Full text data of CD70
CD70
(CD27L, CD27LG, TNFSF7)
[Confidence: low (only semi-automatic identification from reviews)]
CD70 antigen (CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD70)
CD70 antigen (CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD70)
UniProt
P32970
ID CD70_HUMAN Reviewed; 193 AA.
AC P32970; Q96J57;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 06-JUN-2002, sequence version 2.
DT 22-JAN-2014, entry version 121.
DE RecName: Full=CD70 antigen;
DE AltName: Full=CD27 ligand;
DE Short=CD27-L;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 7;
DE AltName: CD_antigen=CD70;
GN Name=CD70; Synonyms=CD27L, CD27LG, TNFSF7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=B-cell;
RX PubMed=8387892; DOI=10.1016/0092-8674(93)90133-B;
RA Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T.,
RA Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K.,
RA Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H.,
RA Farrah T., Giri J.G., Beckmann M.P.;
RT "Molecular and biological characterization of a ligand for CD27
RT defines a new family of cytokines with homology to tumor necrosis
RT factor.";
RL Cell 73:447-456(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8120384;
RA Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K.,
RA Herrmann S.;
RT "The cloning of CD70 and its identification as the ligand for CD27.";
RL J. Immunol. 152:1756-1761(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Cytokine that binds to CD27. Plays a role in T-cell
CC activation. Induces the proliferation of costimulated T-cells and
CC enhances the generation of cytolytic T-cells.
CC -!- SUBUNIT: Homotrimer (Probable).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
CC protein.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L08096; AAA36175.1; -; mRNA.
DR EMBL; S69339; AAB30121.1; -; mRNA.
DR EMBL; BC000725; AAH00725.1; -; mRNA.
DR PIR; I56214; A40738.
DR RefSeq; NP_001243.1; NM_001252.3.
DR UniGene; Hs.501497; -.
DR UniGene; Hs.715224; -.
DR ProteinModelPortal; P32970; -.
DR SMR; P32970; 68-190.
DR STRING; 9606.ENSP00000245903; -.
DR PhosphoSite; P32970; -.
DR DMDM; 21431837; -.
DR PaxDb; P32970; -.
DR PeptideAtlas; P32970; -.
DR PRIDE; P32970; -.
DR DNASU; 970; -.
DR Ensembl; ENST00000245903; ENSP00000245903; ENSG00000125726.
DR GeneID; 970; -.
DR KEGG; hsa:970; -.
DR UCSC; uc002mfi.3; human.
DR CTD; 970; -.
DR GeneCards; GC19M006583; -.
DR HGNC; HGNC:11937; CD70.
DR MIM; 602840; gene.
DR neXtProt; NX_P32970; -.
DR PharmGKB; PA36627; -.
DR eggNOG; NOG46932; -.
DR HOGENOM; HOG000070045; -.
DR HOVERGEN; HBG054184; -.
DR InParanoid; P32970; -.
DR KO; K05470; -.
DR OMA; QVTLANC; -.
DR PhylomeDB; P32970; -.
DR GenomeRNAi; 970; -.
DR NextBio; 4060; -.
DR PRO; PR:P32970; -.
DR ArrayExpress; P32970; -.
DR Bgee; P32970; -.
DR CleanEx; HS_CD70; -.
DR Genevestigator; P32970; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR GO; GO:0005102; F:receptor binding; TAS:ProtInc.
DR GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 193 CD70 antigen.
FT /FTId=PRO_0000185497.
FT TOPO_DOM 1 17 Cytoplasmic (Potential).
FT TRANSMEM 18 38 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 39 193 Extracellular (Potential).
FT CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
FT DISULFID 133 151 Potential.
FT CONFLICT 154 154 A -> V (in Ref. 1; AAA36175).
SQ SEQUENCE 193 AA; 21118 MW; 9265856E33BE4D50 CRC64;
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL
QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA
SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN
TDETFFGVQW VRP
//
ID CD70_HUMAN Reviewed; 193 AA.
AC P32970; Q96J57;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 06-JUN-2002, sequence version 2.
DT 22-JAN-2014, entry version 121.
DE RecName: Full=CD70 antigen;
DE AltName: Full=CD27 ligand;
DE Short=CD27-L;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 7;
DE AltName: CD_antigen=CD70;
GN Name=CD70; Synonyms=CD27L, CD27LG, TNFSF7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=B-cell;
RX PubMed=8387892; DOI=10.1016/0092-8674(93)90133-B;
RA Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T.,
RA Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K.,
RA Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H.,
RA Farrah T., Giri J.G., Beckmann M.P.;
RT "Molecular and biological characterization of a ligand for CD27
RT defines a new family of cytokines with homology to tumor necrosis
RT factor.";
RL Cell 73:447-456(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8120384;
RA Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K.,
RA Herrmann S.;
RT "The cloning of CD70 and its identification as the ligand for CD27.";
RL J. Immunol. 152:1756-1761(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Cytokine that binds to CD27. Plays a role in T-cell
CC activation. Induces the proliferation of costimulated T-cells and
CC enhances the generation of cytolytic T-cells.
CC -!- SUBUNIT: Homotrimer (Probable).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
CC protein.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L08096; AAA36175.1; -; mRNA.
DR EMBL; S69339; AAB30121.1; -; mRNA.
DR EMBL; BC000725; AAH00725.1; -; mRNA.
DR PIR; I56214; A40738.
DR RefSeq; NP_001243.1; NM_001252.3.
DR UniGene; Hs.501497; -.
DR UniGene; Hs.715224; -.
DR ProteinModelPortal; P32970; -.
DR SMR; P32970; 68-190.
DR STRING; 9606.ENSP00000245903; -.
DR PhosphoSite; P32970; -.
DR DMDM; 21431837; -.
DR PaxDb; P32970; -.
DR PeptideAtlas; P32970; -.
DR PRIDE; P32970; -.
DR DNASU; 970; -.
DR Ensembl; ENST00000245903; ENSP00000245903; ENSG00000125726.
DR GeneID; 970; -.
DR KEGG; hsa:970; -.
DR UCSC; uc002mfi.3; human.
DR CTD; 970; -.
DR GeneCards; GC19M006583; -.
DR HGNC; HGNC:11937; CD70.
DR MIM; 602840; gene.
DR neXtProt; NX_P32970; -.
DR PharmGKB; PA36627; -.
DR eggNOG; NOG46932; -.
DR HOGENOM; HOG000070045; -.
DR HOVERGEN; HBG054184; -.
DR InParanoid; P32970; -.
DR KO; K05470; -.
DR OMA; QVTLANC; -.
DR PhylomeDB; P32970; -.
DR GenomeRNAi; 970; -.
DR NextBio; 4060; -.
DR PRO; PR:P32970; -.
DR ArrayExpress; P32970; -.
DR Bgee; P32970; -.
DR CleanEx; HS_CD70; -.
DR Genevestigator; P32970; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR GO; GO:0005102; F:receptor binding; TAS:ProtInc.
DR GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 193 CD70 antigen.
FT /FTId=PRO_0000185497.
FT TOPO_DOM 1 17 Cytoplasmic (Potential).
FT TRANSMEM 18 38 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 39 193 Extracellular (Potential).
FT CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
FT DISULFID 133 151 Potential.
FT CONFLICT 154 154 A -> V (in Ref. 1; AAA36175).
SQ SEQUENCE 193 AA; 21118 MW; 9265856E33BE4D50 CRC64;
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL
QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA
SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN
TDETFFGVQW VRP
//
MIM
602840
*RECORD*
*FIELD* NO
602840
*FIELD* TI
*602840 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY, MEMBER 7; TNFSF7
;;CD70 ANTIGEN; CD70;;
read moreCD27 LIGAND; CD27L
*FIELD* TX
CLONING
To identify the ligand for CD27 (186711), Goodwin et al. (1993) screened
a cDNA expression library derived from EBV-transformed human B cells
(MP1 cells) with a fusion protein containing the extracellular domain of
CD27. They isolated a cDNA encoding a protein with CD27-binding
characteristics similar to those of the native cell surface CD27 ligand.
The predicted 193-amino acid protein, which they called CD27L for 'CD27
ligand,' has a 20-amino acid hydrophilic N-terminal domain that lacks a
signal sequence; an 18-amino acid hydrophobic region that presumably
functions as a transmembrane anchor; and a C-terminal domain that
contains 2 potential N-linked glycosylation sites. Based on these
features, the authors suggested that the C-terminal domain of CD27L is
extracellular, and thus classified CD27L as a type II transmembrane
protein. CD27L is homologous to the ligands of the TNF receptor family,
including TNF-alpha (191160), TNF-beta (153440), and the CD40 ligand
(300386), showing 19 to 24% amino acid sequence identity in the
extracellular region. Immunoprecipitation analysis of MP1 cell lysates
using the CD27 fusion protein, followed by SDS-PAGE analysis, detected a
predominant protein with an apparent Mr of approximately 50 kD. Since
the calculated Mr of unmodified CD27L is 21 kD, Goodwin et al. (1993)
suggested that the N-linked glycosylation sites of CD27L are used. By
Northern blot analysis, they detected an approximately 1.2-kb CD27L
transcript in tonsillar T cells, peripheral blood T cells, and some
monocytic, B-, and pre-B-cell lines, but not in a lung fibroblast cell
line.
CD70 is a surface antigen found on activated, but not resting, T and B
lymphocytes. It was first detected on the surface of Hodgkin and
Reed-Sternberg cells (see 236000). Using a monoclonal antibody against
CD70 for fluorescence-activated cell sorting (FACS) of COS cells
expressing cDNAs derived from EBV-transformed human B cells, Bowman et
al. (1994) isolated cDNAs encoding CD70. Except for 2 basepair
differences, the sequences of these CD70 cDNAs are identical to the
sequence of the CD27L cDNA isolated by Goodwin et al. (1993).
GENE FUNCTION
Goodwin et al. (1993) demonstrated that CD27L induced proliferation of
costimulated T cells and enhanced generation of cytolytic T cells.
MAPPING
By fluorescence in situ hybridization, Goodwin et al. (1993) mapped the
human CD27L gene to 19p13.
ANIMAL MODEL
Arens et al. (2001) generated transgenic mice constitutively expressing
Cd70 on B cells. Cd70-transgenic mice had enhanced formation of both Cd4
(186940)-positive and Cd8 (see 186910)-positive effector/memory, Ifng
(147570)-secreting T cells. B-cell numbers, however, progressively
decreased in primary and secondary lymphoid organs due to Cd27-induced
Ifng production. Cd70-transgenic/Ifng-deficient mice also had an
activated T-cell compartment, but they retained normal B-cell numbers.
Arens et al. (2001) concluded that the CD27/CD70 system is a potent
activator of T cells in vivo.
Tesselaar et al. (2003) found that although activated T-cell numbers
increased in Cd70-transgenic mice, there was a depletion of naive T
cells. Flow cytometric analysis of peripheral lymph nodes demonstrated
that T-cell numbers were only 10% of wildtype mice at 20 weeks of age.
Moreover, after a healthy appearance over the first few months,
Cd70-transgenic mice had reduced body mass at 5 months of age and
succumbed to Pneumocystis carinii pneumonia, a hallmark of T-cell
immunodeficiency, by 7 months of age. Tesselaar et al. (2003) concluded
that Cd70-transgenic mice show persistent immune activation, similar to
that in humans unable to control human immunodeficiency virus-1
replication, that can result in a state of lethal immunodeficiency.
*FIELD* RF
1. Arens, R.; Tesselaar, K.; Baars, P. A.; van Schijndel, G. M. W.;
Hendriks, J.; Pals, S. T.; Krimpenfort, P.; Borst, J.; van Oers, M.
H. J.; van Lier, R. A. W.: Constitutive CD27/CD70 interaction induces
expansion of effector-type T cells and results in IFN-gamma-mediated
B cell depletion. Immunity 15: 801-812, 2001.
2. Bowman, M. R.; Crimmins, M. A. V.; Yetz-Aldape, J.; Kriz, R.; Kelleher,
K.; Herrmann, S.: The cloning of CD70 and its identification as the
ligand for CD27. J. Immun. 152: 1756-1761, 1994.
3. Goodwin, R. G.; Alderson, M. R.; Smith, C. A.; Armitage, R. J.;
VandenBos, T.; Jerzy, R.; Tough, T. W.; Schoenborn, M. A.; Davis-Smith,
T.; Hennen, K.; Falk, B.; Cosman, D.; Baker, E.; Sutherland, G. R.;
Grabstein, K. H.; Farrah, T.; Giri, J. G.; Beckmann, M. P.: Molecular
and biological characterization of a ligand for CD27 defines a new
family of cytokines with homology to tumor necrosis factor. Cell 73:
447-456, 1993.
4. Tesselaar, K.; Arens, R.; van Schijndel, G. M. W.; Baars, P. A.;
van der Valk, M. A.; Borst, J.; van Oers, M. H. J.; van Lier, R. A.
W.: Lethal T cell immunodeficiency induced by chronic costimulation
via CD27-CD70 interactions. Nature Immun. 4: 49-54, 2003. Note:
Erratum: Nature Immun. 4: 295 only, 2003.
*FIELD* CN
Paul J. Converse - updated: 2/14/2006
*FIELD* CD
Patti M. Sherman: 7/13/1998
*FIELD* ED
terry: 11/28/2012
mgross: 2/15/2006
terry: 2/14/2006
cwells: 4/8/2002
carol: 12/14/1998
carol: 7/24/1998
dkim: 7/23/1998
carol: 7/14/1998
*RECORD*
*FIELD* NO
602840
*FIELD* TI
*602840 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY, MEMBER 7; TNFSF7
;;CD70 ANTIGEN; CD70;;
read moreCD27 LIGAND; CD27L
*FIELD* TX
CLONING
To identify the ligand for CD27 (186711), Goodwin et al. (1993) screened
a cDNA expression library derived from EBV-transformed human B cells
(MP1 cells) with a fusion protein containing the extracellular domain of
CD27. They isolated a cDNA encoding a protein with CD27-binding
characteristics similar to those of the native cell surface CD27 ligand.
The predicted 193-amino acid protein, which they called CD27L for 'CD27
ligand,' has a 20-amino acid hydrophilic N-terminal domain that lacks a
signal sequence; an 18-amino acid hydrophobic region that presumably
functions as a transmembrane anchor; and a C-terminal domain that
contains 2 potential N-linked glycosylation sites. Based on these
features, the authors suggested that the C-terminal domain of CD27L is
extracellular, and thus classified CD27L as a type II transmembrane
protein. CD27L is homologous to the ligands of the TNF receptor family,
including TNF-alpha (191160), TNF-beta (153440), and the CD40 ligand
(300386), showing 19 to 24% amino acid sequence identity in the
extracellular region. Immunoprecipitation analysis of MP1 cell lysates
using the CD27 fusion protein, followed by SDS-PAGE analysis, detected a
predominant protein with an apparent Mr of approximately 50 kD. Since
the calculated Mr of unmodified CD27L is 21 kD, Goodwin et al. (1993)
suggested that the N-linked glycosylation sites of CD27L are used. By
Northern blot analysis, they detected an approximately 1.2-kb CD27L
transcript in tonsillar T cells, peripheral blood T cells, and some
monocytic, B-, and pre-B-cell lines, but not in a lung fibroblast cell
line.
CD70 is a surface antigen found on activated, but not resting, T and B
lymphocytes. It was first detected on the surface of Hodgkin and
Reed-Sternberg cells (see 236000). Using a monoclonal antibody against
CD70 for fluorescence-activated cell sorting (FACS) of COS cells
expressing cDNAs derived from EBV-transformed human B cells, Bowman et
al. (1994) isolated cDNAs encoding CD70. Except for 2 basepair
differences, the sequences of these CD70 cDNAs are identical to the
sequence of the CD27L cDNA isolated by Goodwin et al. (1993).
GENE FUNCTION
Goodwin et al. (1993) demonstrated that CD27L induced proliferation of
costimulated T cells and enhanced generation of cytolytic T cells.
MAPPING
By fluorescence in situ hybridization, Goodwin et al. (1993) mapped the
human CD27L gene to 19p13.
ANIMAL MODEL
Arens et al. (2001) generated transgenic mice constitutively expressing
Cd70 on B cells. Cd70-transgenic mice had enhanced formation of both Cd4
(186940)-positive and Cd8 (see 186910)-positive effector/memory, Ifng
(147570)-secreting T cells. B-cell numbers, however, progressively
decreased in primary and secondary lymphoid organs due to Cd27-induced
Ifng production. Cd70-transgenic/Ifng-deficient mice also had an
activated T-cell compartment, but they retained normal B-cell numbers.
Arens et al. (2001) concluded that the CD27/CD70 system is a potent
activator of T cells in vivo.
Tesselaar et al. (2003) found that although activated T-cell numbers
increased in Cd70-transgenic mice, there was a depletion of naive T
cells. Flow cytometric analysis of peripheral lymph nodes demonstrated
that T-cell numbers were only 10% of wildtype mice at 20 weeks of age.
Moreover, after a healthy appearance over the first few months,
Cd70-transgenic mice had reduced body mass at 5 months of age and
succumbed to Pneumocystis carinii pneumonia, a hallmark of T-cell
immunodeficiency, by 7 months of age. Tesselaar et al. (2003) concluded
that Cd70-transgenic mice show persistent immune activation, similar to
that in humans unable to control human immunodeficiency virus-1
replication, that can result in a state of lethal immunodeficiency.
*FIELD* RF
1. Arens, R.; Tesselaar, K.; Baars, P. A.; van Schijndel, G. M. W.;
Hendriks, J.; Pals, S. T.; Krimpenfort, P.; Borst, J.; van Oers, M.
H. J.; van Lier, R. A. W.: Constitutive CD27/CD70 interaction induces
expansion of effector-type T cells and results in IFN-gamma-mediated
B cell depletion. Immunity 15: 801-812, 2001.
2. Bowman, M. R.; Crimmins, M. A. V.; Yetz-Aldape, J.; Kriz, R.; Kelleher,
K.; Herrmann, S.: The cloning of CD70 and its identification as the
ligand for CD27. J. Immun. 152: 1756-1761, 1994.
3. Goodwin, R. G.; Alderson, M. R.; Smith, C. A.; Armitage, R. J.;
VandenBos, T.; Jerzy, R.; Tough, T. W.; Schoenborn, M. A.; Davis-Smith,
T.; Hennen, K.; Falk, B.; Cosman, D.; Baker, E.; Sutherland, G. R.;
Grabstein, K. H.; Farrah, T.; Giri, J. G.; Beckmann, M. P.: Molecular
and biological characterization of a ligand for CD27 defines a new
family of cytokines with homology to tumor necrosis factor. Cell 73:
447-456, 1993.
4. Tesselaar, K.; Arens, R.; van Schijndel, G. M. W.; Baars, P. A.;
van der Valk, M. A.; Borst, J.; van Oers, M. H. J.; van Lier, R. A.
W.: Lethal T cell immunodeficiency induced by chronic costimulation
via CD27-CD70 interactions. Nature Immun. 4: 49-54, 2003. Note:
Erratum: Nature Immun. 4: 295 only, 2003.
*FIELD* CN
Paul J. Converse - updated: 2/14/2006
*FIELD* CD
Patti M. Sherman: 7/13/1998
*FIELD* ED
terry: 11/28/2012
mgross: 2/15/2006
terry: 2/14/2006
cwells: 4/8/2002
carol: 12/14/1998
carol: 7/24/1998
dkim: 7/23/1998
carol: 7/14/1998