Full text data of C2CD2L
C2CD2L
(KIAA0285, TMEM24)
[Confidence: high (present in two of the MS resources)]
C2 domain-containing protein 2-like (Transmembrane protein 24)
C2 domain-containing protein 2-like (Transmembrane protein 24)
hRBCD
IPI00394781
IPI00394781 transmembrane protein 24 transmembrane protein 24 membrane n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a 2 1 n/a 2 1 n/a 1 n/a n/a n/a integral memrbane protein n/a found at its expected molecular weight found at molecular weight
IPI00394781 transmembrane protein 24 transmembrane protein 24 membrane n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a 2 1 n/a 2 1 n/a 1 n/a n/a n/a integral memrbane protein n/a found at its expected molecular weight found at molecular weight
UniProt
O14523
ID C2C2L_HUMAN Reviewed; 706 AA.
AC O14523; Q86UT7; Q86V04; Q8N522; Q8TBN4; Q96G10;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 26-APR-2004, sequence version 3.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=C2 domain-containing protein 2-like;
DE AltName: Full=Transmembrane protein 24;
GN Name=C2CD2L; Synonyms=KIAA0285, TMEM24; ORFNames=DLNB23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T.,
RA Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.;
RT "Identification of a 500-kb region of common allelic loss in
RT chromosome 11q23 in non-MYCN amplified type of neuroblastoma.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 381-706 (ISOFORM 2).
RC TISSUE=Blood, Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-706 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9179496; DOI=10.1093/dnares/4.1.53;
RA Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N.,
RA Nomura N.;
RT "Construction and characterization of human brain cDNA libraries
RT suitable for analysis of cDNA clones encoding relatively large
RT proteins.";
RL DNA Res. 4:53-59(1997).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417 AND SER-464, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (By
CC similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O14523-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O14523-2; Sequence=VSP_021158;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10071.2; Type=Erroneous initiation;
CC Sequence=AAH21254.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
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CC Distributed under the Creative Commons Attribution-NoDerivs License
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DR EMBL; AB094094; BAC76048.1; -; mRNA.
DR EMBL; BC010071; AAH10071.2; ALT_INIT; mRNA.
DR EMBL; BC021254; AAH21254.2; ALT_INIT; mRNA.
DR EMBL; BC022219; AAH22219.1; -; mRNA.
DR EMBL; BC033083; AAH33083.1; -; mRNA.
DR EMBL; BC052246; AAH52246.1; -; mRNA.
DR EMBL; AB006623; BAA22954.2; -; mRNA.
DR RefSeq; NP_055622.3; NM_014807.3.
DR RefSeq; XP_005271795.1; XM_005271738.1.
DR UniGene; Hs.26899; -.
DR ProteinModelPortal; O14523; -.
DR STRING; 9606.ENSP00000338885; -.
DR PhosphoSite; O14523; -.
DR PaxDb; O14523; -.
DR PRIDE; O14523; -.
DR Ensembl; ENST00000336702; ENSP00000338885; ENSG00000172375.
DR GeneID; 9854; -.
DR KEGG; hsa:9854; -.
DR UCSC; uc001pvo.3; human.
DR CTD; 9854; -.
DR GeneCards; GC11P118978; -.
DR H-InvDB; HIX0201586; -.
DR HGNC; HGNC:29000; C2CD2L.
DR HPA; HPA011044; -.
DR neXtProt; NX_O14523; -.
DR PharmGKB; PA162379049; -.
DR eggNOG; NOG47970; -.
DR HOGENOM; HOG000008704; -.
DR HOVERGEN; HBG058857; -.
DR InParanoid; O14523; -.
DR OMA; CCVAELD; -.
DR OrthoDB; EOG7ZWD1F; -.
DR GenomeRNAi; 9854; -.
DR NextBio; 37138; -.
DR PRO; PR:O14523; -.
DR ArrayExpress; O14523; -.
DR Bgee; O14523; -.
DR CleanEx; HS_C2CD2L; -.
DR Genevestigator; O14523; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000008; C2_dom.
DR SUPFAM; SSF49562; SSF49562; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Membrane; Phosphoprotein;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 706 C2 domain-containing protein 2-like.
FT /FTId=PRO_0000072596.
FT TRANSMEM 10 30 Helical; (Potential).
FT MOD_RES 417 417 Phosphothreonine.
FT MOD_RES 464 464 Phosphoserine.
FT MOD_RES 613 613 Phosphoserine (By similarity).
FT MOD_RES 619 619 Phosphoserine (By similarity).
FT MOD_RES 623 623 Phosphoserine.
FT VAR_SEQ 497 497 R -> PG (in isoform 2).
FT /FTId=VSP_021158.
FT VARIANT 413 413 R -> W (in dbSNP:rs2239896).
FT /FTId=VAR_028797.
SQ SEQUENCE 706 AA; 76181 MW; 9301A8BDF6D4D5B6 CRC64;
MDPGWGQRDV GWAALLILFA ASLLTVFAWL LQYARGLWLA RARGDRGPGP ALAGEPAGSL
RELGVWRSLL RLRATRAGAA EEPGVRGLLA SLFAFKSFRE NWQRAWVRAL NEQACRNGSS
IQIAFEEVPQ LPPRASISHV TCVDQSEHTM VLRCQLSAEE VRFPVSVTQQ SPAAVSMETY
HVTLTLPPTQ LEVNLEEIPG EGLLISWAFT DRPDLSLTVL PKLQARERGE EQVELSTIEE
LIKDAIVSTQ PAMMVNLRAC SAPGGLVPSE KPPMMPQAQP AIPRPNRLFL RQLRASHLGN
ELEGTEELCC VAELDNPMQQ KWTKPARAGS EVEWTEDLAL DLGPQSRELT LKVLRSSSCG
DTELLGQATL PVGSPSRPLS RRQLCPLTPG PGKALGPAAT MAVELHYEEG SPRNLGTPTS
STPRPSITPT KKIELDRTIM PDGTIVTTVT TVQSRPRIDG KLDSPSRSPS KVEVTEKTTT
VLSESSGPSN TSHSSSRDSH LSNGLDPVAE TAIRQLTEPS GRVAKKTPTK RSTLIISGVS
KVPIAQDELA LSLGYAASLE ASVQDDAGTS GGPSSPPSDP PAMSPGPLDA LSSPTSVQEA
DETTRSDISE RPSVDDIESE TGSTGALETR SLKDHKVSFL RSGTKLIFRR RPRQKEAGLS
QSHDDLSNAT ATPSVRKKAG SFSRRLIKRF SFKSKPKANG NPSPQL
//
ID C2C2L_HUMAN Reviewed; 706 AA.
AC O14523; Q86UT7; Q86V04; Q8N522; Q8TBN4; Q96G10;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 26-APR-2004, sequence version 3.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=C2 domain-containing protein 2-like;
DE AltName: Full=Transmembrane protein 24;
GN Name=C2CD2L; Synonyms=KIAA0285, TMEM24; ORFNames=DLNB23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T.,
RA Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.;
RT "Identification of a 500-kb region of common allelic loss in
RT chromosome 11q23 in non-MYCN amplified type of neuroblastoma.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 381-706 (ISOFORM 2).
RC TISSUE=Blood, Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-706 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9179496; DOI=10.1093/dnares/4.1.53;
RA Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N.,
RA Nomura N.;
RT "Construction and characterization of human brain cDNA libraries
RT suitable for analysis of cDNA clones encoding relatively large
RT proteins.";
RL DNA Res. 4:53-59(1997).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417 AND SER-464, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (By
CC similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O14523-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O14523-2; Sequence=VSP_021158;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10071.2; Type=Erroneous initiation;
CC Sequence=AAH21254.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB094094; BAC76048.1; -; mRNA.
DR EMBL; BC010071; AAH10071.2; ALT_INIT; mRNA.
DR EMBL; BC021254; AAH21254.2; ALT_INIT; mRNA.
DR EMBL; BC022219; AAH22219.1; -; mRNA.
DR EMBL; BC033083; AAH33083.1; -; mRNA.
DR EMBL; BC052246; AAH52246.1; -; mRNA.
DR EMBL; AB006623; BAA22954.2; -; mRNA.
DR RefSeq; NP_055622.3; NM_014807.3.
DR RefSeq; XP_005271795.1; XM_005271738.1.
DR UniGene; Hs.26899; -.
DR ProteinModelPortal; O14523; -.
DR STRING; 9606.ENSP00000338885; -.
DR PhosphoSite; O14523; -.
DR PaxDb; O14523; -.
DR PRIDE; O14523; -.
DR Ensembl; ENST00000336702; ENSP00000338885; ENSG00000172375.
DR GeneID; 9854; -.
DR KEGG; hsa:9854; -.
DR UCSC; uc001pvo.3; human.
DR CTD; 9854; -.
DR GeneCards; GC11P118978; -.
DR H-InvDB; HIX0201586; -.
DR HGNC; HGNC:29000; C2CD2L.
DR HPA; HPA011044; -.
DR neXtProt; NX_O14523; -.
DR PharmGKB; PA162379049; -.
DR eggNOG; NOG47970; -.
DR HOGENOM; HOG000008704; -.
DR HOVERGEN; HBG058857; -.
DR InParanoid; O14523; -.
DR OMA; CCVAELD; -.
DR OrthoDB; EOG7ZWD1F; -.
DR GenomeRNAi; 9854; -.
DR NextBio; 37138; -.
DR PRO; PR:O14523; -.
DR ArrayExpress; O14523; -.
DR Bgee; O14523; -.
DR CleanEx; HS_C2CD2L; -.
DR Genevestigator; O14523; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000008; C2_dom.
DR SUPFAM; SSF49562; SSF49562; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Membrane; Phosphoprotein;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 706 C2 domain-containing protein 2-like.
FT /FTId=PRO_0000072596.
FT TRANSMEM 10 30 Helical; (Potential).
FT MOD_RES 417 417 Phosphothreonine.
FT MOD_RES 464 464 Phosphoserine.
FT MOD_RES 613 613 Phosphoserine (By similarity).
FT MOD_RES 619 619 Phosphoserine (By similarity).
FT MOD_RES 623 623 Phosphoserine.
FT VAR_SEQ 497 497 R -> PG (in isoform 2).
FT /FTId=VSP_021158.
FT VARIANT 413 413 R -> W (in dbSNP:rs2239896).
FT /FTId=VAR_028797.
SQ SEQUENCE 706 AA; 76181 MW; 9301A8BDF6D4D5B6 CRC64;
MDPGWGQRDV GWAALLILFA ASLLTVFAWL LQYARGLWLA RARGDRGPGP ALAGEPAGSL
RELGVWRSLL RLRATRAGAA EEPGVRGLLA SLFAFKSFRE NWQRAWVRAL NEQACRNGSS
IQIAFEEVPQ LPPRASISHV TCVDQSEHTM VLRCQLSAEE VRFPVSVTQQ SPAAVSMETY
HVTLTLPPTQ LEVNLEEIPG EGLLISWAFT DRPDLSLTVL PKLQARERGE EQVELSTIEE
LIKDAIVSTQ PAMMVNLRAC SAPGGLVPSE KPPMMPQAQP AIPRPNRLFL RQLRASHLGN
ELEGTEELCC VAELDNPMQQ KWTKPARAGS EVEWTEDLAL DLGPQSRELT LKVLRSSSCG
DTELLGQATL PVGSPSRPLS RRQLCPLTPG PGKALGPAAT MAVELHYEEG SPRNLGTPTS
STPRPSITPT KKIELDRTIM PDGTIVTTVT TVQSRPRIDG KLDSPSRSPS KVEVTEKTTT
VLSESSGPSN TSHSSSRDSH LSNGLDPVAE TAIRQLTEPS GRVAKKTPTK RSTLIISGVS
KVPIAQDELA LSLGYAASLE ASVQDDAGTS GGPSSPPSDP PAMSPGPLDA LSSPTSVQEA
DETTRSDISE RPSVDDIESE TGSTGALETR SLKDHKVSFL RSGTKLIFRR RPRQKEAGLS
QSHDDLSNAT ATPSVRKKAG SFSRRLIKRF SFKSKPKANG NPSPQL
//