Full text data of CEACAM6
CEACAM6
(NCA)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen; Normal cross-reacting antigen; CD66c; Flags: Precursor)
Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen; Normal cross-reacting antigen; CD66c; Flags: Precursor)
UniProt
P40199
ID CEAM6_HUMAN Reviewed; 344 AA.
AC P40199; Q13774; Q14920; Q53XP7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 3.
DT 22-JAN-2014, entry version 128.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 6;
DE AltName: Full=Non-specific crossreacting antigen;
DE AltName: Full=Normal cross-reacting antigen;
DE AltName: CD_antigen=CD66c;
DE Flags: Precursor;
GN Name=CEACAM6; Synonyms=NCA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3220478; DOI=10.1016/0888-7543(88)90160-7;
RA Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J.;
RT "Carcinoembryonic antigen family: characterization of cDNAs coding for
RT NCA and CEA and suggestion of nonrandom sequence variation in their
RT conserved loop-domains.";
RL Genomics 3:59-66(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-239.
RC TISSUE=Lung carcinoma;
RX PubMed=3337731; DOI=10.1016/0006-291X(88)90490-1;
RA Tawaragi Y., Oikawa S., Matsuoka Y., Kosaki G., Nakazato H.;
RT "Primary structure of nonspecific crossreacting antigen (NCA), a
RT member of carcinoembryonic antigen (CEA) gene family, deduced from
RT cDNA sequence.";
RL Biochem. Biophys. Res. Commun. 150:89-96(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2830274;
RA Neumaier M., Zimmermann W., Shively L., Hinoda Y., Riggs A.D.,
RA Shively J.E.;
RT "Characterization of a cDNA clone for the nonspecific cross-reacting
RT antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.";
RL J. Biol. Chem. 263:3202-3207(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-239.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-239.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-239.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PROTEIN SEQUENCE OF 35-49.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally
RT verified cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197, AND MASS
RP SPECTROMETRY.
RC TISSUE=Saliva;
RX PubMed=16740002; DOI=10.1021/pr050492k;
RA Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,
RA Loo J.A.;
RT "Identification of N-linked glycoproteins in human saliva by
RT glycoprotein capture and mass spectrometry.";
RL J. Proteome Res. 5:1493-1503(2006).
RN [11]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-224, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [12]
RP VARIANT [LARGE SCALE ANALYSIS] VAL-239, AND MASS SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by
RT enrichment and fractionation of phosphopeptides with strong anion
RT exchange chromatography.";
RL Proteomics 8:1346-1361(2008).
CC -!- INTERACTION:
CC Q16568:CARTPT; NbExp=3; IntAct=EBI-4314501, EBI-4314526;
CC P13688:CEACAM1; NbExp=2; IntAct=EBI-4314501, EBI-4314481;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC -!- SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like)
CC domains.
CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC domain.
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DR EMBL; M29541; AAA59915.1; -; mRNA.
DR EMBL; M18728; AAA59907.1; -; mRNA.
DR EMBL; M18216; AAA51739.1; -; mRNA.
DR EMBL; BT009774; AAP88776.1; -; mRNA.
DR EMBL; AK312542; BAG35441.1; -; mRNA.
DR EMBL; AC011513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW57061.1; -; Genomic_DNA.
DR EMBL; BC005008; AAH05008.1; -; mRNA.
DR RefSeq; NP_002474.3; NM_002483.4.
DR UniGene; Hs.466814; -.
DR ProteinModelPortal; P40199; -.
DR SMR; P40199; 34-305.
DR IntAct; P40199; 5.
DR MINT; MINT-5002810; -.
DR STRING; 9606.ENSP00000199764; -.
DR PhosphoSite; P40199; -.
DR DMDM; 296439410; -.
DR PaxDb; P40199; -.
DR PRIDE; P40199; -.
DR DNASU; 4680; -.
DR Ensembl; ENST00000199764; ENSP00000199764; ENSG00000086548.
DR GeneID; 4680; -.
DR KEGG; hsa:4680; -.
DR UCSC; uc002orm.2; human.
DR CTD; 4680; -.
DR GeneCards; GC19P042260; -.
DR HGNC; HGNC:1818; CEACAM6.
DR HPA; CAB008370; -.
DR HPA; HPA011041; -.
DR MIM; 163980; gene.
DR neXtProt; NX_P40199; -.
DR PharmGKB; PA26362; -.
DR eggNOG; NOG151357; -.
DR HOGENOM; HOG000233417; -.
DR HOVERGEN; HBG007922; -.
DR InParanoid; P40199; -.
DR KO; K06499; -.
DR OMA; PWKEVLL; -.
DR OrthoDB; EOG74BJS7; -.
DR PhylomeDB; P40199; -.
DR ChiTaRS; CEACAM6; human.
DR GeneWiki; CEACAM6; -.
DR GenomeRNAi; 4680; -.
DR NextBio; 18040; -.
DR PRO; PR:P40199; -.
DR ArrayExpress; P40199; -.
DR Bgee; P40199; -.
DR CleanEx; HS_CEACAM6; -.
DR Genevestigator; P40199; -.
DR GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Complete proteome; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain;
KW Lipoprotein; Membrane; Polymorphism; Reference proteome; Repeat;
KW Signal.
FT SIGNAL 1 34
FT CHAIN 35 320 Carcinoembryonic antigen-related cell
FT adhesion molecule 6.
FT /FTId=PRO_0000014568.
FT PROPEP 321 344 Removed in mature form (By similarity).
FT /FTId=PRO_0000014569.
FT DOMAIN 35 142 Ig-like V-type.
FT DOMAIN 145 232 Ig-like C2-type 1.
FT DOMAIN 237 314 Ig-like C2-type 2.
FT LIPID 320 320 GPI-anchor amidated glycine (By
FT similarity).
FT CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 152 152 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 197 197 N-linked (GlcNAc...).
FT CARBOHYD 224 224 N-linked (GlcNAc...).
FT CARBOHYD 256 256 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
FT DISULFID 167 215 Probable.
FT DISULFID 259 299 Probable.
FT VARIANT 239 239 G -> V (in dbSNP:rs11548735).
FT /FTId=VAR_034680.
FT CONFLICT 138 138 F -> L (in Ref. 1; AAA59915).
SQ SEQUENCE 344 AA; 37195 MW; 28469487A74C18A4 CRC64;
MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLAHNLPQ
NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET IYPNASLLIQ NVTQNDTGFY
TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV
NGQSLPVSPR LQLSNGNMTL TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP
TISPSKANYR PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI
//
ID CEAM6_HUMAN Reviewed; 344 AA.
AC P40199; Q13774; Q14920; Q53XP7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 3.
DT 22-JAN-2014, entry version 128.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 6;
DE AltName: Full=Non-specific crossreacting antigen;
DE AltName: Full=Normal cross-reacting antigen;
DE AltName: CD_antigen=CD66c;
DE Flags: Precursor;
GN Name=CEACAM6; Synonyms=NCA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3220478; DOI=10.1016/0888-7543(88)90160-7;
RA Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J.;
RT "Carcinoembryonic antigen family: characterization of cDNAs coding for
RT NCA and CEA and suggestion of nonrandom sequence variation in their
RT conserved loop-domains.";
RL Genomics 3:59-66(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-239.
RC TISSUE=Lung carcinoma;
RX PubMed=3337731; DOI=10.1016/0006-291X(88)90490-1;
RA Tawaragi Y., Oikawa S., Matsuoka Y., Kosaki G., Nakazato H.;
RT "Primary structure of nonspecific crossreacting antigen (NCA), a
RT member of carcinoembryonic antigen (CEA) gene family, deduced from
RT cDNA sequence.";
RL Biochem. Biophys. Res. Commun. 150:89-96(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2830274;
RA Neumaier M., Zimmermann W., Shively L., Hinoda Y., Riggs A.D.,
RA Shively J.E.;
RT "Characterization of a cDNA clone for the nonspecific cross-reacting
RT antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.";
RL J. Biol. Chem. 263:3202-3207(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-239.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-239.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-239.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PROTEIN SEQUENCE OF 35-49.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally
RT verified cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197, AND MASS
RP SPECTROMETRY.
RC TISSUE=Saliva;
RX PubMed=16740002; DOI=10.1021/pr050492k;
RA Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,
RA Loo J.A.;
RT "Identification of N-linked glycoproteins in human saliva by
RT glycoprotein capture and mass spectrometry.";
RL J. Proteome Res. 5:1493-1503(2006).
RN [11]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-224, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [12]
RP VARIANT [LARGE SCALE ANALYSIS] VAL-239, AND MASS SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by
RT enrichment and fractionation of phosphopeptides with strong anion
RT exchange chromatography.";
RL Proteomics 8:1346-1361(2008).
CC -!- INTERACTION:
CC Q16568:CARTPT; NbExp=3; IntAct=EBI-4314501, EBI-4314526;
CC P13688:CEACAM1; NbExp=2; IntAct=EBI-4314501, EBI-4314481;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC -!- SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like)
CC domains.
CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
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DR EMBL; M29541; AAA59915.1; -; mRNA.
DR EMBL; M18728; AAA59907.1; -; mRNA.
DR EMBL; M18216; AAA51739.1; -; mRNA.
DR EMBL; BT009774; AAP88776.1; -; mRNA.
DR EMBL; AK312542; BAG35441.1; -; mRNA.
DR EMBL; AC011513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW57061.1; -; Genomic_DNA.
DR EMBL; BC005008; AAH05008.1; -; mRNA.
DR RefSeq; NP_002474.3; NM_002483.4.
DR UniGene; Hs.466814; -.
DR ProteinModelPortal; P40199; -.
DR SMR; P40199; 34-305.
DR IntAct; P40199; 5.
DR MINT; MINT-5002810; -.
DR STRING; 9606.ENSP00000199764; -.
DR PhosphoSite; P40199; -.
DR DMDM; 296439410; -.
DR PaxDb; P40199; -.
DR PRIDE; P40199; -.
DR DNASU; 4680; -.
DR Ensembl; ENST00000199764; ENSP00000199764; ENSG00000086548.
DR GeneID; 4680; -.
DR KEGG; hsa:4680; -.
DR UCSC; uc002orm.2; human.
DR CTD; 4680; -.
DR GeneCards; GC19P042260; -.
DR HGNC; HGNC:1818; CEACAM6.
DR HPA; CAB008370; -.
DR HPA; HPA011041; -.
DR MIM; 163980; gene.
DR neXtProt; NX_P40199; -.
DR PharmGKB; PA26362; -.
DR eggNOG; NOG151357; -.
DR HOGENOM; HOG000233417; -.
DR HOVERGEN; HBG007922; -.
DR InParanoid; P40199; -.
DR KO; K06499; -.
DR OMA; PWKEVLL; -.
DR OrthoDB; EOG74BJS7; -.
DR PhylomeDB; P40199; -.
DR ChiTaRS; CEACAM6; human.
DR GeneWiki; CEACAM6; -.
DR GenomeRNAi; 4680; -.
DR NextBio; 18040; -.
DR PRO; PR:P40199; -.
DR ArrayExpress; P40199; -.
DR Bgee; P40199; -.
DR CleanEx; HS_CEACAM6; -.
DR Genevestigator; P40199; -.
DR GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Complete proteome; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain;
KW Lipoprotein; Membrane; Polymorphism; Reference proteome; Repeat;
KW Signal.
FT SIGNAL 1 34
FT CHAIN 35 320 Carcinoembryonic antigen-related cell
FT adhesion molecule 6.
FT /FTId=PRO_0000014568.
FT PROPEP 321 344 Removed in mature form (By similarity).
FT /FTId=PRO_0000014569.
FT DOMAIN 35 142 Ig-like V-type.
FT DOMAIN 145 232 Ig-like C2-type 1.
FT DOMAIN 237 314 Ig-like C2-type 2.
FT LIPID 320 320 GPI-anchor amidated glycine (By
FT similarity).
FT CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 152 152 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 197 197 N-linked (GlcNAc...).
FT CARBOHYD 224 224 N-linked (GlcNAc...).
FT CARBOHYD 256 256 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
FT DISULFID 167 215 Probable.
FT DISULFID 259 299 Probable.
FT VARIANT 239 239 G -> V (in dbSNP:rs11548735).
FT /FTId=VAR_034680.
FT CONFLICT 138 138 F -> L (in Ref. 1; AAA59915).
SQ SEQUENCE 344 AA; 37195 MW; 28469487A74C18A4 CRC64;
MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLAHNLPQ
NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET IYPNASLLIQ NVTQNDTGFY
TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV
NGQSLPVSPR LQLSNGNMTL TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP
TISPSKANYR PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI
//
MIM
163980
*RECORD*
*FIELD* NO
163980
*FIELD* TI
*163980 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 6; CEACAM6
;;NONSPECIFIC CROSSREACTING ANTIGEN; NCA;;
read moreNORMAL CROSSREACTING ANTIGEN;;
CEA-LIKE PROTEIN; CEAL
*FIELD* TX
DESCRIPTION
Carcinoembryonic antigen (CEA; 114890) is one of the most widely used
tumor markers in serum immunoassay determinations of carcinoma. An
apparent lack of absolute cancer specificity for CEA probably results in
part from the presence in normal and neoplastic tissues of antigens that
share antigenic determinants with the 180-kD form of CEA (Barnett et
al., 1988). For background information on the CEA family of genes, see
CEACAM1 (109770).
CLONING
Barnett et al. (1988) presented sequences of a 'normal crossreacting
antigen' (NCA) and showed that CEA and NCA, although closely related in
sequence, are structurally and probably functionally distinct.
MAPPING
By in situ hybridization, Willcocks et al. (1989) mapped NCA to 19q13 in
the same region as CEA. The localization was supported by studies with a
somatic cell hybrid cell line. By a combination of Southern blot
analysis and in situ hybridization, Inazawa et al. (1989) localized the
gene to 19q13.2.
GENE FUNCTION
In 15 patients with Crohn disease (CD; see 266600) and 9 controls,
Barnich et al. (2007) found that adherent-invasive E. coli (AIEC)
adhesion was dependent on type 1 pili expression on the bacterial
surface and on CEACAM6 expression on the apical surface of ileal
epithelial cells. CEACAM6 acted as a receptor for AIEC adhesion and was
upregulated in the ileal mucosa of CD patients compared to colonic
mucosa or to controls. In vitro studies showed increased CEACAM6
expression in cultured intestinal epithelial cells after IFN-gamma
(147570) or TNF-alpha (191160) stimulation and after infection with
AIEC.
By screening a panel of pancreatic cancer cell lines for sensitivity to
adenovirus, followed by differential gene expression analysis between
sensitive and insensitive cells, Wang et al. (2009) found that CEACAM6
expression correlated with the sensitivity of tumor cells to the virus.
CEACAM6 blocked adenovirus trafficking to the nucleus through the SRC
(190090) pathway, interfering with cancer cell cytoskeleton and reducing
adenoviral infection. Knockdown of CEACAM6 with small interfering RNA
significantly increased adenovirus replication and antitumor efficacy of
oncolytic adenovirus in a mouse xenograft tumor model. Wang et al.
(2009) concluded that CEACAM6 is a tumor-associated gene that affects
the ability of cancer cells to be infected with adenovirus.
Mouse neutrophils do not bind the human-restricted pathogen Neisseria
gonorrhoeae. Sarantis and Gray-Owen (2012) showed that introducing any
of the gonorrheal Opa-binding human neutrophil CEACAMs into a murine
neutrophil cell line allowed binding and entry of Neisseria. CEACAM1 and
CEACAM6 both bound and allowed entry of the bacterium, but they mediated
little neutrophil activation. In contrast, uptake via CEACAM3 (609142)
induced an oxidative burst and intracellular granule release comparable
to that seen during human neutrophil infection. Coexpression of CEACAM3
with either CEACAM1 or CEACAM6 potentiated CEACAM3-dependent responses.
Sarantis and Gray-Owen (2012) concluded that, although CEACAMs have
different functions in neutrophils, they cooperate during gonorrheal
infection. Their findings implicated CEACAM3 in the neutrophil innate
response to neisserial infection.
NOMENCLATURE
Beauchemin et al. (1999) provided a revised nomenclature for the CEA
gene family. Based on this nomenclature, the CEA family is composed of
the PSG subfamily (see 176390); the CEACAM subfamily, which includes
CEACAM1 (BGP), CEACAM3 (CGM1; 609142), CEACAM4 (CGM7), CEACAM5 (CEA),
CEACAM6 (NCA), CEACAM7 (CGM2), and CEACAM8 (CGM6); and the CEACAM
pseudogene (CEACAMP) subfamily, CEACAMP1 through CEACAMP11, which had
originally been named CGM8 through CGM18 (see 109770). The NCA gene was
renamed CEACAM6.
*FIELD* RF
1. Barnett, T.; Goebel, S. J.; Nothdurft, M. A.; Elting, J. J.: Carcinoembryonic
antigen family: characterization of cDNAs coding for NCA and CEA and
suggestion of nonrandom sequence variation in their conserved loop-domains. Genomics 3:
59-66, 1988.
2. Barnich, N.; Carvalho, F. A.; Glasser, A.-L.; Darcha, C.; Jantscheff,
P.; Allez, M.; Peeters, H.; Bommelaer, G.; Desreumaux, P.; Colombel,
J.-F.; Darfeuille-Michaud, A.: CEACAM6 acts as a receptor for adherent-invasive
E. coli, supporting ileal mucosa colonization in Crohn disease. J.
Clin. Invest. 117: 1566-1574, 2007.
3. Beauchemin, N.; Draber, P.; Dveksler, G.; Gold, P.; Gray-Owen,
S.; Grunert, F.; Hammarstrom, S.; Holmes, K. V.; Karlsson, A.; Kuroki,
M.; Lin, S.-H.; Lucka, L.; and 13 others: Redefined nomenclature
for members of the carcinoembryonic antigen family. Exp. Cell Res. 252:
243-249, 1999.
4. Inazawa, J.; Abe, T.; Inoue, K.; Misawa, S.; Oikawa, S.; Nakazato,
H.; Yoshida, M. C.: Regional assignment of nonspecific cross-reacting
antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2. Cytogenet.
Cell Genet. 52: 28-31, 1989.
5. Sarantis, H.; Gray-Owen, S. D.: Defining the roles of human carcinoembryonic
antigen-related cellular adhesion molecules during neutrophil responses
to Neisseria gonorrhoeae. Infect. Immun. 80: 345-358, 2012.
6. Wang, Y.; Gangeswaran, R.; Zhao, X.; Wang, P.; Tysome, J.; Bhakta,
V.; Yuan, M.; Chikkanna-Gowda, C. P.; Jiang, G.; Gao, D.; Cao, F.;
Francis, J.; Yu, J.; Liu, K.; Yang, H.; Zhang, Y.; Zang, W.; Chelala,
C.; Dong, Z.; Lemoine, N.: CEACAM6 attenuates adenovirus infection
by antagonizing viral trafficking in cancer cells. J. Clin. Invest. 119:
1604-1615, 2009.
7. Willcocks, T. C.; Craig, S. P.; Craig, I. W.: Assignment of the
coding sequence for carcinoembryonic antigen (CEA) and normal cross-reacting
antigen (NCA) to human chromosome 19q13. Ann. Hum. Genet. 53: 141-148,
1989.
*FIELD* CN
Paul J. Converse - updated: 5/1/2012
': 1/4/2010
Paul J. Converse - updated: 12/11/2009
Marla J. F. O'Neill - updated: 8/1/2007
*FIELD* CD
Victor A. McKusick: 8/1/1988
*FIELD* ED
mgross: 05/03/2012
terry: 5/1/2012
mgross: 1/4/2010
terry: 12/11/2009
carol: 10/29/2009
carol: 10/24/2008
ckniffin: 8/21/2007
wwang: 8/13/2007
terry: 8/1/2007
mgross: 1/5/2005
mgross: 2/17/2000
carol: 10/20/1998
carol: 12/1/1992
carol: 4/1/1992
supermim: 3/16/1992
carol: 9/8/1990
supermim: 3/20/1990
ddp: 10/27/1989
*RECORD*
*FIELD* NO
163980
*FIELD* TI
*163980 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 6; CEACAM6
;;NONSPECIFIC CROSSREACTING ANTIGEN; NCA;;
read moreNORMAL CROSSREACTING ANTIGEN;;
CEA-LIKE PROTEIN; CEAL
*FIELD* TX
DESCRIPTION
Carcinoembryonic antigen (CEA; 114890) is one of the most widely used
tumor markers in serum immunoassay determinations of carcinoma. An
apparent lack of absolute cancer specificity for CEA probably results in
part from the presence in normal and neoplastic tissues of antigens that
share antigenic determinants with the 180-kD form of CEA (Barnett et
al., 1988). For background information on the CEA family of genes, see
CEACAM1 (109770).
CLONING
Barnett et al. (1988) presented sequences of a 'normal crossreacting
antigen' (NCA) and showed that CEA and NCA, although closely related in
sequence, are structurally and probably functionally distinct.
MAPPING
By in situ hybridization, Willcocks et al. (1989) mapped NCA to 19q13 in
the same region as CEA. The localization was supported by studies with a
somatic cell hybrid cell line. By a combination of Southern blot
analysis and in situ hybridization, Inazawa et al. (1989) localized the
gene to 19q13.2.
GENE FUNCTION
In 15 patients with Crohn disease (CD; see 266600) and 9 controls,
Barnich et al. (2007) found that adherent-invasive E. coli (AIEC)
adhesion was dependent on type 1 pili expression on the bacterial
surface and on CEACAM6 expression on the apical surface of ileal
epithelial cells. CEACAM6 acted as a receptor for AIEC adhesion and was
upregulated in the ileal mucosa of CD patients compared to colonic
mucosa or to controls. In vitro studies showed increased CEACAM6
expression in cultured intestinal epithelial cells after IFN-gamma
(147570) or TNF-alpha (191160) stimulation and after infection with
AIEC.
By screening a panel of pancreatic cancer cell lines for sensitivity to
adenovirus, followed by differential gene expression analysis between
sensitive and insensitive cells, Wang et al. (2009) found that CEACAM6
expression correlated with the sensitivity of tumor cells to the virus.
CEACAM6 blocked adenovirus trafficking to the nucleus through the SRC
(190090) pathway, interfering with cancer cell cytoskeleton and reducing
adenoviral infection. Knockdown of CEACAM6 with small interfering RNA
significantly increased adenovirus replication and antitumor efficacy of
oncolytic adenovirus in a mouse xenograft tumor model. Wang et al.
(2009) concluded that CEACAM6 is a tumor-associated gene that affects
the ability of cancer cells to be infected with adenovirus.
Mouse neutrophils do not bind the human-restricted pathogen Neisseria
gonorrhoeae. Sarantis and Gray-Owen (2012) showed that introducing any
of the gonorrheal Opa-binding human neutrophil CEACAMs into a murine
neutrophil cell line allowed binding and entry of Neisseria. CEACAM1 and
CEACAM6 both bound and allowed entry of the bacterium, but they mediated
little neutrophil activation. In contrast, uptake via CEACAM3 (609142)
induced an oxidative burst and intracellular granule release comparable
to that seen during human neutrophil infection. Coexpression of CEACAM3
with either CEACAM1 or CEACAM6 potentiated CEACAM3-dependent responses.
Sarantis and Gray-Owen (2012) concluded that, although CEACAMs have
different functions in neutrophils, they cooperate during gonorrheal
infection. Their findings implicated CEACAM3 in the neutrophil innate
response to neisserial infection.
NOMENCLATURE
Beauchemin et al. (1999) provided a revised nomenclature for the CEA
gene family. Based on this nomenclature, the CEA family is composed of
the PSG subfamily (see 176390); the CEACAM subfamily, which includes
CEACAM1 (BGP), CEACAM3 (CGM1; 609142), CEACAM4 (CGM7), CEACAM5 (CEA),
CEACAM6 (NCA), CEACAM7 (CGM2), and CEACAM8 (CGM6); and the CEACAM
pseudogene (CEACAMP) subfamily, CEACAMP1 through CEACAMP11, which had
originally been named CGM8 through CGM18 (see 109770). The NCA gene was
renamed CEACAM6.
*FIELD* RF
1. Barnett, T.; Goebel, S. J.; Nothdurft, M. A.; Elting, J. J.: Carcinoembryonic
antigen family: characterization of cDNAs coding for NCA and CEA and
suggestion of nonrandom sequence variation in their conserved loop-domains. Genomics 3:
59-66, 1988.
2. Barnich, N.; Carvalho, F. A.; Glasser, A.-L.; Darcha, C.; Jantscheff,
P.; Allez, M.; Peeters, H.; Bommelaer, G.; Desreumaux, P.; Colombel,
J.-F.; Darfeuille-Michaud, A.: CEACAM6 acts as a receptor for adherent-invasive
E. coli, supporting ileal mucosa colonization in Crohn disease. J.
Clin. Invest. 117: 1566-1574, 2007.
3. Beauchemin, N.; Draber, P.; Dveksler, G.; Gold, P.; Gray-Owen,
S.; Grunert, F.; Hammarstrom, S.; Holmes, K. V.; Karlsson, A.; Kuroki,
M.; Lin, S.-H.; Lucka, L.; and 13 others: Redefined nomenclature
for members of the carcinoembryonic antigen family. Exp. Cell Res. 252:
243-249, 1999.
4. Inazawa, J.; Abe, T.; Inoue, K.; Misawa, S.; Oikawa, S.; Nakazato,
H.; Yoshida, M. C.: Regional assignment of nonspecific cross-reacting
antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2. Cytogenet.
Cell Genet. 52: 28-31, 1989.
5. Sarantis, H.; Gray-Owen, S. D.: Defining the roles of human carcinoembryonic
antigen-related cellular adhesion molecules during neutrophil responses
to Neisseria gonorrhoeae. Infect. Immun. 80: 345-358, 2012.
6. Wang, Y.; Gangeswaran, R.; Zhao, X.; Wang, P.; Tysome, J.; Bhakta,
V.; Yuan, M.; Chikkanna-Gowda, C. P.; Jiang, G.; Gao, D.; Cao, F.;
Francis, J.; Yu, J.; Liu, K.; Yang, H.; Zhang, Y.; Zang, W.; Chelala,
C.; Dong, Z.; Lemoine, N.: CEACAM6 attenuates adenovirus infection
by antagonizing viral trafficking in cancer cells. J. Clin. Invest. 119:
1604-1615, 2009.
7. Willcocks, T. C.; Craig, S. P.; Craig, I. W.: Assignment of the
coding sequence for carcinoembryonic antigen (CEA) and normal cross-reacting
antigen (NCA) to human chromosome 19q13. Ann. Hum. Genet. 53: 141-148,
1989.
*FIELD* CN
Paul J. Converse - updated: 5/1/2012
': 1/4/2010
Paul J. Converse - updated: 12/11/2009
Marla J. F. O'Neill - updated: 8/1/2007
*FIELD* CD
Victor A. McKusick: 8/1/1988
*FIELD* ED
mgross: 05/03/2012
terry: 5/1/2012
mgross: 1/4/2010
terry: 12/11/2009
carol: 10/29/2009
carol: 10/24/2008
ckniffin: 8/21/2007
wwang: 8/13/2007
terry: 8/1/2007
mgross: 1/5/2005
mgross: 2/17/2000
carol: 10/20/1998
carol: 12/1/1992
carol: 4/1/1992
supermim: 3/16/1992
carol: 9/8/1990
supermim: 3/20/1990
ddp: 10/27/1989