Full text data of ACTR3C
ACTR3C
(ARP11)
[Confidence: low (only semi-automatic identification from reviews)]
Actin-related protein 3C (Actin-related protein 11; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Actin-related protein 3C (Actin-related protein 11; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9C0K3
ID ARP3C_HUMAN Reviewed; 210 AA.
AC Q9C0K3; Q5CZI4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 82.
DE RecName: Full=Actin-related protein 3C;
DE AltName: Full=Actin-related protein 11;
DE Flags: Precursor;
GN Name=ACTR3C; Synonyms=ARP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=11162478; DOI=10.1006/bbrc.2000.4059;
RA Shindo-Okada N., Shimizu K.;
RT "Isolation of a novel actin-related gene expressed in low-metastatic
RT PC-14 human lung adenocarcinoma.";
RL Biochem. Biophys. Res. Commun. 280:61-67(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May play a role in the suppression of metastatic
CC potential in lung adenoma carcinoma cells.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C0K3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0K3-2; Sequence=VSP_032218;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed in kidney, stomach, spleen, bone
CC marrow, uterus, testis, placenta, skeletal muscle, mammary gland,
CC lung, fetal liver, and fetal kidney, but not detected in small
CC intestine, brain, and thymus. Expressed in low-metastatic lung
CC adenocarcinoma cells but not in high-metastatic ones.
CC -!- SIMILARITY: Belongs to the actin family.
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DR EMBL; AB039791; BAB21501.1; -; mRNA.
DR EMBL; BX640643; CAI56711.1; -; mRNA.
DR PIR; JC7580; JC7580.
DR RefSeq; NP_001157930.1; NM_001164458.1.
DR RefSeq; NP_001157931.1; NM_001164459.1.
DR UniGene; Hs.664579; -.
DR ProteinModelPortal; Q9C0K3; -.
DR SMR; Q9C0K3; 1-188.
DR PhosphoSite; Q9C0K3; -.
DR DMDM; 74739414; -.
DR PaxDb; Q9C0K3; -.
DR PRIDE; Q9C0K3; -.
DR Ensembl; ENST00000252071; ENSP00000252071; ENSG00000106526.
DR Ensembl; ENST00000539352; ENSP00000440990; ENSG00000106526.
DR GeneID; 653857; -.
DR KEGG; hsa:653857; -.
DR UCSC; uc003wgu.2; human.
DR CTD; 653857; -.
DR GeneCards; GC07M149942; -.
DR H-InvDB; HIX0041149; -.
DR H-InvDB; HIX0201521; -.
DR HGNC; HGNC:37282; ACTR3C.
DR HPA; HPA055957; -.
DR neXtProt; NX_Q9C0K3; -.
DR PharmGKB; PA165617588; -.
DR eggNOG; COG5277; -.
DR HOGENOM; HOG000034070; -.
DR HOVERGEN; HBG075770; -.
DR InParanoid; Q9C0K3; -.
DR OMA; MESISNV; -.
DR PhylomeDB; Q9C0K3; -.
DR SignaLink; Q9C0K3; -.
DR ChiTaRS; ACTR3C; human.
DR GenomeRNAi; 653857; -.
DR NextBio; 123684; -.
DR PRO; PR:Q9C0K3; -.
DR ArrayExpress; Q9C0K3; -.
DR Bgee; Q9C0K3; -.
DR Genevestigator; Q9C0K3; -.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR InterPro; IPR004000; Actin-related.
DR InterPro; IPR015623; Arp3.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF31; PTHR11937:SF31; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR PROSITE; PS00432; ACTINS_2; FALSE_NEG.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Actin-binding; Alternative splicing; ATP-binding; Complete proteome;
KW Nucleotide-binding; Reference proteome; Signal.
FT SIGNAL 1 21 Potential.
FT CHAIN 22 210 Actin-related protein 3C.
FT /FTId=PRO_0000324333.
FT VAR_SEQ 1 163 Missing (in isoform 2).
FT /FTId=VSP_032218.
FT CONFLICT 189 189 M -> V (in Ref. 2; CAI56711).
SQ SEQUENCE 210 AA; 23712 MW; AB94A33B440CD35B CRC64;
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC
IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP
QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI
DVRRPLYKME QIPLSYPQGH GFHPLSPPFH
//
ID ARP3C_HUMAN Reviewed; 210 AA.
AC Q9C0K3; Q5CZI4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 82.
DE RecName: Full=Actin-related protein 3C;
DE AltName: Full=Actin-related protein 11;
DE Flags: Precursor;
GN Name=ACTR3C; Synonyms=ARP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=11162478; DOI=10.1006/bbrc.2000.4059;
RA Shindo-Okada N., Shimizu K.;
RT "Isolation of a novel actin-related gene expressed in low-metastatic
RT PC-14 human lung adenocarcinoma.";
RL Biochem. Biophys. Res. Commun. 280:61-67(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May play a role in the suppression of metastatic
CC potential in lung adenoma carcinoma cells.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C0K3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0K3-2; Sequence=VSP_032218;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed in kidney, stomach, spleen, bone
CC marrow, uterus, testis, placenta, skeletal muscle, mammary gland,
CC lung, fetal liver, and fetal kidney, but not detected in small
CC intestine, brain, and thymus. Expressed in low-metastatic lung
CC adenocarcinoma cells but not in high-metastatic ones.
CC -!- SIMILARITY: Belongs to the actin family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB039791; BAB21501.1; -; mRNA.
DR EMBL; BX640643; CAI56711.1; -; mRNA.
DR PIR; JC7580; JC7580.
DR RefSeq; NP_001157930.1; NM_001164458.1.
DR RefSeq; NP_001157931.1; NM_001164459.1.
DR UniGene; Hs.664579; -.
DR ProteinModelPortal; Q9C0K3; -.
DR SMR; Q9C0K3; 1-188.
DR PhosphoSite; Q9C0K3; -.
DR DMDM; 74739414; -.
DR PaxDb; Q9C0K3; -.
DR PRIDE; Q9C0K3; -.
DR Ensembl; ENST00000252071; ENSP00000252071; ENSG00000106526.
DR Ensembl; ENST00000539352; ENSP00000440990; ENSG00000106526.
DR GeneID; 653857; -.
DR KEGG; hsa:653857; -.
DR UCSC; uc003wgu.2; human.
DR CTD; 653857; -.
DR GeneCards; GC07M149942; -.
DR H-InvDB; HIX0041149; -.
DR H-InvDB; HIX0201521; -.
DR HGNC; HGNC:37282; ACTR3C.
DR HPA; HPA055957; -.
DR neXtProt; NX_Q9C0K3; -.
DR PharmGKB; PA165617588; -.
DR eggNOG; COG5277; -.
DR HOGENOM; HOG000034070; -.
DR HOVERGEN; HBG075770; -.
DR InParanoid; Q9C0K3; -.
DR OMA; MESISNV; -.
DR PhylomeDB; Q9C0K3; -.
DR SignaLink; Q9C0K3; -.
DR ChiTaRS; ACTR3C; human.
DR GenomeRNAi; 653857; -.
DR NextBio; 123684; -.
DR PRO; PR:Q9C0K3; -.
DR ArrayExpress; Q9C0K3; -.
DR Bgee; Q9C0K3; -.
DR Genevestigator; Q9C0K3; -.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR InterPro; IPR004000; Actin-related.
DR InterPro; IPR015623; Arp3.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF31; PTHR11937:SF31; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR PROSITE; PS00432; ACTINS_2; FALSE_NEG.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Actin-binding; Alternative splicing; ATP-binding; Complete proteome;
KW Nucleotide-binding; Reference proteome; Signal.
FT SIGNAL 1 21 Potential.
FT CHAIN 22 210 Actin-related protein 3C.
FT /FTId=PRO_0000324333.
FT VAR_SEQ 1 163 Missing (in isoform 2).
FT /FTId=VSP_032218.
FT CONFLICT 189 189 M -> V (in Ref. 2; CAI56711).
SQ SEQUENCE 210 AA; 23712 MW; AB94A33B440CD35B CRC64;
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC
IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP
QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI
DVRRPLYKME QIPLSYPQGH GFHPLSPPFH
//