Full text data of COX5A
COX5A
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va; Flags: Precursor)
Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va; Flags: Precursor)
UniProt
P20674
ID COX5A_HUMAN Reviewed; 150 AA.
AC P20674; P30045; Q8TB65;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
read moreDT 16-DEC-2008, sequence version 2.
DT 22-JAN-2014, entry version 125.
DE RecName: Full=Cytochrome c oxidase subunit 5A, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide Va;
DE Flags: Precursor;
GN Name=COX5A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2853101; DOI=10.1016/0378-1119(88)90435-0;
RA Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A.;
RT "Subunit Va of human and bovine cytochrome c oxidase is highly
RT conserved.";
RL Gene 69:245-256(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18197981; DOI=10.1186/1471-2148-8-8;
RA Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R.,
RA Goodman M., Grossman L.I.;
RT "Molecular evolution of the cytochrome c oxidase subunit 5A gene in
RT primates.";
RL BMC Evol. Biol. 8:8-8(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 42-52.
RC TISSUE=Liver;
RX PubMed=8313870; DOI=10.1002/elps.11501401181;
RA Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C.,
RA Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.;
RT "Human liver protein map: update 1993.";
RL Electrophoresis 14:1216-1222(1993).
RN [8]
RP PROTEIN SEQUENCE OF 56-64 AND 73-80.
RC TISSUE=Heart;
RX PubMed=7498159; DOI=10.1002/elps.11501601192;
RA Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A.,
RA Ershova E.S., Egorov T.A., Musalyamov A.K.;
RT "The major protein expression profile and two-dimensional protein
RT database of human heart.";
RL Electrophoresis 16:1160-1169(1995).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: This is the heme A-containing chain of cytochrome c
CC oxidase, the terminal oxidase in mitochondrial electron transport.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 5A family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M22760; AAA99220.1; -; mRNA.
DR EMBL; DQ987236; ABK92283.1; -; mRNA.
DR EMBL; DQ987237; ABK92284.1; -; mRNA.
DR EMBL; CR407649; CAG28577.1; -; mRNA.
DR EMBL; AC125435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99288.1; -; Genomic_DNA.
DR EMBL; BC024240; AAH24240.1; -; mRNA.
DR PIR; JT0342; OTHU5A.
DR RefSeq; NP_004246.2; NM_004255.3.
DR UniGene; Hs.401903; -.
DR ProteinModelPortal; P20674; -.
DR SMR; P20674; 47-150.
DR IntAct; P20674; 8.
DR MINT; MINT-1386385; -.
DR STRING; 9606.ENSP00000317780; -.
DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR PhosphoSite; P20674; -.
DR DMDM; 218511986; -.
DR DOSAC-COBS-2DPAGE; P20674; -.
DR OGP; P20674; -.
DR SWISS-2DPAGE; P20674; -.
DR UCD-2DPAGE; P20674; -.
DR PaxDb; P20674; -.
DR PRIDE; P20674; -.
DR DNASU; 9377; -.
DR Ensembl; ENST00000322347; ENSP00000317780; ENSG00000178741.
DR Ensembl; ENST00000564811; ENSP00000456386; ENSG00000178741.
DR GeneID; 9377; -.
DR KEGG; hsa:9377; -.
DR UCSC; uc002azi.4; human.
DR CTD; 9377; -.
DR GeneCards; GC15M075212; -.
DR HGNC; HGNC:2267; COX5A.
DR HPA; HPA027526; -.
DR MIM; 603773; gene.
DR neXtProt; NX_P20674; -.
DR PharmGKB; PA26784; -.
DR eggNOG; NOG284808; -.
DR HOGENOM; HOG000160656; -.
DR HOVERGEN; HBG051088; -.
DR InParanoid; P20674; -.
DR KO; K02264; -.
DR OMA; SIRCYSH; -.
DR OrthoDB; EOG74J99R; -.
DR PhylomeDB; P20674; -.
DR Reactome; REACT_111217; Metabolism.
DR ChiTaRS; COX5A; human.
DR GenomeRNAi; 9377; -.
DR NextBio; 35130; -.
DR PRO; PR:P20674; -.
DR ArrayExpress; P20674; -.
DR Bgee; P20674; -.
DR CleanEx; HS_COX5A; -.
DR Genevestigator; P20674; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
DR GO; GO:0009055; F:electron carrier activity; TAS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR Gene3D; 1.25.40.40; -; 1.
DR InterPro; IPR003204; Cyt_c_oxidase_su5A/6.
DR PANTHER; PTHR14200; PTHR14200; 1.
DR Pfam; PF02284; COX5A; 1.
DR SUPFAM; SSF48479; SSF48479; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron;
KW Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide.
FT TRANSIT 1 41 Mitochondrion.
FT CHAIN 42 150 Cytochrome c oxidase subunit 5A,
FT mitochondrial.
FT /FTId=PRO_0000006100.
FT MOD_RES 87 87 N6-acetyllysine (By similarity).
FT MOD_RES 113 113 N6-acetyllysine (By similarity).
FT CONFLICT 105 105 T -> L (in Ref. 1; AAA99220).
SQ SEQUENCE 150 AA; 16762 MW; 104DAF468BD302FC CRC64;
MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF
NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK
EIYPYVIQEL RPTLNELGIS TPEELGLDKV
//
ID COX5A_HUMAN Reviewed; 150 AA.
AC P20674; P30045; Q8TB65;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
read moreDT 16-DEC-2008, sequence version 2.
DT 22-JAN-2014, entry version 125.
DE RecName: Full=Cytochrome c oxidase subunit 5A, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide Va;
DE Flags: Precursor;
GN Name=COX5A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2853101; DOI=10.1016/0378-1119(88)90435-0;
RA Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A.;
RT "Subunit Va of human and bovine cytochrome c oxidase is highly
RT conserved.";
RL Gene 69:245-256(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18197981; DOI=10.1186/1471-2148-8-8;
RA Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R.,
RA Goodman M., Grossman L.I.;
RT "Molecular evolution of the cytochrome c oxidase subunit 5A gene in
RT primates.";
RL BMC Evol. Biol. 8:8-8(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 42-52.
RC TISSUE=Liver;
RX PubMed=8313870; DOI=10.1002/elps.11501401181;
RA Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C.,
RA Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.;
RT "Human liver protein map: update 1993.";
RL Electrophoresis 14:1216-1222(1993).
RN [8]
RP PROTEIN SEQUENCE OF 56-64 AND 73-80.
RC TISSUE=Heart;
RX PubMed=7498159; DOI=10.1002/elps.11501601192;
RA Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A.,
RA Ershova E.S., Egorov T.A., Musalyamov A.K.;
RT "The major protein expression profile and two-dimensional protein
RT database of human heart.";
RL Electrophoresis 16:1160-1169(1995).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: This is the heme A-containing chain of cytochrome c
CC oxidase, the terminal oxidase in mitochondrial electron transport.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 5A family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M22760; AAA99220.1; -; mRNA.
DR EMBL; DQ987236; ABK92283.1; -; mRNA.
DR EMBL; DQ987237; ABK92284.1; -; mRNA.
DR EMBL; CR407649; CAG28577.1; -; mRNA.
DR EMBL; AC125435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99288.1; -; Genomic_DNA.
DR EMBL; BC024240; AAH24240.1; -; mRNA.
DR PIR; JT0342; OTHU5A.
DR RefSeq; NP_004246.2; NM_004255.3.
DR UniGene; Hs.401903; -.
DR ProteinModelPortal; P20674; -.
DR SMR; P20674; 47-150.
DR IntAct; P20674; 8.
DR MINT; MINT-1386385; -.
DR STRING; 9606.ENSP00000317780; -.
DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR PhosphoSite; P20674; -.
DR DMDM; 218511986; -.
DR DOSAC-COBS-2DPAGE; P20674; -.
DR OGP; P20674; -.
DR SWISS-2DPAGE; P20674; -.
DR UCD-2DPAGE; P20674; -.
DR PaxDb; P20674; -.
DR PRIDE; P20674; -.
DR DNASU; 9377; -.
DR Ensembl; ENST00000322347; ENSP00000317780; ENSG00000178741.
DR Ensembl; ENST00000564811; ENSP00000456386; ENSG00000178741.
DR GeneID; 9377; -.
DR KEGG; hsa:9377; -.
DR UCSC; uc002azi.4; human.
DR CTD; 9377; -.
DR GeneCards; GC15M075212; -.
DR HGNC; HGNC:2267; COX5A.
DR HPA; HPA027526; -.
DR MIM; 603773; gene.
DR neXtProt; NX_P20674; -.
DR PharmGKB; PA26784; -.
DR eggNOG; NOG284808; -.
DR HOGENOM; HOG000160656; -.
DR HOVERGEN; HBG051088; -.
DR InParanoid; P20674; -.
DR KO; K02264; -.
DR OMA; SIRCYSH; -.
DR OrthoDB; EOG74J99R; -.
DR PhylomeDB; P20674; -.
DR Reactome; REACT_111217; Metabolism.
DR ChiTaRS; COX5A; human.
DR GenomeRNAi; 9377; -.
DR NextBio; 35130; -.
DR PRO; PR:P20674; -.
DR ArrayExpress; P20674; -.
DR Bgee; P20674; -.
DR CleanEx; HS_COX5A; -.
DR Genevestigator; P20674; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
DR GO; GO:0009055; F:electron carrier activity; TAS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR Gene3D; 1.25.40.40; -; 1.
DR InterPro; IPR003204; Cyt_c_oxidase_su5A/6.
DR PANTHER; PTHR14200; PTHR14200; 1.
DR Pfam; PF02284; COX5A; 1.
DR SUPFAM; SSF48479; SSF48479; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron;
KW Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide.
FT TRANSIT 1 41 Mitochondrion.
FT CHAIN 42 150 Cytochrome c oxidase subunit 5A,
FT mitochondrial.
FT /FTId=PRO_0000006100.
FT MOD_RES 87 87 N6-acetyllysine (By similarity).
FT MOD_RES 113 113 N6-acetyllysine (By similarity).
FT CONFLICT 105 105 T -> L (in Ref. 1; AAA99220).
SQ SEQUENCE 150 AA; 16762 MW; 104DAF468BD302FC CRC64;
MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF
NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK
EIYPYVIQEL RPTLNELGIS TPEELGLDKV
//
MIM
603773
*RECORD*
*FIELD* NO
603773
*FIELD* TI
*603773 CYTOCHROME c OXIDASE, SUBUNIT Va; COX5A
*FIELD* TX
Cytochrome c oxidase (COX), the terminal component of the respiratory
read morechain complex of most aerobic organisms, is composed of 13 subunits in
mammals. See 123870. The COX Va subunit is found in all mammalian
tissues. By screening a fetal muscle library with an oligonucleotide
based on the amino acid sequence of bovine COX Va, Rizzuto et al. (1988)
isolated a partial cDNA encoding the human homolog. They screened an
endothelial cell library with the partial cDNA and recovered a cDNA
corresponding to the complete COX Va coding region. The predicted
150-amino acid human protein contains a 41-amino acid presequence. The
authors reported that although the presequence is rich in basic and
hydroxylated residues, it differs from those of previously isolated COX
subunits in that it also contains a negatively charged residue. The
mature human COX Va polypeptide shares 35% and 95% protein sequence
identity with the corresponding S. cerevisiae COX subunit VI and bovine
COX Va, respectively. Northern blot analysis revealed that COX Va was
expressed as a 750-nucleotide mRNA in all human tissues tested. Southern
blot analysis indicated that the COX Va gene is part of a multicopy
family in the human genome.
By fluorescence in situ hybridization and by radiation hybrid mapping,
Hofmann et al. (1998) mapped the COX5A gene to 15q25, and a COX5A
pseudogene, COX5AP1, to 14q22.
*FIELD* RF
1. Hofmann, S.; Lichtner, P.; Schuffenhauer, S.; Gerbitz, K.-D.; Meitinger,
T.: Assignment of the human genes coding for cytochrome c oxidase
subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands
15q25, 8q22-q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1,
COX7CP1) to 14q22, 16p12 and 13q14-q21 by FISH and radiation hybrid
mapping. Cytogenet. Cell Genet. 83: 226-227, 1998.
2. Rizzuto, R.; Nakase, H.; Zeviani, M.; DiMauro, S.; Schon, E. A.
: Subunit Va of human and bovine cytochrome c oxidase is highly conserved. Gene 69:
245-256, 1988.
*FIELD* CD
Rebekah S. Rasooly: 4/26/1999
*FIELD* ED
alopez: 04/26/1999
alopez: 4/26/1999
*RECORD*
*FIELD* NO
603773
*FIELD* TI
*603773 CYTOCHROME c OXIDASE, SUBUNIT Va; COX5A
*FIELD* TX
Cytochrome c oxidase (COX), the terminal component of the respiratory
read morechain complex of most aerobic organisms, is composed of 13 subunits in
mammals. See 123870. The COX Va subunit is found in all mammalian
tissues. By screening a fetal muscle library with an oligonucleotide
based on the amino acid sequence of bovine COX Va, Rizzuto et al. (1988)
isolated a partial cDNA encoding the human homolog. They screened an
endothelial cell library with the partial cDNA and recovered a cDNA
corresponding to the complete COX Va coding region. The predicted
150-amino acid human protein contains a 41-amino acid presequence. The
authors reported that although the presequence is rich in basic and
hydroxylated residues, it differs from those of previously isolated COX
subunits in that it also contains a negatively charged residue. The
mature human COX Va polypeptide shares 35% and 95% protein sequence
identity with the corresponding S. cerevisiae COX subunit VI and bovine
COX Va, respectively. Northern blot analysis revealed that COX Va was
expressed as a 750-nucleotide mRNA in all human tissues tested. Southern
blot analysis indicated that the COX Va gene is part of a multicopy
family in the human genome.
By fluorescence in situ hybridization and by radiation hybrid mapping,
Hofmann et al. (1998) mapped the COX5A gene to 15q25, and a COX5A
pseudogene, COX5AP1, to 14q22.
*FIELD* RF
1. Hofmann, S.; Lichtner, P.; Schuffenhauer, S.; Gerbitz, K.-D.; Meitinger,
T.: Assignment of the human genes coding for cytochrome c oxidase
subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands
15q25, 8q22-q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1,
COX7CP1) to 14q22, 16p12 and 13q14-q21 by FISH and radiation hybrid
mapping. Cytogenet. Cell Genet. 83: 226-227, 1998.
2. Rizzuto, R.; Nakase, H.; Zeviani, M.; DiMauro, S.; Schon, E. A.
: Subunit Va of human and bovine cytochrome c oxidase is highly conserved. Gene 69:
245-256, 1988.
*FIELD* CD
Rebekah S. Rasooly: 4/26/1999
*FIELD* ED
alopez: 04/26/1999
alopez: 4/26/1999