Full text data of BCL2A1
BCL2A1
(BCL2L5, BFL1, GRS, HBPA1)
[Confidence: low (only semi-automatic identification from reviews)]
Bcl-2-related protein A1 (Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Bcl-2-related protein A1 (Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q16548
ID B2LA1_HUMAN Reviewed; 175 AA.
AC Q16548; Q6FGZ4; Q6FH19; Q86W13; Q99524;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1996, sequence version 1.
DT 22-JAN-2014, entry version 133.
DE RecName: Full=Bcl-2-related protein A1;
DE AltName: Full=Bcl-2-like protein 5;
DE Short=Bcl2-L-5;
DE AltName: Full=Hemopoietic-specific early response protein;
DE AltName: Full=Protein BFL-1;
DE AltName: Full=Protein GRS;
GN Name=BCL2A1; Synonyms=BCL2L5, BFL1, GRS, HBPA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=7478596;
RA Choi S.S., Park I.-C., Yun J.W., Sung Y.C., Hong S.-I., Shin H.-S.;
RT "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer
RT and preferentially expressed in bone marrow.";
RL Oncogene 11:1693-1698(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Umbilical vein;
RX PubMed=8605321;
RA Karsan A., Yee E., Kaushansky K., Harlan J.M.;
RT "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human
RT A1 in cultured endothelial cells.";
RL Blood 87:3089-3096(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=T-cell;
RX PubMed=9050999; DOI=10.1038/sj.onc.1200898;
RA Kenny J.J., Knobloch T.J., Augustus M., Carter K.C., Rosen C.A.,
RA Lang J.C.;
RT "GRS, a novel member of the Bcl-2 gene family, is highly expressed in
RT multiple cancer cell lines and in normal leukocytes.";
RL Oncogene 14:997-1001(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Barnes F.A., Rowe S.J., Whyte M.K.B., Bingle C.D.;
RT "A widely expressed pro-apoptotic splice variant of the human A1 gene
RT is specifically targeted to the nucleus.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP TYR-19; LYS-39 AND ASP-82.
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP INTERACTION WITH BAX.
RX PubMed=10772918; DOI=10.1006/bbrc.2000.2537;
RA Schmitt E., Paquet C., Beauchemin M., Dever-Bertrand J., Bertrand R.;
RT "Characterization of Bax-sigma, a cell death-inducing isoform of
RT Bax.";
RL Biochem. Biophys. Res. Commun. 270:868-879(2000).
RN [11]
RP INTERACTION WITH BOP/C22ORF29.
RX PubMed=23055042; DOI=10.1007/s13238-012-2069-7;
RA Zhang X., Weng C., Li Y., Wang X., Jiang C., Li X., Xu Y., Chen Q.,
RA Pan L., Tang H.;
RT "Human Bop is a novel BH3-only member of the Bcl-2 protein family.";
RL Protein Cell 3:790-801(2012).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-149 IN COMPLEX WITH
RP BCL2L11/BIM.
RX PubMed=18812174; DOI=10.1016/j.febslet.2008.09.028;
RA Herman M.D., Nyman T., Welin M., Lehtio L., Flodin S., Tresaugues L.,
RA Kotenyova T., Flores A., Nordlund P.;
RT "Completing the family portrait of the anti-apoptotic Bcl-2 proteins:
RT crystal structure of human Bfl-1 in complex with Bim.";
RL FEBS Lett. 582:3590-3594(2008).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 149-608 IN COMPLEX WITH
RP BCL2L11.
RG Structural genomics consortium (SGC);
RT "Human BCL-2A1 in complex with BIM.";
RL Submitted (FEB-2008) to the PDB data bank.
RN [14]
RP X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 1-151 IN COMPLEX WITH
RP PMAIP1.
RG Northeast structural genomics consortium (NESG);
RT "Crystal structure of human bfl-1 in complex with noxa bh3 peptide.";
RL Submitted (JUL-2010) to the PDB data bank.
CC -!- FUNCTION: Retards apoptosis induced by IL-3 deprivation. May
CC function in the response of hemopoietic cells to external signals
CC and in maintaining endothelial survival during infection (By
CC similarity).
CC -!- SUBUNIT: Interacts directly with BAK1, BID, BMF and BBC3 (By
CC similarity). Interacts directly with BCL2L11/BIM. Interacts with
CC BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with
CC BOP/C22orf29.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q16548-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q16548-2; Sequence=VSP_043106;
CC -!- TISSUE SPECIFICITY: Seems to be restricted to the hematopoietic
CC compartment. Expressed in peripheral blood, spleen, and bone
CC marrow, at moderate levels in lung, small intestine and testis, at
CC a minimal levels in other tissues. Also found in vascular smooth
CC muscle cells and hematopoietic malignancies.
CC -!- INDUCTION: By phorbol ester and inflammatory cytokines, such as
CC TNF or IL1B/interleukin-1 beta, but not by growth factors.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U27467; AAC50288.1; -; mRNA.
DR EMBL; U29680; AAC50438.1; -; mRNA.
DR EMBL; Y09397; CAA70566.1; -; mRNA.
DR EMBL; AY234180; AAO89009.1; -; mRNA.
DR EMBL; BT007103; AAP35767.1; -; mRNA.
DR EMBL; CR541937; CAG46735.1; -; mRNA.
DR EMBL; CR541962; CAG46760.1; -; mRNA.
DR EMBL; AC015871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99129.1; -; Genomic_DNA.
DR EMBL; BC016281; AAH16281.1; -; mRNA.
DR PIR; I39055; I39055.
DR RefSeq; NP_001108207.1; NM_001114735.1.
DR RefSeq; NP_004040.1; NM_004049.3.
DR UniGene; Hs.227817; -.
DR PDB; 2VM6; X-ray; 2.20 A; A=1-149.
DR PDB; 3I1H; X-ray; 2.20 A; A=1-151.
DR PDB; 3MQP; X-ray; 2.24 A; A=1-151.
DR PDBsum; 2VM6; -.
DR PDBsum; 3I1H; -.
DR PDBsum; 3MQP; -.
DR ProteinModelPortal; Q16548; -.
DR SMR; Q16548; 2-151.
DR IntAct; Q16548; 4.
DR MINT; MINT-89617; -.
DR STRING; 9606.ENSP00000267953; -.
DR BindingDB; Q16548; -.
DR ChEMBL; CHEMBL6044; -.
DR PhosphoSite; Q16548; -.
DR DMDM; 2493280; -.
DR PaxDb; Q16548; -.
DR PRIDE; Q16548; -.
DR DNASU; 597; -.
DR Ensembl; ENST00000267953; ENSP00000267953; ENSG00000140379.
DR Ensembl; ENST00000335661; ENSP00000335250; ENSG00000140379.
DR GeneID; 597; -.
DR KEGG; hsa:597; -.
DR UCSC; uc002bfc.4; human.
DR CTD; 597; -.
DR GeneCards; GC15M080256; -.
DR HGNC; HGNC:991; BCL2A1.
DR MIM; 601056; gene.
DR neXtProt; NX_Q16548; -.
DR PharmGKB; PA25303; -.
DR eggNOG; NOG244426; -.
DR HOGENOM; HOG000059278; -.
DR HOVERGEN; HBG004840; -.
DR InParanoid; Q16548; -.
DR KO; K02162; -.
DR OMA; LTFLEVT; -.
DR OrthoDB; EOG70GMGD; -.
DR PhylomeDB; Q16548; -.
DR ChiTaRS; BCL2A1; human.
DR EvolutionaryTrace; Q16548; -.
DR GeneWiki; BCL2-related_protein_A1; -.
DR GenomeRNAi; 597; -.
DR NextBio; 2429; -.
DR PRO; PR:Q16548; -.
DR Bgee; Q16548; -.
DR CleanEx; HS_BCL2A1; -.
DR Genevestigator; Q16548; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR InterPro; IPR013282; Bcl2A1.
DR InterPro; IPR026298; Blc2_fam.
DR PANTHER; PTHR11256; PTHR11256; 1.
DR PANTHER; PTHR11256:SF10; PTHR11256:SF10; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR PRINTS; PR01867; BCL2RLATEDA1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01080; BH1; 1.
DR PROSITE; PS01258; BH2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Apoptosis; Complete proteome;
KW Cytoplasm; Polymorphism; Reference proteome.
FT CHAIN 1 175 Bcl-2-related protein A1.
FT /FTId=PRO_0000143094.
FT MOTIF 77 97 BH1.
FT MOTIF 132 147 BH2.
FT COMPBIAS 24 33 Ala/Pro-rich.
FT VAR_SEQ 141 175 ENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC -> GK
FT WHNHTPMLVESVAHKKRKMAL (in isoform 2).
FT /FTId=VSP_043106.
FT VARIANT 19 19 C -> Y (in dbSNP:rs1138357).
FT /FTId=VAR_020342.
FT VARIANT 39 39 N -> K (in dbSNP:rs1138358).
FT /FTId=VAR_020343.
FT VARIANT 82 82 G -> D (in dbSNP:rs3826007).
FT /FTId=VAR_020344.
FT VARIANT 117 117 E -> D (in dbSNP:rs34080999).
FT /FTId=VAR_044059.
FT CONFLICT 72 72 N -> T (in Ref. 3; CAA70566).
FT CONFLICT 107 107 Q -> H (in Ref. 3; CAA70566).
FT HELIX 1 20
FT HELIX 32 51
FT HELIX 53 56
FT HELIX 64 79
FT HELIX 86 106
FT HELIX 113 115
FT HELIX 116 136
FT HELIX 139 142
FT HELIX 144 148
SQ SEQUENCE 175 AA; 20132 MW; 329D98AF2BE07A0D CRC64;
MTDCEFGYIY RLAQDYLQCV LQIPQPGSGP SKTSRVLQNV AFSVQKEVEK NLKSCLDNVN
VVSVDTARTL FNQVMEKEFE DGIINWGRIV TIFAFEGILI KKLLRQQIAP DVDTYKEISY
FVAEFIMNNT GEWIRQNGGW ENGFVKKFEP KSGWMTFLEV TGKICEMLSL LKQYC
//
ID B2LA1_HUMAN Reviewed; 175 AA.
AC Q16548; Q6FGZ4; Q6FH19; Q86W13; Q99524;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1996, sequence version 1.
DT 22-JAN-2014, entry version 133.
DE RecName: Full=Bcl-2-related protein A1;
DE AltName: Full=Bcl-2-like protein 5;
DE Short=Bcl2-L-5;
DE AltName: Full=Hemopoietic-specific early response protein;
DE AltName: Full=Protein BFL-1;
DE AltName: Full=Protein GRS;
GN Name=BCL2A1; Synonyms=BCL2L5, BFL1, GRS, HBPA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=7478596;
RA Choi S.S., Park I.-C., Yun J.W., Sung Y.C., Hong S.-I., Shin H.-S.;
RT "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer
RT and preferentially expressed in bone marrow.";
RL Oncogene 11:1693-1698(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Umbilical vein;
RX PubMed=8605321;
RA Karsan A., Yee E., Kaushansky K., Harlan J.M.;
RT "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human
RT A1 in cultured endothelial cells.";
RL Blood 87:3089-3096(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=T-cell;
RX PubMed=9050999; DOI=10.1038/sj.onc.1200898;
RA Kenny J.J., Knobloch T.J., Augustus M., Carter K.C., Rosen C.A.,
RA Lang J.C.;
RT "GRS, a novel member of the Bcl-2 gene family, is highly expressed in
RT multiple cancer cell lines and in normal leukocytes.";
RL Oncogene 14:997-1001(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Barnes F.A., Rowe S.J., Whyte M.K.B., Bingle C.D.;
RT "A widely expressed pro-apoptotic splice variant of the human A1 gene
RT is specifically targeted to the nucleus.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP TYR-19; LYS-39 AND ASP-82.
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP INTERACTION WITH BAX.
RX PubMed=10772918; DOI=10.1006/bbrc.2000.2537;
RA Schmitt E., Paquet C., Beauchemin M., Dever-Bertrand J., Bertrand R.;
RT "Characterization of Bax-sigma, a cell death-inducing isoform of
RT Bax.";
RL Biochem. Biophys. Res. Commun. 270:868-879(2000).
RN [11]
RP INTERACTION WITH BOP/C22ORF29.
RX PubMed=23055042; DOI=10.1007/s13238-012-2069-7;
RA Zhang X., Weng C., Li Y., Wang X., Jiang C., Li X., Xu Y., Chen Q.,
RA Pan L., Tang H.;
RT "Human Bop is a novel BH3-only member of the Bcl-2 protein family.";
RL Protein Cell 3:790-801(2012).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-149 IN COMPLEX WITH
RP BCL2L11/BIM.
RX PubMed=18812174; DOI=10.1016/j.febslet.2008.09.028;
RA Herman M.D., Nyman T., Welin M., Lehtio L., Flodin S., Tresaugues L.,
RA Kotenyova T., Flores A., Nordlund P.;
RT "Completing the family portrait of the anti-apoptotic Bcl-2 proteins:
RT crystal structure of human Bfl-1 in complex with Bim.";
RL FEBS Lett. 582:3590-3594(2008).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 149-608 IN COMPLEX WITH
RP BCL2L11.
RG Structural genomics consortium (SGC);
RT "Human BCL-2A1 in complex with BIM.";
RL Submitted (FEB-2008) to the PDB data bank.
RN [14]
RP X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 1-151 IN COMPLEX WITH
RP PMAIP1.
RG Northeast structural genomics consortium (NESG);
RT "Crystal structure of human bfl-1 in complex with noxa bh3 peptide.";
RL Submitted (JUL-2010) to the PDB data bank.
CC -!- FUNCTION: Retards apoptosis induced by IL-3 deprivation. May
CC function in the response of hemopoietic cells to external signals
CC and in maintaining endothelial survival during infection (By
CC similarity).
CC -!- SUBUNIT: Interacts directly with BAK1, BID, BMF and BBC3 (By
CC similarity). Interacts directly with BCL2L11/BIM. Interacts with
CC BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with
CC BOP/C22orf29.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q16548-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q16548-2; Sequence=VSP_043106;
CC -!- TISSUE SPECIFICITY: Seems to be restricted to the hematopoietic
CC compartment. Expressed in peripheral blood, spleen, and bone
CC marrow, at moderate levels in lung, small intestine and testis, at
CC a minimal levels in other tissues. Also found in vascular smooth
CC muscle cells and hematopoietic malignancies.
CC -!- INDUCTION: By phorbol ester and inflammatory cytokines, such as
CC TNF or IL1B/interleukin-1 beta, but not by growth factors.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U27467; AAC50288.1; -; mRNA.
DR EMBL; U29680; AAC50438.1; -; mRNA.
DR EMBL; Y09397; CAA70566.1; -; mRNA.
DR EMBL; AY234180; AAO89009.1; -; mRNA.
DR EMBL; BT007103; AAP35767.1; -; mRNA.
DR EMBL; CR541937; CAG46735.1; -; mRNA.
DR EMBL; CR541962; CAG46760.1; -; mRNA.
DR EMBL; AC015871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99129.1; -; Genomic_DNA.
DR EMBL; BC016281; AAH16281.1; -; mRNA.
DR PIR; I39055; I39055.
DR RefSeq; NP_001108207.1; NM_001114735.1.
DR RefSeq; NP_004040.1; NM_004049.3.
DR UniGene; Hs.227817; -.
DR PDB; 2VM6; X-ray; 2.20 A; A=1-149.
DR PDB; 3I1H; X-ray; 2.20 A; A=1-151.
DR PDB; 3MQP; X-ray; 2.24 A; A=1-151.
DR PDBsum; 2VM6; -.
DR PDBsum; 3I1H; -.
DR PDBsum; 3MQP; -.
DR ProteinModelPortal; Q16548; -.
DR SMR; Q16548; 2-151.
DR IntAct; Q16548; 4.
DR MINT; MINT-89617; -.
DR STRING; 9606.ENSP00000267953; -.
DR BindingDB; Q16548; -.
DR ChEMBL; CHEMBL6044; -.
DR PhosphoSite; Q16548; -.
DR DMDM; 2493280; -.
DR PaxDb; Q16548; -.
DR PRIDE; Q16548; -.
DR DNASU; 597; -.
DR Ensembl; ENST00000267953; ENSP00000267953; ENSG00000140379.
DR Ensembl; ENST00000335661; ENSP00000335250; ENSG00000140379.
DR GeneID; 597; -.
DR KEGG; hsa:597; -.
DR UCSC; uc002bfc.4; human.
DR CTD; 597; -.
DR GeneCards; GC15M080256; -.
DR HGNC; HGNC:991; BCL2A1.
DR MIM; 601056; gene.
DR neXtProt; NX_Q16548; -.
DR PharmGKB; PA25303; -.
DR eggNOG; NOG244426; -.
DR HOGENOM; HOG000059278; -.
DR HOVERGEN; HBG004840; -.
DR InParanoid; Q16548; -.
DR KO; K02162; -.
DR OMA; LTFLEVT; -.
DR OrthoDB; EOG70GMGD; -.
DR PhylomeDB; Q16548; -.
DR ChiTaRS; BCL2A1; human.
DR EvolutionaryTrace; Q16548; -.
DR GeneWiki; BCL2-related_protein_A1; -.
DR GenomeRNAi; 597; -.
DR NextBio; 2429; -.
DR PRO; PR:Q16548; -.
DR Bgee; Q16548; -.
DR CleanEx; HS_BCL2A1; -.
DR Genevestigator; Q16548; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR InterPro; IPR013282; Bcl2A1.
DR InterPro; IPR026298; Blc2_fam.
DR PANTHER; PTHR11256; PTHR11256; 1.
DR PANTHER; PTHR11256:SF10; PTHR11256:SF10; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR PRINTS; PR01867; BCL2RLATEDA1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01080; BH1; 1.
DR PROSITE; PS01258; BH2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Apoptosis; Complete proteome;
KW Cytoplasm; Polymorphism; Reference proteome.
FT CHAIN 1 175 Bcl-2-related protein A1.
FT /FTId=PRO_0000143094.
FT MOTIF 77 97 BH1.
FT MOTIF 132 147 BH2.
FT COMPBIAS 24 33 Ala/Pro-rich.
FT VAR_SEQ 141 175 ENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC -> GK
FT WHNHTPMLVESVAHKKRKMAL (in isoform 2).
FT /FTId=VSP_043106.
FT VARIANT 19 19 C -> Y (in dbSNP:rs1138357).
FT /FTId=VAR_020342.
FT VARIANT 39 39 N -> K (in dbSNP:rs1138358).
FT /FTId=VAR_020343.
FT VARIANT 82 82 G -> D (in dbSNP:rs3826007).
FT /FTId=VAR_020344.
FT VARIANT 117 117 E -> D (in dbSNP:rs34080999).
FT /FTId=VAR_044059.
FT CONFLICT 72 72 N -> T (in Ref. 3; CAA70566).
FT CONFLICT 107 107 Q -> H (in Ref. 3; CAA70566).
FT HELIX 1 20
FT HELIX 32 51
FT HELIX 53 56
FT HELIX 64 79
FT HELIX 86 106
FT HELIX 113 115
FT HELIX 116 136
FT HELIX 139 142
FT HELIX 144 148
SQ SEQUENCE 175 AA; 20132 MW; 329D98AF2BE07A0D CRC64;
MTDCEFGYIY RLAQDYLQCV LQIPQPGSGP SKTSRVLQNV AFSVQKEVEK NLKSCLDNVN
VVSVDTARTL FNQVMEKEFE DGIINWGRIV TIFAFEGILI KKLLRQQIAP DVDTYKEISY
FVAEFIMNNT GEWIRQNGGW ENGFVKKFEP KSGWMTFLEV TGKICEMLSL LKQYC
//
MIM
601056
*RECORD*
*FIELD* NO
601056
*FIELD* TI
*601056 BCL2-RELATED PROTEIN A1; BCL2A1
;;BCL2-RELATED GENE BFL1; BFL1
*FIELD* TX
read moreCLONING
Programmed cell death (apoptosis) plays an important role in embryonic
development, deletion of autoreactive T lymphocytes, and homeostasis.
Genes regulating apoptosis include p53 (191170), a tumor suppressor
gene, MYC (190080), a protooncogene, and BCL2 (151430). Lin et al.
(1993) isolated a novel mouse cDNA sequence, designated BCL2-related
protein A1 (Bcl2a1) by them, and identified it as a member of the BCL2
family of apoptosis regulators by the predicted protein sequence. Lin et
al. (1996) demonstrated that the A1 protein, although regulated
differently from BCL2, has similar antiapoptotic activity. The BCL2A1
gene has also been referred to as BCL2L5, BFL1, and GRS.
Choi et al. (1995) isolated a BCL2-related gene from human fetal liver.
Homology to the BH1 and BH2 domains of BCL2 was striking. BFL1 is
abundantly expressed in bone marrow and at a low level in some other
tissues. A correlation was noted between the expression level of BFL1
and the development of stomach cancer in 8 sets of clinical samples.
Choi et al. (1995) speculated that BFL1 is involved in the promotion of
cell survival during development or progression of stomach cancer. Choi
et al. (1997) showed that BFL1 is the human homolog of murine A1.
GENE FUNCTION
D'Sa-Eipper et al. (1996) showed that the BFL1 protein suppresses
apoptosis induced by the p53 tumor suppressor protein in a manner
similar to other BCL2 family members. The BFL1 gene showed a dominant
cooperating oncogenic activity with the E1A oncogene in transformation
of primary rodent epithelial cells.
By expression profiling of ALK (105590)-positive anaplastic large cell
lymphomas (ALCLs), Piva et al. (2006) identified a large group of
ALK-regulated genes. Functional RNA interference screening on a set of
these transcriptional targets revealed that CEBPB (189965) and BCL2A1
were absolutely necessary to induce cell transformation and/or to
sustain growth and survival of ALK-positive ALCL cells.
MAPPING
Lin et al. (1997) sequenced a portion of the A1 gene, and using the A1
probe on mouse and human DNA panels, demonstrated that the mouse gene is
situated on chromosome 9 and the human homolog is on chromosome 15. By
fluorescence in situ hybridization analysis, Choi et al. (1997) mapped
the human BCL2A1 gene to 15q24.3.
MOLECULAR GENETICS
Akatsuka et al. (2003) identified 3 SNPs in the BCL2A1 gene, 2 of which
encode minor histocompatibility antigens expressing epitopes for
HLA-A*2402- and HLA-B*4403-restricted T-cell clones. They proposed that
these minor histocompatibility antigens could be immunotherapeutic
targets in cases of recurrent malignancies after allogeneic hemopoietic
cell transplantation.
ANIMAL MODEL
Using mast cells from wildtype and Bcl2a1-deficient mice, Xiang et al.
(2001) showed that knockout mice had normal numbers of mast cells in
skin, lung, and spleen. Bone marrow-derived mast cells from normal mice
expressed Bcl2a1 after activation and, like Bcl2a1-deficient mice,
released granule mediators. However, mast cells from Bcl2a1-deficient
mice did not survive allergen activation in vitro, and mast cell number
was reduced in vivo after allergen sensitization and provocation. Xiang
et al. (2001) proposed that BCL2A1 could be a target in the treatment of
allergic diseases.
He et al. (2005) studied hyperoxic acute lung injury in wildtype and
Bcl2a1-null mice. In wildtype mice exposed to 100% oxygen,
TUNEL-positive cell death was accompanied by induction of Bcl2a1, Bcl2,
and Bclxl (see 600039) as an apparent protective response, whereas in
Bcl2a1-null mice the toxic effects of hyperoxia were exaggerated, Bcl2
and Bclxl were not induced, and premature death was seen. Overexpression
of IL11 (147681) in Bcl2a1-null mice revealed significantly reduced
IL11-induced protection, survival advantage, and Bcl2 and Bclxl
induction compared to wildtype mice. Overexpression of VEGF (192240)
conferred protection via a Bcl2a1-dependent mechanism. In vitro
hyperoxia also stimulated Bcl2a1, and Bcl2a1 overexpression inhibited
oxidant-induced epithelial cell apoptosis and necrosis. He et al. (2005)
concluded that BCL2A1 is an important regulator of oxidant-induced lung
injury, apoptosis, necrosis, and BCL2 and BCLXL gene expression and a
critical mediator of IL11 and VEGF-induced cytoprotection.
*FIELD* RF
1. Akatsuka, Y.; Nishida, T.; Kondo, E.; Miyazaki, M.; Taji, H.; Iida,
H.; Tsujimura, K.; Yazaki, M.; Naoe, T.; Morishima, Y.; Kodera, Y.;
Kuzushima, K.; Takahashi, T.: Identification of a polymorphic gene,
BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility
antigens. J. Exp. Med. 197: 1489-1500, 2003.
2. Choi, S. S.; Park, I.-C.; Yun, J. W.; Sung, Y. C.; Hong, S.-I.;
Shin, H.-S.: A novel Bcl-2 related gene, Bfl-1, is overexpressed
in stomach cancer and preferentially expressed in bone marrow. Oncogene 11:
1693-1698, 1995.
3. Choi, S. S.; Park, S. H.; Kim, U.-J.; Shin, H.-S.: Bfl-1, a Bcl-2-related
gene, is the human homolog of the murine A1, and maps to chromosome
15q24.3. Mammalian Genome 8: 781-782, 1997.
4. D'Sa-Eipper, C.; Subramanian, T.; Chinnadurai, G.: Bfl-1, a bcl-2
homologue, suppresses p53-induced apoptosis and exhibits potent cooperative
transforming activity. Cancer Res. 56: 3879-3882, 1996.
5. He, C. H.; Waxman, A. B.; Lee, C. G.; Link, H.; Rabach, M. E.;
Ma, B.; Chen, Q.; Zhu, Z.; Zhong, M.; Nakayama, K.; Nakayama, K. I.;
Homer, R.; Elias, J. A.: Bcl-2-related protein A1 is an endogenous
and cytokine-stimulated mediator of cytoprotection in hyperoxic acute
lung injury. J. Clin. Invest. 115: 1039-1048, 2005.
6. Lin, E. Y.; Kozak, C. A.; Orlofsky, A.; Prystowsky, M. B.: The
bcl-2 family member, Bcl2al, maps to mouse chromosome 9 and human
chromosome 15. Mammalian Genome 8: 293-294, 1997.
7. Lin, E. Y.; Orlofsky, A.; Berger, M. S.; Prystowsky, M. B.: Characterization
of A1, a novel hemopoietic-specific early-response gene with sequence
similarity to bcl-2. J. Immun. 151: 1979-1988, 1993.
8. Lin, E. Y.; Orlofsky, A.; Wang, H.-G.; Reed, J. C.; Prystowsky,
M. B.: A1, a Bcl-2 family member, prolongs cell survival and permits
myeloid differentiation. Blood 87: 983-992, 1996.
9. Piva, R.; Pellegrino, E.; Mattioli, M.; Agnelli, L.; Lombardi,
L.; Boccalatte, F.; Costa, G.; Ruggeri, B. A.; Cheng, M.; Chiarle,
R.; Palestro, G.; Neri, A.; Inghirami, G.: Functional validation
of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1
as critical target genes. J. Clin. Invest. 116: 3171-3182, 2006.
10. Xiang, Z.; Ahmed, A. A.; Moller, C.; Nakayama, K.; Hatakeyama,
S.; Nilsson, G.: Essential role of the prosurvival bcl-2 homologue
A1 in mast cell survival after allergic activation. J. Exp. Med. 194:
1561-1569, 2001.
*FIELD* CN
Patricia A. Hartz - updated: 01/25/2007
Paul J. Converse - updated: 3/14/2006
Marla J. F. O'Neill - updated: 7/8/2005
Paul J. Converse - updated: 2/8/2002
Victor A. McKusick - updated: 10/14/1997
*FIELD* CD
Victor A. McKusick: 2/10/1996
*FIELD* ED
mgross: 01/25/2007
mgross: 3/14/2006
wwang: 7/14/2005
terry: 7/8/2005
mgross: 2/8/2002
alopez: 1/20/1999
mark: 10/17/1997
terry: 10/14/1997
jamie: 2/5/1997
jamie: 11/13/1996
terry: 5/24/1996
mark: 2/10/1996
*RECORD*
*FIELD* NO
601056
*FIELD* TI
*601056 BCL2-RELATED PROTEIN A1; BCL2A1
;;BCL2-RELATED GENE BFL1; BFL1
*FIELD* TX
read moreCLONING
Programmed cell death (apoptosis) plays an important role in embryonic
development, deletion of autoreactive T lymphocytes, and homeostasis.
Genes regulating apoptosis include p53 (191170), a tumor suppressor
gene, MYC (190080), a protooncogene, and BCL2 (151430). Lin et al.
(1993) isolated a novel mouse cDNA sequence, designated BCL2-related
protein A1 (Bcl2a1) by them, and identified it as a member of the BCL2
family of apoptosis regulators by the predicted protein sequence. Lin et
al. (1996) demonstrated that the A1 protein, although regulated
differently from BCL2, has similar antiapoptotic activity. The BCL2A1
gene has also been referred to as BCL2L5, BFL1, and GRS.
Choi et al. (1995) isolated a BCL2-related gene from human fetal liver.
Homology to the BH1 and BH2 domains of BCL2 was striking. BFL1 is
abundantly expressed in bone marrow and at a low level in some other
tissues. A correlation was noted between the expression level of BFL1
and the development of stomach cancer in 8 sets of clinical samples.
Choi et al. (1995) speculated that BFL1 is involved in the promotion of
cell survival during development or progression of stomach cancer. Choi
et al. (1997) showed that BFL1 is the human homolog of murine A1.
GENE FUNCTION
D'Sa-Eipper et al. (1996) showed that the BFL1 protein suppresses
apoptosis induced by the p53 tumor suppressor protein in a manner
similar to other BCL2 family members. The BFL1 gene showed a dominant
cooperating oncogenic activity with the E1A oncogene in transformation
of primary rodent epithelial cells.
By expression profiling of ALK (105590)-positive anaplastic large cell
lymphomas (ALCLs), Piva et al. (2006) identified a large group of
ALK-regulated genes. Functional RNA interference screening on a set of
these transcriptional targets revealed that CEBPB (189965) and BCL2A1
were absolutely necessary to induce cell transformation and/or to
sustain growth and survival of ALK-positive ALCL cells.
MAPPING
Lin et al. (1997) sequenced a portion of the A1 gene, and using the A1
probe on mouse and human DNA panels, demonstrated that the mouse gene is
situated on chromosome 9 and the human homolog is on chromosome 15. By
fluorescence in situ hybridization analysis, Choi et al. (1997) mapped
the human BCL2A1 gene to 15q24.3.
MOLECULAR GENETICS
Akatsuka et al. (2003) identified 3 SNPs in the BCL2A1 gene, 2 of which
encode minor histocompatibility antigens expressing epitopes for
HLA-A*2402- and HLA-B*4403-restricted T-cell clones. They proposed that
these minor histocompatibility antigens could be immunotherapeutic
targets in cases of recurrent malignancies after allogeneic hemopoietic
cell transplantation.
ANIMAL MODEL
Using mast cells from wildtype and Bcl2a1-deficient mice, Xiang et al.
(2001) showed that knockout mice had normal numbers of mast cells in
skin, lung, and spleen. Bone marrow-derived mast cells from normal mice
expressed Bcl2a1 after activation and, like Bcl2a1-deficient mice,
released granule mediators. However, mast cells from Bcl2a1-deficient
mice did not survive allergen activation in vitro, and mast cell number
was reduced in vivo after allergen sensitization and provocation. Xiang
et al. (2001) proposed that BCL2A1 could be a target in the treatment of
allergic diseases.
He et al. (2005) studied hyperoxic acute lung injury in wildtype and
Bcl2a1-null mice. In wildtype mice exposed to 100% oxygen,
TUNEL-positive cell death was accompanied by induction of Bcl2a1, Bcl2,
and Bclxl (see 600039) as an apparent protective response, whereas in
Bcl2a1-null mice the toxic effects of hyperoxia were exaggerated, Bcl2
and Bclxl were not induced, and premature death was seen. Overexpression
of IL11 (147681) in Bcl2a1-null mice revealed significantly reduced
IL11-induced protection, survival advantage, and Bcl2 and Bclxl
induction compared to wildtype mice. Overexpression of VEGF (192240)
conferred protection via a Bcl2a1-dependent mechanism. In vitro
hyperoxia also stimulated Bcl2a1, and Bcl2a1 overexpression inhibited
oxidant-induced epithelial cell apoptosis and necrosis. He et al. (2005)
concluded that BCL2A1 is an important regulator of oxidant-induced lung
injury, apoptosis, necrosis, and BCL2 and BCLXL gene expression and a
critical mediator of IL11 and VEGF-induced cytoprotection.
*FIELD* RF
1. Akatsuka, Y.; Nishida, T.; Kondo, E.; Miyazaki, M.; Taji, H.; Iida,
H.; Tsujimura, K.; Yazaki, M.; Naoe, T.; Morishima, Y.; Kodera, Y.;
Kuzushima, K.; Takahashi, T.: Identification of a polymorphic gene,
BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility
antigens. J. Exp. Med. 197: 1489-1500, 2003.
2. Choi, S. S.; Park, I.-C.; Yun, J. W.; Sung, Y. C.; Hong, S.-I.;
Shin, H.-S.: A novel Bcl-2 related gene, Bfl-1, is overexpressed
in stomach cancer and preferentially expressed in bone marrow. Oncogene 11:
1693-1698, 1995.
3. Choi, S. S.; Park, S. H.; Kim, U.-J.; Shin, H.-S.: Bfl-1, a Bcl-2-related
gene, is the human homolog of the murine A1, and maps to chromosome
15q24.3. Mammalian Genome 8: 781-782, 1997.
4. D'Sa-Eipper, C.; Subramanian, T.; Chinnadurai, G.: Bfl-1, a bcl-2
homologue, suppresses p53-induced apoptosis and exhibits potent cooperative
transforming activity. Cancer Res. 56: 3879-3882, 1996.
5. He, C. H.; Waxman, A. B.; Lee, C. G.; Link, H.; Rabach, M. E.;
Ma, B.; Chen, Q.; Zhu, Z.; Zhong, M.; Nakayama, K.; Nakayama, K. I.;
Homer, R.; Elias, J. A.: Bcl-2-related protein A1 is an endogenous
and cytokine-stimulated mediator of cytoprotection in hyperoxic acute
lung injury. J. Clin. Invest. 115: 1039-1048, 2005.
6. Lin, E. Y.; Kozak, C. A.; Orlofsky, A.; Prystowsky, M. B.: The
bcl-2 family member, Bcl2al, maps to mouse chromosome 9 and human
chromosome 15. Mammalian Genome 8: 293-294, 1997.
7. Lin, E. Y.; Orlofsky, A.; Berger, M. S.; Prystowsky, M. B.: Characterization
of A1, a novel hemopoietic-specific early-response gene with sequence
similarity to bcl-2. J. Immun. 151: 1979-1988, 1993.
8. Lin, E. Y.; Orlofsky, A.; Wang, H.-G.; Reed, J. C.; Prystowsky,
M. B.: A1, a Bcl-2 family member, prolongs cell survival and permits
myeloid differentiation. Blood 87: 983-992, 1996.
9. Piva, R.; Pellegrino, E.; Mattioli, M.; Agnelli, L.; Lombardi,
L.; Boccalatte, F.; Costa, G.; Ruggeri, B. A.; Cheng, M.; Chiarle,
R.; Palestro, G.; Neri, A.; Inghirami, G.: Functional validation
of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1
as critical target genes. J. Clin. Invest. 116: 3171-3182, 2006.
10. Xiang, Z.; Ahmed, A. A.; Moller, C.; Nakayama, K.; Hatakeyama,
S.; Nilsson, G.: Essential role of the prosurvival bcl-2 homologue
A1 in mast cell survival after allergic activation. J. Exp. Med. 194:
1561-1569, 2001.
*FIELD* CN
Patricia A. Hartz - updated: 01/25/2007
Paul J. Converse - updated: 3/14/2006
Marla J. F. O'Neill - updated: 7/8/2005
Paul J. Converse - updated: 2/8/2002
Victor A. McKusick - updated: 10/14/1997
*FIELD* CD
Victor A. McKusick: 2/10/1996
*FIELD* ED
mgross: 01/25/2007
mgross: 3/14/2006
wwang: 7/14/2005
terry: 7/8/2005
mgross: 2/8/2002
alopez: 1/20/1999
mark: 10/17/1997
terry: 10/14/1997
jamie: 2/5/1997
jamie: 11/13/1996
terry: 5/24/1996
mark: 2/10/1996