Full text data of COMMD9
COMMD9
[Confidence: low (only semi-automatic identification from reviews)]
COMM domain-containing protein 9
Note: presumably soluble (membrane word is not in UniProt keywords or features)
COMM domain-containing protein 9
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9P000
ID COMD9_HUMAN Reviewed; 198 AA.
AC Q9P000; E9PAN2; Q96FI2; Q9H0R0;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 86.
DE RecName: Full=COMM domain-containing protein 9;
GN Name=COMMD9; ORFNames=HSPC166;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=15799966; DOI=10.1074/jbc.M501928200;
RA Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A.,
RA Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.;
RT "COMMD proteins, a novel family of structural and functional homologs
RT of MURR1.";
RL J. Biol. Chem. 280:22222-22232(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P000-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P000-2; Sequence=VSP_041499;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Contains 1 COMM domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY542164; AAS22246.1; -; mRNA.
DR EMBL; AF161515; AAF29130.1; -; mRNA.
DR EMBL; AL136688; CAB66623.1; -; mRNA.
DR EMBL; AC087277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010892; AAH10892.1; -; mRNA.
DR RefSeq; NP_054905.2; NM_014186.3.
DR UniGene; Hs.279836; -.
DR ProteinModelPortal; Q9P000; -.
DR IntAct; Q9P000; 2.
DR STRING; 9606.ENSP00000263401; -.
DR PhosphoSite; Q9P000; -.
DR DMDM; 124056492; -.
DR PaxDb; Q9P000; -.
DR PeptideAtlas; Q9P000; -.
DR PRIDE; Q9P000; -.
DR DNASU; 29099; -.
DR Ensembl; ENST00000263401; ENSP00000263401; ENSG00000110442.
DR Ensembl; ENST00000452374; ENSP00000392510; ENSG00000110442.
DR GeneID; 29099; -.
DR KEGG; hsa:29099; -.
DR UCSC; uc001mwn.4; human.
DR CTD; 29099; -.
DR GeneCards; GC11M036251; -.
DR HGNC; HGNC:25014; COMMD9.
DR HPA; HPA009142; -.
DR MIM; 612299; gene.
DR neXtProt; NX_Q9P000; -.
DR PharmGKB; PA134930445; -.
DR eggNOG; NOG41673; -.
DR HOGENOM; HOG000232004; -.
DR HOVERGEN; HBG080522; -.
DR InParanoid; Q9P000; -.
DR OMA; QMKIQED; -.
DR OrthoDB; EOG718KDD; -.
DR PhylomeDB; Q9P000; -.
DR GeneWiki; COMMD9; -.
DR GenomeRNAi; 29099; -.
DR NextBio; 52128; -.
DR PRO; PR:Q9P000; -.
DR ArrayExpress; Q9P000; -.
DR Bgee; Q9P000; -.
DR CleanEx; HS_COMMD9; -.
DR Genevestigator; Q9P000; -.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR009886; HCaRG.
DR Pfam; PF07258; HCaRG; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Reference proteome.
FT CHAIN 1 198 COMM domain-containing protein 9.
FT /FTId=PRO_0000077403.
FT DOMAIN 122 196 COMM.
FT VAR_SEQ 18 59 Missing (in isoform 2).
FT /FTId=VSP_041499.
FT CONFLICT 45 45 V -> F (in Ref. 3; CAB66623).
FT CONFLICT 161 161 G -> R (in Ref. 1; AAS22246 and 2;
FT AAF29130).
SQ SEQUENCE 198 AA; 21819 MW; 54DA2FE525C3A24F CRC64;
MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL
LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSTWR TEAQANQISL
PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDKPSISAVT VELSKETLDT
MLDGLGRIRD QLSAVASK
//
ID COMD9_HUMAN Reviewed; 198 AA.
AC Q9P000; E9PAN2; Q96FI2; Q9H0R0;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 86.
DE RecName: Full=COMM domain-containing protein 9;
GN Name=COMMD9; ORFNames=HSPC166;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=15799966; DOI=10.1074/jbc.M501928200;
RA Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A.,
RA Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.;
RT "COMMD proteins, a novel family of structural and functional homologs
RT of MURR1.";
RL J. Biol. Chem. 280:22222-22232(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P000-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P000-2; Sequence=VSP_041499;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Contains 1 COMM domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY542164; AAS22246.1; -; mRNA.
DR EMBL; AF161515; AAF29130.1; -; mRNA.
DR EMBL; AL136688; CAB66623.1; -; mRNA.
DR EMBL; AC087277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010892; AAH10892.1; -; mRNA.
DR RefSeq; NP_054905.2; NM_014186.3.
DR UniGene; Hs.279836; -.
DR ProteinModelPortal; Q9P000; -.
DR IntAct; Q9P000; 2.
DR STRING; 9606.ENSP00000263401; -.
DR PhosphoSite; Q9P000; -.
DR DMDM; 124056492; -.
DR PaxDb; Q9P000; -.
DR PeptideAtlas; Q9P000; -.
DR PRIDE; Q9P000; -.
DR DNASU; 29099; -.
DR Ensembl; ENST00000263401; ENSP00000263401; ENSG00000110442.
DR Ensembl; ENST00000452374; ENSP00000392510; ENSG00000110442.
DR GeneID; 29099; -.
DR KEGG; hsa:29099; -.
DR UCSC; uc001mwn.4; human.
DR CTD; 29099; -.
DR GeneCards; GC11M036251; -.
DR HGNC; HGNC:25014; COMMD9.
DR HPA; HPA009142; -.
DR MIM; 612299; gene.
DR neXtProt; NX_Q9P000; -.
DR PharmGKB; PA134930445; -.
DR eggNOG; NOG41673; -.
DR HOGENOM; HOG000232004; -.
DR HOVERGEN; HBG080522; -.
DR InParanoid; Q9P000; -.
DR OMA; QMKIQED; -.
DR OrthoDB; EOG718KDD; -.
DR PhylomeDB; Q9P000; -.
DR GeneWiki; COMMD9; -.
DR GenomeRNAi; 29099; -.
DR NextBio; 52128; -.
DR PRO; PR:Q9P000; -.
DR ArrayExpress; Q9P000; -.
DR Bgee; Q9P000; -.
DR CleanEx; HS_COMMD9; -.
DR Genevestigator; Q9P000; -.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR009886; HCaRG.
DR Pfam; PF07258; HCaRG; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Reference proteome.
FT CHAIN 1 198 COMM domain-containing protein 9.
FT /FTId=PRO_0000077403.
FT DOMAIN 122 196 COMM.
FT VAR_SEQ 18 59 Missing (in isoform 2).
FT /FTId=VSP_041499.
FT CONFLICT 45 45 V -> F (in Ref. 3; CAB66623).
FT CONFLICT 161 161 G -> R (in Ref. 1; AAS22246 and 2;
FT AAF29130).
SQ SEQUENCE 198 AA; 21819 MW; 54DA2FE525C3A24F CRC64;
MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL
LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSTWR TEAQANQISL
PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDKPSISAVT VELSKETLDT
MLDGLGRIRD QLSAVASK
//
MIM
612299
*RECORD*
*FIELD* NO
612299
*FIELD* TI
*612299 COMM DOMAIN-CONTAINING PROTEIN 9; COMMD9
;;COPPER METABOLISM MURR1 DOMAIN-CONTAINING PROTEIN 9
read more*FIELD* TX
CLONING
By searching for genes in a region of chromosome 11 associated with WAGR
syndrome (194072), Gawin et al. (1999) identified and cloned COMMD9,
which they designated clone 41188. Northern blot analysis detected
robust expression of a 1.5-kb transcript in all human tissues examined.
In mouse, expression was strong in all adult tissues and at all
embryonic stages examined.
MAPPING
By analysis of a PAC contig covering chromosome 11p14.1-p13, Gawin et
al. (1999) mapped the COMMD9 gene to chromosome 11p13, centromeric to
the 3K gene (FJX1; 612206) and telomeric to the TRAF6 gene (602355).
*FIELD* RF
1. Gawin, B.; Niederfuhr, A.; Schumacher, N.; Hummerich, H.; Little,
P. F. R.; Gessler, M.: A 7.5 Mb sequence-ready PAC contig and gene
expression map of human chromosome 11p13-p14.1. Genome Res. 9: 1074-1086,
1999.
*FIELD* CD
Patricia A. Hartz: 9/17/2008
*FIELD* ED
mgross: 02/27/2009
mgross: 9/17/2008
*RECORD*
*FIELD* NO
612299
*FIELD* TI
*612299 COMM DOMAIN-CONTAINING PROTEIN 9; COMMD9
;;COPPER METABOLISM MURR1 DOMAIN-CONTAINING PROTEIN 9
read more*FIELD* TX
CLONING
By searching for genes in a region of chromosome 11 associated with WAGR
syndrome (194072), Gawin et al. (1999) identified and cloned COMMD9,
which they designated clone 41188. Northern blot analysis detected
robust expression of a 1.5-kb transcript in all human tissues examined.
In mouse, expression was strong in all adult tissues and at all
embryonic stages examined.
MAPPING
By analysis of a PAC contig covering chromosome 11p14.1-p13, Gawin et
al. (1999) mapped the COMMD9 gene to chromosome 11p13, centromeric to
the 3K gene (FJX1; 612206) and telomeric to the TRAF6 gene (602355).
*FIELD* RF
1. Gawin, B.; Niederfuhr, A.; Schumacher, N.; Hummerich, H.; Little,
P. F. R.; Gessler, M.: A 7.5 Mb sequence-ready PAC contig and gene
expression map of human chromosome 11p13-p14.1. Genome Res. 9: 1074-1086,
1999.
*FIELD* CD
Patricia A. Hartz: 9/17/2008
*FIELD* ED
mgross: 02/27/2009
mgross: 9/17/2008