Full text data of ARMC8
ARMC8
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Armadillo repeat-containing protein 8
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Armadillo repeat-containing protein 8
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8IUR7
ID ARMC8_HUMAN Reviewed; 673 AA.
AC Q8IUR7; A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; Q6PIL2; Q96D19;
read moreAC Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Armadillo repeat-containing protein 8;
GN Name=ARMC8; ORFNames=S863-2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Aorta;
RA Liu B., Zhao B., Wang X.Y., Xu Y.Y., Liu Y.Q., Song L., Ye J.,
RA Sheng H., Gao Y., Zhang C.L., Wei Y.J., Zhang J., Song L., Jiang Y.X.,
RA Zhao Z.W., Ding J.F., Liu L.S., Gao R.L., Wu Q.Y., Qiang B.Q.,
RA Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.;
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6; 7 AND 8), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-673 (ISOFORMS 1/2/3).
RC TISSUE=Cerebellum, Placenta, Teratocarcinoma, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
RC TISSUE=Brain, Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-22; 36-44; 55-65; 247-258; 364-376; 379-399;
RP 510-530; 591-602 AND 642-651, CLEAVAGE OF INITIATOR METHIONINE,
RP ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Lempens A., Norman J.C.;
RL Submitted (OCT-2009) to UniProtKB.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-673 (ISOFORMS 1/2/3).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8IUR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IUR7-2; Sequence=VSP_024509;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q8IUR7-3; Sequence=VSP_024512;
CC Note=No experimental confirmation available;
CC Name=6;
CC IsoId=Q8IUR7-6; Sequence=VSP_024509, VSP_024513, VSP_024514;
CC Name=7;
CC IsoId=Q8IUR7-7; Sequence=VSP_044774;
CC Note=No experimental confirmation available;
CC Name=8;
CC IsoId=Q8IUR7-8; Sequence=VSP_045137;
CC -!- SIMILARITY: Contains 14 ARM repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91861.1; Type=Frameshift; Positions=468;
CC Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention;
CC Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention;
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DR EMBL; AF109184; AAQ13493.1; -; mRNA.
DR EMBL; AK001721; BAA91861.1; ALT_FRAME; mRNA.
DR EMBL; AK001882; BAA91959.1; ALT_SEQ; mRNA.
DR EMBL; AK289577; BAF82266.1; -; mRNA.
DR EMBL; AK296757; BAH12427.1; -; mRNA.
DR EMBL; AK296837; BAH12439.1; -; mRNA.
DR EMBL; AC022337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79076.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79075.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79079.1; -; Genomic_DNA.
DR EMBL; BC013424; AAH13424.1; -; mRNA.
DR EMBL; BC032661; AAH32661.1; -; mRNA.
DR EMBL; BC041699; AAH41699.1; -; mRNA.
DR EMBL; AL096748; CAB46423.1; ALT_SEQ; mRNA.
DR PIR; T12513; T12513.
DR RefSeq; NP_001253970.1; NM_001267041.2.
DR RefSeq; NP_001253971.1; NM_001267042.2.
DR RefSeq; NP_001269271.1; NM_001282342.1.
DR RefSeq; NP_054873.2; NM_014154.4.
DR RefSeq; NP_056211.2; NM_015396.5.
DR RefSeq; NP_998819.1; NM_213654.3.
DR UniGene; Hs.744868; -.
DR ProteinModelPortal; Q8IUR7; -.
DR SMR; Q8IUR7; 25-208, 384-625.
DR IntAct; Q8IUR7; 3.
DR STRING; 9606.ENSP00000351221; -.
DR PhosphoSite; Q8IUR7; -.
DR DMDM; 145558852; -.
DR PaxDb; Q8IUR7; -.
DR PRIDE; Q8IUR7; -.
DR DNASU; 25852; -.
DR Ensembl; ENST00000358441; ENSP00000351221; ENSG00000114098.
DR Ensembl; ENST00000461822; ENSP00000420706; ENSG00000114098.
DR Ensembl; ENST00000469044; ENSP00000419413; ENSG00000114098.
DR Ensembl; ENST00000471453; ENSP00000420440; ENSG00000114098.
DR Ensembl; ENST00000481646; ENSP00000420333; ENSG00000114098.
DR Ensembl; ENST00000491704; ENSP00000417304; ENSG00000114098.
DR Ensembl; ENST00000538260; ENSP00000441592; ENSG00000114098.
DR GeneID; 25852; -.
DR KEGG; hsa:25852; -.
DR UCSC; uc011bmg.2; human.
DR CTD; 25852; -.
DR GeneCards; GC03P137906; -.
DR H-InvDB; HIX0003713; -.
DR HGNC; HGNC:24999; ARMC8.
DR HPA; HPA036996; -.
DR neXtProt; NX_Q8IUR7; -.
DR PharmGKB; PA134984953; -.
DR eggNOG; NOG307826; -.
DR HOVERGEN; HBG106422; -.
DR InParanoid; Q8IUR7; -.
DR OMA; GHSNVKL; -.
DR OrthoDB; EOG73V6K3; -.
DR SignaLink; Q8IUR7; -.
DR ChiTaRS; ARMC8; human.
DR GenomeRNAi; 25852; -.
DR NextBio; 47196; -.
DR PRO; PR:Q8IUR7; -.
DR ArrayExpress; Q8IUR7; -.
DR Bgee; Q8IUR7; -.
DR CleanEx; HS_ARMC8; -.
DR Genevestigator; Q8IUR7; -.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Reference proteome; Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 673 Armadillo repeat-containing protein 8.
FT /FTId=PRO_0000284408.
FT REPEAT 51 92 ARM 1.
FT REPEAT 95 134 ARM 2.
FT REPEAT 138 176 ARM 3.
FT REPEAT 178 217 ARM 4.
FT REPEAT 224 265 ARM 5.
FT REPEAT 269 309 ARM 6.
FT REPEAT 313 352 ARM 7.
FT REPEAT 374 413 ARM 8.
FT REPEAT 416 455 ARM 9.
FT REPEAT 458 497 ARM 10.
FT REPEAT 501 540 ARM 11.
FT REPEAT 543 585 ARM 12.
FT REPEAT 588 627 ARM 13.
FT REPEAT 634 673 ARM 14.
FT MOD_RES 2 2 N-acetylalanine.
FT VAR_SEQ 1 42 Missing (in isoform 3).
FT /FTId=VSP_024512.
FT VAR_SEQ 2 15 Missing (in isoform 2 and isoform 6).
FT /FTId=VSP_024509.
FT VAR_SEQ 146 176 Missing (in isoform 7).
FT /FTId=VSP_044774.
FT VAR_SEQ 280 346 Missing (in isoform 8).
FT /FTId=VSP_045137.
FT VAR_SEQ 379 399 IIETENMMDRIVTGLSESSVK -> VSLGEGRPPVLTASRQ
FT GVTST (in isoform 6).
FT /FTId=VSP_024513.
FT VAR_SEQ 400 673 Missing (in isoform 6).
FT /FTId=VSP_024514.
FT CONFLICT 78 78 E -> G (in Ref. 2; BAA91861).
FT CONFLICT 128 128 C -> R (in Ref. 2; BAH12439).
FT CONFLICT 231 231 V -> A (in Ref. 5; AAH32661).
FT CONFLICT 327 327 M -> V (in Ref. 2; BAA91861).
FT CONFLICT 397 397 S -> N (in Ref. 2; BAA91959).
FT CONFLICT 462 462 E -> G (in Ref. 2; BAH12439).
FT CONFLICT 495 495 M -> I (in Ref. 2; BAH12439).
FT CONFLICT 537 537 N -> S (in Ref. 2; BAA91959).
SQ SEQUENCE 673 AA; 75509 MW; 726BAC0A373485E8 CRC64;
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS
TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL
CDKAKMALQQ YLA
//
ID ARMC8_HUMAN Reviewed; 673 AA.
AC Q8IUR7; A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; Q6PIL2; Q96D19;
read moreAC Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Armadillo repeat-containing protein 8;
GN Name=ARMC8; ORFNames=S863-2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Aorta;
RA Liu B., Zhao B., Wang X.Y., Xu Y.Y., Liu Y.Q., Song L., Ye J.,
RA Sheng H., Gao Y., Zhang C.L., Wei Y.J., Zhang J., Song L., Jiang Y.X.,
RA Zhao Z.W., Ding J.F., Liu L.S., Gao R.L., Wu Q.Y., Qiang B.Q.,
RA Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.;
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6; 7 AND 8), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-673 (ISOFORMS 1/2/3).
RC TISSUE=Cerebellum, Placenta, Teratocarcinoma, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
RC TISSUE=Brain, Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-22; 36-44; 55-65; 247-258; 364-376; 379-399;
RP 510-530; 591-602 AND 642-651, CLEAVAGE OF INITIATOR METHIONINE,
RP ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Lempens A., Norman J.C.;
RL Submitted (OCT-2009) to UniProtKB.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-673 (ISOFORMS 1/2/3).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8IUR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IUR7-2; Sequence=VSP_024509;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q8IUR7-3; Sequence=VSP_024512;
CC Note=No experimental confirmation available;
CC Name=6;
CC IsoId=Q8IUR7-6; Sequence=VSP_024509, VSP_024513, VSP_024514;
CC Name=7;
CC IsoId=Q8IUR7-7; Sequence=VSP_044774;
CC Note=No experimental confirmation available;
CC Name=8;
CC IsoId=Q8IUR7-8; Sequence=VSP_045137;
CC -!- SIMILARITY: Contains 14 ARM repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91861.1; Type=Frameshift; Positions=468;
CC Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention;
CC Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention;
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DR EMBL; AF109184; AAQ13493.1; -; mRNA.
DR EMBL; AK001721; BAA91861.1; ALT_FRAME; mRNA.
DR EMBL; AK001882; BAA91959.1; ALT_SEQ; mRNA.
DR EMBL; AK289577; BAF82266.1; -; mRNA.
DR EMBL; AK296757; BAH12427.1; -; mRNA.
DR EMBL; AK296837; BAH12439.1; -; mRNA.
DR EMBL; AC022337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79076.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79075.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79079.1; -; Genomic_DNA.
DR EMBL; BC013424; AAH13424.1; -; mRNA.
DR EMBL; BC032661; AAH32661.1; -; mRNA.
DR EMBL; BC041699; AAH41699.1; -; mRNA.
DR EMBL; AL096748; CAB46423.1; ALT_SEQ; mRNA.
DR PIR; T12513; T12513.
DR RefSeq; NP_001253970.1; NM_001267041.2.
DR RefSeq; NP_001253971.1; NM_001267042.2.
DR RefSeq; NP_001269271.1; NM_001282342.1.
DR RefSeq; NP_054873.2; NM_014154.4.
DR RefSeq; NP_056211.2; NM_015396.5.
DR RefSeq; NP_998819.1; NM_213654.3.
DR UniGene; Hs.744868; -.
DR ProteinModelPortal; Q8IUR7; -.
DR SMR; Q8IUR7; 25-208, 384-625.
DR IntAct; Q8IUR7; 3.
DR STRING; 9606.ENSP00000351221; -.
DR PhosphoSite; Q8IUR7; -.
DR DMDM; 145558852; -.
DR PaxDb; Q8IUR7; -.
DR PRIDE; Q8IUR7; -.
DR DNASU; 25852; -.
DR Ensembl; ENST00000358441; ENSP00000351221; ENSG00000114098.
DR Ensembl; ENST00000461822; ENSP00000420706; ENSG00000114098.
DR Ensembl; ENST00000469044; ENSP00000419413; ENSG00000114098.
DR Ensembl; ENST00000471453; ENSP00000420440; ENSG00000114098.
DR Ensembl; ENST00000481646; ENSP00000420333; ENSG00000114098.
DR Ensembl; ENST00000491704; ENSP00000417304; ENSG00000114098.
DR Ensembl; ENST00000538260; ENSP00000441592; ENSG00000114098.
DR GeneID; 25852; -.
DR KEGG; hsa:25852; -.
DR UCSC; uc011bmg.2; human.
DR CTD; 25852; -.
DR GeneCards; GC03P137906; -.
DR H-InvDB; HIX0003713; -.
DR HGNC; HGNC:24999; ARMC8.
DR HPA; HPA036996; -.
DR neXtProt; NX_Q8IUR7; -.
DR PharmGKB; PA134984953; -.
DR eggNOG; NOG307826; -.
DR HOVERGEN; HBG106422; -.
DR InParanoid; Q8IUR7; -.
DR OMA; GHSNVKL; -.
DR OrthoDB; EOG73V6K3; -.
DR SignaLink; Q8IUR7; -.
DR ChiTaRS; ARMC8; human.
DR GenomeRNAi; 25852; -.
DR NextBio; 47196; -.
DR PRO; PR:Q8IUR7; -.
DR ArrayExpress; Q8IUR7; -.
DR Bgee; Q8IUR7; -.
DR CleanEx; HS_ARMC8; -.
DR Genevestigator; Q8IUR7; -.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Reference proteome; Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 673 Armadillo repeat-containing protein 8.
FT /FTId=PRO_0000284408.
FT REPEAT 51 92 ARM 1.
FT REPEAT 95 134 ARM 2.
FT REPEAT 138 176 ARM 3.
FT REPEAT 178 217 ARM 4.
FT REPEAT 224 265 ARM 5.
FT REPEAT 269 309 ARM 6.
FT REPEAT 313 352 ARM 7.
FT REPEAT 374 413 ARM 8.
FT REPEAT 416 455 ARM 9.
FT REPEAT 458 497 ARM 10.
FT REPEAT 501 540 ARM 11.
FT REPEAT 543 585 ARM 12.
FT REPEAT 588 627 ARM 13.
FT REPEAT 634 673 ARM 14.
FT MOD_RES 2 2 N-acetylalanine.
FT VAR_SEQ 1 42 Missing (in isoform 3).
FT /FTId=VSP_024512.
FT VAR_SEQ 2 15 Missing (in isoform 2 and isoform 6).
FT /FTId=VSP_024509.
FT VAR_SEQ 146 176 Missing (in isoform 7).
FT /FTId=VSP_044774.
FT VAR_SEQ 280 346 Missing (in isoform 8).
FT /FTId=VSP_045137.
FT VAR_SEQ 379 399 IIETENMMDRIVTGLSESSVK -> VSLGEGRPPVLTASRQ
FT GVTST (in isoform 6).
FT /FTId=VSP_024513.
FT VAR_SEQ 400 673 Missing (in isoform 6).
FT /FTId=VSP_024514.
FT CONFLICT 78 78 E -> G (in Ref. 2; BAA91861).
FT CONFLICT 128 128 C -> R (in Ref. 2; BAH12439).
FT CONFLICT 231 231 V -> A (in Ref. 5; AAH32661).
FT CONFLICT 327 327 M -> V (in Ref. 2; BAA91861).
FT CONFLICT 397 397 S -> N (in Ref. 2; BAA91959).
FT CONFLICT 462 462 E -> G (in Ref. 2; BAH12439).
FT CONFLICT 495 495 M -> I (in Ref. 2; BAH12439).
FT CONFLICT 537 537 N -> S (in Ref. 2; BAA91959).
SQ SEQUENCE 673 AA; 75509 MW; 726BAC0A373485E8 CRC64;
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS
TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL
CDKAKMALQQ YLA
//