR NextBio; 1579; -.
DR PRO; PR:P61204; -.
DR ArrayExpress; P61204; -.
DR Bgee; P61204; -.
DR CleanEx; HS_ARF3; -.
DR Genevestigator; P61204; -.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; TAS:ProtInc.
DR GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus;
KW GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW Protein transport; Reference proteome; Transport.
FT INIT_MET 1 1 Removed (Potential).
FT CHAIN 2 181 ADP-ribosylation factor 3.
FT /FTId=PRO_0000207386.
FT NP_BIND 24 31 GTP (By similarity).
FT NP_BIND 67 71 GTP (By similarity).
FT NP_BIND 126 129 GTP (By similarity).
FT LIPID 2 2 N-myristoyl glycine (Potential).
SQ SEQUENCE 181 AA; 20601 MW; D6FA234DFAED3E5F CRC64;
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK
K
//
MIM
103190
*RECORD*
*FIELD* NO
103190
*FIELD* TI
*103190 ADP-RIBOSYLATION FACTOR 3; ARF3
*FIELD* TX
For general information on ADP-ribosylation factors, see 103180.
read more
CLONING
Bobak et al. (1989) identified an ARF3 cDNA from a human cerebellum
library.
Tsai et al. (1991) isolated and characterized the human ARF3 gene. They
also showed that two ARF3 mRNAs of 3.7 and 1.2 kb are generated through
the use of alternative polyadenylation signals.
GENE STRUCTURE
Tsai et al. (1991) found that the ARF3 gene spans approximately 18.3 kb
and contains 5 exons. They found multiple transcription start sites and
determined that the conserved amino acid sequences involved in guanine
nucleotide binding by ARF3 are distributed among separate exons.
MAPPING
By PCR screening of a somatic cell hybrid panel and fluorescence in situ
hybridization, Hirai et al. (1996) mapped the ARF3 gene to 12q13.
*FIELD* RF
1. Bobak, D. A.; Nightingale, M. S.; Murtagh, J. J.; Price, S. R.;
Moss, J.; Vaughan, M.: Molecular cloning, characterization, and expression
of human ADP-ribosylation factors: two guanine nucleotide-dependent
activators of cholera toxin. Proc. Nat. Acad. Sci. 86: 6101-6105,
1989.
2. Hirai, M.; Kusuda, J.; Hashimoto, K.: Assignment of human ADP
ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42
and 12q13, respectively. Genomics 34: 263-265, 1996.
3. Tsai, S.-C.; Haun, R. S.; Tsuchiya, M.; Moss, J.; Vaughan, M.:
Isolation and characterization of the human gene for ADP-ribosylation
factor 3, a 20-kDa guanine nucleotide-binding protein activator of
cholera toxin. J. Biol. Chem. 266: 23053-23059, 1991.
*FIELD* CN
Lori M. Kelman - updated: 12/7/2001
Joanna S. Amberger - updated: 5/6/1998
*FIELD* CD
Victor A. McKusick: 9/26/1989
*FIELD* ED
terry: 09/08/2010
joanna: 12/7/2001
dkim: 6/26/1998
carol: 5/6/1998
joanna: 5/6/1998
supermim: 3/16/1992
supermim: 3/20/1990
ddp: 10/26/1989
root: 10/9/1989
root: 9/26/1989
*RECORD*
*FIELD* NO
103190
*FIELD* TI
*103190 ADP-RIBOSYLATION FACTOR 3; ARF3
*FIELD* TX
For general information on ADP-ribosylation factors, see 103180.
read more
CLONING
Bobak et al. (1989) identified an ARF3 cDNA from a human cerebellum
library.
Tsai et al. (1991) isolated and characterized the human ARF3 gene. They
also showed that two ARF3 mRNAs of 3.7 and 1.2 kb are generated through
the use of alternative polyadenylation signals.
GENE STRUCTURE
Tsai et al. (1991) found that the ARF3 gene spans approximately 18.3 kb
and contains 5 exons. They found multiple transcription start sites and
determined that the conserved amino acid sequences involved in guanine
nucleotide binding by ARF3 are distributed among separate exons.
MAPPING
By PCR screening of a somatic cell hybrid panel and fluorescence in situ
hybridization, Hirai et al. (1996) mapped the ARF3 gene to 12q13.
*FIELD* RF
1. Bobak, D. A.; Nightingale, M. S.; Murtagh, J. J.; Price, S. R.;
Moss, J.; Vaughan, M.: Molecular cloning, characterization, and expression
of human ADP-ribosylation factors: two guanine nucleotide-dependent
activators of cholera toxin. Proc. Nat. Acad. Sci. 86: 6101-6105,
1989.
2. Hirai, M.; Kusuda, J.; Hashimoto, K.: Assignment of human ADP
ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42
and 12q13, respectively. Genomics 34: 263-265, 1996.
3. Tsai, S.-C.; Haun, R. S.; Tsuchiya, M.; Moss, J.; Vaughan, M.:
Isolation and characterization of the human gene for ADP-ribosylation
factor 3, a 20-kDa guanine nucleotide-binding protein activator of
cholera toxin. J. Biol. Chem. 266: 23053-23059, 1991.
*FIELD* CN
Lori M. Kelman - updated: 12/7/2001
Joanna S. Amberger - updated: 5/6/1998
*FIELD* CD
Victor A. McKusick: 9/26/1989
*FIELD* ED
terry: 09/08/2010
joanna: 12/7/2001
dkim: 6/26/1998
carol: 5/6/1998
joanna: 5/6/1998
supermim: 3/16/1992
supermim: 3/20/1990
ddp: 10/26/1989
root: 10/9/1989
root: 9/26/1989