Full text data of ZZZZ
B4DPM0
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Pyruvate kinase; 2.7.1.40
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Pyruvate kinase; 2.7.1.40
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
B4DPM0
ID B4DPM0_HUMAN Unreviewed; 488 AA.
AC B4DPM0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
read moreDT 22-JAN-2014, entry version 42.
DE RecName: Full=Pyruvate kinase;
DE EC=2.7.1.40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver;
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 5/5.
CC -!- SIMILARITY: Belongs to the pyruvate kinase family.
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DR EMBL; AK298399; BAG60632.1; -; mRNA.
DR UniGene; Hs.95990; -.
DR ProteinModelPortal; B4DPM0; -.
DR SMR; B4DPM0; 1-487.
DR PRIDE; B4DPM0; -.
DR HOGENOM; HOG000021559; -.
DR HOVERGEN; HBG000941; -.
DR UniPathway; UPA00109; UER00188.
DR NextBio; 35473905; -.
DR ArrayExpress; B4DPM0; -.
DR Bgee; B4DPM0; -.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR GO; GO:0004743; F:pyruvate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006754; P:ATP biosynthetic process; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
DR GO; GO:0042866; P:pyruvate biosynthetic process; IEA:Ensembl.
DR GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0010226; P:response to lithium ion; IEA:Ensembl.
DR GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
DR GO; GO:0051707; P:response to other organism; IEA:Ensembl.
DR Gene3D; 2.40.33.10; -; 1.
DR Gene3D; 3.20.20.60; -; 2.
DR Gene3D; 3.40.1380.20; -; 1.
DR InterPro; IPR001697; Pyr_Knase.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR011037; Pyrv_Knase-like_insert_dom.
DR InterPro; IPR015794; Pyrv_Knase_a/b.
DR InterPro; IPR018209; Pyrv_Knase_AS.
DR InterPro; IPR015793; Pyrv_Knase_brl.
DR InterPro; IPR015795; Pyrv_Knase_C.
DR InterPro; IPR015806; Pyrv_Knase_insert_dom.
DR PANTHER; PTHR11817; PTHR11817; 1.
DR Pfam; PF00224; PK; 1.
DR Pfam; PF02887; PK_C; 1.
DR PRINTS; PR01050; PYRUVTKNASE.
DR SUPFAM; SSF50800; SSF50800; 1.
DR SUPFAM; SSF51621; SSF51621; 2.
DR SUPFAM; SSF52935; SSF52935; 1.
DR TIGRFAMs; TIGR01064; pyruv_kin; 1.
DR PROSITE; PS00110; PYRUVATE_KINASE; 1.
PE 2: Evidence at transcript level;
KW Glycolysis; Kinase; Magnesium; Pyruvate; Transferase.
SQ SEQUENCE 488 AA; 52618 MW; 440F2FD7679AECD9 CRC64;
MADTFLEHLC LLDIDSEPVA ARSTSIIATI GPASRSVERL KEMIKAGMNI ARLNFSHGSH
EYHAESIALD TKGPEIRTGI LQGGPESEVE LVKGSQVLVT VDPAFRTRGN ANTVWVDYPN
IVRVVPVGGR IYIDDGLISL VVQKIGPEGL VTQVENGGVL GSRKGVNLPG AQVDLPGLSE
QDVRDLRFGV EHGVDIVFAS FVRKASDVAA VRAALGPEGH GIKIISKIEN HEGVKRFDEI
LEVSDGIMVA RGDLGIEIPA EKVFLAQKMM IGRCNLAGKP VVCATQMLES MITKPRPTRA
ETSDVANAVL DGADCIMLSG ETAKGNFPVE AVKMQHAIAR EAEAAVYHRQ LFEELRRAAP
LSRDPTEVTA IGAVEAAFKC CAAAIIVLTT TGRSAQLLSR YRPRAAVIAV TRSAQAARQV
HLCRGVFPLL YREPPEAIWA DDVDRRVQFG IESGKLRGFL RVGDLVIVVT GWRPGSGYTN
IMRVLSIS
//
ID B4DPM0_HUMAN Unreviewed; 488 AA.
AC B4DPM0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
read moreDT 22-JAN-2014, entry version 42.
DE RecName: Full=Pyruvate kinase;
DE EC=2.7.1.40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver;
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 5/5.
CC -!- SIMILARITY: Belongs to the pyruvate kinase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK298399; BAG60632.1; -; mRNA.
DR UniGene; Hs.95990; -.
DR ProteinModelPortal; B4DPM0; -.
DR SMR; B4DPM0; 1-487.
DR PRIDE; B4DPM0; -.
DR HOGENOM; HOG000021559; -.
DR HOVERGEN; HBG000941; -.
DR UniPathway; UPA00109; UER00188.
DR NextBio; 35473905; -.
DR ArrayExpress; B4DPM0; -.
DR Bgee; B4DPM0; -.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR GO; GO:0004743; F:pyruvate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006754; P:ATP biosynthetic process; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
DR GO; GO:0042866; P:pyruvate biosynthetic process; IEA:Ensembl.
DR GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0010226; P:response to lithium ion; IEA:Ensembl.
DR GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
DR GO; GO:0051707; P:response to other organism; IEA:Ensembl.
DR Gene3D; 2.40.33.10; -; 1.
DR Gene3D; 3.20.20.60; -; 2.
DR Gene3D; 3.40.1380.20; -; 1.
DR InterPro; IPR001697; Pyr_Knase.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR011037; Pyrv_Knase-like_insert_dom.
DR InterPro; IPR015794; Pyrv_Knase_a/b.
DR InterPro; IPR018209; Pyrv_Knase_AS.
DR InterPro; IPR015793; Pyrv_Knase_brl.
DR InterPro; IPR015795; Pyrv_Knase_C.
DR InterPro; IPR015806; Pyrv_Knase_insert_dom.
DR PANTHER; PTHR11817; PTHR11817; 1.
DR Pfam; PF00224; PK; 1.
DR Pfam; PF02887; PK_C; 1.
DR PRINTS; PR01050; PYRUVTKNASE.
DR SUPFAM; SSF50800; SSF50800; 1.
DR SUPFAM; SSF51621; SSF51621; 2.
DR SUPFAM; SSF52935; SSF52935; 1.
DR TIGRFAMs; TIGR01064; pyruv_kin; 1.
DR PROSITE; PS00110; PYRUVATE_KINASE; 1.
PE 2: Evidence at transcript level;
KW Glycolysis; Kinase; Magnesium; Pyruvate; Transferase.
SQ SEQUENCE 488 AA; 52618 MW; 440F2FD7679AECD9 CRC64;
MADTFLEHLC LLDIDSEPVA ARSTSIIATI GPASRSVERL KEMIKAGMNI ARLNFSHGSH
EYHAESIALD TKGPEIRTGI LQGGPESEVE LVKGSQVLVT VDPAFRTRGN ANTVWVDYPN
IVRVVPVGGR IYIDDGLISL VVQKIGPEGL VTQVENGGVL GSRKGVNLPG AQVDLPGLSE
QDVRDLRFGV EHGVDIVFAS FVRKASDVAA VRAALGPEGH GIKIISKIEN HEGVKRFDEI
LEVSDGIMVA RGDLGIEIPA EKVFLAQKMM IGRCNLAGKP VVCATQMLES MITKPRPTRA
ETSDVANAVL DGADCIMLSG ETAKGNFPVE AVKMQHAIAR EAEAAVYHRQ LFEELRRAAP
LSRDPTEVTA IGAVEAAFKC CAAAIIVLTT TGRSAQLLSR YRPRAAVIAV TRSAQAARQV
HLCRGVFPLL YREPPEAIWA DDVDRRVQFG IESGKLRGFL RVGDLVIVVT GWRPGSGYTN
IMRVLSIS
//