Full text data of CHCHD6
CHCHD6
(CHCM1)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial (Coiled coil helix cristae morphology protein 1)
Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial (Coiled coil helix cristae morphology protein 1)
hRBCD
IPI00031622
IPI00031622 Conserved hypothetical protein Conserved hypothetical protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00031622 Conserved hypothetical protein Conserved hypothetical protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q9BRQ6
ID CHCH6_HUMAN Reviewed; 235 AA.
AC Q9BRQ6; D6R9U0; D6RIB4; H8Y0Y7;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 77.
DE RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial;
DE AltName: Full=Coiled coil helix cristae morphology protein 1;
GN Name=CHCHD6; Synonyms=CHCM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION,
RP AND INTERACTION WITH CHCHD3; DISC1 AND IMMT.
RX PubMed=22228767; DOI=10.1074/jbc.M111.277103;
RA An J., Shi J., He Q., Lui K., Liu Y., Huang Y., Sheikh M.S.;
RT "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of
RT mitofilin and mitochondrial cristae morphology.";
RL J. Biol. Chem. 287:7411-7426(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION IN A COMPLEX WITH IMMT.
RX PubMed=17624330; DOI=10.1016/j.febslet.2007.06.052;
RA Xie J., Marusich M.F., Souda P., Whitelegge J., Capaldi R.A.;
RT "The mitochondrial inner membrane protein mitofilin exists as a
RT complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-
RT helix domain-containing protein 3 and 6 and DnaJC11.";
RL FEBS Lett. 581:3545-3549(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Required for maintaining mitochondrial crista
CC morphology, ATP production and oxygen consumption.
CC -!- SUBUNIT: Interacts with CHCHD3 and DISC1. Interacts with IMMT; the
CC interaction is direct.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Lipid-anchor
CC (Probable).
CC -!- INDUCTION: Down-regulated following genotoxic stress.
CC -!- SIMILARITY: Belongs to the CHCHD6 family.
CC -!- SIMILARITY: Contains 1 CHCH domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; JF264889; AEA95848.1; -; mRNA.
DR EMBL; AC078867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC117450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79352.1; -; Genomic_DNA.
DR EMBL; BC006123; AAH06123.1; -; mRNA.
DR RefSeq; NP_115719.1; NM_032343.2.
DR UniGene; Hs.518119; -.
DR ProteinModelPortal; Q9BRQ6; -.
DR IntAct; Q9BRQ6; 4.
DR MINT; MINT-4830561; -.
DR STRING; 9606.ENSP00000290913; -.
DR PhosphoSite; Q9BRQ6; -.
DR DMDM; 62510505; -.
DR PaxDb; Q9BRQ6; -.
DR PeptideAtlas; Q9BRQ6; -.
DR PRIDE; Q9BRQ6; -.
DR Ensembl; ENST00000290913; ENSP00000290913; ENSG00000159685.
DR GeneID; 84303; -.
DR KEGG; hsa:84303; -.
DR UCSC; uc003ejf.2; human.
DR CTD; 84303; -.
DR GeneCards; GC03P126423; -.
DR HGNC; HGNC:28184; CHCHD6.
DR HPA; HPA047673; -.
DR neXtProt; NX_Q9BRQ6; -.
DR PharmGKB; PA134899331; -.
DR eggNOG; NOG325011; -.
DR HOGENOM; HOG000252969; -.
DR HOVERGEN; HBG050936; -.
DR InParanoid; Q9BRQ6; -.
DR KO; K17564; -.
DR OrthoDB; EOG7NW6C3; -.
DR PhylomeDB; Q9BRQ6; -.
DR GenomeRNAi; 84303; -.
DR NextBio; 73976; -.
DR PRO; PR:Q9BRQ6; -.
DR ArrayExpress; Q9BRQ6; -.
DR Bgee; Q9BRQ6; -.
DR CleanEx; HS_CHCHD6; -.
DR Genevestigator; Q9BRQ6; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
DR GO; GO:0042407; P:cristae formation; IMP:UniProtKB.
DR InterPro; IPR007964; DUF737.
DR Pfam; PF05300; DUF737; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Disulfide bond; Lipoprotein; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Myristate; Polymorphism;
KW Reference proteome.
FT INIT_MET 1 1 Removed (Potential).
FT CHAIN 2 235 Coiled-coil-helix-coiled-coil-helix
FT domain-containing protein 6,
FT mitochondrial.
FT /FTId=PRO_0000129169.
FT DOMAIN 190 231 CHCH.
FT COILED 129 176 Potential.
FT LIPID 2 2 N-myristoyl glycine (Potential).
FT DISULFID 197 228 By similarity.
FT DISULFID 207 218 By similarity.
FT VARIANT 95 95 A -> S (in dbSNP:rs2272487).
FT /FTId=VAR_024412.
SQ SEQUENCE 235 AA; 26458 MW; 674DE387557AF4F0 CRC64;
MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL
RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL
PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA
ASKMESTIKP RRVEPVCSGL QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG
//
ID CHCH6_HUMAN Reviewed; 235 AA.
AC Q9BRQ6; D6R9U0; D6RIB4; H8Y0Y7;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 77.
DE RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial;
DE AltName: Full=Coiled coil helix cristae morphology protein 1;
GN Name=CHCHD6; Synonyms=CHCM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION,
RP AND INTERACTION WITH CHCHD3; DISC1 AND IMMT.
RX PubMed=22228767; DOI=10.1074/jbc.M111.277103;
RA An J., Shi J., He Q., Lui K., Liu Y., Huang Y., Sheikh M.S.;
RT "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of
RT mitofilin and mitochondrial cristae morphology.";
RL J. Biol. Chem. 287:7411-7426(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION IN A COMPLEX WITH IMMT.
RX PubMed=17624330; DOI=10.1016/j.febslet.2007.06.052;
RA Xie J., Marusich M.F., Souda P., Whitelegge J., Capaldi R.A.;
RT "The mitochondrial inner membrane protein mitofilin exists as a
RT complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-
RT helix domain-containing protein 3 and 6 and DnaJC11.";
RL FEBS Lett. 581:3545-3549(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Required for maintaining mitochondrial crista
CC morphology, ATP production and oxygen consumption.
CC -!- SUBUNIT: Interacts with CHCHD3 and DISC1. Interacts with IMMT; the
CC interaction is direct.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Lipid-anchor
CC (Probable).
CC -!- INDUCTION: Down-regulated following genotoxic stress.
CC -!- SIMILARITY: Belongs to the CHCHD6 family.
CC -!- SIMILARITY: Contains 1 CHCH domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; JF264889; AEA95848.1; -; mRNA.
DR EMBL; AC078867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC117450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79352.1; -; Genomic_DNA.
DR EMBL; BC006123; AAH06123.1; -; mRNA.
DR RefSeq; NP_115719.1; NM_032343.2.
DR UniGene; Hs.518119; -.
DR ProteinModelPortal; Q9BRQ6; -.
DR IntAct; Q9BRQ6; 4.
DR MINT; MINT-4830561; -.
DR STRING; 9606.ENSP00000290913; -.
DR PhosphoSite; Q9BRQ6; -.
DR DMDM; 62510505; -.
DR PaxDb; Q9BRQ6; -.
DR PeptideAtlas; Q9BRQ6; -.
DR PRIDE; Q9BRQ6; -.
DR Ensembl; ENST00000290913; ENSP00000290913; ENSG00000159685.
DR GeneID; 84303; -.
DR KEGG; hsa:84303; -.
DR UCSC; uc003ejf.2; human.
DR CTD; 84303; -.
DR GeneCards; GC03P126423; -.
DR HGNC; HGNC:28184; CHCHD6.
DR HPA; HPA047673; -.
DR neXtProt; NX_Q9BRQ6; -.
DR PharmGKB; PA134899331; -.
DR eggNOG; NOG325011; -.
DR HOGENOM; HOG000252969; -.
DR HOVERGEN; HBG050936; -.
DR InParanoid; Q9BRQ6; -.
DR KO; K17564; -.
DR OrthoDB; EOG7NW6C3; -.
DR PhylomeDB; Q9BRQ6; -.
DR GenomeRNAi; 84303; -.
DR NextBio; 73976; -.
DR PRO; PR:Q9BRQ6; -.
DR ArrayExpress; Q9BRQ6; -.
DR Bgee; Q9BRQ6; -.
DR CleanEx; HS_CHCHD6; -.
DR Genevestigator; Q9BRQ6; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
DR GO; GO:0042407; P:cristae formation; IMP:UniProtKB.
DR InterPro; IPR007964; DUF737.
DR Pfam; PF05300; DUF737; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Disulfide bond; Lipoprotein; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Myristate; Polymorphism;
KW Reference proteome.
FT INIT_MET 1 1 Removed (Potential).
FT CHAIN 2 235 Coiled-coil-helix-coiled-coil-helix
FT domain-containing protein 6,
FT mitochondrial.
FT /FTId=PRO_0000129169.
FT DOMAIN 190 231 CHCH.
FT COILED 129 176 Potential.
FT LIPID 2 2 N-myristoyl glycine (Potential).
FT DISULFID 197 228 By similarity.
FT DISULFID 207 218 By similarity.
FT VARIANT 95 95 A -> S (in dbSNP:rs2272487).
FT /FTId=VAR_024412.
SQ SEQUENCE 235 AA; 26458 MW; 674DE387557AF4F0 CRC64;
MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL
RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL
PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA
ASKMESTIKP RRVEPVCSGL QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG
//