Full text data of CCDC9
CCDC9
[Confidence: low (only semi-automatic identification from reviews)]
Coiled-coil domain-containing protein 9
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Coiled-coil domain-containing protein 9
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9Y3X0
ID CCDC9_HUMAN Reviewed; 531 AA.
AC Q9Y3X0;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1999, sequence version 1.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=Coiled-coil domain-containing protein 9;
GN Name=CCDC9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,
RA Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
RT efficient phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202 AND SER-521, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-95; SER-202 AND SER-521,
RP AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL050284; CAB43385.1; -; mRNA.
DR EMBL; BC002787; AAH02787.1; -; mRNA.
DR EMBL; BC009743; AAH09743.1; -; mRNA.
DR PIR; T08760; T08760.
DR RefSeq; NP_056418.1; NM_015603.2.
DR UniGene; Hs.227782; -.
DR ProteinModelPortal; Q9Y3X0; -.
DR IntAct; Q9Y3X0; 5.
DR MINT; MINT-4715960; -.
DR STRING; 9606.ENSP00000221922; -.
DR PhosphoSite; Q9Y3X0; -.
DR DMDM; 50400700; -.
DR PaxDb; Q9Y3X0; -.
DR PeptideAtlas; Q9Y3X0; -.
DR PRIDE; Q9Y3X0; -.
DR DNASU; 26093; -.
DR Ensembl; ENST00000221922; ENSP00000221922; ENSG00000105321.
DR GeneID; 26093; -.
DR KEGG; hsa:26093; -.
DR UCSC; uc010xym.2; human.
DR CTD; 26093; -.
DR GeneCards; GC19P047759; -.
DR HGNC; HGNC:24560; CCDC9.
DR HPA; HPA045624; -.
DR neXtProt; NX_Q9Y3X0; -.
DR PharmGKB; PA134946561; -.
DR eggNOG; NOG43531; -.
DR HOGENOM; HOG000273887; -.
DR HOVERGEN; HBG050826; -.
DR InParanoid; Q9Y3X0; -.
DR OMA; GRASRSW; -.
DR OrthoDB; EOG7F7W99; -.
DR GenomeRNAi; 26093; -.
DR NextBio; 48037; -.
DR PMAP-CutDB; Q9Y3X0; -.
DR PRO; PR:Q9Y3X0; -.
DR ArrayExpress; Q9Y3X0; -.
DR Bgee; Q9Y3X0; -.
DR CleanEx; HS_CCDC9; -.
DR Genevestigator; Q9Y3X0; -.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT CHAIN 1 531 Coiled-coil domain-containing protein 9.
FT /FTId=PRO_0000089403.
FT COILED 149 185 Potential.
FT COMPBIAS 88 144 Gly-rich.
FT COMPBIAS 344 347 Poly-Arg.
FT COMPBIAS 377 409 Pro-rich.
FT COMPBIAS 410 445 Glu-rich.
FT COMPBIAS 429 440 Poly-Glu.
FT MOD_RES 95 95 Phosphothreonine.
FT MOD_RES 202 202 Phosphoserine.
FT MOD_RES 521 521 Phosphoserine.
FT VARIANT 215 215 E -> D (in dbSNP:rs2032811).
FT /FTId=VAR_033670.
FT VARIANT 456 456 A -> V (in dbSNP:rs35119724).
FT /FTId=VAR_033671.
FT VARIANT 478 478 L -> P (in dbSNP:rs888836).
FT /FTId=VAR_050767.
SQ SEQUENCE 531 AA; 59703 MW; DE6C474F3253C30C CRC64;
MAATLDLKSK EEKDAELDKR IEALRRKNEA LIRRYQEIEE DRKKAELEGV AVTAPRKGRS
VEKENVAVES EKNLGPSRRS PGTPRPPGAS KGGRTPPQQG GRAGMGRASR SWEGSPGEQP
RGGGAGGRGR RGRGRGSPHL SGAGDTSISD RKSKEWEERR RQNIEKMNEE MEKIAEYERN
QREGVLEPNP VRNFLDDPRR RSGPLEESER DRREESRRHG RNWGGPDFER VRCGLEHERQ
GRRAGLGSAG DMTLSMTGRE RSEYLRWKQE REKIDQERLQ RHRKPTGQWR REWDAEKTDG
MFKDGPVPAH EPSHRYDDQA WARPPKPPTF GEFLSQHKAE ASSRRRRKSS RPQAKAAPRA
YSDHDDRWET KEGAASPAPE TPQPTSPETS PKETPMQPPE IPAPAHRPPE DEGEENEGEE
DEEWEDISED EEEEEIEVEE GDEEEPAQDH QAPEAAPTGI PCSEQAHGVP FSPEEPLLEP
QAPGTPSSPF SPPSGHQPVS DWGEEVELNS PRTTHLAGAL SPGEAWPFES V
//
ID CCDC9_HUMAN Reviewed; 531 AA.
AC Q9Y3X0;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1999, sequence version 1.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=Coiled-coil domain-containing protein 9;
GN Name=CCDC9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,
RA Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
RT efficient phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202 AND SER-521, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-95; SER-202 AND SER-521,
RP AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL050284; CAB43385.1; -; mRNA.
DR EMBL; BC002787; AAH02787.1; -; mRNA.
DR EMBL; BC009743; AAH09743.1; -; mRNA.
DR PIR; T08760; T08760.
DR RefSeq; NP_056418.1; NM_015603.2.
DR UniGene; Hs.227782; -.
DR ProteinModelPortal; Q9Y3X0; -.
DR IntAct; Q9Y3X0; 5.
DR MINT; MINT-4715960; -.
DR STRING; 9606.ENSP00000221922; -.
DR PhosphoSite; Q9Y3X0; -.
DR DMDM; 50400700; -.
DR PaxDb; Q9Y3X0; -.
DR PeptideAtlas; Q9Y3X0; -.
DR PRIDE; Q9Y3X0; -.
DR DNASU; 26093; -.
DR Ensembl; ENST00000221922; ENSP00000221922; ENSG00000105321.
DR GeneID; 26093; -.
DR KEGG; hsa:26093; -.
DR UCSC; uc010xym.2; human.
DR CTD; 26093; -.
DR GeneCards; GC19P047759; -.
DR HGNC; HGNC:24560; CCDC9.
DR HPA; HPA045624; -.
DR neXtProt; NX_Q9Y3X0; -.
DR PharmGKB; PA134946561; -.
DR eggNOG; NOG43531; -.
DR HOGENOM; HOG000273887; -.
DR HOVERGEN; HBG050826; -.
DR InParanoid; Q9Y3X0; -.
DR OMA; GRASRSW; -.
DR OrthoDB; EOG7F7W99; -.
DR GenomeRNAi; 26093; -.
DR NextBio; 48037; -.
DR PMAP-CutDB; Q9Y3X0; -.
DR PRO; PR:Q9Y3X0; -.
DR ArrayExpress; Q9Y3X0; -.
DR Bgee; Q9Y3X0; -.
DR CleanEx; HS_CCDC9; -.
DR Genevestigator; Q9Y3X0; -.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT CHAIN 1 531 Coiled-coil domain-containing protein 9.
FT /FTId=PRO_0000089403.
FT COILED 149 185 Potential.
FT COMPBIAS 88 144 Gly-rich.
FT COMPBIAS 344 347 Poly-Arg.
FT COMPBIAS 377 409 Pro-rich.
FT COMPBIAS 410 445 Glu-rich.
FT COMPBIAS 429 440 Poly-Glu.
FT MOD_RES 95 95 Phosphothreonine.
FT MOD_RES 202 202 Phosphoserine.
FT MOD_RES 521 521 Phosphoserine.
FT VARIANT 215 215 E -> D (in dbSNP:rs2032811).
FT /FTId=VAR_033670.
FT VARIANT 456 456 A -> V (in dbSNP:rs35119724).
FT /FTId=VAR_033671.
FT VARIANT 478 478 L -> P (in dbSNP:rs888836).
FT /FTId=VAR_050767.
SQ SEQUENCE 531 AA; 59703 MW; DE6C474F3253C30C CRC64;
MAATLDLKSK EEKDAELDKR IEALRRKNEA LIRRYQEIEE DRKKAELEGV AVTAPRKGRS
VEKENVAVES EKNLGPSRRS PGTPRPPGAS KGGRTPPQQG GRAGMGRASR SWEGSPGEQP
RGGGAGGRGR RGRGRGSPHL SGAGDTSISD RKSKEWEERR RQNIEKMNEE MEKIAEYERN
QREGVLEPNP VRNFLDDPRR RSGPLEESER DRREESRRHG RNWGGPDFER VRCGLEHERQ
GRRAGLGSAG DMTLSMTGRE RSEYLRWKQE REKIDQERLQ RHRKPTGQWR REWDAEKTDG
MFKDGPVPAH EPSHRYDDQA WARPPKPPTF GEFLSQHKAE ASSRRRRKSS RPQAKAAPRA
YSDHDDRWET KEGAASPAPE TPQPTSPETS PKETPMQPPE IPAPAHRPPE DEGEENEGEE
DEEWEDISED EEEEEIEVEE GDEEEPAQDH QAPEAAPTGI PCSEQAHGVP FSPEEPLLEP
QAPGTPSSPF SPPSGHQPVS DWGEEVELNS PRTTHLAGAL SPGEAWPFES V
//