Full text data of DHRS12
DHRS12
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Dehydrogenase/reductase SDR family member 12; 1.1.-.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Dehydrogenase/reductase SDR family member 12; 1.1.-.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00062441
IPI00062441 Hypothetical protein Hypothetical protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00062441 Hypothetical protein Hypothetical protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
A0PJE2
ID DHR12_HUMAN Reviewed; 317 AA.
AC A0PJE2; Q96GB2; Q9H8H1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 04-DEC-2007, sequence version 2.
DT 22-JAN-2014, entry version 63.
DE RecName: Full=Dehydrogenase/reductase SDR family member 12;
DE EC=1.1.-.-;
GN Name=DHRS12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
RP SPLICING.
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 6-317 (ISOFORM 1).
RC TISSUE=Kidney, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative oxidoreductase (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A0PJE2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0PJE2-2; Sequence=VSP_029724, VSP_029726, VSP_029727;
CC Name=3;
CC IsoId=A0PJE2-3; Sequence=VSP_029724, VSP_029725;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK023701; BAB14646.1; -; mRNA.
DR EMBL; AL136525; CAH70586.1; -; Genomic_DNA.
DR EMBL; AL162377; CAH70586.1; JOINED; Genomic_DNA.
DR EMBL; AL162377; CAI13427.1; -; Genomic_DNA.
DR EMBL; AL136525; CAI13427.1; JOINED; Genomic_DNA.
DR EMBL; CH471075; EAX08884.1; -; Genomic_DNA.
DR EMBL; CH471075; EAX08888.1; -; Genomic_DNA.
DR EMBL; BC009825; AAH09825.1; -; mRNA.
DR EMBL; BC026024; AAH26024.1; -; mRNA.
DR RefSeq; NP_001026889.1; NM_001031719.2.
DR RefSeq; NP_001257353.1; NM_001270424.1.
DR RefSeq; NP_078981.1; NM_024705.2.
DR UniGene; Hs.266728; -.
DR ProteinModelPortal; A0PJE2; -.
DR SMR; A0PJE2; 38-278.
DR STRING; 9606.ENSP00000280056; -.
DR PaxDb; A0PJE2; -.
DR PRIDE; A0PJE2; -.
DR DNASU; 79758; -.
DR Ensembl; ENST00000218981; ENSP00000218981; ENSG00000102796.
DR Ensembl; ENST00000280056; ENSP00000280056; ENSG00000102796.
DR Ensembl; ENST00000444610; ENSP00000411565; ENSG00000102796.
DR GeneID; 79758; -.
DR KEGG; hsa:79758; -.
DR UCSC; uc001vfq.4; human.
DR CTD; 79758; -.
DR GeneCards; GC13M052342; -.
DR HGNC; HGNC:25832; DHRS12.
DR HPA; CAB034238; -.
DR neXtProt; NX_A0PJE2; -.
DR PharmGKB; PA147358124; -.
DR eggNOG; COG1028; -.
DR HOVERGEN; HBG060423; -.
DR KO; K11168; -.
DR OMA; DGTMAYA; -.
DR OrthoDB; EOG7JMGDX; -.
DR ChiTaRS; DHRS12; human.
DR GenomeRNAi; 79758; -.
DR NextBio; 69215; -.
DR PRO; PR:A0PJE2; -.
DR Bgee; A0PJE2; -.
DR CleanEx; HS_DHRS12; -.
DR Genevestigator; A0PJE2; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR002347; Glc/ribitol_DH.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; NAD; NADP; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1 317 Dehydrogenase/reductase SDR family member
FT 12.
FT /FTId=PRO_0000312175.
FT NP_BIND 47 53 NAD or NADP (By similarity).
FT ACT_SITE 201 201 Proton acceptor (By similarity).
FT BINDING 175 175 Substrate (Potential).
FT VAR_SEQ 1 91 MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGR
FT VFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARG
FT EIIRESGNQ -> MNLHVKTLSLMTWRSRFLEESFWSLEET
FT AALAKQLPLKSPSE (in isoform 2 and isoform
FT 3).
FT /FTId=VSP_029724.
FT VAR_SEQ 236 317 GVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPS
FT GRFFQDRKPVSTHLPLATASSSPAEEEKLIEILEQLAQTFK
FT -> DRNEQELRKVVGEAQTASPLPRFLEIMMHEGKCQPQGH
FT SSNDLEACWSSGGGEQNSLPDWPHQLHDLRQLTWALCSSFL
FT LYKQGN (in isoform 3).
FT /FTId=VSP_029725.
FT VAR_SEQ 282 296 DRKPVSTHLPLATAS -> GDFLPGCEGS (in isoform
FT 2).
FT /FTId=VSP_029726.
FT VAR_SEQ 297 317 Missing (in isoform 2).
FT /FTId=VSP_029727.
SQ SEQUENCE 317 AA; 35146 MW; C5BCF344FB4625D4 CRC64;
MSLYRSVVWF AKGLREYTKS GYESACKDFV PHDLEVQIPG RVFLVTGGNS GIGKATALEI
AKRGGTVHLV CRDQAPAEDA RGEIIRESGN QNIFLHIVDL SDPKQIWKFV ENFKQEHKLH
VLINNAGCMV NKRELTEDGL EKNFAANTLG VYILTTGLIP VLEKEHDPRV ITVSSGGMLV
QKLNTNDLQS ERTPFDGTMV YAQNKRQQVV LTERWAQGHP AIHFSSMHPG WADTPGVRQA
MPGFHARFGD RLRSEAQGAD TMLWLALSSA AAAQPSGRFF QDRKPVSTHL PLATASSSPA
EEEKLIEILE QLAQTFK
//
ID DHR12_HUMAN Reviewed; 317 AA.
AC A0PJE2; Q96GB2; Q9H8H1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 04-DEC-2007, sequence version 2.
DT 22-JAN-2014, entry version 63.
DE RecName: Full=Dehydrogenase/reductase SDR family member 12;
DE EC=1.1.-.-;
GN Name=DHRS12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
RP SPLICING.
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 6-317 (ISOFORM 1).
RC TISSUE=Kidney, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative oxidoreductase (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A0PJE2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0PJE2-2; Sequence=VSP_029724, VSP_029726, VSP_029727;
CC Name=3;
CC IsoId=A0PJE2-3; Sequence=VSP_029724, VSP_029725;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK023701; BAB14646.1; -; mRNA.
DR EMBL; AL136525; CAH70586.1; -; Genomic_DNA.
DR EMBL; AL162377; CAH70586.1; JOINED; Genomic_DNA.
DR EMBL; AL162377; CAI13427.1; -; Genomic_DNA.
DR EMBL; AL136525; CAI13427.1; JOINED; Genomic_DNA.
DR EMBL; CH471075; EAX08884.1; -; Genomic_DNA.
DR EMBL; CH471075; EAX08888.1; -; Genomic_DNA.
DR EMBL; BC009825; AAH09825.1; -; mRNA.
DR EMBL; BC026024; AAH26024.1; -; mRNA.
DR RefSeq; NP_001026889.1; NM_001031719.2.
DR RefSeq; NP_001257353.1; NM_001270424.1.
DR RefSeq; NP_078981.1; NM_024705.2.
DR UniGene; Hs.266728; -.
DR ProteinModelPortal; A0PJE2; -.
DR SMR; A0PJE2; 38-278.
DR STRING; 9606.ENSP00000280056; -.
DR PaxDb; A0PJE2; -.
DR PRIDE; A0PJE2; -.
DR DNASU; 79758; -.
DR Ensembl; ENST00000218981; ENSP00000218981; ENSG00000102796.
DR Ensembl; ENST00000280056; ENSP00000280056; ENSG00000102796.
DR Ensembl; ENST00000444610; ENSP00000411565; ENSG00000102796.
DR GeneID; 79758; -.
DR KEGG; hsa:79758; -.
DR UCSC; uc001vfq.4; human.
DR CTD; 79758; -.
DR GeneCards; GC13M052342; -.
DR HGNC; HGNC:25832; DHRS12.
DR HPA; CAB034238; -.
DR neXtProt; NX_A0PJE2; -.
DR PharmGKB; PA147358124; -.
DR eggNOG; COG1028; -.
DR HOVERGEN; HBG060423; -.
DR KO; K11168; -.
DR OMA; DGTMAYA; -.
DR OrthoDB; EOG7JMGDX; -.
DR ChiTaRS; DHRS12; human.
DR GenomeRNAi; 79758; -.
DR NextBio; 69215; -.
DR PRO; PR:A0PJE2; -.
DR Bgee; A0PJE2; -.
DR CleanEx; HS_DHRS12; -.
DR Genevestigator; A0PJE2; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR002347; Glc/ribitol_DH.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; NAD; NADP; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1 317 Dehydrogenase/reductase SDR family member
FT 12.
FT /FTId=PRO_0000312175.
FT NP_BIND 47 53 NAD or NADP (By similarity).
FT ACT_SITE 201 201 Proton acceptor (By similarity).
FT BINDING 175 175 Substrate (Potential).
FT VAR_SEQ 1 91 MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGR
FT VFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARG
FT EIIRESGNQ -> MNLHVKTLSLMTWRSRFLEESFWSLEET
FT AALAKQLPLKSPSE (in isoform 2 and isoform
FT 3).
FT /FTId=VSP_029724.
FT VAR_SEQ 236 317 GVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPS
FT GRFFQDRKPVSTHLPLATASSSPAEEEKLIEILEQLAQTFK
FT -> DRNEQELRKVVGEAQTASPLPRFLEIMMHEGKCQPQGH
FT SSNDLEACWSSGGGEQNSLPDWPHQLHDLRQLTWALCSSFL
FT LYKQGN (in isoform 3).
FT /FTId=VSP_029725.
FT VAR_SEQ 282 296 DRKPVSTHLPLATAS -> GDFLPGCEGS (in isoform
FT 2).
FT /FTId=VSP_029726.
FT VAR_SEQ 297 317 Missing (in isoform 2).
FT /FTId=VSP_029727.
SQ SEQUENCE 317 AA; 35146 MW; C5BCF344FB4625D4 CRC64;
MSLYRSVVWF AKGLREYTKS GYESACKDFV PHDLEVQIPG RVFLVTGGNS GIGKATALEI
AKRGGTVHLV CRDQAPAEDA RGEIIRESGN QNIFLHIVDL SDPKQIWKFV ENFKQEHKLH
VLINNAGCMV NKRELTEDGL EKNFAANTLG VYILTTGLIP VLEKEHDPRV ITVSSGGMLV
QKLNTNDLQS ERTPFDGTMV YAQNKRQQVV LTERWAQGHP AIHFSSMHPG WADTPGVRQA
MPGFHARFGD RLRSEAQGAD TMLWLALSSA AAAQPSGRFF QDRKPVSTHL PLATASSSPA
EEEKLIEILE QLAQTFK
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