Full text data of BSDC1
BSDC1
[Confidence: low (only semi-automatic identification from reviews)]
BSD domain-containing protein 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
BSD domain-containing protein 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9NW68
ID BSDC1_HUMAN Reviewed; 430 AA.
AC Q9NW68; B4DMS7; B4DTI7; B4DTP7; B4E2X8; Q49AT8; Q68DY6; Q6IAA3;
read moreAC Q6MZK1; Q6UXS1; Q9HAL9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 86.
DE RecName: Full=BSD domain-containing protein 1;
GN Name=BSDC1; ORFNames=UNQ2494/PRO5781;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4; 5; 7; 8 AND 9).
RC TISSUE=Brain, Embryo, Placenta, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Prostate;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND SER-418, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1;
CC IsoId=Q9NW68-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NW68-2; Sequence=VSP_024222, VSP_024223;
CC Name=3;
CC IsoId=Q9NW68-3; Sequence=VSP_024218, VSP_024224;
CC Name=4;
CC IsoId=Q9NW68-4; Sequence=VSP_024217, VSP_024224;
CC Name=5;
CC IsoId=Q9NW68-5; Sequence=VSP_024219, VSP_024220;
CC Note=No experimental confirmation available;
CC Name=6;
CC IsoId=Q9NW68-6; Sequence=VSP_024216, VSP_024221, VSP_024224;
CC Note=No experimental confirmation available;
CC Name=7;
CC IsoId=Q9NW68-7; Sequence=VSP_024218;
CC Name=8;
CC IsoId=Q9NW68-8; Sequence=VSP_041673;
CC Name=9;
CC IsoId=Q9NW68-9; Sequence=VSP_041672;
CC -!- SIMILARITY: Contains 1 BSD domain.
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DR EMBL; AY358230; AAQ88597.1; -; mRNA.
DR EMBL; AK001138; BAA91517.1; -; mRNA.
DR EMBL; AK021440; BAB13825.1; -; mRNA.
DR EMBL; AK297604; BAG59989.1; -; mRNA.
DR EMBL; AK300231; BAG61999.1; -; mRNA.
DR EMBL; AK300306; BAG62059.1; -; mRNA.
DR EMBL; AK304477; BAG65290.1; -; mRNA.
DR EMBL; CR457252; CAG33533.1; -; mRNA.
DR EMBL; BX641056; CAE46029.1; -; mRNA.
DR EMBL; CR749228; CAH18084.1; -; mRNA.
DR EMBL; AL109945; CAI22889.1; -; Genomic_DNA.
DR EMBL; AL109945; CAI22890.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07526.1; -; Genomic_DNA.
DR EMBL; BC026322; AAH26322.1; -; mRNA.
DR EMBL; BC028381; AAH28381.1; -; mRNA.
DR RefSeq; NP_001137360.1; NM_001143888.1.
DR RefSeq; NP_001137361.1; NM_001143889.1.
DR RefSeq; NP_001137362.1; NM_001143890.1.
DR RefSeq; NP_060515.3; NM_018045.6.
DR RefSeq; XP_005271042.1; XM_005270985.1.
DR RefSeq; XP_005271044.1; XM_005270987.1.
DR UniGene; Hs.353454; -.
DR ProteinModelPortal; Q9NW68; -.
DR IntAct; Q9NW68; 5.
DR MINT; MINT-8343011; -.
DR STRING; 9606.ENSP00000397759; -.
DR PhosphoSite; Q9NW68; -.
DR DMDM; 74753009; -.
DR PaxDb; Q9NW68; -.
DR PRIDE; Q9NW68; -.
DR DNASU; 55108; -.
DR Ensembl; ENST00000341071; ENSP00000344816; ENSG00000160058.
DR Ensembl; ENST00000419121; ENSP00000405752; ENSG00000160058.
DR Ensembl; ENST00000444377; ENSP00000414103; ENSG00000160058.
DR Ensembl; ENST00000446293; ENSP00000397759; ENSG00000160058.
DR Ensembl; ENST00000455895; ENSP00000412173; ENSG00000160058.
DR Ensembl; ENST00000526031; ENSP00000432382; ENSG00000160058.
DR GeneID; 55108; -.
DR KEGG; hsa:55108; -.
DR UCSC; uc001bvh.4; human.
DR CTD; 55108; -.
DR GeneCards; GC01M032833; -.
DR HGNC; HGNC:25501; BSDC1.
DR HPA; HPA031360; -.
DR neXtProt; NX_Q9NW68; -.
DR PharmGKB; PA142672548; -.
DR eggNOG; NOG249350; -.
DR HOVERGEN; HBG106482; -.
DR OMA; EDVEWED; -.
DR OrthoDB; EOG71G9V2; -.
DR ChiTaRS; BSDC1; human.
DR GenomeRNAi; 55108; -.
DR NextBio; 58721; -.
DR PRO; PR:Q9NW68; -.
DR ArrayExpress; Q9NW68; -.
DR Bgee; Q9NW68; -.
DR CleanEx; HS_BSDC1; -.
DR Genevestigator; Q9NW68; -.
DR InterPro; IPR005607; BSD.
DR Pfam; PF03909; BSD; 1.
DR SMART; SM00751; BSD; 1.
DR PROSITE; PS50858; BSD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1 430 BSD domain-containing protein 1.
FT /FTId=PRO_0000282639.
FT DOMAIN 146 198 BSD.
FT MOD_RES 92 92 Phosphoserine.
FT MOD_RES 418 418 Phosphoserine.
FT VAR_SEQ 1 359 Missing (in isoform 6).
FT /FTId=VSP_024216.
FT VAR_SEQ 1 104 Missing (in isoform 4).
FT /FTId=VSP_024217.
FT VAR_SEQ 25 119 Missing (in isoform 9).
FT /FTId=VSP_041672.
FT VAR_SEQ 63 63 A -> AIAACSRGACFLCPFSIQ (in isoform 3 and
FT isoform 7).
FT /FTId=VSP_024218.
FT VAR_SEQ 64 120 TEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITL
FT MGTPSGTAEPYDGTKA -> A (in isoform 8).
FT /FTId=VSP_041673.
FT VAR_SEQ 146 173 WLSQFCLEEKKGEISELLVGSPSIRALY -> CQPELWAQI
FT LVAPCWPSWASAHTWEGAL (in isoform 5).
FT /FTId=VSP_024219.
FT VAR_SEQ 174 430 Missing (in isoform 5).
FT /FTId=VSP_024220.
FT VAR_SEQ 360 385 EAPTDLRVFELNSDSGKSTPSNNGKK -> MLSPQLHPLQV
FT PLPCLLLLFTLWLVVP (in isoform 6).
FT /FTId=VSP_024221.
FT VAR_SEQ 386 386 G -> ETRSQFTVDFLWKISVTLLEPLGQSASPLFSNLPFP
FT RLKHGHQ (in isoform 2).
FT /FTId=VSP_024222.
FT VAR_SEQ 387 430 Missing (in isoform 2).
FT /FTId=VSP_024223.
FT VAR_SEQ 421 430 LEDVEWEDWE -> VSGPGGSEGSEPNGPGCESSPQPAQLS
FT PQEGPCSCLR (in isoform 3, isoform 4 and
FT isoform 6).
FT /FTId=VSP_024224.
FT CONFLICT 128 128 D -> G (in Ref. 4; CAH18084).
FT CONFLICT 137 137 D -> G (in Ref. 7; AAH26322).
FT CONFLICT 143 143 F -> L (in Ref. 2; BAB13825).
FT CONFLICT 149 149 Q -> K (in Ref. 7; AAH26322).
FT CONFLICT 250 250 P -> H (in Ref. 7; AAH26322).
FT CONFLICT 287 287 T -> A (in Ref. 7; AAH26322).
FT CONFLICT 430 430 E -> D (in Ref. 3; CAG33533).
SQ SEQUENCE 430 AA; 47163 MW; 4031A3DC18A33646 CRC64;
MAEGEDVGWW RSWLQQSYQA VKEKSSEALE FMKRDLTEFT QVVQHDTACT IAATASVVKE
KLATEGSSGA TEKMKKGLSD FLGVISDTFA PSPDKTIDCD VITLMGTPSG TAEPYDGTKA
RLYSLQSDPA TYCNEPDGPP ELFDAWLSQF CLEEKKGEIS ELLVGSPSIR ALYTKMVPAA
VSHSEFWHRY FYKVHQLEQE QARRDALKQR AEQSISEEPG WEEEEEELMG ISPISPKEAK
VPVAKISTFP EGEPGPQSPC EENLVTSVEP PAEVTPSESS ESISLVTQIA NPATAPEARV
LPKDLSQKLL EASLEEQGLA VDVGETGPSP PIHSKPLTPA GHTGGPEPRP PARVETLREE
APTDLRVFEL NSDSGKSTPS NNGKKGSSTD ISEDWEKDFD LDMTEEEVQM ALSKVDASGE
LEDVEWEDWE
//
ID BSDC1_HUMAN Reviewed; 430 AA.
AC Q9NW68; B4DMS7; B4DTI7; B4DTP7; B4E2X8; Q49AT8; Q68DY6; Q6IAA3;
read moreAC Q6MZK1; Q6UXS1; Q9HAL9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 86.
DE RecName: Full=BSD domain-containing protein 1;
GN Name=BSDC1; ORFNames=UNQ2494/PRO5781;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4; 5; 7; 8 AND 9).
RC TISSUE=Brain, Embryo, Placenta, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Prostate;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND SER-418, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1;
CC IsoId=Q9NW68-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NW68-2; Sequence=VSP_024222, VSP_024223;
CC Name=3;
CC IsoId=Q9NW68-3; Sequence=VSP_024218, VSP_024224;
CC Name=4;
CC IsoId=Q9NW68-4; Sequence=VSP_024217, VSP_024224;
CC Name=5;
CC IsoId=Q9NW68-5; Sequence=VSP_024219, VSP_024220;
CC Note=No experimental confirmation available;
CC Name=6;
CC IsoId=Q9NW68-6; Sequence=VSP_024216, VSP_024221, VSP_024224;
CC Note=No experimental confirmation available;
CC Name=7;
CC IsoId=Q9NW68-7; Sequence=VSP_024218;
CC Name=8;
CC IsoId=Q9NW68-8; Sequence=VSP_041673;
CC Name=9;
CC IsoId=Q9NW68-9; Sequence=VSP_041672;
CC -!- SIMILARITY: Contains 1 BSD domain.
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DR EMBL; AY358230; AAQ88597.1; -; mRNA.
DR EMBL; AK001138; BAA91517.1; -; mRNA.
DR EMBL; AK021440; BAB13825.1; -; mRNA.
DR EMBL; AK297604; BAG59989.1; -; mRNA.
DR EMBL; AK300231; BAG61999.1; -; mRNA.
DR EMBL; AK300306; BAG62059.1; -; mRNA.
DR EMBL; AK304477; BAG65290.1; -; mRNA.
DR EMBL; CR457252; CAG33533.1; -; mRNA.
DR EMBL; BX641056; CAE46029.1; -; mRNA.
DR EMBL; CR749228; CAH18084.1; -; mRNA.
DR EMBL; AL109945; CAI22889.1; -; Genomic_DNA.
DR EMBL; AL109945; CAI22890.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07526.1; -; Genomic_DNA.
DR EMBL; BC026322; AAH26322.1; -; mRNA.
DR EMBL; BC028381; AAH28381.1; -; mRNA.
DR RefSeq; NP_001137360.1; NM_001143888.1.
DR RefSeq; NP_001137361.1; NM_001143889.1.
DR RefSeq; NP_001137362.1; NM_001143890.1.
DR RefSeq; NP_060515.3; NM_018045.6.
DR RefSeq; XP_005271042.1; XM_005270985.1.
DR RefSeq; XP_005271044.1; XM_005270987.1.
DR UniGene; Hs.353454; -.
DR ProteinModelPortal; Q9NW68; -.
DR IntAct; Q9NW68; 5.
DR MINT; MINT-8343011; -.
DR STRING; 9606.ENSP00000397759; -.
DR PhosphoSite; Q9NW68; -.
DR DMDM; 74753009; -.
DR PaxDb; Q9NW68; -.
DR PRIDE; Q9NW68; -.
DR DNASU; 55108; -.
DR Ensembl; ENST00000341071; ENSP00000344816; ENSG00000160058.
DR Ensembl; ENST00000419121; ENSP00000405752; ENSG00000160058.
DR Ensembl; ENST00000444377; ENSP00000414103; ENSG00000160058.
DR Ensembl; ENST00000446293; ENSP00000397759; ENSG00000160058.
DR Ensembl; ENST00000455895; ENSP00000412173; ENSG00000160058.
DR Ensembl; ENST00000526031; ENSP00000432382; ENSG00000160058.
DR GeneID; 55108; -.
DR KEGG; hsa:55108; -.
DR UCSC; uc001bvh.4; human.
DR CTD; 55108; -.
DR GeneCards; GC01M032833; -.
DR HGNC; HGNC:25501; BSDC1.
DR HPA; HPA031360; -.
DR neXtProt; NX_Q9NW68; -.
DR PharmGKB; PA142672548; -.
DR eggNOG; NOG249350; -.
DR HOVERGEN; HBG106482; -.
DR OMA; EDVEWED; -.
DR OrthoDB; EOG71G9V2; -.
DR ChiTaRS; BSDC1; human.
DR GenomeRNAi; 55108; -.
DR NextBio; 58721; -.
DR PRO; PR:Q9NW68; -.
DR ArrayExpress; Q9NW68; -.
DR Bgee; Q9NW68; -.
DR CleanEx; HS_BSDC1; -.
DR Genevestigator; Q9NW68; -.
DR InterPro; IPR005607; BSD.
DR Pfam; PF03909; BSD; 1.
DR SMART; SM00751; BSD; 1.
DR PROSITE; PS50858; BSD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1 430 BSD domain-containing protein 1.
FT /FTId=PRO_0000282639.
FT DOMAIN 146 198 BSD.
FT MOD_RES 92 92 Phosphoserine.
FT MOD_RES 418 418 Phosphoserine.
FT VAR_SEQ 1 359 Missing (in isoform 6).
FT /FTId=VSP_024216.
FT VAR_SEQ 1 104 Missing (in isoform 4).
FT /FTId=VSP_024217.
FT VAR_SEQ 25 119 Missing (in isoform 9).
FT /FTId=VSP_041672.
FT VAR_SEQ 63 63 A -> AIAACSRGACFLCPFSIQ (in isoform 3 and
FT isoform 7).
FT /FTId=VSP_024218.
FT VAR_SEQ 64 120 TEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITL
FT MGTPSGTAEPYDGTKA -> A (in isoform 8).
FT /FTId=VSP_041673.
FT VAR_SEQ 146 173 WLSQFCLEEKKGEISELLVGSPSIRALY -> CQPELWAQI
FT LVAPCWPSWASAHTWEGAL (in isoform 5).
FT /FTId=VSP_024219.
FT VAR_SEQ 174 430 Missing (in isoform 5).
FT /FTId=VSP_024220.
FT VAR_SEQ 360 385 EAPTDLRVFELNSDSGKSTPSNNGKK -> MLSPQLHPLQV
FT PLPCLLLLFTLWLVVP (in isoform 6).
FT /FTId=VSP_024221.
FT VAR_SEQ 386 386 G -> ETRSQFTVDFLWKISVTLLEPLGQSASPLFSNLPFP
FT RLKHGHQ (in isoform 2).
FT /FTId=VSP_024222.
FT VAR_SEQ 387 430 Missing (in isoform 2).
FT /FTId=VSP_024223.
FT VAR_SEQ 421 430 LEDVEWEDWE -> VSGPGGSEGSEPNGPGCESSPQPAQLS
FT PQEGPCSCLR (in isoform 3, isoform 4 and
FT isoform 6).
FT /FTId=VSP_024224.
FT CONFLICT 128 128 D -> G (in Ref. 4; CAH18084).
FT CONFLICT 137 137 D -> G (in Ref. 7; AAH26322).
FT CONFLICT 143 143 F -> L (in Ref. 2; BAB13825).
FT CONFLICT 149 149 Q -> K (in Ref. 7; AAH26322).
FT CONFLICT 250 250 P -> H (in Ref. 7; AAH26322).
FT CONFLICT 287 287 T -> A (in Ref. 7; AAH26322).
FT CONFLICT 430 430 E -> D (in Ref. 3; CAG33533).
SQ SEQUENCE 430 AA; 47163 MW; 4031A3DC18A33646 CRC64;
MAEGEDVGWW RSWLQQSYQA VKEKSSEALE FMKRDLTEFT QVVQHDTACT IAATASVVKE
KLATEGSSGA TEKMKKGLSD FLGVISDTFA PSPDKTIDCD VITLMGTPSG TAEPYDGTKA
RLYSLQSDPA TYCNEPDGPP ELFDAWLSQF CLEEKKGEIS ELLVGSPSIR ALYTKMVPAA
VSHSEFWHRY FYKVHQLEQE QARRDALKQR AEQSISEEPG WEEEEEELMG ISPISPKEAK
VPVAKISTFP EGEPGPQSPC EENLVTSVEP PAEVTPSESS ESISLVTQIA NPATAPEARV
LPKDLSQKLL EASLEEQGLA VDVGETGPSP PIHSKPLTPA GHTGGPEPRP PARVETLREE
APTDLRVFEL NSDSGKSTPS NNGKKGSSTD ISEDWEKDFD LDMTEEEVQM ALSKVDASGE
LEDVEWEDWE
//