Full text data of CNRIP1
CNRIP1
(C2orf32)
[Confidence: high (present in two of the MS resources)]
CB1 cannabinoid receptor-interacting protein 1; CRIP-1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
CB1 cannabinoid receptor-interacting protein 1; CRIP-1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00073958
IPI00073958 Chromosome 2 open reading frame 32 Chromosome 2 open reading frame 32 membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 3 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00073958 Chromosome 2 open reading frame 32 Chromosome 2 open reading frame 32 membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 3 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q96F85
ID CNRP1_HUMAN Reviewed; 164 AA.
AC Q96F85; B2R4D0; Q49AN4; Q9UFZ0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 82.
DE RecName: Full=CB1 cannabinoid receptor-interacting protein 1;
DE Short=CRIP-1;
GN Name=CNRIP1; Synonyms=C2orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH
RP CNR1, AND ALTERNATIVE SPLICING.
RC TISSUE=Brain;
RX PubMed=17895407; DOI=10.1124/mol.107.039263;
RA Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G.,
RA Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C.,
RA Elphick M.R., Lewis D.L.;
RT "CB1 cannabinoid receptor activity is modulated by the cannabinoid
RT receptor interacting protein CRIP 1a.";
RL Mol. Pharmacol. 72:1557-1566(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-164 (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP PROTEIN SEQUENCE OF 16-26; 52-74; 83-98 AND 154-160, AND MASS
RP SPECTROMETRY.
RC TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
RA Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Isoform 1 suppresses cannabinoid receptor CNR1-mediated
CC tonic inhibition of voltage-gated calcium channels. Isoform 2 does
CC not have this effect.
CC -!- SUBUNIT: Interacts with the cannabinoid receptor CNR1 (via C-
CC terminus). Does not interact with cannabinoid receptor CNR2.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=CRIP1a;
CC IsoId=Q96F85-1; Sequence=Displayed;
CC Name=2; Synonyms=CRIP1b;
CC IsoId=Q96F85-2; Sequence=VSP_035598;
CC -!- SIMILARITY: Belongs to the CNRIP family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY144596; AAN41658.1; -; mRNA.
DR EMBL; AK311784; BAG34727.1; -; mRNA.
DR EMBL; AC015969; AAX93120.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99877.1; -; Genomic_DNA.
DR EMBL; BC011535; AAH11535.1; -; mRNA.
DR EMBL; AL110235; CAB53688.1; -; mRNA.
DR PIR; T14768; T14768.
DR RefSeq; NP_001104571.1; NM_001111101.1.
DR RefSeq; NP_056278.1; NM_015463.2.
DR RefSeq; XP_005264306.1; XM_005264249.1.
DR UniGene; Hs.212885; -.
DR ProteinModelPortal; Q96F85; -.
DR IntAct; Q96F85; 1.
DR STRING; 9606.ENSP00000263655; -.
DR PhosphoSite; Q96F85; -.
DR UCD-2DPAGE; Q96F85; -.
DR PaxDb; Q96F85; -.
DR PRIDE; Q96F85; -.
DR DNASU; 25927; -.
DR Ensembl; ENST00000263655; ENSP00000263655; ENSG00000119865.
DR Ensembl; ENST00000409559; ENSP00000386883; ENSG00000119865.
DR GeneID; 25927; -.
DR KEGG; hsa:25927; -.
DR UCSC; uc002sek.4; human.
DR CTD; 25927; -.
DR GeneCards; GC02M068511; -.
DR HGNC; HGNC:24546; CNRIP1.
DR HPA; HPA035337; -.
DR neXtProt; NX_Q96F85; -.
DR PharmGKB; PA162382635; -.
DR eggNOG; NOG76756; -.
DR HOGENOM; HOG000089982; -.
DR HOVERGEN; HBG056498; -.
DR InParanoid; Q96F85; -.
DR OMA; YYKREHC; -.
DR OrthoDB; EOG7Z0JXS; -.
DR PhylomeDB; Q96F85; -.
DR GenomeRNAi; 25927; -.
DR NextBio; 47464; -.
DR PRO; PR:Q96F85; -.
DR ArrayExpress; Q96F85; -.
DR Bgee; Q96F85; -.
DR CleanEx; HS_CNRIP1; -.
DR Genevestigator; Q96F85; -.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Direct protein sequencing;
KW Reference proteome.
FT CHAIN 1 164 CB1 cannabinoid receptor-interacting
FT protein 1.
FT /FTId=PRO_0000089360.
FT VAR_SEQ 111 164 FTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNE
FT TRSLMWVNKESFL -> ECLEQRPQEISLTYECEE (in
FT isoform 2).
FT /FTId=VSP_035598.
FT CONFLICT 16 16 I -> T (in Ref. 6; CAB53688).
SQ SEQUENCE 164 AA; 18648 MW; AB8432C13F44FF04 CRC64;
MGDLPGLVRL SIALRIQPND GPVFYKVDGQ RFGQNRTIKL LTGSSYKVEV KIKPSTLQVE
NISIGGVLVP LELKSKEPDG DRVVYTGTYD TEGVTPTKSG ERQPIQITMP FTDIGTFETV
WQVKFYNYHK RDHCQWGSPF SVIEYECKPN ETRSLMWVNK ESFL
//
ID CNRP1_HUMAN Reviewed; 164 AA.
AC Q96F85; B2R4D0; Q49AN4; Q9UFZ0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 82.
DE RecName: Full=CB1 cannabinoid receptor-interacting protein 1;
DE Short=CRIP-1;
GN Name=CNRIP1; Synonyms=C2orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH
RP CNR1, AND ALTERNATIVE SPLICING.
RC TISSUE=Brain;
RX PubMed=17895407; DOI=10.1124/mol.107.039263;
RA Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G.,
RA Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C.,
RA Elphick M.R., Lewis D.L.;
RT "CB1 cannabinoid receptor activity is modulated by the cannabinoid
RT receptor interacting protein CRIP 1a.";
RL Mol. Pharmacol. 72:1557-1566(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-164 (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP PROTEIN SEQUENCE OF 16-26; 52-74; 83-98 AND 154-160, AND MASS
RP SPECTROMETRY.
RC TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
RA Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Isoform 1 suppresses cannabinoid receptor CNR1-mediated
CC tonic inhibition of voltage-gated calcium channels. Isoform 2 does
CC not have this effect.
CC -!- SUBUNIT: Interacts with the cannabinoid receptor CNR1 (via C-
CC terminus). Does not interact with cannabinoid receptor CNR2.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=CRIP1a;
CC IsoId=Q96F85-1; Sequence=Displayed;
CC Name=2; Synonyms=CRIP1b;
CC IsoId=Q96F85-2; Sequence=VSP_035598;
CC -!- SIMILARITY: Belongs to the CNRIP family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY144596; AAN41658.1; -; mRNA.
DR EMBL; AK311784; BAG34727.1; -; mRNA.
DR EMBL; AC015969; AAX93120.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99877.1; -; Genomic_DNA.
DR EMBL; BC011535; AAH11535.1; -; mRNA.
DR EMBL; AL110235; CAB53688.1; -; mRNA.
DR PIR; T14768; T14768.
DR RefSeq; NP_001104571.1; NM_001111101.1.
DR RefSeq; NP_056278.1; NM_015463.2.
DR RefSeq; XP_005264306.1; XM_005264249.1.
DR UniGene; Hs.212885; -.
DR ProteinModelPortal; Q96F85; -.
DR IntAct; Q96F85; 1.
DR STRING; 9606.ENSP00000263655; -.
DR PhosphoSite; Q96F85; -.
DR UCD-2DPAGE; Q96F85; -.
DR PaxDb; Q96F85; -.
DR PRIDE; Q96F85; -.
DR DNASU; 25927; -.
DR Ensembl; ENST00000263655; ENSP00000263655; ENSG00000119865.
DR Ensembl; ENST00000409559; ENSP00000386883; ENSG00000119865.
DR GeneID; 25927; -.
DR KEGG; hsa:25927; -.
DR UCSC; uc002sek.4; human.
DR CTD; 25927; -.
DR GeneCards; GC02M068511; -.
DR HGNC; HGNC:24546; CNRIP1.
DR HPA; HPA035337; -.
DR neXtProt; NX_Q96F85; -.
DR PharmGKB; PA162382635; -.
DR eggNOG; NOG76756; -.
DR HOGENOM; HOG000089982; -.
DR HOVERGEN; HBG056498; -.
DR InParanoid; Q96F85; -.
DR OMA; YYKREHC; -.
DR OrthoDB; EOG7Z0JXS; -.
DR PhylomeDB; Q96F85; -.
DR GenomeRNAi; 25927; -.
DR NextBio; 47464; -.
DR PRO; PR:Q96F85; -.
DR ArrayExpress; Q96F85; -.
DR Bgee; Q96F85; -.
DR CleanEx; HS_CNRIP1; -.
DR Genevestigator; Q96F85; -.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Direct protein sequencing;
KW Reference proteome.
FT CHAIN 1 164 CB1 cannabinoid receptor-interacting
FT protein 1.
FT /FTId=PRO_0000089360.
FT VAR_SEQ 111 164 FTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNE
FT TRSLMWVNKESFL -> ECLEQRPQEISLTYECEE (in
FT isoform 2).
FT /FTId=VSP_035598.
FT CONFLICT 16 16 I -> T (in Ref. 6; CAB53688).
SQ SEQUENCE 164 AA; 18648 MW; AB8432C13F44FF04 CRC64;
MGDLPGLVRL SIALRIQPND GPVFYKVDGQ RFGQNRTIKL LTGSSYKVEV KIKPSTLQVE
NISIGGVLVP LELKSKEPDG DRVVYTGTYD TEGVTPTKSG ERQPIQITMP FTDIGTFETV
WQVKFYNYHK RDHCQWGSPF SVIEYECKPN ETRSLMWVNK ESFL
//