Full text data of C19orf10
C19orf10
(IL25)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
UPF0556 protein C19orf10 (Interleukin-25; IL-25; Stromal cell-derived growth factor SF20; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UPF0556 protein C19orf10 (Interleukin-25; IL-25; Stromal cell-derived growth factor SF20; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q969H8
ID CS010_HUMAN Reviewed; 173 AA.
AC Q969H8; D6W628; O75256; O75272; Q9BTK7; Q9NP69;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 91.
DE RecName: Full=UPF0556 protein C19orf10;
DE AltName: Full=Interleukin-25;
DE Short=IL-25;
DE AltName: Full=Stromal cell-derived growth factor SF20;
DE Flags: Precursor;
GN Name=C19orf10; Synonyms=IL25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone marrow;
RX PubMed=11714798;
RA Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H.,
RA Kitamura T.;
RT "SF20/IL-25, a novel bone marrow stroma-derived growth factor that
RT binds to mouse thymic shared antigen-1 and supports lymphoid cell
RT proliferation.";
RL J. Immunol. 167:6338-6347(2001).
RN [2]
RP ERRATUM, AND RETRACTION.
RX PubMed=12538725;
RA Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H.,
RA Kitamura T.;
RL J. Immunol. 170:1593-1593(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
RG The European IMAGE consortium;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44.
RC TISSUE=Leukemic T-cell;
RX PubMed=19892738; DOI=10.1073/pnas.0908958106;
RA Xu G., Shin S.B., Jaffrey S.R.;
RT "Global profiling of protease cleavage sites by chemoselective
RT labeling of protein N-termini.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=17362502; DOI=10.1186/ar2145;
RA Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H.,
RA Wilkins J.A.;
RT "The identification and characterization of a novel protein, c19orf10,
RT in the synovium.";
RL Arthritis Res. Ther. 9:R30-R30(2007).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum-Golgi
CC intermediate compartment.
CC -!- TISSUE SPECIFICITY: Expressed in synovial tissue. Found in
CC synovial fluid of patients with arthropaties.
CC -!- SIMILARITY: Belongs to the UPF0556 family.
CC -!- CAUTION: Was originally (PubMed:11714798) thought to signal
CC lymphoid cells to proliferate via thymic shared antigen 1, but
CC this work has been later retracted.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27824.1; Type=Erroneous gene model prediction;
CC Sequence=AAC33800.1; Type=Erroneous gene model prediction;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC005594; AAC33800.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC005339; AAC27824.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471139; EAW69202.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69203.1; -; Genomic_DNA.
DR EMBL; BC003639; AAH03639.2; -; mRNA.
DR EMBL; BC010129; AAH10129.1; -; mRNA.
DR EMBL; BC014655; AAH14655.1; -; mRNA.
DR EMBL; AL365373; CAB96947.1; -; mRNA.
DR EMBL; AL365374; CAB96948.1; -; mRNA.
DR RefSeq; NP_061980.1; NM_019107.3.
DR UniGene; Hs.465645; -.
DR ProteinModelPortal; Q969H8; -.
DR IntAct; Q969H8; 3.
DR MINT; MINT-1421098; -.
DR STRING; 9606.ENSP00000262947; -.
DR PhosphoSite; Q969H8; -.
DR DMDM; 61221730; -.
DR UCD-2DPAGE; Q969H8; -.
DR PaxDb; Q969H8; -.
DR PeptideAtlas; Q969H8; -.
DR PRIDE; Q969H8; -.
DR Ensembl; ENST00000262947; ENSP00000262947; ENSG00000074842.
DR GeneID; 56005; -.
DR KEGG; hsa:56005; -.
DR UCSC; uc002may.3; human.
DR CTD; 56005; -.
DR GeneCards; GC19M004608; -.
DR H-InvDB; HIX0014670; -.
DR HGNC; HGNC:16948; C19orf10.
DR HPA; HPA041872; -.
DR HPA; HPA046744; -.
DR MIM; 606746; gene.
DR neXtProt; NX_Q969H8; -.
DR PharmGKB; PA29827; -.
DR eggNOG; NOG46744; -.
DR HOGENOM; HOG000236299; -.
DR HOVERGEN; HBG051127; -.
DR InParanoid; Q969H8; -.
DR OMA; EIEYGMA; -.
DR PhylomeDB; Q969H8; -.
DR Reactome; REACT_17015; Metabolism of proteins.
DR GenomeRNAi; 56005; -.
DR NextBio; 61458; -.
DR ArrayExpress; Q969H8; -.
DR Bgee; Q969H8; -.
DR CleanEx; HS_C19orf10; -.
DR CleanEx; HS_IL25; -.
DR Genevestigator; Q969H8; -.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
DR GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
DR InterPro; IPR018887; UPF0556.
DR Pfam; PF10572; UPF0556; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Direct protein sequencing; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 31
FT CHAIN 32 173 UPF0556 protein C19orf10.
FT /FTId=PRO_0000021008.
FT VARIANT 12 12 G -> R (in dbSNP:rs2270090).
FT /FTId=VAR_060183.
SQ SEQUENCE 173 AA; 18795 MW; DD8910DEFEA5E3FC CRC64;
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS FSHNVGPGDK
YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK SYLYFTQFKA EVRGAEIEYA
MAYSKAAFER ESDVPLKTEE FEVTKTAVAH RPGAFKAELS KLVIVAKASR TEL
//
ID CS010_HUMAN Reviewed; 173 AA.
AC Q969H8; D6W628; O75256; O75272; Q9BTK7; Q9NP69;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 91.
DE RecName: Full=UPF0556 protein C19orf10;
DE AltName: Full=Interleukin-25;
DE Short=IL-25;
DE AltName: Full=Stromal cell-derived growth factor SF20;
DE Flags: Precursor;
GN Name=C19orf10; Synonyms=IL25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone marrow;
RX PubMed=11714798;
RA Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H.,
RA Kitamura T.;
RT "SF20/IL-25, a novel bone marrow stroma-derived growth factor that
RT binds to mouse thymic shared antigen-1 and supports lymphoid cell
RT proliferation.";
RL J. Immunol. 167:6338-6347(2001).
RN [2]
RP ERRATUM, AND RETRACTION.
RX PubMed=12538725;
RA Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H.,
RA Kitamura T.;
RL J. Immunol. 170:1593-1593(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
RG The European IMAGE consortium;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44.
RC TISSUE=Leukemic T-cell;
RX PubMed=19892738; DOI=10.1073/pnas.0908958106;
RA Xu G., Shin S.B., Jaffrey S.R.;
RT "Global profiling of protease cleavage sites by chemoselective
RT labeling of protein N-termini.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=17362502; DOI=10.1186/ar2145;
RA Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H.,
RA Wilkins J.A.;
RT "The identification and characterization of a novel protein, c19orf10,
RT in the synovium.";
RL Arthritis Res. Ther. 9:R30-R30(2007).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum-Golgi
CC intermediate compartment.
CC -!- TISSUE SPECIFICITY: Expressed in synovial tissue. Found in
CC synovial fluid of patients with arthropaties.
CC -!- SIMILARITY: Belongs to the UPF0556 family.
CC -!- CAUTION: Was originally (PubMed:11714798) thought to signal
CC lymphoid cells to proliferate via thymic shared antigen 1, but
CC this work has been later retracted.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27824.1; Type=Erroneous gene model prediction;
CC Sequence=AAC33800.1; Type=Erroneous gene model prediction;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC005594; AAC33800.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC005339; AAC27824.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471139; EAW69202.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69203.1; -; Genomic_DNA.
DR EMBL; BC003639; AAH03639.2; -; mRNA.
DR EMBL; BC010129; AAH10129.1; -; mRNA.
DR EMBL; BC014655; AAH14655.1; -; mRNA.
DR EMBL; AL365373; CAB96947.1; -; mRNA.
DR EMBL; AL365374; CAB96948.1; -; mRNA.
DR RefSeq; NP_061980.1; NM_019107.3.
DR UniGene; Hs.465645; -.
DR ProteinModelPortal; Q969H8; -.
DR IntAct; Q969H8; 3.
DR MINT; MINT-1421098; -.
DR STRING; 9606.ENSP00000262947; -.
DR PhosphoSite; Q969H8; -.
DR DMDM; 61221730; -.
DR UCD-2DPAGE; Q969H8; -.
DR PaxDb; Q969H8; -.
DR PeptideAtlas; Q969H8; -.
DR PRIDE; Q969H8; -.
DR Ensembl; ENST00000262947; ENSP00000262947; ENSG00000074842.
DR GeneID; 56005; -.
DR KEGG; hsa:56005; -.
DR UCSC; uc002may.3; human.
DR CTD; 56005; -.
DR GeneCards; GC19M004608; -.
DR H-InvDB; HIX0014670; -.
DR HGNC; HGNC:16948; C19orf10.
DR HPA; HPA041872; -.
DR HPA; HPA046744; -.
DR MIM; 606746; gene.
DR neXtProt; NX_Q969H8; -.
DR PharmGKB; PA29827; -.
DR eggNOG; NOG46744; -.
DR HOGENOM; HOG000236299; -.
DR HOVERGEN; HBG051127; -.
DR InParanoid; Q969H8; -.
DR OMA; EIEYGMA; -.
DR PhylomeDB; Q969H8; -.
DR Reactome; REACT_17015; Metabolism of proteins.
DR GenomeRNAi; 56005; -.
DR NextBio; 61458; -.
DR ArrayExpress; Q969H8; -.
DR Bgee; Q969H8; -.
DR CleanEx; HS_C19orf10; -.
DR CleanEx; HS_IL25; -.
DR Genevestigator; Q969H8; -.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
DR GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
DR InterPro; IPR018887; UPF0556.
DR Pfam; PF10572; UPF0556; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Direct protein sequencing; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 31
FT CHAIN 32 173 UPF0556 protein C19orf10.
FT /FTId=PRO_0000021008.
FT VARIANT 12 12 G -> R (in dbSNP:rs2270090).
FT /FTId=VAR_060183.
SQ SEQUENCE 173 AA; 18795 MW; DD8910DEFEA5E3FC CRC64;
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS FSHNVGPGDK
YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK SYLYFTQFKA EVRGAEIEYA
MAYSKAAFER ESDVPLKTEE FEVTKTAVAH RPGAFKAELS KLVIVAKASR TEL
//
MIM
606746
*RECORD*
*FIELD* NO
606746
*FIELD* TI
*606746 CHROMOSOME 19 OPEN READING FRAME 10; C19ORF10
;;INTERLEUKIN 25; IL25;;
STROMA-DERIVED GROWTH FACTOR 20; SF20
read more*FIELD* TX
CLONING
By profiling proteins secreted from preadipocytes (mouse 3T3-L1 cells)
by means of 2-dimensional electrophoresis mass spectrometry, Wang et al.
(2004) identified c19orf10 (SF10; IL25), which was upregulated during
differentiation of adipocytes, leading to the suggestion that it is
involved in adipogenesis.
During a proteomic analysis of fibroblast-like synoviocytes (FLSs),
Weiler et al. (2007) identified C19ORF10, which was produced in
significant amounts by these cells. The deduced 173-amino acid protein
contains 2 O-glycosylation sites and several potential phosphorylation
sites. There was evidence of 2 additional splice variants. The human and
mouse C19ORF10 proteins share 91% sequence identity.
Immunohistochemistry analyses of recombinant C19ORF10 in cultured FLSs
and in synovial tissue sections from patients with rheumatoid arthritis
(RA) or osteoarthritis (OA) revealed intracellular staining consistent
with localization in the endoplasmic reticulum/Golgi apparatus. Sections
of RA and OA synovia expressed similar patterns of C19ORF10 distribution
with perivascular and synovial lining staining. Double-staining in situ
analysis suggested that fibroblast-like synovial cells produced
C19ORF10, whereas macrophages, B cells, or T cells produced little or
none of this protein.
GENE STRUCTURE
By surveying available cDNA clones, Weiler et al. (2007) found evidence
of 3 splice variants of C19ORF10. The most common variant, C19ORF10b,
has 6 exons and was supported by sequence data from 468 clones. The
other 2 predicted variants, a and c, were supported by 1 clone each.
MAPPING
By database analysis, Weiler et al. (2007) mapped the C29ORF10 gene to
chromosome 19p13.3.
HISTORY
Tulin et al. (2001) reported the cloning of full-length cDNAs encoding
mouse and human SF20, which they also referred to as interleukin-25
(IL25). However, they retracted their paper in 2003.
*FIELD* RF
1. Tulin, E. E.; Onoda, N.; Nakata, Y.; Maeda, M.; Hasegawa, M.; Nomura,
H.; Kitamura, T.: SF20/IL-25, a novel bone marrow stroma-derived
growth factor that binds to mouse thymic shared antigen-1 and supports
lymphoid cell proliferation. J. Immun. 167: 6338-6347, 2001. Note:
Retraction: J. Immun. 170: 1593 only, 2003.
2. Wang, P.; Mariman, E.; Keijer, J.; Bouwman, F.; Noben, J.-P.; Robben,
J.; Renes, J.: Profiling of the secreted proteins during 3T3-L1 adipocyte
differentiation leads to the identification of novel adipokines. Cell.
Molec. Life Sci. 61: 2405-2417, 2004.
3. Weiler, T.; Du, Q.; Krokhin, O.; Ens, W.; Standing, K.; El-Gabalawy,
H.; Wilkins, J. A.: The identification and characterization of a
novel protein, c19orf10, in the synovium. Arthritis Res. Ther. 9:
R30, 2007. Note: Electronic Article.
*FIELD* CN
Carol A. Bocchini - updated: 7/2/2009
*FIELD* CD
Paul J. Converse: 3/5/2002
*FIELD* ED
carol: 07/07/2009
carol: 7/2/2009
mgross: 12/17/2003
mgross: 11/20/2003
mgross: 5/28/2003
mgross: 3/24/2003
mgross: 4/19/2002
mgross: 3/6/2002
mgross: 3/5/2002
*RECORD*
*FIELD* NO
606746
*FIELD* TI
*606746 CHROMOSOME 19 OPEN READING FRAME 10; C19ORF10
;;INTERLEUKIN 25; IL25;;
STROMA-DERIVED GROWTH FACTOR 20; SF20
read more*FIELD* TX
CLONING
By profiling proteins secreted from preadipocytes (mouse 3T3-L1 cells)
by means of 2-dimensional electrophoresis mass spectrometry, Wang et al.
(2004) identified c19orf10 (SF10; IL25), which was upregulated during
differentiation of adipocytes, leading to the suggestion that it is
involved in adipogenesis.
During a proteomic analysis of fibroblast-like synoviocytes (FLSs),
Weiler et al. (2007) identified C19ORF10, which was produced in
significant amounts by these cells. The deduced 173-amino acid protein
contains 2 O-glycosylation sites and several potential phosphorylation
sites. There was evidence of 2 additional splice variants. The human and
mouse C19ORF10 proteins share 91% sequence identity.
Immunohistochemistry analyses of recombinant C19ORF10 in cultured FLSs
and in synovial tissue sections from patients with rheumatoid arthritis
(RA) or osteoarthritis (OA) revealed intracellular staining consistent
with localization in the endoplasmic reticulum/Golgi apparatus. Sections
of RA and OA synovia expressed similar patterns of C19ORF10 distribution
with perivascular and synovial lining staining. Double-staining in situ
analysis suggested that fibroblast-like synovial cells produced
C19ORF10, whereas macrophages, B cells, or T cells produced little or
none of this protein.
GENE STRUCTURE
By surveying available cDNA clones, Weiler et al. (2007) found evidence
of 3 splice variants of C19ORF10. The most common variant, C19ORF10b,
has 6 exons and was supported by sequence data from 468 clones. The
other 2 predicted variants, a and c, were supported by 1 clone each.
MAPPING
By database analysis, Weiler et al. (2007) mapped the C29ORF10 gene to
chromosome 19p13.3.
HISTORY
Tulin et al. (2001) reported the cloning of full-length cDNAs encoding
mouse and human SF20, which they also referred to as interleukin-25
(IL25). However, they retracted their paper in 2003.
*FIELD* RF
1. Tulin, E. E.; Onoda, N.; Nakata, Y.; Maeda, M.; Hasegawa, M.; Nomura,
H.; Kitamura, T.: SF20/IL-25, a novel bone marrow stroma-derived
growth factor that binds to mouse thymic shared antigen-1 and supports
lymphoid cell proliferation. J. Immun. 167: 6338-6347, 2001. Note:
Retraction: J. Immun. 170: 1593 only, 2003.
2. Wang, P.; Mariman, E.; Keijer, J.; Bouwman, F.; Noben, J.-P.; Robben,
J.; Renes, J.: Profiling of the secreted proteins during 3T3-L1 adipocyte
differentiation leads to the identification of novel adipokines. Cell.
Molec. Life Sci. 61: 2405-2417, 2004.
3. Weiler, T.; Du, Q.; Krokhin, O.; Ens, W.; Standing, K.; El-Gabalawy,
H.; Wilkins, J. A.: The identification and characterization of a
novel protein, c19orf10, in the synovium. Arthritis Res. Ther. 9:
R30, 2007. Note: Electronic Article.
*FIELD* CN
Carol A. Bocchini - updated: 7/2/2009
*FIELD* CD
Paul J. Converse: 3/5/2002
*FIELD* ED
carol: 07/07/2009
carol: 7/2/2009
mgross: 12/17/2003
mgross: 11/20/2003
mgross: 5/28/2003
mgross: 3/24/2003
mgross: 4/19/2002
mgross: 3/6/2002
mgross: 3/5/2002