Full text data of DNAJB4
DNAJB4
(DNAJW, HLJ1)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein)
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein)
UniProt
Q9UDY4
ID DNJB4_HUMAN Reviewed; 337 AA.
AC Q9UDY4; B2R824; Q13431;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2000, sequence version 1.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=DnaJ homolog subfamily B member 4;
DE AltName: Full=Heat shock 40 kDa protein 1 homolog;
DE Short=HSP40 homolog;
DE Short=Heat shock protein 40 homolog;
DE AltName: Full=Human liver DnaJ-like protein;
GN Name=DNAJB4; Synonyms=DNAJW, HLJ1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=9546042; DOI=10.1016/S0167-4838(97)00207-0;
RA Hoe K.L., Won M., Chung K.S., Jang Y.J., Lee S.B., Kim D.U., Lee J.W.,
RA Yun J.H., Yoo H.S.;
RT "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40)
RT from human liver.";
RL Biochim. Biophys. Acta 1383:4-8(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RA Won M., Moon K.-M., Lee C.-E., Yoo H.-S.;
RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PROTEIN SEQUENCE OF 2-13; 45-59; 166-177; 219-236; 260-275 AND
RP 293-302, CLEAVAGE OF INITIATOR METHIONINE, LACK OF N-TERMINAL
RP ACETYLATION, AND MASS SPECTROMETRY.
RC TISSUE=Embryonic kidney;
RA Bienvenut W.V., Waridel P., Quadroni M.;
RL Submitted (MAR-2009) to UniProtKB.
RN [7]
RP HOMODIMERIZATION.
RX PubMed=15661747; DOI=10.1074/jbc.M408349200;
RA Borges J.C., Fischer H., Craievich A.F., Ramos C.H.I.;
RT "Low resolution structural study of two human HSP40 chaperones in
RT solution. DJA1 from subfamily A and DJB4 from subfamily B have
RT different quaternary structures.";
RL J. Biol. Chem. 280:13671-13681(2005).
RN [8]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH OPRM1.
RX PubMed=16542645; DOI=10.1016/j.brainres.2006.01.125;
RA Ancevska-Taneva N., Onoprishvili I., Andria M.L., Hiller J.M.,
RA Simon E.J.;
RT "A member of the heat shock protein 40 family, hlj1, binds to the
RT carboxyl tail of the human mu opioid receptor.";
RL Brain Res. 1081:28-33(2006).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=18837411;
RA Lin X., Ma L., Wang J., Tan Y., Wen Q., Luo W., Su J., Lin Y.,
RA Wang X.;
RT "Preparation of the anti-HLJ1 monoclonal antibodies and establishment
RT of method for detection of the antigen.";
RL Sheng Wu Gong Cheng Xue Bao 24:1293-1299(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-148, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP INTERACTION WITH SDIM1.
RX PubMed=21255413; DOI=10.1186/1750-1326-6-9;
RA Lei J.X., Cassone C.G., Luebbert C., Liu Q.Y.;
RT "A novel neuron-enriched protein SDIM1 is down regulated in
RT Alzheimer's brains and attenuates cell death induced by DNAJB4 over-
RT expression in neuro-progenitor cells.";
RL Mol. Neurodegener. 6:9-9(2011).
CC -!- FUNCTION: Probable chaperone.
CC -!- SUBUNIT: Homodimer. The C-terminal section interacts with the C-
CC terminal tail of OPRM1. Interacts also with SDIM1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Cytoplasmic
CC according to PubMed:18837411 and membrane-associated according to
CC PubMed:16542645.
CC -!- TISSUE SPECIFICITY: Expressed in heart, pancreas and skeletal
CC muscle, and to a lesser extent in brain, placenta and liver.
CC -!- INDUCTION: By heat shock.
CC -!- SIMILARITY: Contains 1 J domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U40992; AAC14483.2; -; mRNA.
DR EMBL; AK313205; BAG36021.1; -; mRNA.
DR EMBL; CH471059; EAX06354.1; -; Genomic_DNA.
DR EMBL; BC034721; AAH34721.1; -; mRNA.
DR EMBL; U41290; AAB07346.1; ALT_FRAME; Genomic_DNA.
DR PIR; G02272; G02272.
DR RefSeq; NP_008965.2; NM_007034.3.
DR UniGene; Hs.13852; -.
DR ProteinModelPortal; Q9UDY4; -.
DR SMR; Q9UDY4; 1-74, 155-335.
DR IntAct; Q9UDY4; 8.
DR MINT; MINT-1142940; -.
DR STRING; 9606.ENSP00000359799; -.
DR PhosphoSite; Q9UDY4; -.
DR DMDM; 8928155; -.
DR PaxDb; Q9UDY4; -.
DR PRIDE; Q9UDY4; -.
DR DNASU; 11080; -.
DR Ensembl; ENST00000370763; ENSP00000359799; ENSG00000162616.
DR GeneID; 11080; -.
DR KEGG; hsa:11080; -.
DR UCSC; uc001dij.3; human.
DR CTD; 11080; -.
DR GeneCards; GC01P078444; -.
DR HGNC; HGNC:14886; DNAJB4.
DR HPA; CAB004995; -.
DR HPA; HPA028383; -.
DR HPA; HPA028385; -.
DR MIM; 611327; gene.
DR neXtProt; NX_Q9UDY4; -.
DR PharmGKB; PA27416; -.
DR eggNOG; COG2214; -.
DR HOVERGEN; HBG066727; -.
DR InParanoid; Q9UDY4; -.
DR KO; K09510; -.
DR OMA; YYHILGI; -.
DR PhylomeDB; Q9UDY4; -.
DR GeneWiki; DNAJB4; -.
DR GenomeRNAi; 11080; -.
DR NextBio; 42126; -.
DR PRO; PR:Q9UDY4; -.
DR ArrayExpress; Q9UDY4; -.
DR Bgee; Q9UDY4; -.
DR CleanEx; HS_DNAJB4; -.
DR Genevestigator; Q9UDY4; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0051082; F:unfolded protein binding; TAS:ProtInc.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0009408; P:response to heat; TAS:ProtInc.
DR GO; GO:0006986; P:response to unfolded protein; TAS:ProtInc.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR Pfam; PF01556; CTDII; 1.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF49493; SSF49493; 2.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chaperone; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Membrane; Phosphoprotein;
KW Reference proteome; Stress response.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 337 DnaJ homolog subfamily B member 4.
FT /FTId=PRO_0000071021.
FT DOMAIN 2 70 J.
FT MOD_RES 122 122 Phosphoserine.
FT MOD_RES 148 148 Phosphoserine.
SQ SEQUENCE 337 AA; 37807 MW; C7A9C613F73BCDAC CRC64;
MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE AYEVLSDPKK
REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA FFGGSNPFEI FFGRRMGGGR
DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG PSRLKQDPPV IHELRVSLEE IYSGCTKRMK
ISRKRLNADG RSYRSEDKIL TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH
PKFKRDGSNI IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF
PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS
//
ID DNJB4_HUMAN Reviewed; 337 AA.
AC Q9UDY4; B2R824; Q13431;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2000, sequence version 1.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=DnaJ homolog subfamily B member 4;
DE AltName: Full=Heat shock 40 kDa protein 1 homolog;
DE Short=HSP40 homolog;
DE Short=Heat shock protein 40 homolog;
DE AltName: Full=Human liver DnaJ-like protein;
GN Name=DNAJB4; Synonyms=DNAJW, HLJ1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=9546042; DOI=10.1016/S0167-4838(97)00207-0;
RA Hoe K.L., Won M., Chung K.S., Jang Y.J., Lee S.B., Kim D.U., Lee J.W.,
RA Yun J.H., Yoo H.S.;
RT "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40)
RT from human liver.";
RL Biochim. Biophys. Acta 1383:4-8(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RA Won M., Moon K.-M., Lee C.-E., Yoo H.-S.;
RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PROTEIN SEQUENCE OF 2-13; 45-59; 166-177; 219-236; 260-275 AND
RP 293-302, CLEAVAGE OF INITIATOR METHIONINE, LACK OF N-TERMINAL
RP ACETYLATION, AND MASS SPECTROMETRY.
RC TISSUE=Embryonic kidney;
RA Bienvenut W.V., Waridel P., Quadroni M.;
RL Submitted (MAR-2009) to UniProtKB.
RN [7]
RP HOMODIMERIZATION.
RX PubMed=15661747; DOI=10.1074/jbc.M408349200;
RA Borges J.C., Fischer H., Craievich A.F., Ramos C.H.I.;
RT "Low resolution structural study of two human HSP40 chaperones in
RT solution. DJA1 from subfamily A and DJB4 from subfamily B have
RT different quaternary structures.";
RL J. Biol. Chem. 280:13671-13681(2005).
RN [8]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH OPRM1.
RX PubMed=16542645; DOI=10.1016/j.brainres.2006.01.125;
RA Ancevska-Taneva N., Onoprishvili I., Andria M.L., Hiller J.M.,
RA Simon E.J.;
RT "A member of the heat shock protein 40 family, hlj1, binds to the
RT carboxyl tail of the human mu opioid receptor.";
RL Brain Res. 1081:28-33(2006).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=18837411;
RA Lin X., Ma L., Wang J., Tan Y., Wen Q., Luo W., Su J., Lin Y.,
RA Wang X.;
RT "Preparation of the anti-HLJ1 monoclonal antibodies and establishment
RT of method for detection of the antigen.";
RL Sheng Wu Gong Cheng Xue Bao 24:1293-1299(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-148, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP INTERACTION WITH SDIM1.
RX PubMed=21255413; DOI=10.1186/1750-1326-6-9;
RA Lei J.X., Cassone C.G., Luebbert C., Liu Q.Y.;
RT "A novel neuron-enriched protein SDIM1 is down regulated in
RT Alzheimer's brains and attenuates cell death induced by DNAJB4 over-
RT expression in neuro-progenitor cells.";
RL Mol. Neurodegener. 6:9-9(2011).
CC -!- FUNCTION: Probable chaperone.
CC -!- SUBUNIT: Homodimer. The C-terminal section interacts with the C-
CC terminal tail of OPRM1. Interacts also with SDIM1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Cytoplasmic
CC according to PubMed:18837411 and membrane-associated according to
CC PubMed:16542645.
CC -!- TISSUE SPECIFICITY: Expressed in heart, pancreas and skeletal
CC muscle, and to a lesser extent in brain, placenta and liver.
CC -!- INDUCTION: By heat shock.
CC -!- SIMILARITY: Contains 1 J domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U40992; AAC14483.2; -; mRNA.
DR EMBL; AK313205; BAG36021.1; -; mRNA.
DR EMBL; CH471059; EAX06354.1; -; Genomic_DNA.
DR EMBL; BC034721; AAH34721.1; -; mRNA.
DR EMBL; U41290; AAB07346.1; ALT_FRAME; Genomic_DNA.
DR PIR; G02272; G02272.
DR RefSeq; NP_008965.2; NM_007034.3.
DR UniGene; Hs.13852; -.
DR ProteinModelPortal; Q9UDY4; -.
DR SMR; Q9UDY4; 1-74, 155-335.
DR IntAct; Q9UDY4; 8.
DR MINT; MINT-1142940; -.
DR STRING; 9606.ENSP00000359799; -.
DR PhosphoSite; Q9UDY4; -.
DR DMDM; 8928155; -.
DR PaxDb; Q9UDY4; -.
DR PRIDE; Q9UDY4; -.
DR DNASU; 11080; -.
DR Ensembl; ENST00000370763; ENSP00000359799; ENSG00000162616.
DR GeneID; 11080; -.
DR KEGG; hsa:11080; -.
DR UCSC; uc001dij.3; human.
DR CTD; 11080; -.
DR GeneCards; GC01P078444; -.
DR HGNC; HGNC:14886; DNAJB4.
DR HPA; CAB004995; -.
DR HPA; HPA028383; -.
DR HPA; HPA028385; -.
DR MIM; 611327; gene.
DR neXtProt; NX_Q9UDY4; -.
DR PharmGKB; PA27416; -.
DR eggNOG; COG2214; -.
DR HOVERGEN; HBG066727; -.
DR InParanoid; Q9UDY4; -.
DR KO; K09510; -.
DR OMA; YYHILGI; -.
DR PhylomeDB; Q9UDY4; -.
DR GeneWiki; DNAJB4; -.
DR GenomeRNAi; 11080; -.
DR NextBio; 42126; -.
DR PRO; PR:Q9UDY4; -.
DR ArrayExpress; Q9UDY4; -.
DR Bgee; Q9UDY4; -.
DR CleanEx; HS_DNAJB4; -.
DR Genevestigator; Q9UDY4; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0051082; F:unfolded protein binding; TAS:ProtInc.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0009408; P:response to heat; TAS:ProtInc.
DR GO; GO:0006986; P:response to unfolded protein; TAS:ProtInc.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR Pfam; PF01556; CTDII; 1.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF49493; SSF49493; 2.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chaperone; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Membrane; Phosphoprotein;
KW Reference proteome; Stress response.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 337 DnaJ homolog subfamily B member 4.
FT /FTId=PRO_0000071021.
FT DOMAIN 2 70 J.
FT MOD_RES 122 122 Phosphoserine.
FT MOD_RES 148 148 Phosphoserine.
SQ SEQUENCE 337 AA; 37807 MW; C7A9C613F73BCDAC CRC64;
MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE AYEVLSDPKK
REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA FFGGSNPFEI FFGRRMGGGR
DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG PSRLKQDPPV IHELRVSLEE IYSGCTKRMK
ISRKRLNADG RSYRSEDKIL TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH
PKFKRDGSNI IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF
PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS
//
MIM
611327
*RECORD*
*FIELD* NO
611327
*FIELD* TI
*611327 DNAJ/HSP40 HOMOLOG, SUBFAMILY B, MEMBER 4; DNAJB4
;;HUMAN LIVER DNAJ-LIKE; HLJ1
read more*FIELD* TX
DESCRIPTION
DNAJB4 belongs to the evolutionarily conserved DNAJ/HSP40 protein
family. For background information on the DNAJ family, see 608375.
CLONING
Using the G protein beta subunit (GNB1; 139380) as bait in a yeast
2-hybrid screen of a liver cDNA library, Hoe et al. (1998) cloned
DNAJB4, which they called HLJ1. The deduced 337-amino acid protein
contains an N-terminal J domain and a glycine and phenylalanine
(G/F)-rich region. It shares 84% sequence similarity with DNAJB1
(604572). Northern blot analysis detected high expression in skeletal
muscle, heart, and pancreas, and lower expression in brain, placenta,
and liver.
GENE FUNCTION
By Northern blot analysis, Hoe et al. (1998) demonstrated that the
expression of DNAJB4 increased following heat-shock treatment in human
liver and pancreas carcinoma cell lines.
MAPPING
Hartz (2007) mapped the DNAJB4 gene to chromosome 1p31.1 based on an
alignment of the DNAJB4 sequence (GenBank GENBANK U40992) with the
genomic sequence (build 36.1).
*FIELD* RF
1. Hartz, P. A.: Personal Communication. Baltimore, Md. 6/28/2007.
2. Hoe, K.-L.; Won, M.; Chung, K.-S.; Jang, Y.-J.; Lee, S. B.; Kim,
D.-U.; Lee, J.-W.; Yun, J.-H.; Yoo, H.-S.: Isolation of a new member
of DnaJ-like heat shock protein 40 (Hsp40) from human liver. Biochim.
Biophys. Acta 1383: 4-8, 1998.
*FIELD* CD
Patricia A. Hartz: 8/16/2007
*FIELD* ED
carol: 08/16/2007
carol: 8/16/2007
*RECORD*
*FIELD* NO
611327
*FIELD* TI
*611327 DNAJ/HSP40 HOMOLOG, SUBFAMILY B, MEMBER 4; DNAJB4
;;HUMAN LIVER DNAJ-LIKE; HLJ1
read more*FIELD* TX
DESCRIPTION
DNAJB4 belongs to the evolutionarily conserved DNAJ/HSP40 protein
family. For background information on the DNAJ family, see 608375.
CLONING
Using the G protein beta subunit (GNB1; 139380) as bait in a yeast
2-hybrid screen of a liver cDNA library, Hoe et al. (1998) cloned
DNAJB4, which they called HLJ1. The deduced 337-amino acid protein
contains an N-terminal J domain and a glycine and phenylalanine
(G/F)-rich region. It shares 84% sequence similarity with DNAJB1
(604572). Northern blot analysis detected high expression in skeletal
muscle, heart, and pancreas, and lower expression in brain, placenta,
and liver.
GENE FUNCTION
By Northern blot analysis, Hoe et al. (1998) demonstrated that the
expression of DNAJB4 increased following heat-shock treatment in human
liver and pancreas carcinoma cell lines.
MAPPING
Hartz (2007) mapped the DNAJB4 gene to chromosome 1p31.1 based on an
alignment of the DNAJB4 sequence (GenBank GENBANK U40992) with the
genomic sequence (build 36.1).
*FIELD* RF
1. Hartz, P. A.: Personal Communication. Baltimore, Md. 6/28/2007.
2. Hoe, K.-L.; Won, M.; Chung, K.-S.; Jang, Y.-J.; Lee, S. B.; Kim,
D.-U.; Lee, J.-W.; Yun, J.-H.; Yoo, H.-S.: Isolation of a new member
of DnaJ-like heat shock protein 40 (Hsp40) from human liver. Biochim.
Biophys. Acta 1383: 4-8, 1998.
*FIELD* CD
Patricia A. Hartz: 8/16/2007
*FIELD* ED
carol: 08/16/2007
carol: 8/16/2007