Full text data of DNAJA4
DNAJA4
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
DnaJ homolog subfamily A member 4; Flags: Precursor
DnaJ homolog subfamily A member 4; Flags: Precursor
UniProt
Q8WW22
ID DNJA4_HUMAN Reviewed; 397 AA.
AC Q8WW22; E9PDM9; Q6AW87; Q8N5Z4; Q8N7P2;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 105.
DE RecName: Full=DnaJ homolog subfamily A member 4;
DE Flags: Precursor;
GN Name=DNAJA4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endometrial tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP ARG-226.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WW22-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WW22-2; Sequence=VSP_038965;
CC Name=3;
CC IsoId=Q8WW22-3; Sequence=VSP_045696;
CC Note=No experimental confirmation available. Ref.5 (AAH31044)
CC sequence is in conflict in position: 1:M->T;
CC -!- SIMILARITY: Contains 1 CR-type zinc finger.
CC -!- SIMILARITY: Contains 1 J domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK096616; BAC04828.1; -; mRNA.
DR EMBL; AK098079; BAC05229.1; -; mRNA.
DR EMBL; BX648710; CAH10558.1; -; mRNA.
DR EMBL; AC092755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99177.1; -; Genomic_DNA.
DR EMBL; BC021720; AAH21720.1; ALT_INIT; mRNA.
DR EMBL; BC031044; AAH31044.2; ALT_INIT; mRNA.
DR RefSeq; NP_001123654.1; NM_001130182.1.
DR RefSeq; NP_001123655.1; NM_001130183.1.
DR RefSeq; NP_061072.3; NM_018602.3.
DR RefSeq; XP_005254592.1; XM_005254535.1.
DR UniGene; Hs.513053; -.
DR ProteinModelPortal; Q8WW22; -.
DR SMR; Q8WW22; 1-70, 103-331.
DR IntAct; Q8WW22; 4.
DR STRING; 9606.ENSP00000378324; -.
DR PhosphoSite; Q8WW22; -.
DR DMDM; 27805462; -.
DR PaxDb; Q8WW22; -.
DR PRIDE; Q8WW22; -.
DR Ensembl; ENST00000343789; ENSP00000339581; ENSG00000140403.
DR Ensembl; ENST00000394852; ENSP00000378321; ENSG00000140403.
DR Ensembl; ENST00000394855; ENSP00000378324; ENSG00000140403.
DR Ensembl; ENST00000446172; ENSP00000413499; ENSG00000140403.
DR GeneID; 55466; -.
DR KEGG; hsa:55466; -.
DR UCSC; uc002bdk.3; human.
DR CTD; 55466; -.
DR GeneCards; GC15P078556; -.
DR HGNC; HGNC:14885; DNAJA4.
DR HPA; CAB004646; -.
DR neXtProt; NX_Q8WW22; -.
DR PharmGKB; PA27411; -.
DR eggNOG; COG0484; -.
DR HOGENOM; HOG000226718; -.
DR HOVERGEN; HBG066727; -.
DR InParanoid; Q8WW22; -.
DR KO; K09505; -.
DR OMA; CVRDEGM; -.
DR OrthoDB; EOG7XM2XK; -.
DR PhylomeDB; Q8WW22; -.
DR ChiTaRS; DNAJA4; human.
DR GenomeRNAi; 55466; -.
DR NextBio; 59854; -.
DR PRO; PR:Q8WW22; -.
DR ArrayExpress; Q8WW22; -.
DR Bgee; Q8WW22; -.
DR CleanEx; HS_DNAJA4; -.
DR Genevestigator; Q8WW22; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0009408; P:response to heat; IEA:InterPro.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 2.10.230.10; -; 1.
DR InterPro; IPR012724; DnaJ.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
DR Pfam; PF01556; CTDII; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00684; DnaJ_CXXCXGXG; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF49493; SSF49493; 3.
DR SUPFAM; SSF57938; SSF57938; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51188; ZF_CR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chaperone; Complete proteome; Lipoprotein;
KW Membrane; Metal-binding; Methylation; Polymorphism; Prenylation;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1 394 DnaJ homolog subfamily A member 4.
FT /FTId=PRO_0000071014.
FT PROPEP 395 397 Removed in mature form (By similarity).
FT /FTId=PRO_0000396760.
FT DOMAIN 4 70 J.
FT REPEAT 135 142 CXXCXGXG motif.
FT REPEAT 151 158 CXXCXGXG motif.
FT REPEAT 178 185 CXXCXGXG motif.
FT REPEAT 194 201 CXXCXGXG motif.
FT ZN_FING 122 206 CR-type.
FT COMPBIAS 75 96 Gly-rich.
FT METAL 135 135 Zinc 1 (By similarity).
FT METAL 138 138 Zinc 1 (By similarity).
FT METAL 151 151 Zinc 2 (By similarity).
FT METAL 154 154 Zinc 2 (By similarity).
FT METAL 178 178 Zinc 2 (By similarity).
FT METAL 181 181 Zinc 2 (By similarity).
FT METAL 194 194 Zinc 1 (By similarity).
FT METAL 197 197 Zinc 1 (By similarity).
FT MOD_RES 394 394 Cysteine methyl ester (By similarity).
FT LIPID 394 394 S-farnesyl cysteine (By similarity).
FT VAR_SEQ 1 44 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE
FT GEK -> MWESLTLDSGQISALTR (in isoform 3).
FT /FTId=VSP_045696.
FT VAR_SEQ 1 1 M -> MARGGSQSWSSGESDGQPKEQTPEKPRHKM (in
FT isoform 2).
FT /FTId=VSP_038965.
FT VARIANT 226 226 H -> R (in dbSNP:rs17852881).
FT /FTId=VAR_069064.
FT CONFLICT 33 33 Y -> C (in Ref. 1; BAC05229).
SQ SEQUENCE 397 AA; 44798 MW; 60D6AAD12C9B2529 CRC64;
MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ AYEVLSDPKK
RDVYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMA RERRGKNVVH QLSVTLEDLY
NGVTKKLALQ KNVICEKCEG VGGKKGSVEK CPLCKGRGMQ IHIQQIGPGM VQQIQTVCIE
CKGQGERINP KDRCESCSGA KVIREKKIIE VHVEKGMKDG QKILFHGEGD QEPELEPGDV
IIVLDQKDHS VFQRRGHDLI MKMKIQLSEA LCGFKKTIKT LDNRILVITS KAGEVIKHGD
LRCVRDEGMP IYKAPLEKGI LIIQFLVIFP EKHWLSLEKL PQLEALLPPR QKVRITDDMD
QVELKEFCPN EQNWRQHREA YEEDEDGPQA GVQCQTA
//
ID DNJA4_HUMAN Reviewed; 397 AA.
AC Q8WW22; E9PDM9; Q6AW87; Q8N5Z4; Q8N7P2;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 105.
DE RecName: Full=DnaJ homolog subfamily A member 4;
DE Flags: Precursor;
GN Name=DNAJA4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endometrial tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP ARG-226.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WW22-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WW22-2; Sequence=VSP_038965;
CC Name=3;
CC IsoId=Q8WW22-3; Sequence=VSP_045696;
CC Note=No experimental confirmation available. Ref.5 (AAH31044)
CC sequence is in conflict in position: 1:M->T;
CC -!- SIMILARITY: Contains 1 CR-type zinc finger.
CC -!- SIMILARITY: Contains 1 J domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK096616; BAC04828.1; -; mRNA.
DR EMBL; AK098079; BAC05229.1; -; mRNA.
DR EMBL; BX648710; CAH10558.1; -; mRNA.
DR EMBL; AC092755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99177.1; -; Genomic_DNA.
DR EMBL; BC021720; AAH21720.1; ALT_INIT; mRNA.
DR EMBL; BC031044; AAH31044.2; ALT_INIT; mRNA.
DR RefSeq; NP_001123654.1; NM_001130182.1.
DR RefSeq; NP_001123655.1; NM_001130183.1.
DR RefSeq; NP_061072.3; NM_018602.3.
DR RefSeq; XP_005254592.1; XM_005254535.1.
DR UniGene; Hs.513053; -.
DR ProteinModelPortal; Q8WW22; -.
DR SMR; Q8WW22; 1-70, 103-331.
DR IntAct; Q8WW22; 4.
DR STRING; 9606.ENSP00000378324; -.
DR PhosphoSite; Q8WW22; -.
DR DMDM; 27805462; -.
DR PaxDb; Q8WW22; -.
DR PRIDE; Q8WW22; -.
DR Ensembl; ENST00000343789; ENSP00000339581; ENSG00000140403.
DR Ensembl; ENST00000394852; ENSP00000378321; ENSG00000140403.
DR Ensembl; ENST00000394855; ENSP00000378324; ENSG00000140403.
DR Ensembl; ENST00000446172; ENSP00000413499; ENSG00000140403.
DR GeneID; 55466; -.
DR KEGG; hsa:55466; -.
DR UCSC; uc002bdk.3; human.
DR CTD; 55466; -.
DR GeneCards; GC15P078556; -.
DR HGNC; HGNC:14885; DNAJA4.
DR HPA; CAB004646; -.
DR neXtProt; NX_Q8WW22; -.
DR PharmGKB; PA27411; -.
DR eggNOG; COG0484; -.
DR HOGENOM; HOG000226718; -.
DR HOVERGEN; HBG066727; -.
DR InParanoid; Q8WW22; -.
DR KO; K09505; -.
DR OMA; CVRDEGM; -.
DR OrthoDB; EOG7XM2XK; -.
DR PhylomeDB; Q8WW22; -.
DR ChiTaRS; DNAJA4; human.
DR GenomeRNAi; 55466; -.
DR NextBio; 59854; -.
DR PRO; PR:Q8WW22; -.
DR ArrayExpress; Q8WW22; -.
DR Bgee; Q8WW22; -.
DR CleanEx; HS_DNAJA4; -.
DR Genevestigator; Q8WW22; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0009408; P:response to heat; IEA:InterPro.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 2.10.230.10; -; 1.
DR InterPro; IPR012724; DnaJ.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
DR Pfam; PF01556; CTDII; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00684; DnaJ_CXXCXGXG; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF49493; SSF49493; 3.
DR SUPFAM; SSF57938; SSF57938; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51188; ZF_CR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chaperone; Complete proteome; Lipoprotein;
KW Membrane; Metal-binding; Methylation; Polymorphism; Prenylation;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1 394 DnaJ homolog subfamily A member 4.
FT /FTId=PRO_0000071014.
FT PROPEP 395 397 Removed in mature form (By similarity).
FT /FTId=PRO_0000396760.
FT DOMAIN 4 70 J.
FT REPEAT 135 142 CXXCXGXG motif.
FT REPEAT 151 158 CXXCXGXG motif.
FT REPEAT 178 185 CXXCXGXG motif.
FT REPEAT 194 201 CXXCXGXG motif.
FT ZN_FING 122 206 CR-type.
FT COMPBIAS 75 96 Gly-rich.
FT METAL 135 135 Zinc 1 (By similarity).
FT METAL 138 138 Zinc 1 (By similarity).
FT METAL 151 151 Zinc 2 (By similarity).
FT METAL 154 154 Zinc 2 (By similarity).
FT METAL 178 178 Zinc 2 (By similarity).
FT METAL 181 181 Zinc 2 (By similarity).
FT METAL 194 194 Zinc 1 (By similarity).
FT METAL 197 197 Zinc 1 (By similarity).
FT MOD_RES 394 394 Cysteine methyl ester (By similarity).
FT LIPID 394 394 S-farnesyl cysteine (By similarity).
FT VAR_SEQ 1 44 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE
FT GEK -> MWESLTLDSGQISALTR (in isoform 3).
FT /FTId=VSP_045696.
FT VAR_SEQ 1 1 M -> MARGGSQSWSSGESDGQPKEQTPEKPRHKM (in
FT isoform 2).
FT /FTId=VSP_038965.
FT VARIANT 226 226 H -> R (in dbSNP:rs17852881).
FT /FTId=VAR_069064.
FT CONFLICT 33 33 Y -> C (in Ref. 1; BAC05229).
SQ SEQUENCE 397 AA; 44798 MW; 60D6AAD12C9B2529 CRC64;
MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ AYEVLSDPKK
RDVYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMA RERRGKNVVH QLSVTLEDLY
NGVTKKLALQ KNVICEKCEG VGGKKGSVEK CPLCKGRGMQ IHIQQIGPGM VQQIQTVCIE
CKGQGERINP KDRCESCSGA KVIREKKIIE VHVEKGMKDG QKILFHGEGD QEPELEPGDV
IIVLDQKDHS VFQRRGHDLI MKMKIQLSEA LCGFKKTIKT LDNRILVITS KAGEVIKHGD
LRCVRDEGMP IYKAPLEKGI LIIQFLVIFP EKHWLSLEKL PQLEALLPPR QKVRITDDMD
QVELKEFCPN EQNWRQHREA YEEDEDGPQA GVQCQTA
//