Full text data of TMEM30A
TMEM30A
(C6orf67, CDC50A)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Cell cycle control protein 50A (Transmembrane protein 30A)
Cell cycle control protein 50A (Transmembrane protein 30A)
UniProt
Q9NV96
ID CC50A_HUMAN Reviewed; 361 AA.
AC Q9NV96; A8K9V8; E1P539; Q658Z3; Q96H09; Q9NSL9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Cell cycle control protein 50A;
DE AltName: Full=Transmembrane protein 30A;
GN Name=TMEM30A; Synonyms=C6orf67, CDC50A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Amygdala, Lymph node, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=15375526;
RA Katoh Y., Katoh M.;
RT "Identification and characterization of CDC50A, CDC50B and CDC50C
RT genes in silico.";
RL Oncol. Rep. 12:939-943(2004).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-294, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-
RT linked cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NV96-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NV96-2; Sequence=VSP_019568;
CC Name=3;
CC IsoId=Q9NV96-3; Sequence=VSP_019567;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family.
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DR EMBL; AK001718; BAA91859.1; -; mRNA.
DR EMBL; AK292823; BAF85512.1; -; mRNA.
DR EMBL; AL832815; CAH56262.1; -; mRNA.
DR EMBL; AL832490; CAH56205.1; -; mRNA.
DR EMBL; AL162046; CAB82389.1; -; mRNA.
DR EMBL; AL080250; CAI19900.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48743.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48744.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48745.1; -; Genomic_DNA.
DR EMBL; BC009006; AAH09006.1; -; mRNA.
DR PIR; T47140; T47140.
DR RefSeq; NP_001137430.1; NM_001143958.1.
DR RefSeq; NP_060717.1; NM_018247.3.
DR UniGene; Hs.108530; -.
DR ProteinModelPortal; Q9NV96; -.
DR IntAct; Q9NV96; 2.
DR MINT; MINT-5006648; -.
DR STRING; 9606.ENSP00000359067; -.
DR PhosphoSite; Q9NV96; -.
DR DMDM; 74752991; -.
DR PaxDb; Q9NV96; -.
DR PeptideAtlas; Q9NV96; -.
DR PRIDE; Q9NV96; -.
DR DNASU; 55754; -.
DR Ensembl; ENST00000230461; ENSP00000230461; ENSG00000112697.
DR Ensembl; ENST00000370050; ENSP00000359067; ENSG00000112697.
DR Ensembl; ENST00000475111; ENSP00000431007; ENSG00000112697.
DR GeneID; 55754; -.
DR KEGG; hsa:55754; -.
DR UCSC; uc003phw.2; human.
DR CTD; 55754; -.
DR GeneCards; GC06M075962; -.
DR HGNC; HGNC:16667; TMEM30A.
DR HPA; HPA014561; -.
DR MIM; 611028; gene.
DR neXtProt; NX_Q9NV96; -.
DR PharmGKB; PA134936902; -.
DR eggNOG; COG5035; -.
DR HOGENOM; HOG000209057; -.
DR HOVERGEN; HBG055537; -.
DR InParanoid; Q9NV96; -.
DR OMA; DVTPCIC; -.
DR OrthoDB; EOG7C5M8D; -.
DR PhylomeDB; Q9NV96; -.
DR ChiTaRS; TMEM30A; human.
DR GenomeRNAi; 55754; -.
DR NextBio; 60753; -.
DR PRO; PR:Q9NV96; -.
DR ArrayExpress; Q9NV96; -.
DR Bgee; Q9NV96; -.
DR CleanEx; HS_TMEM30A; -.
DR Genevestigator; Q9NV96; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0036010; P:protein localization to endosome; IMP:UniProtKB.
DR InterPro; IPR005045; DUF284_TM_euk.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR Pfam; PF03381; CDC50; 1.
DR PIRSF; PIRSF015840; DUF284_TM_euk; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 361 Cell cycle control protein 50A.
FT /FTId=PRO_0000244469.
FT TRANSMEM 50 70 Helical; (Potential).
FT TRANSMEM 326 346 Helical; (Potential).
FT MOD_RES 2 2 N-acetylalanine.
FT CARBOHYD 180 180 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 190 190 N-linked (GlcNAc...).
FT CARBOHYD 294 294 N-linked (GlcNAc...).
FT VAR_SEQ 1 119 Missing (in isoform 3).
FT /FTId=VSP_019567.
FT VAR_SEQ 79 114 Missing (in isoform 2).
FT /FTId=VSP_019568.
SQ SEQUENCE 361 AA; 40684 MW; 64B3F28C3EB7801B CRC64;
MAMNYNAKDE VDGGPPCAPG GTAKTRRPDN TAFKQQRLPA WQPILTAGTV LPIFFIIGLI
FIPIGIGIFV TSNNIREIEI DYTGTEPSSP CNKCLSPDVT PCFCTINFTL EKSFEGNVFM
YYGLSNFYQN HRRYVKSRDD SQLNGDSSAL LNPSKECEPY RRNEDKPIAP CGAIANSMFN
DTLELFLIGN DSYPIPIALK KKGIAWWTDK NVKFRNPPGG DNLEERFKGT TKPVNWLKPV
YMLDSDPDNN GFINEDFIVW MRTAALPTFR KLYRLIERKS DLHPTLPAGR YSLNVTYNYP
VHYFDGRKRM ILSTISWMGG KNPFLGIAYI AVGSISFLLG VVLLVINHKY RNSSNTADIT
I
//
ID CC50A_HUMAN Reviewed; 361 AA.
AC Q9NV96; A8K9V8; E1P539; Q658Z3; Q96H09; Q9NSL9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Cell cycle control protein 50A;
DE AltName: Full=Transmembrane protein 30A;
GN Name=TMEM30A; Synonyms=C6orf67, CDC50A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Amygdala, Lymph node, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=15375526;
RA Katoh Y., Katoh M.;
RT "Identification and characterization of CDC50A, CDC50B and CDC50C
RT genes in silico.";
RL Oncol. Rep. 12:939-943(2004).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-294, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-
RT linked cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NV96-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NV96-2; Sequence=VSP_019568;
CC Name=3;
CC IsoId=Q9NV96-3; Sequence=VSP_019567;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family.
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DR EMBL; AK001718; BAA91859.1; -; mRNA.
DR EMBL; AK292823; BAF85512.1; -; mRNA.
DR EMBL; AL832815; CAH56262.1; -; mRNA.
DR EMBL; AL832490; CAH56205.1; -; mRNA.
DR EMBL; AL162046; CAB82389.1; -; mRNA.
DR EMBL; AL080250; CAI19900.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48743.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48744.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48745.1; -; Genomic_DNA.
DR EMBL; BC009006; AAH09006.1; -; mRNA.
DR PIR; T47140; T47140.
DR RefSeq; NP_001137430.1; NM_001143958.1.
DR RefSeq; NP_060717.1; NM_018247.3.
DR UniGene; Hs.108530; -.
DR ProteinModelPortal; Q9NV96; -.
DR IntAct; Q9NV96; 2.
DR MINT; MINT-5006648; -.
DR STRING; 9606.ENSP00000359067; -.
DR PhosphoSite; Q9NV96; -.
DR DMDM; 74752991; -.
DR PaxDb; Q9NV96; -.
DR PeptideAtlas; Q9NV96; -.
DR PRIDE; Q9NV96; -.
DR DNASU; 55754; -.
DR Ensembl; ENST00000230461; ENSP00000230461; ENSG00000112697.
DR Ensembl; ENST00000370050; ENSP00000359067; ENSG00000112697.
DR Ensembl; ENST00000475111; ENSP00000431007; ENSG00000112697.
DR GeneID; 55754; -.
DR KEGG; hsa:55754; -.
DR UCSC; uc003phw.2; human.
DR CTD; 55754; -.
DR GeneCards; GC06M075962; -.
DR HGNC; HGNC:16667; TMEM30A.
DR HPA; HPA014561; -.
DR MIM; 611028; gene.
DR neXtProt; NX_Q9NV96; -.
DR PharmGKB; PA134936902; -.
DR eggNOG; COG5035; -.
DR HOGENOM; HOG000209057; -.
DR HOVERGEN; HBG055537; -.
DR InParanoid; Q9NV96; -.
DR OMA; DVTPCIC; -.
DR OrthoDB; EOG7C5M8D; -.
DR PhylomeDB; Q9NV96; -.
DR ChiTaRS; TMEM30A; human.
DR GenomeRNAi; 55754; -.
DR NextBio; 60753; -.
DR PRO; PR:Q9NV96; -.
DR ArrayExpress; Q9NV96; -.
DR Bgee; Q9NV96; -.
DR CleanEx; HS_TMEM30A; -.
DR Genevestigator; Q9NV96; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0036010; P:protein localization to endosome; IMP:UniProtKB.
DR InterPro; IPR005045; DUF284_TM_euk.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR Pfam; PF03381; CDC50; 1.
DR PIRSF; PIRSF015840; DUF284_TM_euk; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 361 Cell cycle control protein 50A.
FT /FTId=PRO_0000244469.
FT TRANSMEM 50 70 Helical; (Potential).
FT TRANSMEM 326 346 Helical; (Potential).
FT MOD_RES 2 2 N-acetylalanine.
FT CARBOHYD 180 180 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 190 190 N-linked (GlcNAc...).
FT CARBOHYD 294 294 N-linked (GlcNAc...).
FT VAR_SEQ 1 119 Missing (in isoform 3).
FT /FTId=VSP_019567.
FT VAR_SEQ 79 114 Missing (in isoform 2).
FT /FTId=VSP_019568.
SQ SEQUENCE 361 AA; 40684 MW; 64B3F28C3EB7801B CRC64;
MAMNYNAKDE VDGGPPCAPG GTAKTRRPDN TAFKQQRLPA WQPILTAGTV LPIFFIIGLI
FIPIGIGIFV TSNNIREIEI DYTGTEPSSP CNKCLSPDVT PCFCTINFTL EKSFEGNVFM
YYGLSNFYQN HRRYVKSRDD SQLNGDSSAL LNPSKECEPY RRNEDKPIAP CGAIANSMFN
DTLELFLIGN DSYPIPIALK KKGIAWWTDK NVKFRNPPGG DNLEERFKGT TKPVNWLKPV
YMLDSDPDNN GFINEDFIVW MRTAALPTFR KLYRLIERKS DLHPTLPAGR YSLNVTYNYP
VHYFDGRKRM ILSTISWMGG KNPFLGIAYI AVGSISFLLG VVLLVINHKY RNSSNTADIT
I
//
MIM
611028
*RECORD*
*FIELD* NO
611028
*FIELD* TI
*611028 TRANSMEMBRANE PROTEIN 30A; TMEM30A
;;CDC50, S. CEREVISIAE, HOMOLOG OF, A; CDC50A
read more*FIELD* TX
CLONING
By searching databases for homologs of yeast Cdc50 family proteins,
which are involved in polarized cell division, Katoh and Katoh (2004)
identified 3 human CDC50 genes, including TMEM30A, which they called
CDC50A. The predicted CDC50A protein contains 361 amino acids. The human
and yeast CDC50 proteins all have 2 transmembrane domains and an
extracellular loop with 3 cysteines and an N-glycosylation site. In
silico expression analysis revealed that CDC50A was expressed in
embryonic stem cells, placenta, brain, and chondrosarcoma.
MAPPING
By genomic sequence analysis, Katoh and Katoh (2004) mapped the TMEM30A
gene to chromosome 6q14.1.
*FIELD* RF
1. Katoh, Y.; Katoh, M.: Identification and characterization of CDC50A,
CDC50B and CDC50C genes in silico. Oncol. Rep. 12: 939-943, 2004.
*FIELD* CD
Alan F. Scott: 5/15/2007
*FIELD* ED
mgross: 05/15/2007
*RECORD*
*FIELD* NO
611028
*FIELD* TI
*611028 TRANSMEMBRANE PROTEIN 30A; TMEM30A
;;CDC50, S. CEREVISIAE, HOMOLOG OF, A; CDC50A
read more*FIELD* TX
CLONING
By searching databases for homologs of yeast Cdc50 family proteins,
which are involved in polarized cell division, Katoh and Katoh (2004)
identified 3 human CDC50 genes, including TMEM30A, which they called
CDC50A. The predicted CDC50A protein contains 361 amino acids. The human
and yeast CDC50 proteins all have 2 transmembrane domains and an
extracellular loop with 3 cysteines and an N-glycosylation site. In
silico expression analysis revealed that CDC50A was expressed in
embryonic stem cells, placenta, brain, and chondrosarcoma.
MAPPING
By genomic sequence analysis, Katoh and Katoh (2004) mapped the TMEM30A
gene to chromosome 6q14.1.
*FIELD* RF
1. Katoh, Y.; Katoh, M.: Identification and characterization of CDC50A,
CDC50B and CDC50C genes in silico. Oncol. Rep. 12: 939-943, 2004.
*FIELD* CD
Alan F. Scott: 5/15/2007
*FIELD* ED
mgross: 05/15/2007