Full text data of CPNE2
CPNE2
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Copine-2 (Copine II)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Copine-2 (Copine II)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00220526
IPI00220526 Copine II no information available soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00220526 Copine II no information available soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q96FN4
ID CPNE2_HUMAN Reviewed; 548 AA.
AC Q96FN4; Q68D19; Q86XP9;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-AUG-2003, sequence version 3.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=Copine-2;
DE AltName: Full=Copine II;
GN Name=CPNE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Ding P., Han W., Shi S., Rui M., Wang Y., Song Q., Ma D.;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-548.
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the copine family.
CC -!- SIMILARITY: Contains 2 C2 domains.
CC -!- SIMILARITY: Contains 1 VWFA domain.
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DR EMBL; AF492484; AAO85483.1; -; mRNA.
DR EMBL; BC053658; AAH53658.1; -; mRNA.
DR EMBL; CR749617; CAH18411.1; -; mRNA.
DR RefSeq; NP_689940.3; NM_152727.5.
DR UniGene; Hs.339809; -.
DR UniGene; Hs.736510; -.
DR ProteinModelPortal; Q96FN4; -.
DR SMR; Q96FN4; 163-255.
DR IntAct; Q96FN4; 2.
DR MINT; MINT-8049255; -.
DR STRING; 9606.ENSP00000290776; -.
DR PhosphoSite; Q96FN4; -.
DR DMDM; 33860150; -.
DR PaxDb; Q96FN4; -.
DR PRIDE; Q96FN4; -.
DR Ensembl; ENST00000290776; ENSP00000290776; ENSG00000140848.
DR Ensembl; ENST00000535318; ENSP00000439018; ENSG00000140848.
DR Ensembl; ENST00000565874; ENSP00000456042; ENSG00000140848.
DR GeneID; 221184; -.
DR KEGG; hsa:221184; -.
DR UCSC; uc002eks.2; human.
DR CTD; 221184; -.
DR GeneCards; GC16P057126; -.
DR HGNC; HGNC:2315; CPNE2.
DR HPA; HPA041132; -.
DR MIM; 604206; gene.
DR neXtProt; NX_Q96FN4; -.
DR PharmGKB; PA26832; -.
DR eggNOG; NOG269302; -.
DR HOGENOM; HOG000220898; -.
DR HOVERGEN; HBG066841; -.
DR InParanoid; Q96FN4; -.
DR OMA; LFTENNG; -.
DR OrthoDB; EOG77DJ57; -.
DR PhylomeDB; Q96FN4; -.
DR ChiTaRS; CPNE2; human.
DR GenomeRNAi; 221184; -.
DR NextBio; 91227; -.
DR PRO; PR:Q96FN4; -.
DR ArrayExpress; Q96FN4; -.
DR Bgee; Q96FN4; -.
DR CleanEx; HS_CPNE2; -.
DR Genevestigator; Q96FN4; -.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR010734; Copine.
DR InterPro; IPR002035; VWF_A.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50234; VWFA; FALSE_NEG.
PE 1: Evidence at protein level;
KW Complete proteome; Reference proteome; Repeat.
FT CHAIN 1 548 Copine-2.
FT /FTId=PRO_0000144836.
FT DOMAIN 10 115 C2 1.
FT DOMAIN 141 246 C2 2.
FT DOMAIN 305 507 VWFA.
FT CONFLICT 100 100 K -> E (in Ref. 3; CAH18411).
SQ SEQUENCE 548 AA; 61190 MW; 39B962C82C591DA0 CRC64;
MAHIPSGGAP AAGAAPMGPQ YCVCKVELSV SGQNLLDRDV TSKSDPFCVL FTENNGRWIE
YDRTETAINN LNPAFSKKFV LDYHFEEVQK LKFALFDQDK SSMRLDEHDF LGQFSCSLGT
IVSSKKITRP LLLLNDKPAG KGLITIAAQE LSDNRVITLS LAGRRLDKKD LFGKSDPFLE
FYKPGDDGKW MLVHRTEVIK YTLDPVWKPF TVPLVSLCDG DMEKPIQVMC YDYDNDGGHD
FIGEFQTSVS QMCEARDSVP LEFECINPKK QRKKKNYKNS GIIILRSCKI NRDYSFLDYI
LGGCQLMFTV GIDFTASNGN PLDPSSLHYI NPMGTNEYLS AIWAVGQIIQ DYDSDKMFPA
LGFGAQLPPD WKVSHEFAIN FNPTNPFCSG VDGIAQAYSA CLPHIRFYGP TNFSPIVNHV
ARFAAQATQQ RTATQYFILL IITDGVISDM EETRHAVVQA SKLPMSIIIV GVGNADFAAM
EFLDGDSRML RSHTGEEAAR DIVQFVPFRE FRNAAKETLA KAVLAELPQQ VVQYFKHKNL
PPTNSEPA
//
ID CPNE2_HUMAN Reviewed; 548 AA.
AC Q96FN4; Q68D19; Q86XP9;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-AUG-2003, sequence version 3.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=Copine-2;
DE AltName: Full=Copine II;
GN Name=CPNE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Ding P., Han W., Shi S., Rui M., Wang Y., Song Q., Ma D.;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-548.
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the copine family.
CC -!- SIMILARITY: Contains 2 C2 domains.
CC -!- SIMILARITY: Contains 1 VWFA domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF492484; AAO85483.1; -; mRNA.
DR EMBL; BC053658; AAH53658.1; -; mRNA.
DR EMBL; CR749617; CAH18411.1; -; mRNA.
DR RefSeq; NP_689940.3; NM_152727.5.
DR UniGene; Hs.339809; -.
DR UniGene; Hs.736510; -.
DR ProteinModelPortal; Q96FN4; -.
DR SMR; Q96FN4; 163-255.
DR IntAct; Q96FN4; 2.
DR MINT; MINT-8049255; -.
DR STRING; 9606.ENSP00000290776; -.
DR PhosphoSite; Q96FN4; -.
DR DMDM; 33860150; -.
DR PaxDb; Q96FN4; -.
DR PRIDE; Q96FN4; -.
DR Ensembl; ENST00000290776; ENSP00000290776; ENSG00000140848.
DR Ensembl; ENST00000535318; ENSP00000439018; ENSG00000140848.
DR Ensembl; ENST00000565874; ENSP00000456042; ENSG00000140848.
DR GeneID; 221184; -.
DR KEGG; hsa:221184; -.
DR UCSC; uc002eks.2; human.
DR CTD; 221184; -.
DR GeneCards; GC16P057126; -.
DR HGNC; HGNC:2315; CPNE2.
DR HPA; HPA041132; -.
DR MIM; 604206; gene.
DR neXtProt; NX_Q96FN4; -.
DR PharmGKB; PA26832; -.
DR eggNOG; NOG269302; -.
DR HOGENOM; HOG000220898; -.
DR HOVERGEN; HBG066841; -.
DR InParanoid; Q96FN4; -.
DR OMA; LFTENNG; -.
DR OrthoDB; EOG77DJ57; -.
DR PhylomeDB; Q96FN4; -.
DR ChiTaRS; CPNE2; human.
DR GenomeRNAi; 221184; -.
DR NextBio; 91227; -.
DR PRO; PR:Q96FN4; -.
DR ArrayExpress; Q96FN4; -.
DR Bgee; Q96FN4; -.
DR CleanEx; HS_CPNE2; -.
DR Genevestigator; Q96FN4; -.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR010734; Copine.
DR InterPro; IPR002035; VWF_A.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50234; VWFA; FALSE_NEG.
PE 1: Evidence at protein level;
KW Complete proteome; Reference proteome; Repeat.
FT CHAIN 1 548 Copine-2.
FT /FTId=PRO_0000144836.
FT DOMAIN 10 115 C2 1.
FT DOMAIN 141 246 C2 2.
FT DOMAIN 305 507 VWFA.
FT CONFLICT 100 100 K -> E (in Ref. 3; CAH18411).
SQ SEQUENCE 548 AA; 61190 MW; 39B962C82C591DA0 CRC64;
MAHIPSGGAP AAGAAPMGPQ YCVCKVELSV SGQNLLDRDV TSKSDPFCVL FTENNGRWIE
YDRTETAINN LNPAFSKKFV LDYHFEEVQK LKFALFDQDK SSMRLDEHDF LGQFSCSLGT
IVSSKKITRP LLLLNDKPAG KGLITIAAQE LSDNRVITLS LAGRRLDKKD LFGKSDPFLE
FYKPGDDGKW MLVHRTEVIK YTLDPVWKPF TVPLVSLCDG DMEKPIQVMC YDYDNDGGHD
FIGEFQTSVS QMCEARDSVP LEFECINPKK QRKKKNYKNS GIIILRSCKI NRDYSFLDYI
LGGCQLMFTV GIDFTASNGN PLDPSSLHYI NPMGTNEYLS AIWAVGQIIQ DYDSDKMFPA
LGFGAQLPPD WKVSHEFAIN FNPTNPFCSG VDGIAQAYSA CLPHIRFYGP TNFSPIVNHV
ARFAAQATQQ RTATQYFILL IITDGVISDM EETRHAVVQA SKLPMSIIIV GVGNADFAAM
EFLDGDSRML RSHTGEEAAR DIVQFVPFRE FRNAAKETLA KAVLAELPQQ VVQYFKHKNL
PPTNSEPA
//
MIM
604206
*RECORD*
*FIELD* NO
604206
*FIELD* TI
*604206 COPINE II; CPNE2
;;CPN2
*FIELD* TX
Copines are calcium-dependent phospholipid-binding proteins. See CPNE1
read more(604205) for background information.
By searching sequence databases for genes with sequence similarity to
the Paramecium copine genes, Creutz et al. (1998) identified human ESTs
corresponding to 5 copine genes, including copine II (GenBank GENBANK
R87434).
*FIELD* RF
1. Creutz, C. E.; Tomsig, J. L.; Snyder, S. L.; Gautier, M.-C.; Skouri,
F.; Beisson, J.; Cohen, J.: The copines, a novel class of C2 domain-containing,
calcium-dependent, phospholipid-binding proteins conserved from Paramecium
to humans. J. Biol. Chem. 273: 1393-1402, 1998.
*FIELD* CD
Patti M. Sherman: 9/29/1999
*FIELD* ED
mgross: 09/30/1999
psherman: 9/30/1999
*RECORD*
*FIELD* NO
604206
*FIELD* TI
*604206 COPINE II; CPNE2
;;CPN2
*FIELD* TX
Copines are calcium-dependent phospholipid-binding proteins. See CPNE1
read more(604205) for background information.
By searching sequence databases for genes with sequence similarity to
the Paramecium copine genes, Creutz et al. (1998) identified human ESTs
corresponding to 5 copine genes, including copine II (GenBank GENBANK
R87434).
*FIELD* RF
1. Creutz, C. E.; Tomsig, J. L.; Snyder, S. L.; Gautier, M.-C.; Skouri,
F.; Beisson, J.; Cohen, J.: The copines, a novel class of C2 domain-containing,
calcium-dependent, phospholipid-binding proteins conserved from Paramecium
to humans. J. Biol. Chem. 273: 1393-1402, 1998.
*FIELD* CD
Patti M. Sherman: 9/29/1999
*FIELD* ED
mgross: 09/30/1999
psherman: 9/30/1999