Full text data of CCDC124
CCDC124
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Coiled-coil domain-containing protein 124
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Coiled-coil domain-containing protein 124
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96CT7
ID CC124_HUMAN Reviewed; 223 AA.
AC Q96CT7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 84.
DE RecName: Full=Coiled-coil domain-containing protein 124;
GN Name=CCDC124;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RASGEF1B, TISSUE
RP SPECIFICITY, AND PHOSPHORYLATION AT SER-141.
RX PubMed=23894443; DOI=10.1371/journal.pone.0069289;
RA Telkoparan P., Erkek S., Yaman E., Alotaibi H., Bayik D.,
RA Tazebay U.H.;
RT "Coiled-coil domain containing protein 124 is a novel centrosome and
RT midbody protein that interacts with the ras-guanine nucleotide
RT exchange factor 1B and is involved in cytokinesis.";
RL PLoS ONE 8:E69289-E69289(2013).
CC -!- FUNCTION: Required for proper progression of late cytokinetic
CC stages.
CC -!- SUBUNIT: Interacts with RASGEF1B.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome. Midbody. Note=Colocalizes with
CC gamma-tubulin at interphase, prophase, metaphase, and anaphase.
CC Relocates from centrosome to midbody at telophase.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC -!- SIMILARITY: Belongs to the CCDC124 family.
CC -----------------------------------------------------------------------
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CC Distributed under the Creative Commons Attribution-NoDerivs License
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DR EMBL; BC013949; AAH13949.1; -; mRNA.
DR RefSeq; NP_001129675.1; NM_001136203.1.
DR RefSeq; NP_612451.1; NM_138442.3.
DR UniGene; Hs.100043; -.
DR ProteinModelPortal; Q96CT7; -.
DR IntAct; Q96CT7; 2.
DR MINT; MINT-5003411; -.
DR STRING; 9606.ENSP00000262801; -.
DR PhosphoSite; Q96CT7; -.
DR DMDM; 74731379; -.
DR PaxDb; Q96CT7; -.
DR PeptideAtlas; Q96CT7; -.
DR PRIDE; Q96CT7; -.
DR DNASU; 115098; -.
DR Ensembl; ENST00000445755; ENSP00000408730; ENSG00000007080.
DR Ensembl; ENST00000597436; ENSP00000471455; ENSG00000007080.
DR GeneID; 115098; -.
DR KEGG; hsa:115098; -.
DR UCSC; uc002nhs.3; human.
DR CTD; 115098; -.
DR GeneCards; GC19P018043; -.
DR HGNC; HGNC:25171; CCDC124.
DR HPA; HPA041708; -.
DR HPA; HPA046765; -.
DR neXtProt; NX_Q96CT7; -.
DR PharmGKB; PA147358292; -.
DR eggNOG; NOG303684; -.
DR HOGENOM; HOG000204343; -.
DR HOVERGEN; HBG080942; -.
DR InParanoid; Q96CT7; -.
DR OMA; DRHPEKR; -.
DR OrthoDB; EOG75F4G4; -.
DR PhylomeDB; Q96CT7; -.
DR ChiTaRS; CCDC124; human.
DR GenomeRNAi; 115098; -.
DR NextBio; 79502; -.
DR PRO; PR:Q96CT7; -.
DR ArrayExpress; Q96CT7; -.
DR Bgee; Q96CT7; -.
DR CleanEx; HS_CCDC124; -.
DR Genevestigator; Q96CT7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR010422; DUF1014.
DR InterPro; IPR009071; HMG_box_dom.
DR PANTHER; PTHR21680; PTHR21680; 1.
DR Pfam; PF06244; DUF1014; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome.
FT CHAIN 1 223 Coiled-coil domain-containing protein
FT 124.
FT /FTId=PRO_0000263735.
FT COILED 15 82 Potential.
FT MOD_RES 141 141 Phosphoserine.
FT VARIANT 138 138 E -> Q (in dbSNP:rs8104153).
FT /FTId=VAR_053809.
SQ SEQUENCE 223 AA; 25835 MW; DFC65D526057DE27 CRC64;
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE QRKEEKEKRR
LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI EDTLRRDHQL REAPDTAEKA
KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ
LPRLKQENPN MRLSQLKQLL KKEWLRSPDN PMNQRAVPFN APK
//
ID CC124_HUMAN Reviewed; 223 AA.
AC Q96CT7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 84.
DE RecName: Full=Coiled-coil domain-containing protein 124;
GN Name=CCDC124;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RASGEF1B, TISSUE
RP SPECIFICITY, AND PHOSPHORYLATION AT SER-141.
RX PubMed=23894443; DOI=10.1371/journal.pone.0069289;
RA Telkoparan P., Erkek S., Yaman E., Alotaibi H., Bayik D.,
RA Tazebay U.H.;
RT "Coiled-coil domain containing protein 124 is a novel centrosome and
RT midbody protein that interacts with the ras-guanine nucleotide
RT exchange factor 1B and is involved in cytokinesis.";
RL PLoS ONE 8:E69289-E69289(2013).
CC -!- FUNCTION: Required for proper progression of late cytokinetic
CC stages.
CC -!- SUBUNIT: Interacts with RASGEF1B.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome. Midbody. Note=Colocalizes with
CC gamma-tubulin at interphase, prophase, metaphase, and anaphase.
CC Relocates from centrosome to midbody at telophase.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC -!- SIMILARITY: Belongs to the CCDC124 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BC013949; AAH13949.1; -; mRNA.
DR RefSeq; NP_001129675.1; NM_001136203.1.
DR RefSeq; NP_612451.1; NM_138442.3.
DR UniGene; Hs.100043; -.
DR ProteinModelPortal; Q96CT7; -.
DR IntAct; Q96CT7; 2.
DR MINT; MINT-5003411; -.
DR STRING; 9606.ENSP00000262801; -.
DR PhosphoSite; Q96CT7; -.
DR DMDM; 74731379; -.
DR PaxDb; Q96CT7; -.
DR PeptideAtlas; Q96CT7; -.
DR PRIDE; Q96CT7; -.
DR DNASU; 115098; -.
DR Ensembl; ENST00000445755; ENSP00000408730; ENSG00000007080.
DR Ensembl; ENST00000597436; ENSP00000471455; ENSG00000007080.
DR GeneID; 115098; -.
DR KEGG; hsa:115098; -.
DR UCSC; uc002nhs.3; human.
DR CTD; 115098; -.
DR GeneCards; GC19P018043; -.
DR HGNC; HGNC:25171; CCDC124.
DR HPA; HPA041708; -.
DR HPA; HPA046765; -.
DR neXtProt; NX_Q96CT7; -.
DR PharmGKB; PA147358292; -.
DR eggNOG; NOG303684; -.
DR HOGENOM; HOG000204343; -.
DR HOVERGEN; HBG080942; -.
DR InParanoid; Q96CT7; -.
DR OMA; DRHPEKR; -.
DR OrthoDB; EOG75F4G4; -.
DR PhylomeDB; Q96CT7; -.
DR ChiTaRS; CCDC124; human.
DR GenomeRNAi; 115098; -.
DR NextBio; 79502; -.
DR PRO; PR:Q96CT7; -.
DR ArrayExpress; Q96CT7; -.
DR Bgee; Q96CT7; -.
DR CleanEx; HS_CCDC124; -.
DR Genevestigator; Q96CT7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR010422; DUF1014.
DR InterPro; IPR009071; HMG_box_dom.
DR PANTHER; PTHR21680; PTHR21680; 1.
DR Pfam; PF06244; DUF1014; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome.
FT CHAIN 1 223 Coiled-coil domain-containing protein
FT 124.
FT /FTId=PRO_0000263735.
FT COILED 15 82 Potential.
FT MOD_RES 141 141 Phosphoserine.
FT VARIANT 138 138 E -> Q (in dbSNP:rs8104153).
FT /FTId=VAR_053809.
SQ SEQUENCE 223 AA; 25835 MW; DFC65D526057DE27 CRC64;
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE QRKEEKEKRR
LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI EDTLRRDHQL REAPDTAEKA
KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ
LPRLKQENPN MRLSQLKQLL KKEWLRSPDN PMNQRAVPFN APK
//