Full text data of CD5L
CD5L
(API6)
[Confidence: low (only semi-automatic identification from reviews)]
CD5 antigen-like (CT-2; IgM-associated peptide; SP-alpha; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
CD5 antigen-like (CT-2; IgM-associated peptide; SP-alpha; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
O43866
ID CD5L_HUMAN Reviewed; 347 AA.
AC O43866; A8K7M5; Q6UX63;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-1998, sequence version 1.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=CD5 antigen-like;
DE AltName: Full=CT-2;
DE AltName: Full=IgM-associated peptide;
DE AltName: Full=SP-alpha;
DE Flags: Precursor;
GN Name=CD5L; Synonyms=API6; ORFNames=UNQ203/PRO229;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Spleen;
RX PubMed=9045627; DOI=10.1074/jbc.272.10.6151;
RA Gebe J.A., Kiener P.A., Ring H.Z., Li X., Francke U., Aruffo A.;
RT "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell
RT binding characteristics of Spalpha, a new member of the scavenger
RT receptor cysteine-rich (SRCR) family of proteins.";
RL J. Biol. Chem. 272:6151-6158(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Miyazaki T., Yusa S.;
RT "Human CT-2 cDNA.";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 20-31, AND BINDING TO IGM.
RX PubMed=8034987; DOI=10.1016/0022-1759(94)90284-4;
RA Tissot J.-D., Schifferli J.A., Hochstrasser D.F., Pasquali C.,
RA Spertini F., Clement F., Frutiger S., Paquet N., Hughes G.J.,
RA Schneider P.;
RT "Two-dimensional polyacrylamide gel electrophoresis analysis of
RT cryoglobulins and identification of an IgM-associated peptide.";
RL J. Immunol. Methods 173:63-75(1994).
RN [9]
RP PARTIAL PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX PubMed=11981870;
RX DOI=10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1;
RA Tissot J.D., Sanchez J.-C., Vuadens F., Scherl A., Schifferli J.A.,
RA Hochstrasser D.F., Schneider P., Duchosal M.A.;
RT "IgM are associated to Spalpha (CD5 antigen-like).";
RL Electrophoresis 23:1203-1206(2002).
RN [10]
RP PROTEIN SEQUENCE OF 20-34.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally
RT verified cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: May play a role in the regulation of the immune system.
CC Seems to play a role as an inhibitor of apoptosis.
CC -!- SUBUNIT: Associated with IgM.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, bone
CC marrow, and fetal liver, but not in non-lymphoid tissues.
CC -!- SIMILARITY: Contains 3 SRCR domains.
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DR EMBL; U82812; AAB91989.1; -; mRNA.
DR EMBL; AF011429; AAD01446.1; -; mRNA.
DR EMBL; AY358494; AAQ88858.1; -; mRNA.
DR EMBL; AK292040; BAF84729.1; -; mRNA.
DR EMBL; AL139409; CAC19458.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52859.1; -; Genomic_DNA.
DR EMBL; BC033586; AAH33586.1; -; mRNA.
DR RefSeq; NP_005885.1; NM_005894.2.
DR RefSeq; XP_005245659.1; XM_005245602.1.
DR UniGene; Hs.134035; -.
DR ProteinModelPortal; O43866; -.
DR SMR; O43866; 24-126, 138-240, 244-346.
DR IntAct; O43866; 6.
DR MINT; MINT-6769012; -.
DR STRING; 9606.ENSP00000357156; -.
DR PaxDb; O43866; -.
DR PeptideAtlas; O43866; -.
DR PRIDE; O43866; -.
DR DNASU; 922; -.
DR Ensembl; ENST00000368174; ENSP00000357156; ENSG00000073754.
DR GeneID; 922; -.
DR KEGG; hsa:922; -.
DR UCSC; uc001frk.4; human.
DR CTD; 922; -.
DR GeneCards; GC01M157800; -.
DR HGNC; HGNC:1690; CD5L.
DR MIM; 602592; gene.
DR neXtProt; NX_O43866; -.
DR PharmGKB; PA26229; -.
DR eggNOG; NOG146070; -.
DR HOGENOM; HOG000290652; -.
DR HOVERGEN; HBG031373; -.
DR InParanoid; O43866; -.
DR OMA; MSCSGRE; -.
DR OrthoDB; EOG7RNK07; -.
DR PhylomeDB; O43866; -.
DR GeneWiki; CD5L; -.
DR GenomeRNAi; 922; -.
DR NextBio; 3814; -.
DR PRO; PR:O43866; -.
DR Bgee; O43866; -.
DR CleanEx; HS_CD5L; -.
DR Genevestigator; O43866; -.
DR GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; Srcr_rcpt-rel.
DR Pfam; PF00530; SRCR; 3.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 3.
DR SUPFAM; SSF56487; SSF56487; 3.
DR PROSITE; PS00420; SRCR_1; 2.
DR PROSITE; PS50287; SRCR_2; 3.
PE 1: Evidence at protein level;
KW Apoptosis; Complete proteome; Direct protein sequencing;
KW Disulfide bond; Polymorphism; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1 19
FT CHAIN 20 347 CD5 antigen-like.
FT /FTId=PRO_0000033225.
FT DOMAIN 24 125 SRCR 1.
FT DOMAIN 138 239 SRCR 2.
FT DOMAIN 244 346 SRCR 3.
FT DISULFID 33 67 By similarity.
FT DISULFID 49 114 By similarity.
FT DISULFID 62 124 By similarity.
FT DISULFID 96 106 By similarity.
FT DISULFID 163 228 By similarity.
FT DISULFID 176 238 By similarity.
FT DISULFID 208 218 By similarity.
FT DISULFID 253 287 By similarity.
FT DISULFID 269 335 By similarity.
FT DISULFID 282 345 By similarity.
FT DISULFID 315 325 By similarity.
FT VARIANT 117 117 D -> E (in dbSNP:rs11537583).
FT /FTId=VAR_033728.
FT CONFLICT 347 347 G -> V (in Ref. 3; AAQ88858).
SQ SEQUENCE 347 AA; 38088 MW; 40A8BE08F9495D83 CRC64;
MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV
LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA
GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG
CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED
PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC
YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG
//
ID CD5L_HUMAN Reviewed; 347 AA.
AC O43866; A8K7M5; Q6UX63;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-1998, sequence version 1.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=CD5 antigen-like;
DE AltName: Full=CT-2;
DE AltName: Full=IgM-associated peptide;
DE AltName: Full=SP-alpha;
DE Flags: Precursor;
GN Name=CD5L; Synonyms=API6; ORFNames=UNQ203/PRO229;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Spleen;
RX PubMed=9045627; DOI=10.1074/jbc.272.10.6151;
RA Gebe J.A., Kiener P.A., Ring H.Z., Li X., Francke U., Aruffo A.;
RT "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell
RT binding characteristics of Spalpha, a new member of the scavenger
RT receptor cysteine-rich (SRCR) family of proteins.";
RL J. Biol. Chem. 272:6151-6158(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Miyazaki T., Yusa S.;
RT "Human CT-2 cDNA.";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 20-31, AND BINDING TO IGM.
RX PubMed=8034987; DOI=10.1016/0022-1759(94)90284-4;
RA Tissot J.-D., Schifferli J.A., Hochstrasser D.F., Pasquali C.,
RA Spertini F., Clement F., Frutiger S., Paquet N., Hughes G.J.,
RA Schneider P.;
RT "Two-dimensional polyacrylamide gel electrophoresis analysis of
RT cryoglobulins and identification of an IgM-associated peptide.";
RL J. Immunol. Methods 173:63-75(1994).
RN [9]
RP PARTIAL PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX PubMed=11981870;
RX DOI=10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1;
RA Tissot J.D., Sanchez J.-C., Vuadens F., Scherl A., Schifferli J.A.,
RA Hochstrasser D.F., Schneider P., Duchosal M.A.;
RT "IgM are associated to Spalpha (CD5 antigen-like).";
RL Electrophoresis 23:1203-1206(2002).
RN [10]
RP PROTEIN SEQUENCE OF 20-34.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally
RT verified cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: May play a role in the regulation of the immune system.
CC Seems to play a role as an inhibitor of apoptosis.
CC -!- SUBUNIT: Associated with IgM.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, bone
CC marrow, and fetal liver, but not in non-lymphoid tissues.
CC -!- SIMILARITY: Contains 3 SRCR domains.
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DR EMBL; U82812; AAB91989.1; -; mRNA.
DR EMBL; AF011429; AAD01446.1; -; mRNA.
DR EMBL; AY358494; AAQ88858.1; -; mRNA.
DR EMBL; AK292040; BAF84729.1; -; mRNA.
DR EMBL; AL139409; CAC19458.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52859.1; -; Genomic_DNA.
DR EMBL; BC033586; AAH33586.1; -; mRNA.
DR RefSeq; NP_005885.1; NM_005894.2.
DR RefSeq; XP_005245659.1; XM_005245602.1.
DR UniGene; Hs.134035; -.
DR ProteinModelPortal; O43866; -.
DR SMR; O43866; 24-126, 138-240, 244-346.
DR IntAct; O43866; 6.
DR MINT; MINT-6769012; -.
DR STRING; 9606.ENSP00000357156; -.
DR PaxDb; O43866; -.
DR PeptideAtlas; O43866; -.
DR PRIDE; O43866; -.
DR DNASU; 922; -.
DR Ensembl; ENST00000368174; ENSP00000357156; ENSG00000073754.
DR GeneID; 922; -.
DR KEGG; hsa:922; -.
DR UCSC; uc001frk.4; human.
DR CTD; 922; -.
DR GeneCards; GC01M157800; -.
DR HGNC; HGNC:1690; CD5L.
DR MIM; 602592; gene.
DR neXtProt; NX_O43866; -.
DR PharmGKB; PA26229; -.
DR eggNOG; NOG146070; -.
DR HOGENOM; HOG000290652; -.
DR HOVERGEN; HBG031373; -.
DR InParanoid; O43866; -.
DR OMA; MSCSGRE; -.
DR OrthoDB; EOG7RNK07; -.
DR PhylomeDB; O43866; -.
DR GeneWiki; CD5L; -.
DR GenomeRNAi; 922; -.
DR NextBio; 3814; -.
DR PRO; PR:O43866; -.
DR Bgee; O43866; -.
DR CleanEx; HS_CD5L; -.
DR Genevestigator; O43866; -.
DR GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; Srcr_rcpt-rel.
DR Pfam; PF00530; SRCR; 3.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 3.
DR SUPFAM; SSF56487; SSF56487; 3.
DR PROSITE; PS00420; SRCR_1; 2.
DR PROSITE; PS50287; SRCR_2; 3.
PE 1: Evidence at protein level;
KW Apoptosis; Complete proteome; Direct protein sequencing;
KW Disulfide bond; Polymorphism; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1 19
FT CHAIN 20 347 CD5 antigen-like.
FT /FTId=PRO_0000033225.
FT DOMAIN 24 125 SRCR 1.
FT DOMAIN 138 239 SRCR 2.
FT DOMAIN 244 346 SRCR 3.
FT DISULFID 33 67 By similarity.
FT DISULFID 49 114 By similarity.
FT DISULFID 62 124 By similarity.
FT DISULFID 96 106 By similarity.
FT DISULFID 163 228 By similarity.
FT DISULFID 176 238 By similarity.
FT DISULFID 208 218 By similarity.
FT DISULFID 253 287 By similarity.
FT DISULFID 269 335 By similarity.
FT DISULFID 282 345 By similarity.
FT DISULFID 315 325 By similarity.
FT VARIANT 117 117 D -> E (in dbSNP:rs11537583).
FT /FTId=VAR_033728.
FT CONFLICT 347 347 G -> V (in Ref. 3; AAQ88858).
SQ SEQUENCE 347 AA; 38088 MW; 40A8BE08F9495D83 CRC64;
MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV
LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA
GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG
CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED
PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC
YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG
//
MIM
602592
*RECORD*
*FIELD* NO
602592
*FIELD* TI
*602592 LYMPHOCYTE ANTIGEN CD5-LIKE; CD5L
;;SCAVENGER RECEPTOR CYSTEINE-RICH FAMILY, MEMBER SP-ALPHA;;
read moreSP-ALPHA;;
APOPTOSIS INHIBITOR 6; API6;;
APOPTOSIS INHIBITOR OF MACROPHAGES; AIM
*FIELD* TX
CLONING
Scavenger receptor cysteine-rich (SRCR) family members are among the
proteins that regulate leukocyte function. One group of SRCR proteins
includes CD5 (153340) and CD6 (186720), both of which have 3 SRCR-like
domains each containing 8 cysteine residues in their extracellular
region, a hydrophobic transmembrane domain, and a long cytoplasmic
domain. While searching for new SRCR family members in sequence
databases, Gebe et al. (1997) identified a gene with extensive homology
to CD5 and CD6. The predicted 347-amino acid protein, which they called
Sp-alpha, has a 19-amino acid signal sequence followed by 3
cysteine-rich SRCR domains. Northern blot analysis detected 3 mRNAs of
2.4, 2.1, and 1.8 kb in spleen, lymph node, thymus, bone marrow, and
fetal liver, but not in nonlymphoid tissues. Some resting myeloid cell
lines, as well as peripheral blood monocytes, were capable of binding
Sp-alpha.
GENE FUNCTION
Arai et al. (2005) found that Aim expression was induced in mouse
macrophages in response to loading with highly oxidized low density
lipoprotein (oxLDL), and that Aim was expressed in foam cells within
atherosclerotic lesions. Both the expression of Aim in lesions and its
induction by oxLDL required Lxr (see 602423)/Rxr (see 180245)
heterodimers. Aim-null macrophages were highly susceptible to
oxLDL-induced apoptosis in vitro and underwent accelerated apoptosis in
atherosclerotic lesions in vivo. Double knockout of Aim and Ldlr
(606945) reduced atherosclerotic lesions. Arai et al. (2005) concluded
that AIM expression protects macrophages from apoptosis within
atherosclerotic lesions, promoting early lesion development.
MAPPING
Gebe et al. (1997) mapped the Sp-alpha gene to 1q21-q23 by fluorescence
in situ hybridization.
*FIELD* RF
1. Arai, S.; Shelton, J. M.; Chen, M.; Bradley, M. N.; Castrillo,
A.; Bookout, A. L.; Mak, P. A.; Edwards, P. A.; Mangelsdorf, D. J.;
Tontonoz, P.; Miyazaki, T.: A role for the apoptosis inhibitory factor
AIM/Sp-alpha/Api6 in atherosclerosis development. Cell Metab. 1:
201-213, 2005.
2. Gebe, J. A.; Kiener, P. A.; Ring, H. Z.; Li, X.; Francke, U.; Aruffo,
A.: Molecular cloning, mapping to human chromosome 1 q21-q23, and
cell binding characteristics of Sp-alpha, a new member of the scavenger
receptor cysteine-rich (SRCR) family of proteins. J. Biol. Chem. 272:
6151-6158, 1997.
*FIELD* CN
Patricia A. Hartz - updated: 4/19/2005
*FIELD* CD
Rebekah S. Rasooly: 5/4/1998
*FIELD* ED
mgross: 04/20/2005
terry: 4/19/2005
mgross: 1/12/2005
alopez: 5/8/1998
alopez: 5/4/1998
*RECORD*
*FIELD* NO
602592
*FIELD* TI
*602592 LYMPHOCYTE ANTIGEN CD5-LIKE; CD5L
;;SCAVENGER RECEPTOR CYSTEINE-RICH FAMILY, MEMBER SP-ALPHA;;
read moreSP-ALPHA;;
APOPTOSIS INHIBITOR 6; API6;;
APOPTOSIS INHIBITOR OF MACROPHAGES; AIM
*FIELD* TX
CLONING
Scavenger receptor cysteine-rich (SRCR) family members are among the
proteins that regulate leukocyte function. One group of SRCR proteins
includes CD5 (153340) and CD6 (186720), both of which have 3 SRCR-like
domains each containing 8 cysteine residues in their extracellular
region, a hydrophobic transmembrane domain, and a long cytoplasmic
domain. While searching for new SRCR family members in sequence
databases, Gebe et al. (1997) identified a gene with extensive homology
to CD5 and CD6. The predicted 347-amino acid protein, which they called
Sp-alpha, has a 19-amino acid signal sequence followed by 3
cysteine-rich SRCR domains. Northern blot analysis detected 3 mRNAs of
2.4, 2.1, and 1.8 kb in spleen, lymph node, thymus, bone marrow, and
fetal liver, but not in nonlymphoid tissues. Some resting myeloid cell
lines, as well as peripheral blood monocytes, were capable of binding
Sp-alpha.
GENE FUNCTION
Arai et al. (2005) found that Aim expression was induced in mouse
macrophages in response to loading with highly oxidized low density
lipoprotein (oxLDL), and that Aim was expressed in foam cells within
atherosclerotic lesions. Both the expression of Aim in lesions and its
induction by oxLDL required Lxr (see 602423)/Rxr (see 180245)
heterodimers. Aim-null macrophages were highly susceptible to
oxLDL-induced apoptosis in vitro and underwent accelerated apoptosis in
atherosclerotic lesions in vivo. Double knockout of Aim and Ldlr
(606945) reduced atherosclerotic lesions. Arai et al. (2005) concluded
that AIM expression protects macrophages from apoptosis within
atherosclerotic lesions, promoting early lesion development.
MAPPING
Gebe et al. (1997) mapped the Sp-alpha gene to 1q21-q23 by fluorescence
in situ hybridization.
*FIELD* RF
1. Arai, S.; Shelton, J. M.; Chen, M.; Bradley, M. N.; Castrillo,
A.; Bookout, A. L.; Mak, P. A.; Edwards, P. A.; Mangelsdorf, D. J.;
Tontonoz, P.; Miyazaki, T.: A role for the apoptosis inhibitory factor
AIM/Sp-alpha/Api6 in atherosclerosis development. Cell Metab. 1:
201-213, 2005.
2. Gebe, J. A.; Kiener, P. A.; Ring, H. Z.; Li, X.; Francke, U.; Aruffo,
A.: Molecular cloning, mapping to human chromosome 1 q21-q23, and
cell binding characteristics of Sp-alpha, a new member of the scavenger
receptor cysteine-rich (SRCR) family of proteins. J. Biol. Chem. 272:
6151-6158, 1997.
*FIELD* CN
Patricia A. Hartz - updated: 4/19/2005
*FIELD* CD
Rebekah S. Rasooly: 5/4/1998
*FIELD* ED
mgross: 04/20/2005
terry: 4/19/2005
mgross: 1/12/2005
alopez: 5/8/1998
alopez: 5/4/1998