Full text data of CCDC57
CCDC57
[Confidence: low (only semi-automatic identification from reviews)]
Coiled-coil domain-containing protein 57
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Coiled-coil domain-containing protein 57
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q2TAC2
ID CCD57_HUMAN Reviewed; 916 AA.
AC Q2TAC2; A6NP51; A8MQC7; Q8IWG2; Q8TER3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-JAN-2011, sequence version 2.
DT 22-JAN-2014, entry version 64.
DE RecName: Full=Coiled-coil domain-containing protein 57;
GN Name=CCDC57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP MET-480.
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 458-916 (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen. II. The
RT complete sequences of 81 cDNA clones.";
RL DNA Res. 10:49-57(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TAC2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TAC2-2; Sequence=VSP_025802, VSP_025803;
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW89746.1; Type=Erroneous gene model prediction;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC129510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89746.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC040264; AAH40264.1; -; mRNA.
DR EMBL; BC110997; AAI10998.1; -; mRNA.
DR EMBL; AK074059; BAB84885.1; -; mRNA.
DR RefSeq; NP_932348.2; NM_198082.2.
DR RefSeq; XP_005256402.1; XM_005256345.1.
DR UniGene; Hs.631724; -.
DR ProteinModelPortal; Q2TAC2; -.
DR IntAct; Q2TAC2; 2.
DR PhosphoSite; Q2TAC2; -.
DR DMDM; 121941753; -.
DR PaxDb; Q2TAC2; -.
DR PRIDE; Q2TAC2; -.
DR DNASU; 284001; -.
DR Ensembl; ENST00000389641; ENSP00000374292; ENSG00000176155.
DR Ensembl; ENST00000392343; ENSP00000376154; ENSG00000176155.
DR Ensembl; ENST00000392347; ENSP00000376158; ENSG00000176155.
DR GeneID; 284001; -.
DR KEGG; hsa:284001; -.
DR UCSC; uc002kdx.1; human.
DR CTD; 284001; -.
DR GeneCards; GC17M080059; -.
DR H-InvDB; HIX0019621; -.
DR HGNC; HGNC:27564; CCDC57.
DR HPA; HPA023315; -.
DR HPA; HPA023326; -.
DR HPA; HPA023342; -.
DR HPA; HPA023344; -.
DR neXtProt; NX_Q2TAC2; -.
DR PharmGKB; PA142672173; -.
DR eggNOG; NOG136797; -.
DR HOGENOM; HOG000111424; -.
DR HOVERGEN; HBG096613; -.
DR InParanoid; Q2TAC2; -.
DR OMA; TFKRKHE; -.
DR OrthoDB; EOG76X5ZM; -.
DR GeneWiki; CCDC57; -.
DR GenomeRNAi; 284001; -.
DR NextBio; 94430; -.
DR PRO; PR:Q2TAC2; -.
DR ArrayExpress; Q2TAC2; -.
DR Bgee; Q2TAC2; -.
DR CleanEx; HS_CCDC57; -.
DR Genevestigator; Q2TAC2; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 916 Coiled-coil domain-containing protein 57.
FT /FTId=PRO_0000288871.
FT COILED 25 487 Potential.
FT COILED 518 605 Potential.
FT VAR_SEQ 748 751 QDAK -> VGAR (in isoform 2).
FT /FTId=VSP_025802.
FT VAR_SEQ 752 916 Missing (in isoform 2).
FT /FTId=VSP_025803.
FT VARIANT 237 237 E -> Q (in dbSNP:rs34543170).
FT /FTId=VAR_032516.
FT VARIANT 321 321 Q -> R (in dbSNP:rs7406116).
FT /FTId=VAR_032517.
FT VARIANT 480 480 V -> M (in dbSNP:rs7209474).
FT /FTId=VAR_032518.
FT VARIANT 775 775 R -> G (in dbSNP:rs4625783).
FT /FTId=VAR_032519.
FT VARIANT 777 777 D -> N (in dbSNP:rs7406163).
FT /FTId=VAR_032520.
FT VARIANT 778 778 A -> T (in dbSNP:rs7406162).
FT /FTId=VAR_032521.
FT VARIANT 811 811 Q -> K (in dbSNP:rs7213172).
FT /FTId=VAR_032522.
FT VARIANT 834 834 M -> T (in dbSNP:rs11077969).
FT /FTId=VAR_032523.
FT CONFLICT 458 458 Q -> K (in Ref. 4; BAB84885).
SQ SEQUENCE 916 AA; 103167 MW; 2DFCD179A1994170 CRC64;
MLPLGSEPAL NELLLRKEEE WRALQAHRTQ LQEAALQDTR SQLEEAQGKL RCLQEDFVYN
LQVLEERDLE LERYDAAFAQ AREWEEARRA EVSELKIEAA KLRQALAREA RKVEELQQQQ
QLAFQEHRLE LERVHSDKNG EIDHHREQYE NLKWTLERKL EELDGELALQ RQELLLEFES
KMRKREHEFR LQADNMSNTA LSRELKVKLL HKELEALKEA GAKAAESLQR AEATNAELER
KLQSRAGELQ DLEAMSRARV KDLEDKLHSV QLTRKKEEET FKRKHEELDR LAREKDAVLV
AVKGAHVEQL QELQTRVLEL QAHCETLEAQ LRRAEWRQAD TAKEKDAAID QLREDASTVK
SAWDAQIAQL SKEMVSRDLQ IQTLQEEEVK LKAQVARSQQ DIERYKQQLS LAVERERSLE
RDQVQLGLDW QRRCDDIERD QIQKSEALIQ GLSMAKSQVA AKLQETEQAL QEQEVVLKAV
TLERDQAVQA LRMHGLPRPG AQMLLRQHEE EISKDFPSSE IQRLREQNTS LRNAIAQMRK
EMEALSHQIP PPIQTAAEST DANQPDPEAG GDAATPDYVL ALEAEIRTLK HKFKTLEKHL
EDVLDPLKMS SPHAESQPSV RTSTETTGGS AQAGQAGGSV QAGQAGGSVQ AGPVSSGLAL
RKLGDRVQLL NLLVTRLRQK VLREPLEPAA LQRELPREVD QVHLEVLELR KQVAELGKHL
RIAQHGGAEP SGRKQPPASD AVALGREQDA KSAEDEAPSR HLGKHQPRSA QVGSRLDALQ
GPKTQHSIHT VTCKSPRQKE DRSPKPPQAP QHPEEHGRQS HSSSSFASGT LQDMWRLLDL
GSSPSGVTSQ GDSTPELPAP PAADRRPVKM QAGIATPGMK TAAQAKAKTT GASRSHPAKA
KGCQRPPKIR NYNIMD
//
ID CCD57_HUMAN Reviewed; 916 AA.
AC Q2TAC2; A6NP51; A8MQC7; Q8IWG2; Q8TER3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-JAN-2011, sequence version 2.
DT 22-JAN-2014, entry version 64.
DE RecName: Full=Coiled-coil domain-containing protein 57;
GN Name=CCDC57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP MET-480.
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 458-916 (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen. II. The
RT complete sequences of 81 cDNA clones.";
RL DNA Res. 10:49-57(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TAC2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TAC2-2; Sequence=VSP_025802, VSP_025803;
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW89746.1; Type=Erroneous gene model prediction;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC129510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89746.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC040264; AAH40264.1; -; mRNA.
DR EMBL; BC110997; AAI10998.1; -; mRNA.
DR EMBL; AK074059; BAB84885.1; -; mRNA.
DR RefSeq; NP_932348.2; NM_198082.2.
DR RefSeq; XP_005256402.1; XM_005256345.1.
DR UniGene; Hs.631724; -.
DR ProteinModelPortal; Q2TAC2; -.
DR IntAct; Q2TAC2; 2.
DR PhosphoSite; Q2TAC2; -.
DR DMDM; 121941753; -.
DR PaxDb; Q2TAC2; -.
DR PRIDE; Q2TAC2; -.
DR DNASU; 284001; -.
DR Ensembl; ENST00000389641; ENSP00000374292; ENSG00000176155.
DR Ensembl; ENST00000392343; ENSP00000376154; ENSG00000176155.
DR Ensembl; ENST00000392347; ENSP00000376158; ENSG00000176155.
DR GeneID; 284001; -.
DR KEGG; hsa:284001; -.
DR UCSC; uc002kdx.1; human.
DR CTD; 284001; -.
DR GeneCards; GC17M080059; -.
DR H-InvDB; HIX0019621; -.
DR HGNC; HGNC:27564; CCDC57.
DR HPA; HPA023315; -.
DR HPA; HPA023326; -.
DR HPA; HPA023342; -.
DR HPA; HPA023344; -.
DR neXtProt; NX_Q2TAC2; -.
DR PharmGKB; PA142672173; -.
DR eggNOG; NOG136797; -.
DR HOGENOM; HOG000111424; -.
DR HOVERGEN; HBG096613; -.
DR InParanoid; Q2TAC2; -.
DR OMA; TFKRKHE; -.
DR OrthoDB; EOG76X5ZM; -.
DR GeneWiki; CCDC57; -.
DR GenomeRNAi; 284001; -.
DR NextBio; 94430; -.
DR PRO; PR:Q2TAC2; -.
DR ArrayExpress; Q2TAC2; -.
DR Bgee; Q2TAC2; -.
DR CleanEx; HS_CCDC57; -.
DR Genevestigator; Q2TAC2; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 916 Coiled-coil domain-containing protein 57.
FT /FTId=PRO_0000288871.
FT COILED 25 487 Potential.
FT COILED 518 605 Potential.
FT VAR_SEQ 748 751 QDAK -> VGAR (in isoform 2).
FT /FTId=VSP_025802.
FT VAR_SEQ 752 916 Missing (in isoform 2).
FT /FTId=VSP_025803.
FT VARIANT 237 237 E -> Q (in dbSNP:rs34543170).
FT /FTId=VAR_032516.
FT VARIANT 321 321 Q -> R (in dbSNP:rs7406116).
FT /FTId=VAR_032517.
FT VARIANT 480 480 V -> M (in dbSNP:rs7209474).
FT /FTId=VAR_032518.
FT VARIANT 775 775 R -> G (in dbSNP:rs4625783).
FT /FTId=VAR_032519.
FT VARIANT 777 777 D -> N (in dbSNP:rs7406163).
FT /FTId=VAR_032520.
FT VARIANT 778 778 A -> T (in dbSNP:rs7406162).
FT /FTId=VAR_032521.
FT VARIANT 811 811 Q -> K (in dbSNP:rs7213172).
FT /FTId=VAR_032522.
FT VARIANT 834 834 M -> T (in dbSNP:rs11077969).
FT /FTId=VAR_032523.
FT CONFLICT 458 458 Q -> K (in Ref. 4; BAB84885).
SQ SEQUENCE 916 AA; 103167 MW; 2DFCD179A1994170 CRC64;
MLPLGSEPAL NELLLRKEEE WRALQAHRTQ LQEAALQDTR SQLEEAQGKL RCLQEDFVYN
LQVLEERDLE LERYDAAFAQ AREWEEARRA EVSELKIEAA KLRQALAREA RKVEELQQQQ
QLAFQEHRLE LERVHSDKNG EIDHHREQYE NLKWTLERKL EELDGELALQ RQELLLEFES
KMRKREHEFR LQADNMSNTA LSRELKVKLL HKELEALKEA GAKAAESLQR AEATNAELER
KLQSRAGELQ DLEAMSRARV KDLEDKLHSV QLTRKKEEET FKRKHEELDR LAREKDAVLV
AVKGAHVEQL QELQTRVLEL QAHCETLEAQ LRRAEWRQAD TAKEKDAAID QLREDASTVK
SAWDAQIAQL SKEMVSRDLQ IQTLQEEEVK LKAQVARSQQ DIERYKQQLS LAVERERSLE
RDQVQLGLDW QRRCDDIERD QIQKSEALIQ GLSMAKSQVA AKLQETEQAL QEQEVVLKAV
TLERDQAVQA LRMHGLPRPG AQMLLRQHEE EISKDFPSSE IQRLREQNTS LRNAIAQMRK
EMEALSHQIP PPIQTAAEST DANQPDPEAG GDAATPDYVL ALEAEIRTLK HKFKTLEKHL
EDVLDPLKMS SPHAESQPSV RTSTETTGGS AQAGQAGGSV QAGQAGGSVQ AGPVSSGLAL
RKLGDRVQLL NLLVTRLRQK VLREPLEPAA LQRELPREVD QVHLEVLELR KQVAELGKHL
RIAQHGGAEP SGRKQPPASD AVALGREQDA KSAEDEAPSR HLGKHQPRSA QVGSRLDALQ
GPKTQHSIHT VTCKSPRQKE DRSPKPPQAP QHPEEHGRQS HSSSSFASGT LQDMWRLLDL
GSSPSGVTSQ GDSTPELPAP PAADRRPVKM QAGIATPGMK TAAQAKAKTT GASRSHPAKA
KGCQRPPKIR NYNIMD
//