Full text data of KIF5B-ALK
KIF5B-ALK
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Tyrosine-protein kinase receptor; 2.7.10.1
Tyrosine-protein kinase receptor; 2.7.10.1
UniProt
C1PHA2
ID C1PHA2_HUMAN Unreviewed; 1483 AA.
AC C1PHA2;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
read moreDT 11-DEC-2013, entry version 31.
DE RecName: Full=Tyrosine-protein kinase receptor;
DE EC=2.7.10.1;
GN Name=KIF5B-ALK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19383809; DOI=10.1158/1078-0432.CCR-08-3248;
RA Takeuchi K., Choi Y.L., Togashi Y., Soda M., Hatano S., Inamura K.,
RA Takada S., Ueno T., Yamashita Y., Satoh Y., Okumura S., Nakagawa K.,
RA Ishikawa Y., Mano H.;
RT "KIF5B-ALK, a novel fusion oncokinase identified by an
RT immunohistochemistry-based diagnostic system for ALK-positive lung
RT cancer.";
RL Clin. Cancer Res. 15:3143-3149(2009).
CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC [protein]-L-tyrosine phosphate.
CC -!- SIMILARITY: Belongs to the kinesin-like protein family.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC -!- SIMILARITY: Contains 1 kinesin-motor domain.
CC -!- SIMILARITY: Contains kinesin-motor domain.
CC -!- SIMILARITY: Contains protein kinase domain.
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DR EMBL; AB462413; BAH57337.1; -; mRNA.
DR ProteinModelPortal; C1PHA2; -.
DR HOGENOM; HOG000216718; -.
DR NextBio; 35482582; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:GOC.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF07714; Pkinase_Tyr; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_DOMAIN1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_DOMAIN2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Membrane; Microtubule; Motor protein;
KW Nucleotide-binding; Phosphoprotein; Receptor; Transferase;
KW Transmembrane; Tyrosine-protein kinase.
SQ SEQUENCE 1483 AA; 167906 MW; FD655D27F755274C CRC64;
MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKILRNTIQW
LENELNRWRN GETVPIDEQF DKEKANLEAF TVDKDITLTN DKPATAIGVI GNFTDAERRK
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL
EESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR
DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEIDSD DTGGSAAQKQ KISFLENNLE
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD
RIKEAVRSKN MARRGHSAQI VYRRKHQELQ AMQMELQSPE YKLSKLRTST IMTDYNPNYC
FAGKTSSISD LKEVPRKNIT LIRGLGHGAF GEVYEGQVSG MPNDPSPLQV AVKTLPEVCS
EQDELDFLME ALIISKFNHQ NIVRCIGVSL QSLPRFILLE LMAGGDLKSF LRETRPRPSQ
PSSLAMLDLL HVARDIACGC QYLEENHFIH RDIAARNCLL TCPGPGRVAK IGDFGMARDI
YRASYYRKGG CAMLPVKWMP PEAFMEGIFT SKTDTWSFGV LLWEIFSLGY MPYPSKSNQE
VLEFVTSGGR MDPPKNCPGP VYRIMTQCWQ HQPEDRPNFA IILERIEYCT QDPDVINTAL
PIEYGPLVEE EEKVPVRPKD PEGVPPLLVS QQAKREEERS PAAPPPLPTT SSGKAAKKPT
AAEVSVRVPR GPAVEGGHVN MAFSQSNPPS ELHKVHGSRN KPTSLWNPTY GSWFTEKPTK
KNNPIAKKEP HDRGNLGLEG SCTVPPNVAT GRLPGASLLL EPSSLTANMK EVPLFRLRHF
PCGNVNYGYQ QQGLPLEAAT APGAGHYEDT ILKSKNSMNQ PGP
//
ID C1PHA2_HUMAN Unreviewed; 1483 AA.
AC C1PHA2;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
read moreDT 11-DEC-2013, entry version 31.
DE RecName: Full=Tyrosine-protein kinase receptor;
DE EC=2.7.10.1;
GN Name=KIF5B-ALK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19383809; DOI=10.1158/1078-0432.CCR-08-3248;
RA Takeuchi K., Choi Y.L., Togashi Y., Soda M., Hatano S., Inamura K.,
RA Takada S., Ueno T., Yamashita Y., Satoh Y., Okumura S., Nakagawa K.,
RA Ishikawa Y., Mano H.;
RT "KIF5B-ALK, a novel fusion oncokinase identified by an
RT immunohistochemistry-based diagnostic system for ALK-positive lung
RT cancer.";
RL Clin. Cancer Res. 15:3143-3149(2009).
CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC [protein]-L-tyrosine phosphate.
CC -!- SIMILARITY: Belongs to the kinesin-like protein family.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC -!- SIMILARITY: Contains 1 kinesin-motor domain.
CC -!- SIMILARITY: Contains kinesin-motor domain.
CC -!- SIMILARITY: Contains protein kinase domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB462413; BAH57337.1; -; mRNA.
DR ProteinModelPortal; C1PHA2; -.
DR HOGENOM; HOG000216718; -.
DR NextBio; 35482582; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:GOC.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF07714; Pkinase_Tyr; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_DOMAIN1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_DOMAIN2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Membrane; Microtubule; Motor protein;
KW Nucleotide-binding; Phosphoprotein; Receptor; Transferase;
KW Transmembrane; Tyrosine-protein kinase.
SQ SEQUENCE 1483 AA; 167906 MW; FD655D27F755274C CRC64;
MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKILRNTIQW
LENELNRWRN GETVPIDEQF DKEKANLEAF TVDKDITLTN DKPATAIGVI GNFTDAERRK
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL
EESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR
DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEIDSD DTGGSAAQKQ KISFLENNLE
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD
RIKEAVRSKN MARRGHSAQI VYRRKHQELQ AMQMELQSPE YKLSKLRTST IMTDYNPNYC
FAGKTSSISD LKEVPRKNIT LIRGLGHGAF GEVYEGQVSG MPNDPSPLQV AVKTLPEVCS
EQDELDFLME ALIISKFNHQ NIVRCIGVSL QSLPRFILLE LMAGGDLKSF LRETRPRPSQ
PSSLAMLDLL HVARDIACGC QYLEENHFIH RDIAARNCLL TCPGPGRVAK IGDFGMARDI
YRASYYRKGG CAMLPVKWMP PEAFMEGIFT SKTDTWSFGV LLWEIFSLGY MPYPSKSNQE
VLEFVTSGGR MDPPKNCPGP VYRIMTQCWQ HQPEDRPNFA IILERIEYCT QDPDVINTAL
PIEYGPLVEE EEKVPVRPKD PEGVPPLLVS QQAKREEERS PAAPPPLPTT SSGKAAKKPT
AAEVSVRVPR GPAVEGGHVN MAFSQSNPPS ELHKVHGSRN KPTSLWNPTY GSWFTEKPTK
KNNPIAKKEP HDRGNLGLEG SCTVPPNVAT GRLPGASLLL EPSSLTANMK EVPLFRLRHF
PCGNVNYGYQ QQGLPLEAAT APGAGHYEDT ILKSKNSMNQ PGP
//