Full text data of CLDND1
CLDND1
(C3orf4)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Claudin domain-containing protein 1 (Membrane protein GENX-3745)
Claudin domain-containing protein 1 (Membrane protein GENX-3745)
UniProt
Q9NY35
ID CLDN1_HUMAN Reviewed; 253 AA.
AC Q9NY35; B3KQR1; D3DN36; F2Z2D9; Q502Y8; Q6UVX2; Q9BUZ9; Q9NZZ5;
read moreAC Q9Y4S9;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 107.
DE RecName: Full=Claudin domain-containing protein 1;
DE AltName: Full=Membrane protein GENX-3745;
GN Name=CLDND1; Synonyms=C3orf4;
GN ORFNames=HSPC174, PSEC0054, UNQ2511/PRO6000;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12036590; DOI=10.1016/S0378-1119(02)00507-3;
RA Fayein N.-A., Stankoff B., Auffray C., Devignes M.-D.;
RT "Characterization of tissue expression and full-length coding sequence
RT of a novel human gene mapping at 3q12.1 and transcribed in
RT oligodendrocytes.";
RL Gene 289:119-129(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Liver;
RX PubMed=11752456; DOI=10.1073/pnas.241522398;
RA Xu X.R., Huang J., Xu Z.G., Qian B.Z., Zhu Z.D., Yan Q., Cai T.,
RA Zhang X., Xiao H.S., Qu J., Liu F., Huang Q.H., Cheng Z.H., Li N.G.,
RA Du J.J., Hu W., Shen K.T., Lu G., Fu G., Zhong M., Xu S.H., Gu W.Y.,
RA Huang W., Zhao X.T., Hu G.X., Gu J.R., Chen Z., Han Z.G.;
RT "Insight into hepatocellular carcinogenesis at transcriptome level by
RT comparing gene expression profiles of hepatocellular carcinoma with
RT those of corresponding noncancerous liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:15089-15094(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Eye, Hippocampus, and Spinal cord;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-72, AND MASS SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-
RT linked cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NY35-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NY35-2; Sequence=VSP_013156, VSP_013157;
CC Name=3;
CC IsoId=Q9NY35-3; Sequence=VSP_046865;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Widely distributed in the adult CNS with
CC highest expression in the corpus callosum, caudate nucleus,
CC cerebral cortex, medulla, putamen, spinal cord, substantia nigra
CC and subthalamic nucleus. Weak expression was detected in the adult
CC heart.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF29137.1; Type=Erroneous initiation;
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DR EMBL; AJ270952; CAB89684.1; -; mRNA.
DR EMBL; AF161522; AAF29137.1; ALT_INIT; mRNA.
DR EMBL; AV656305; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY359121; AAQ89479.1; -; mRNA.
DR EMBL; AK075367; BAG52123.1; -; mRNA.
DR EMBL; AL080097; CAB45709.2; -; mRNA.
DR EMBL; AC021660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79856.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79857.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79859.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79860.1; -; Genomic_DNA.
DR EMBL; BC001757; AAH01757.2; -; mRNA.
DR EMBL; BC013610; AAH13610.1; -; mRNA.
DR EMBL; BC022551; AAH22551.1; -; mRNA.
DR EMBL; BC095441; AAH95441.1; -; mRNA.
DR RefSeq; NP_001035271.1; NM_001040181.1.
DR RefSeq; NP_001035272.1; NM_001040182.1.
DR RefSeq; NP_001035273.1; NM_001040183.1.
DR RefSeq; NP_001035289.1; NM_001040199.1.
DR RefSeq; NP_001035290.1; NM_001040200.1.
DR RefSeq; NP_063948.1; NM_019895.2.
DR RefSeq; XP_005247684.1; XM_005247627.1.
DR RefSeq; XP_005247685.1; XM_005247628.1.
DR RefSeq; XP_005247686.1; XM_005247629.1.
DR RefSeq; XP_005247687.1; XM_005247630.1.
DR UniGene; Hs.531371; -.
DR UniGene; Hs.720106; -.
DR ProteinModelPortal; Q9NY35; -.
DR IntAct; Q9NY35; 1.
DR TCDB; 8.A.16.2.9; the ca(+) channel auxiliary subunit 1-8 (cca) family.
DR PhosphoSite; Q9NY35; -.
DR DMDM; 20532022; -.
DR PaxDb; Q9NY35; -.
DR PRIDE; Q9NY35; -.
DR DNASU; 56650; -.
DR Ensembl; ENST00000341181; ENSP00000340247; ENSG00000080822.
DR Ensembl; ENST00000394180; ENSP00000377734; ENSG00000080822.
DR Ensembl; ENST00000394181; ENSP00000377735; ENSG00000080822.
DR Ensembl; ENST00000394185; ENSP00000377739; ENSG00000080822.
DR Ensembl; ENST00000503004; ENSP00000421226; ENSG00000080822.
DR Ensembl; ENST00000510545; ENSP00000423590; ENSG00000080822.
DR Ensembl; ENST00000511081; ENSP00000424669; ENSG00000080822.
DR Ensembl; ENST00000513287; ENSP00000426869; ENSG00000080822.
DR GeneID; 56650; -.
DR KEGG; hsa:56650; -.
DR UCSC; uc003dsr.3; human.
DR CTD; 56650; -.
DR GeneCards; GC03M098234; -.
DR HGNC; HGNC:1322; CLDND1.
DR HPA; HPA029841; -.
DR HPA; HPA029842; -.
DR neXtProt; NX_Q9NY35; -.
DR PharmGKB; PA25901; -.
DR eggNOG; NOG46479; -.
DR HOVERGEN; HBG050817; -.
DR InParanoid; Q9NY35; -.
DR PhylomeDB; Q9NY35; -.
DR ChiTaRS; CLDND1; human.
DR GeneWiki; CLDND1; -.
DR GenomeRNAi; 56650; -.
DR NextBio; 62095; -.
DR PRO; PR:Q9NY35; -.
DR ArrayExpress; Q9NY35; -.
DR Bgee; Q9NY35; -.
DR CleanEx; HS_CLDND1; -.
DR Genevestigator; Q9NY35; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR Pfam; PF13903; Claudin_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 253 Claudin domain-containing protein 1.
FT /FTId=PRO_0000164694.
FT TRANSMEM 5 25 Helical; (Potential).
FT TRANSMEM 141 161 Helical; (Potential).
FT TRANSMEM 175 195 Helical; (Potential).
FT TRANSMEM 216 236 Helical; (Potential).
FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 72 72 N-linked (GlcNAc...).
FT VAR_SEQ 1 97 MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQE
FT NSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCI
FT TIPKNMHWYSPPERT -> MG (in isoform 3).
FT /FTId=VSP_046865.
FT VAR_SEQ 181 184 GLCT -> DTML (in isoform 2).
FT /FTId=VSP_013156.
FT VAR_SEQ 185 253 Missing (in isoform 2).
FT /FTId=VSP_013157.
FT CONFLICT 213 213 G -> E (in Ref. 2; AAF29137).
SQ SEQUENCE 253 AA; 28603 MW; C6459D23B28C9885 CRC64;
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI WDEFISDEAD
EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF DVVTKCVSFT LTEQFMEKFV
DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL MCFGALIGLC ACICRSLYPT IATGILHLLA
GLCTLGSVSC YVAGIELLHQ KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN
RKEYTLMKAY RVA
//
ID CLDN1_HUMAN Reviewed; 253 AA.
AC Q9NY35; B3KQR1; D3DN36; F2Z2D9; Q502Y8; Q6UVX2; Q9BUZ9; Q9NZZ5;
read moreAC Q9Y4S9;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 107.
DE RecName: Full=Claudin domain-containing protein 1;
DE AltName: Full=Membrane protein GENX-3745;
GN Name=CLDND1; Synonyms=C3orf4;
GN ORFNames=HSPC174, PSEC0054, UNQ2511/PRO6000;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12036590; DOI=10.1016/S0378-1119(02)00507-3;
RA Fayein N.-A., Stankoff B., Auffray C., Devignes M.-D.;
RT "Characterization of tissue expression and full-length coding sequence
RT of a novel human gene mapping at 3q12.1 and transcribed in
RT oligodendrocytes.";
RL Gene 289:119-129(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Liver;
RX PubMed=11752456; DOI=10.1073/pnas.241522398;
RA Xu X.R., Huang J., Xu Z.G., Qian B.Z., Zhu Z.D., Yan Q., Cai T.,
RA Zhang X., Xiao H.S., Qu J., Liu F., Huang Q.H., Cheng Z.H., Li N.G.,
RA Du J.J., Hu W., Shen K.T., Lu G., Fu G., Zhong M., Xu S.H., Gu W.Y.,
RA Huang W., Zhao X.T., Hu G.X., Gu J.R., Chen Z., Han Z.G.;
RT "Insight into hepatocellular carcinogenesis at transcriptome level by
RT comparing gene expression profiles of hepatocellular carcinoma with
RT those of corresponding noncancerous liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:15089-15094(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Eye, Hippocampus, and Spinal cord;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-72, AND MASS SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-
RT linked cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NY35-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NY35-2; Sequence=VSP_013156, VSP_013157;
CC Name=3;
CC IsoId=Q9NY35-3; Sequence=VSP_046865;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Widely distributed in the adult CNS with
CC highest expression in the corpus callosum, caudate nucleus,
CC cerebral cortex, medulla, putamen, spinal cord, substantia nigra
CC and subthalamic nucleus. Weak expression was detected in the adult
CC heart.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF29137.1; Type=Erroneous initiation;
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DR EMBL; AJ270952; CAB89684.1; -; mRNA.
DR EMBL; AF161522; AAF29137.1; ALT_INIT; mRNA.
DR EMBL; AV656305; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY359121; AAQ89479.1; -; mRNA.
DR EMBL; AK075367; BAG52123.1; -; mRNA.
DR EMBL; AL080097; CAB45709.2; -; mRNA.
DR EMBL; AC021660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79856.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79857.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79859.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79860.1; -; Genomic_DNA.
DR EMBL; BC001757; AAH01757.2; -; mRNA.
DR EMBL; BC013610; AAH13610.1; -; mRNA.
DR EMBL; BC022551; AAH22551.1; -; mRNA.
DR EMBL; BC095441; AAH95441.1; -; mRNA.
DR RefSeq; NP_001035271.1; NM_001040181.1.
DR RefSeq; NP_001035272.1; NM_001040182.1.
DR RefSeq; NP_001035273.1; NM_001040183.1.
DR RefSeq; NP_001035289.1; NM_001040199.1.
DR RefSeq; NP_001035290.1; NM_001040200.1.
DR RefSeq; NP_063948.1; NM_019895.2.
DR RefSeq; XP_005247684.1; XM_005247627.1.
DR RefSeq; XP_005247685.1; XM_005247628.1.
DR RefSeq; XP_005247686.1; XM_005247629.1.
DR RefSeq; XP_005247687.1; XM_005247630.1.
DR UniGene; Hs.531371; -.
DR UniGene; Hs.720106; -.
DR ProteinModelPortal; Q9NY35; -.
DR IntAct; Q9NY35; 1.
DR TCDB; 8.A.16.2.9; the ca(+) channel auxiliary subunit 1-8 (cca) family.
DR PhosphoSite; Q9NY35; -.
DR DMDM; 20532022; -.
DR PaxDb; Q9NY35; -.
DR PRIDE; Q9NY35; -.
DR DNASU; 56650; -.
DR Ensembl; ENST00000341181; ENSP00000340247; ENSG00000080822.
DR Ensembl; ENST00000394180; ENSP00000377734; ENSG00000080822.
DR Ensembl; ENST00000394181; ENSP00000377735; ENSG00000080822.
DR Ensembl; ENST00000394185; ENSP00000377739; ENSG00000080822.
DR Ensembl; ENST00000503004; ENSP00000421226; ENSG00000080822.
DR Ensembl; ENST00000510545; ENSP00000423590; ENSG00000080822.
DR Ensembl; ENST00000511081; ENSP00000424669; ENSG00000080822.
DR Ensembl; ENST00000513287; ENSP00000426869; ENSG00000080822.
DR GeneID; 56650; -.
DR KEGG; hsa:56650; -.
DR UCSC; uc003dsr.3; human.
DR CTD; 56650; -.
DR GeneCards; GC03M098234; -.
DR HGNC; HGNC:1322; CLDND1.
DR HPA; HPA029841; -.
DR HPA; HPA029842; -.
DR neXtProt; NX_Q9NY35; -.
DR PharmGKB; PA25901; -.
DR eggNOG; NOG46479; -.
DR HOVERGEN; HBG050817; -.
DR InParanoid; Q9NY35; -.
DR PhylomeDB; Q9NY35; -.
DR ChiTaRS; CLDND1; human.
DR GeneWiki; CLDND1; -.
DR GenomeRNAi; 56650; -.
DR NextBio; 62095; -.
DR PRO; PR:Q9NY35; -.
DR ArrayExpress; Q9NY35; -.
DR Bgee; Q9NY35; -.
DR CleanEx; HS_CLDND1; -.
DR Genevestigator; Q9NY35; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR Pfam; PF13903; Claudin_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 253 Claudin domain-containing protein 1.
FT /FTId=PRO_0000164694.
FT TRANSMEM 5 25 Helical; (Potential).
FT TRANSMEM 141 161 Helical; (Potential).
FT TRANSMEM 175 195 Helical; (Potential).
FT TRANSMEM 216 236 Helical; (Potential).
FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 72 72 N-linked (GlcNAc...).
FT VAR_SEQ 1 97 MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQE
FT NSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCI
FT TIPKNMHWYSPPERT -> MG (in isoform 3).
FT /FTId=VSP_046865.
FT VAR_SEQ 181 184 GLCT -> DTML (in isoform 2).
FT /FTId=VSP_013156.
FT VAR_SEQ 185 253 Missing (in isoform 2).
FT /FTId=VSP_013157.
FT CONFLICT 213 213 G -> E (in Ref. 2; AAF29137).
SQ SEQUENCE 253 AA; 28603 MW; C6459D23B28C9885 CRC64;
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI WDEFISDEAD
EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF DVVTKCVSFT LTEQFMEKFV
DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL MCFGALIGLC ACICRSLYPT IATGILHLLA
GLCTLGSVSC YVAGIELLHQ KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN
RKEYTLMKAY RVA
//