Full text data of C16orf13
C16orf13
[Confidence: low (only semi-automatic identification from reviews)]
UPF0585 protein C16orf13
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UPF0585 protein C16orf13
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96S19
ID CP013_HUMAN Reviewed; 204 AA.
AC Q96S19; A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62;
read moreAC F6VM53; Q96IW1; Q96MD6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 22-JAN-2014, entry version 68.
DE RecName: Full=UPF0585 protein C16orf13;
GN Name=C16orf13; ORFNames=JFP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
RC TISSUE=Amygdala, Hippocampus, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K.,
RA Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J.,
RA Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2
RT Mb of the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 1-9; 134-161 AND 181-188, ACETYLATION AT MET-1,
RP AND MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Dozynkiewicz M., Norman J.C.;
RL Submitted (JUN-2009) to UniProtKB.
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP VARIANT PRO-136.
RX PubMed=20797691; DOI=10.1016/j.ajhg.2010.08.001;
RA Corbett M.A., Bahlo M., Jolly L., Afawi Z., Gardner A.E., Oliver K.L.,
RA Tan S., Coffey A., Mulley J.C., Dibbens L.M., Simri W., Shalata A.,
RA Kivity S., Jackson G.D., Berkovic S.F., Gecz J.;
RT "A focal epilepsy and intellectual disability syndrome is due to a
RT mutation in TBC1D24.";
RL Am. J. Hum. Genet. 87:371-375(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q96S19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96S19-2; Sequence=VSP_033918;
CC Name=3;
CC IsoId=Q96S19-3; Sequence=VSP_033919;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=Q96S19-4; Sequence=VSP_045804;
CC Note=No experimental confirmation available. Ref.1 (BAG58505)
CC sequence is in conflict in position: 196:R->G;
CC Name=5;
CC IsoId=Q96S19-5; Sequence=VSP_046838;
CC Note=No experimental confirmation available. Gene prediction
CC based on EST data;
CC Name=6;
CC IsoId=Q96S19-6; Sequence=VSP_046839;
CC Note=No experimental confirmation available. Gene prediction
CC based on EST data;
CC -!- SIMILARITY: Belongs to the UPF0585 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61238.1; Type=Erroneous gene model prediction;
CC Sequence=EAW85785.1; Type=Erroneous gene model prediction;
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DR EMBL; AK057077; BAB71362.1; -; mRNA.
DR EMBL; AK293046; BAF85735.1; -; mRNA.
DR EMBL; AK294482; BAG57706.1; -; mRNA.
DR EMBL; AK295628; BAG58505.1; -; mRNA.
DR EMBL; AE006464; AAK61238.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z84479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85787.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85785.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471112; EAW85786.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85788.1; -; Genomic_DNA.
DR EMBL; BC007207; AAH07207.1; -; mRNA.
DR EMBL; BC047118; AAH47118.1; -; mRNA.
DR RefSeq; NP_001035250.1; NM_001040160.1.
DR RefSeq; NP_001035251.1; NM_001040161.1.
DR RefSeq; NP_001035252.1; NM_001040162.1.
DR RefSeq; NP_001035255.1; NM_001040165.1.
DR RefSeq; NP_115742.3; NM_032366.3.
DR UniGene; Hs.239500; -.
DR ProteinModelPortal; Q96S19; -.
DR STRING; 9606.ENSP00000380784; -.
DR PhosphoSite; Q96S19; -.
DR DMDM; 189082900; -.
DR PaxDb; Q96S19; -.
DR PRIDE; Q96S19; -.
DR Ensembl; ENST00000301686; ENSP00000445926; ENSG00000130731.
DR Ensembl; ENST00000338401; ENSP00000444140; ENSG00000130731.
DR Ensembl; ENST00000397664; ENSP00000440475; ENSG00000130731.
DR Ensembl; ENST00000397665; ENSP00000444460; ENSG00000130731.
DR Ensembl; ENST00000397666; ENSP00000440765; ENSG00000130731.
DR GeneID; 84326; -.
DR KEGG; hsa:84326; -.
DR UCSC; uc002cia.1; human.
DR CTD; 84326; -.
DR GeneCards; GC16M000605; -.
DR H-InvDB; HIX0012656; -.
DR HGNC; HGNC:14141; C16orf13.
DR HPA; HPA044004; -.
DR neXtProt; NX_Q96S19; -.
DR PharmGKB; PA25526; -.
DR eggNOG; NOG82724; -.
DR HOGENOM; HOG000171462; -.
DR HOVERGEN; HBG060382; -.
DR OMA; NINMIHI; -.
DR OrthoDB; EOG7G1V7F; -.
DR GeneWiki; Chromosome_16_open_reading_frame_13; -.
DR GenomeRNAi; 84326; -.
DR NextBio; 35472293; -.
DR ArrayExpress; Q96S19; -.
DR Bgee; Q96S19; -.
DR CleanEx; HS_C16orf13; -.
DR Genevestigator; Q96S19; -.
DR InterPro; IPR010342; DUF938.
DR PANTHER; PTHR20974; PTHR20974; 1.
DR Pfam; PF06080; DUF938; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Polymorphism; Reference proteome.
FT CHAIN 1 204 UPF0585 protein C16orf13.
FT /FTId=PRO_0000337114.
FT MOD_RES 1 1 N-acetylmethionine.
FT VAR_SEQ 66 204 SIAATTQAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLL
FT CINMAHVSPLRCTEGLFRAAGHLLKPRALLITYGPYAINGK
FT ISPQSNVDFDLMLRCRNPEWGLRDTALLEDLGKASGLLLER
FT MVDMPANNKCLIFRKN -> RCGPRGGHFYRCGGPGPQEPT
FT ARSPGGKGCGSGSEGAGWEPGGAPGAGPSCAAPAAAEVGGP
FT RGPPSQPLWSPLLNVPPSLP (in isoform 2).
FT /FTId=VSP_033918.
FT VAR_SEQ 66 163 SIAATTQAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLL
FT CINMAHVSPLRCTEGLFRAAGHLLKPRALLITYGPYAINGK
FT ISPQSNVDFDLMLRCR -> RGSSEQQDTCSNPGPCSSPTG
FT (in isoform 5).
FT /FTId=VSP_046838.
FT VAR_SEQ 66 162 Missing (in isoform 3).
FT /FTId=VSP_033919.
FT VAR_SEQ 121 204 GLFRAAGHLLKPRALLITYGPYAINGKISPQSNVDFDLMLR
FT CRNPEWGLRDTALLEDLGKASGLLLERMVDMPANNKCLIFR
FT KN -> EPRMGASGHSPPGGPGKGQWPAPGEDGGHASQQQM
FT PDLPEKLSPSFTPAHLHPCRRLCEARTLPP (in
FT isoform 6).
FT /FTId=VSP_046839.
FT VAR_SEQ 141 204 PYAINGKISPQSNVDFDLMLRCRNPEWGLRDTALLEDLGKA
FT SGLLLERMVDMPANNKCLIFRKN -> EPRMGASGHSPPGG
FT PGKGQWPAPGEDGGHASQQQMPDLPEKLSPSFTPAHLHPCR
FT RLCEARTLPP (in isoform 4).
FT /FTId=VSP_045804.
FT VARIANT 136 136 L -> P.
FT /FTId=VAR_064368.
SQ SEQUENCE 204 AA; 22578 MW; D927CBB1151FC753 CRC64;
MLVAAAAERN KDPILHVLRQ YLDPAQRGVR VLEVASGSGQ HAAHFARAFP LAEWQPSDVD
QRCLDSIAAT TQAQGLTNVK APLHLDVTWG WEHWGGILPQ SLDLLLCINM AHVSPLRCTE
GLFRAAGHLL KPRALLITYG PYAINGKISP QSNVDFDLML RCRNPEWGLR DTALLEDLGK
ASGLLLERMV DMPANNKCLI FRKN
//
ID CP013_HUMAN Reviewed; 204 AA.
AC Q96S19; A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62;
read moreAC F6VM53; Q96IW1; Q96MD6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 22-JAN-2014, entry version 68.
DE RecName: Full=UPF0585 protein C16orf13;
GN Name=C16orf13; ORFNames=JFP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
RC TISSUE=Amygdala, Hippocampus, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K.,
RA Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J.,
RA Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2
RT Mb of the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 1-9; 134-161 AND 181-188, ACETYLATION AT MET-1,
RP AND MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Dozynkiewicz M., Norman J.C.;
RL Submitted (JUN-2009) to UniProtKB.
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP VARIANT PRO-136.
RX PubMed=20797691; DOI=10.1016/j.ajhg.2010.08.001;
RA Corbett M.A., Bahlo M., Jolly L., Afawi Z., Gardner A.E., Oliver K.L.,
RA Tan S., Coffey A., Mulley J.C., Dibbens L.M., Simri W., Shalata A.,
RA Kivity S., Jackson G.D., Berkovic S.F., Gecz J.;
RT "A focal epilepsy and intellectual disability syndrome is due to a
RT mutation in TBC1D24.";
RL Am. J. Hum. Genet. 87:371-375(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q96S19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96S19-2; Sequence=VSP_033918;
CC Name=3;
CC IsoId=Q96S19-3; Sequence=VSP_033919;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=Q96S19-4; Sequence=VSP_045804;
CC Note=No experimental confirmation available. Ref.1 (BAG58505)
CC sequence is in conflict in position: 196:R->G;
CC Name=5;
CC IsoId=Q96S19-5; Sequence=VSP_046838;
CC Note=No experimental confirmation available. Gene prediction
CC based on EST data;
CC Name=6;
CC IsoId=Q96S19-6; Sequence=VSP_046839;
CC Note=No experimental confirmation available. Gene prediction
CC based on EST data;
CC -!- SIMILARITY: Belongs to the UPF0585 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61238.1; Type=Erroneous gene model prediction;
CC Sequence=EAW85785.1; Type=Erroneous gene model prediction;
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DR EMBL; AK057077; BAB71362.1; -; mRNA.
DR EMBL; AK293046; BAF85735.1; -; mRNA.
DR EMBL; AK294482; BAG57706.1; -; mRNA.
DR EMBL; AK295628; BAG58505.1; -; mRNA.
DR EMBL; AE006464; AAK61238.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z84479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85787.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85785.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471112; EAW85786.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85788.1; -; Genomic_DNA.
DR EMBL; BC007207; AAH07207.1; -; mRNA.
DR EMBL; BC047118; AAH47118.1; -; mRNA.
DR RefSeq; NP_001035250.1; NM_001040160.1.
DR RefSeq; NP_001035251.1; NM_001040161.1.
DR RefSeq; NP_001035252.1; NM_001040162.1.
DR RefSeq; NP_001035255.1; NM_001040165.1.
DR RefSeq; NP_115742.3; NM_032366.3.
DR UniGene; Hs.239500; -.
DR ProteinModelPortal; Q96S19; -.
DR STRING; 9606.ENSP00000380784; -.
DR PhosphoSite; Q96S19; -.
DR DMDM; 189082900; -.
DR PaxDb; Q96S19; -.
DR PRIDE; Q96S19; -.
DR Ensembl; ENST00000301686; ENSP00000445926; ENSG00000130731.
DR Ensembl; ENST00000338401; ENSP00000444140; ENSG00000130731.
DR Ensembl; ENST00000397664; ENSP00000440475; ENSG00000130731.
DR Ensembl; ENST00000397665; ENSP00000444460; ENSG00000130731.
DR Ensembl; ENST00000397666; ENSP00000440765; ENSG00000130731.
DR GeneID; 84326; -.
DR KEGG; hsa:84326; -.
DR UCSC; uc002cia.1; human.
DR CTD; 84326; -.
DR GeneCards; GC16M000605; -.
DR H-InvDB; HIX0012656; -.
DR HGNC; HGNC:14141; C16orf13.
DR HPA; HPA044004; -.
DR neXtProt; NX_Q96S19; -.
DR PharmGKB; PA25526; -.
DR eggNOG; NOG82724; -.
DR HOGENOM; HOG000171462; -.
DR HOVERGEN; HBG060382; -.
DR OMA; NINMIHI; -.
DR OrthoDB; EOG7G1V7F; -.
DR GeneWiki; Chromosome_16_open_reading_frame_13; -.
DR GenomeRNAi; 84326; -.
DR NextBio; 35472293; -.
DR ArrayExpress; Q96S19; -.
DR Bgee; Q96S19; -.
DR CleanEx; HS_C16orf13; -.
DR Genevestigator; Q96S19; -.
DR InterPro; IPR010342; DUF938.
DR PANTHER; PTHR20974; PTHR20974; 1.
DR Pfam; PF06080; DUF938; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Polymorphism; Reference proteome.
FT CHAIN 1 204 UPF0585 protein C16orf13.
FT /FTId=PRO_0000337114.
FT MOD_RES 1 1 N-acetylmethionine.
FT VAR_SEQ 66 204 SIAATTQAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLL
FT CINMAHVSPLRCTEGLFRAAGHLLKPRALLITYGPYAINGK
FT ISPQSNVDFDLMLRCRNPEWGLRDTALLEDLGKASGLLLER
FT MVDMPANNKCLIFRKN -> RCGPRGGHFYRCGGPGPQEPT
FT ARSPGGKGCGSGSEGAGWEPGGAPGAGPSCAAPAAAEVGGP
FT RGPPSQPLWSPLLNVPPSLP (in isoform 2).
FT /FTId=VSP_033918.
FT VAR_SEQ 66 163 SIAATTQAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLL
FT CINMAHVSPLRCTEGLFRAAGHLLKPRALLITYGPYAINGK
FT ISPQSNVDFDLMLRCR -> RGSSEQQDTCSNPGPCSSPTG
FT (in isoform 5).
FT /FTId=VSP_046838.
FT VAR_SEQ 66 162 Missing (in isoform 3).
FT /FTId=VSP_033919.
FT VAR_SEQ 121 204 GLFRAAGHLLKPRALLITYGPYAINGKISPQSNVDFDLMLR
FT CRNPEWGLRDTALLEDLGKASGLLLERMVDMPANNKCLIFR
FT KN -> EPRMGASGHSPPGGPGKGQWPAPGEDGGHASQQQM
FT PDLPEKLSPSFTPAHLHPCRRLCEARTLPP (in
FT isoform 6).
FT /FTId=VSP_046839.
FT VAR_SEQ 141 204 PYAINGKISPQSNVDFDLMLRCRNPEWGLRDTALLEDLGKA
FT SGLLLERMVDMPANNKCLIFRKN -> EPRMGASGHSPPGG
FT PGKGQWPAPGEDGGHASQQQMPDLPEKLSPSFTPAHLHPCR
FT RLCEARTLPP (in isoform 4).
FT /FTId=VSP_045804.
FT VARIANT 136 136 L -> P.
FT /FTId=VAR_064368.
SQ SEQUENCE 204 AA; 22578 MW; D927CBB1151FC753 CRC64;
MLVAAAAERN KDPILHVLRQ YLDPAQRGVR VLEVASGSGQ HAAHFARAFP LAEWQPSDVD
QRCLDSIAAT TQAQGLTNVK APLHLDVTWG WEHWGGILPQ SLDLLLCINM AHVSPLRCTE
GLFRAAGHLL KPRALLITYG PYAINGKISP QSNVDFDLML RCRNPEWGLR DTALLEDLGK
ASGLLLERMV DMPANNKCLI FRKN
//