Full text data of ZZZZ
B7Z3V5
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
B7Z3V5
ID B7Z3V5_HUMAN Unreviewed; 1235 AA.
AC B7Z3V5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
read moreDT 22-JAN-2014, entry version 37.
DE SubName: Full=cDNA FLJ60617, highly similar to Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1);
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thalamus;
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK296396; BAH12341.1; -; mRNA.
DR RefSeq; NP_001229489.1; NM_001242560.1.
DR UniGene; Hs.701013; -.
DR ProteinModelPortal; B7Z3V5; -.
DR PRIDE; B7Z3V5; -.
DR GeneID; 9448; -.
DR KEGG; hsa:9448; -.
DR UCSC; uc010yvy.2; human.
DR CTD; 9448; -.
DR HOGENOM; HOG000290708; -.
DR HOVERGEN; HBG036506; -.
DR KO; K04407; -.
DR SignaLink; B7Z3V5; -.
DR GenomeRNAi; 9448; -.
DR NextBio; 35392; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
DR InterPro; IPR001180; Citron.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 2.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Transferase.
SQ SEQUENCE 1235 AA; 141098 MW; D486AACD86467302 CRC64;
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT
KGNTLKEDWI AYISREILRG LAHLHIHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR
ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR
RQQEREQRRR EQEEKRRLEE LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE
VLQQQLLQEQ AMLLHDHRRP HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVQW
SHLASLKNNV SPVSRSHSFS DPSPKFAHHH LRSQDPCPPS RSEVLSQSSD SKSEAPDPTQ
KAWSRSDSDE VPPRVPVRTT SRSPVLSRRD SPLQGSGQQN SQAGQRNSTS SIEPRLLWER
VEKLVPRPGS GSSSGSSNSG SQPGSHPGSQ SGSGERFRVR SSSKSEGSPS QRLENAVKKP
EDKKEVFRPL KPAGEVDLTA LAKELRAVED VRPPHKVTDY SSSSEESGTT DEEDDDVEQE
GADESTSGPE DTRAASSLNL SNGETESVKT MIVHDDVESE PAMTPSKEGT LIVRQTQSAS
STLQKHKSSS SFTPFIDPRL LQISPSSGTT VTSMVGFSCD GMRPEAIRQD PTRKGSVVNV
NPTNTRPQSD TPEIRKYKKR FNSEILCAAL WGVNLLVGTE SGLMLLDRSG QGKVYPLINR
RRFQQMDVLE GLNVLVTISG KKDKLRVYYL SWLRNKILHN DPEVEKKQGW TTVGDLEGCV
HYKVVKYERI KFLVIALKSS VEVYAWAPKP YHKFMAFKSF GELVHKPLLV DLTVEEGQRL
KVIYGSCAGF HAVDVDSGSV YDIYLPTHIQ CSIKPHAIII LPNTDGMELL VCYEDEGVYV
NTYGRITKDV VLQWGEMPTS VAYIRSNQTM GWGEKAIEIR SVETGHLDGV FMHKRAQRLK
FLCERNDKVF FASVRSGGSS QVYFMTLGRT SLLSW
//
ID B7Z3V5_HUMAN Unreviewed; 1235 AA.
AC B7Z3V5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
read moreDT 22-JAN-2014, entry version 37.
DE SubName: Full=cDNA FLJ60617, highly similar to Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1);
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thalamus;
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK296396; BAH12341.1; -; mRNA.
DR RefSeq; NP_001229489.1; NM_001242560.1.
DR UniGene; Hs.701013; -.
DR ProteinModelPortal; B7Z3V5; -.
DR PRIDE; B7Z3V5; -.
DR GeneID; 9448; -.
DR KEGG; hsa:9448; -.
DR UCSC; uc010yvy.2; human.
DR CTD; 9448; -.
DR HOGENOM; HOG000290708; -.
DR HOVERGEN; HBG036506; -.
DR KO; K04407; -.
DR SignaLink; B7Z3V5; -.
DR GenomeRNAi; 9448; -.
DR NextBio; 35392; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
DR InterPro; IPR001180; Citron.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 2.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Transferase.
SQ SEQUENCE 1235 AA; 141098 MW; D486AACD86467302 CRC64;
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT
KGNTLKEDWI AYISREILRG LAHLHIHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR
ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR
RQQEREQRRR EQEEKRRLEE LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE
VLQQQLLQEQ AMLLHDHRRP HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVQW
SHLASLKNNV SPVSRSHSFS DPSPKFAHHH LRSQDPCPPS RSEVLSQSSD SKSEAPDPTQ
KAWSRSDSDE VPPRVPVRTT SRSPVLSRRD SPLQGSGQQN SQAGQRNSTS SIEPRLLWER
VEKLVPRPGS GSSSGSSNSG SQPGSHPGSQ SGSGERFRVR SSSKSEGSPS QRLENAVKKP
EDKKEVFRPL KPAGEVDLTA LAKELRAVED VRPPHKVTDY SSSSEESGTT DEEDDDVEQE
GADESTSGPE DTRAASSLNL SNGETESVKT MIVHDDVESE PAMTPSKEGT LIVRQTQSAS
STLQKHKSSS SFTPFIDPRL LQISPSSGTT VTSMVGFSCD GMRPEAIRQD PTRKGSVVNV
NPTNTRPQSD TPEIRKYKKR FNSEILCAAL WGVNLLVGTE SGLMLLDRSG QGKVYPLINR
RRFQQMDVLE GLNVLVTISG KKDKLRVYYL SWLRNKILHN DPEVEKKQGW TTVGDLEGCV
HYKVVKYERI KFLVIALKSS VEVYAWAPKP YHKFMAFKSF GELVHKPLLV DLTVEEGQRL
KVIYGSCAGF HAVDVDSGSV YDIYLPTHIQ CSIKPHAIII LPNTDGMELL VCYEDEGVYV
NTYGRITKDV VLQWGEMPTS VAYIRSNQTM GWGEKAIEIR SVETGHLDGV FMHKRAQRLK
FLCERNDKVF FASVRSGGSS QVYFMTLGRT SLLSW
//