Full text data of CPPED1
CPPED1
(CSTP1)
[Confidence: low (only semi-automatic identification from reviews)]
Calcineurin-like phosphoesterase domain-containing protein 1; 3.1.-.- (Complete S-transactivated protein 1)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Calcineurin-like phosphoesterase domain-containing protein 1; 3.1.-.- (Complete S-transactivated protein 1)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9BRF8
ID CPPED_HUMAN Reviewed; 314 AA.
AC Q9BRF8; Q6MZY9; Q9H9M9; Q9NUT6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-JAN-2011, sequence version 3.
DT 22-JAN-2014, entry version 86.
DE RecName: Full=Calcineurin-like phosphoesterase domain-containing protein 1;
DE EC=3.1.-.-;
DE AltName: Full=Complete S-transactivated protein 1;
GN Name=CPPED1; Synonyms=CSTP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-19 AND ARG-241,
RP AND INDUCTION.
RX PubMed=15991289;
RA Bai G.-Q., Liu Y., Cheng J., Zhang S.-L., Yue Y.-F., Huang Y.-P.,
RA Zhang L.-Y.;
RT "Transactivating effect of complete S protein of hepatitis B virus and
RT cloning of genes transactivated by complete S protein using
RT suppression subtractive hybridization technique.";
RL World J. Gastroenterol. 11:3893-3898(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP ASP-19 AND ARG-241.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP ARG-241.
RC TISSUE=Small intestine;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP ASP-19 AND ARG-241.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] ARG-241, AND MASS SPECTROMETRY.
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- COFACTOR: Binds 2 divalent metal cations (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BRF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRF8-2; Sequence=VSP_031658;
CC Note=No experimental confirmation available;
CC -!- INDUCTION: Transactivated by the large envelope protein of the
CC hepatitis B virus (HBV).
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC CPPED1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY553877; AAS64575.1; -; mRNA.
DR EMBL; AK002013; BAA92034.1; -; mRNA.
DR EMBL; AK022710; BAB14194.1; -; mRNA.
DR EMBL; BX640805; CAE45887.1; -; mRNA.
DR EMBL; AC010333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006289; AAH06289.1; -; mRNA.
DR RefSeq; NP_001092925.1; NM_001099455.1.
DR RefSeq; NP_060810.2; NM_018340.2.
DR UniGene; Hs.460002; -.
DR ProteinModelPortal; Q9BRF8; -.
DR STRING; 9606.ENSP00000261660; -.
DR PhosphoSite; Q9BRF8; -.
DR DMDM; 190360377; -.
DR PaxDb; Q9BRF8; -.
DR PeptideAtlas; Q9BRF8; -.
DR PRIDE; Q9BRF8; -.
DR DNASU; 55313; -.
DR Ensembl; ENST00000381774; ENSP00000371193; ENSG00000103381.
DR Ensembl; ENST00000433677; ENSP00000411127; ENSG00000103381.
DR GeneID; 55313; -.
DR KEGG; hsa:55313; -.
DR UCSC; uc002dca.4; human.
DR CTD; 55313; -.
DR GeneCards; GC16M012753; -.
DR H-InvDB; HIX0012827; -.
DR HGNC; HGNC:25632; CPPED1.
DR HPA; HPA040938; -.
DR neXtProt; NX_Q9BRF8; -.
DR PharmGKB; PA164718110; -.
DR eggNOG; COG1409; -.
DR HOGENOM; HOG000291782; -.
DR InParanoid; Q9BRF8; -.
DR OMA; GCQLGED; -.
DR OrthoDB; EOG7QRQW4; -.
DR PhylomeDB; Q9BRF8; -.
DR GenomeRNAi; 55313; -.
DR NextBio; 59550; -.
DR PRO; PR:Q9BRF8; -.
DR ArrayExpress; Q9BRF8; -.
DR Bgee; Q9BRF8; -.
DR Genevestigator; Q9BRF8; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR004843; PEstase_dom.
DR Pfam; PF00149; Metallophos; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Hydrolase; Metal-binding;
KW Polymorphism; Reference proteome.
FT CHAIN 1 314 Calcineurin-like phosphoesterase domain-
FT containing protein 1.
FT /FTId=PRO_0000320556.
FT METAL 53 53 Divalent metal cation 1 (By similarity).
FT METAL 90 90 Divalent metal cation 1 (By similarity).
FT METAL 90 90 Divalent metal cation 2 (By similarity).
FT METAL 127 127 Divalent metal cation 2 (By similarity).
FT METAL 247 247 Divalent metal cation 2 (By similarity).
FT VAR_SEQ 97 238 Missing (in isoform 2).
FT /FTId=VSP_031658.
FT VARIANT 19 19 A -> D (in dbSNP:rs3748976).
FT /FTId=VAR_039204.
FT VARIANT 86 86 V -> I (in dbSNP:rs3748980).
FT /FTId=VAR_039205.
FT VARIANT 241 241 K -> R (in dbSNP:rs1713480).
FT /FTId=VAR_039206.
FT VARIANT 290 290 H -> P (in dbSNP:rs11645068).
FT /FTId=VAR_039207.
FT CONFLICT 47 47 K -> R (in Ref. 3; CAE45887).
FT CONFLICT 77 77 K -> E (in Ref. 2; BAA92034).
FT CONFLICT 148 148 D -> Y (in Ref. 2; BAB14194).
FT CONFLICT 230 230 K -> E (in Ref. 2; BAA92034).
SQ SEQUENCE 314 AA; 35548 MW; D2DC770103053DA7 CRC64;
MSAAEAGGVF HRARGRTLAA FPAEKESEWK GPFYFILGAD PQFGLIKAWS TGDCDNGGDE
WEQEIRLTEQ AVQAINKLNP KPKFFVLCGD LIHAMPGKPW RTEQTEDLKR VLRAVDRAIP
LVLVSGNHDI GNTPTAETVE EFCRTWGDDY FSFWVGGVLF LVLNSQFYEN PSKCPSLKQA
QDQWLDEQLS IARQRHCQHA IVFQHIPLFL ESIDEDDDYY FNLSKSTRKK LADKFIHAGV
KVVFSGHYHR NAGGTYQNLD MVVSSAIGCQ LGRDPHGLRV VVVTAEKIVH RYYSLDELSE
KGIEDDLMDL IKKK
//
ID CPPED_HUMAN Reviewed; 314 AA.
AC Q9BRF8; Q6MZY9; Q9H9M9; Q9NUT6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-JAN-2011, sequence version 3.
DT 22-JAN-2014, entry version 86.
DE RecName: Full=Calcineurin-like phosphoesterase domain-containing protein 1;
DE EC=3.1.-.-;
DE AltName: Full=Complete S-transactivated protein 1;
GN Name=CPPED1; Synonyms=CSTP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-19 AND ARG-241,
RP AND INDUCTION.
RX PubMed=15991289;
RA Bai G.-Q., Liu Y., Cheng J., Zhang S.-L., Yue Y.-F., Huang Y.-P.,
RA Zhang L.-Y.;
RT "Transactivating effect of complete S protein of hepatitis B virus and
RT cloning of genes transactivated by complete S protein using
RT suppression subtractive hybridization technique.";
RL World J. Gastroenterol. 11:3893-3898(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP ASP-19 AND ARG-241.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP ARG-241.
RC TISSUE=Small intestine;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP ASP-19 AND ARG-241.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] ARG-241, AND MASS SPECTROMETRY.
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- COFACTOR: Binds 2 divalent metal cations (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BRF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRF8-2; Sequence=VSP_031658;
CC Note=No experimental confirmation available;
CC -!- INDUCTION: Transactivated by the large envelope protein of the
CC hepatitis B virus (HBV).
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC CPPED1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY553877; AAS64575.1; -; mRNA.
DR EMBL; AK002013; BAA92034.1; -; mRNA.
DR EMBL; AK022710; BAB14194.1; -; mRNA.
DR EMBL; BX640805; CAE45887.1; -; mRNA.
DR EMBL; AC010333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006289; AAH06289.1; -; mRNA.
DR RefSeq; NP_001092925.1; NM_001099455.1.
DR RefSeq; NP_060810.2; NM_018340.2.
DR UniGene; Hs.460002; -.
DR ProteinModelPortal; Q9BRF8; -.
DR STRING; 9606.ENSP00000261660; -.
DR PhosphoSite; Q9BRF8; -.
DR DMDM; 190360377; -.
DR PaxDb; Q9BRF8; -.
DR PeptideAtlas; Q9BRF8; -.
DR PRIDE; Q9BRF8; -.
DR DNASU; 55313; -.
DR Ensembl; ENST00000381774; ENSP00000371193; ENSG00000103381.
DR Ensembl; ENST00000433677; ENSP00000411127; ENSG00000103381.
DR GeneID; 55313; -.
DR KEGG; hsa:55313; -.
DR UCSC; uc002dca.4; human.
DR CTD; 55313; -.
DR GeneCards; GC16M012753; -.
DR H-InvDB; HIX0012827; -.
DR HGNC; HGNC:25632; CPPED1.
DR HPA; HPA040938; -.
DR neXtProt; NX_Q9BRF8; -.
DR PharmGKB; PA164718110; -.
DR eggNOG; COG1409; -.
DR HOGENOM; HOG000291782; -.
DR InParanoid; Q9BRF8; -.
DR OMA; GCQLGED; -.
DR OrthoDB; EOG7QRQW4; -.
DR PhylomeDB; Q9BRF8; -.
DR GenomeRNAi; 55313; -.
DR NextBio; 59550; -.
DR PRO; PR:Q9BRF8; -.
DR ArrayExpress; Q9BRF8; -.
DR Bgee; Q9BRF8; -.
DR Genevestigator; Q9BRF8; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR004843; PEstase_dom.
DR Pfam; PF00149; Metallophos; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Hydrolase; Metal-binding;
KW Polymorphism; Reference proteome.
FT CHAIN 1 314 Calcineurin-like phosphoesterase domain-
FT containing protein 1.
FT /FTId=PRO_0000320556.
FT METAL 53 53 Divalent metal cation 1 (By similarity).
FT METAL 90 90 Divalent metal cation 1 (By similarity).
FT METAL 90 90 Divalent metal cation 2 (By similarity).
FT METAL 127 127 Divalent metal cation 2 (By similarity).
FT METAL 247 247 Divalent metal cation 2 (By similarity).
FT VAR_SEQ 97 238 Missing (in isoform 2).
FT /FTId=VSP_031658.
FT VARIANT 19 19 A -> D (in dbSNP:rs3748976).
FT /FTId=VAR_039204.
FT VARIANT 86 86 V -> I (in dbSNP:rs3748980).
FT /FTId=VAR_039205.
FT VARIANT 241 241 K -> R (in dbSNP:rs1713480).
FT /FTId=VAR_039206.
FT VARIANT 290 290 H -> P (in dbSNP:rs11645068).
FT /FTId=VAR_039207.
FT CONFLICT 47 47 K -> R (in Ref. 3; CAE45887).
FT CONFLICT 77 77 K -> E (in Ref. 2; BAA92034).
FT CONFLICT 148 148 D -> Y (in Ref. 2; BAB14194).
FT CONFLICT 230 230 K -> E (in Ref. 2; BAA92034).
SQ SEQUENCE 314 AA; 35548 MW; D2DC770103053DA7 CRC64;
MSAAEAGGVF HRARGRTLAA FPAEKESEWK GPFYFILGAD PQFGLIKAWS TGDCDNGGDE
WEQEIRLTEQ AVQAINKLNP KPKFFVLCGD LIHAMPGKPW RTEQTEDLKR VLRAVDRAIP
LVLVSGNHDI GNTPTAETVE EFCRTWGDDY FSFWVGGVLF LVLNSQFYEN PSKCPSLKQA
QDQWLDEQLS IARQRHCQHA IVFQHIPLFL ESIDEDDDYY FNLSKSTRKK LADKFIHAGV
KVVFSGHYHR NAGGTYQNLD MVVSSAIGCQ LGRDPHGLRV VVVTAEKIVH RYYSLDELSE
KGIEDDLMDL IKKK
//