Full text data of DHRS7B
DHRS7B
[Confidence: high (present in two of the MS resources)]
Dehydrogenase/reductase SDR family member 7B; 1.1.-.-
Dehydrogenase/reductase SDR family member 7B; 1.1.-.-
UniProt
Q6IAN0
ID DRS7B_HUMAN Reviewed; 325 AA.
AC Q6IAN0; B5MEF4; Q6UX59; Q9BTF9; Q9UFM6; Q9Y3A1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 04-DEC-2007, sequence version 2.
DT 22-JAN-2014, entry version 81.
DE RecName: Full=Dehydrogenase/reductase SDR family member 7B;
DE EC=1.1.-.-;
GN Name=DHRS7B; ORFNames=CGI-93, UNQ212/PRO238;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-325.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Putative oxidoreductase (Potential).
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass type II
CC membrane protein (Potential).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266;
CC Sequence=AAQ88862.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151851; AAD34088.1; ALT_FRAME; mRNA.
DR EMBL; AL117567; CAB55997.1; -; mRNA.
DR EMBL; CR457124; CAG33405.1; -; mRNA.
DR EMBL; AC087393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471210; EAX02596.1; -; Genomic_DNA.
DR EMBL; BC004126; AAH04126.1; -; mRNA.
DR EMBL; BC009679; AAH09679.1; -; mRNA.
DR EMBL; AY358498; AAQ88862.1; ALT_INIT; mRNA.
DR PIR; T17307; T17307.
DR RefSeq; NP_056325.2; NM_015510.4.
DR RefSeq; XP_005256653.1; XM_005256596.1.
DR UniGene; Hs.386989; -.
DR ProteinModelPortal; Q6IAN0; -.
DR SMR; Q6IAN0; 50-265.
DR IntAct; Q6IAN0; 4.
DR MINT; MINT-4901734; -.
DR STRING; 9606.ENSP00000378887; -.
DR PhosphoSite; Q6IAN0; -.
DR DMDM; 162416270; -.
DR PaxDb; Q6IAN0; -.
DR PRIDE; Q6IAN0; -.
DR Ensembl; ENST00000395511; ENSP00000378887; ENSG00000109016.
DR Ensembl; ENST00000579303; ENSP00000468585; ENSG00000109016.
DR GeneID; 25979; -.
DR KEGG; hsa:25979; -.
DR UCSC; uc002gyo.3; human.
DR CTD; 25979; -.
DR GeneCards; GC17P021531; -.
DR H-InvDB; HIX0013628; -.
DR HGNC; HGNC:24547; DHRS7B.
DR HPA; HPA012132; -.
DR HPA; HPA016873; -.
DR neXtProt; NX_Q6IAN0; -.
DR PharmGKB; PA142671976; -.
DR eggNOG; COG1028; -.
DR HOVERGEN; HBG107825; -.
DR InParanoid; Q6IAN0; -.
DR KO; K11166; -.
DR OMA; VQTHKPH; -.
DR PhylomeDB; Q6IAN0; -.
DR ChiTaRS; DHRS7B; human.
DR GeneWiki; DHRS7B; -.
DR GenomeRNAi; 25979; -.
DR NextBio; 47634; -.
DR PRO; PR:Q6IAN0; -.
DR ArrayExpress; Q6IAN0; -.
DR Bgee; Q6IAN0; -.
DR CleanEx; HS_DHRS7B; -.
DR Genevestigator; Q6IAN0; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR002347; Glc/ribitol_DH.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR Pfam; PF00106; adh_short; 1.
DR PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; NAD; NADP; Oxidoreductase; Peroxisome;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 325 Dehydrogenase/reductase SDR family member
FT 7B.
FT /FTId=PRO_0000312105.
FT TOPO_DOM 1 17 Cytoplasmic (Potential).
FT TRANSMEM 18 38 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 39 325 Peroxisomal (Potential).
FT NP_BIND 56 80 NAD or NADP (By similarity).
FT ACT_SITE 207 207 Proton acceptor (By similarity).
FT BINDING 194 194 Substrate (Potential).
FT CONFLICT 210 210 S -> P (in Ref. 2; CAB55997).
FT CONFLICT 256 256 Y -> C (in Ref. 2; CAB55997).
FT CONFLICT 312 312 M -> T (in Ref. 3; CAG33405).
SQ SEQUENCE 325 AA; 35119 MW; 18F4A4C40D3B95CE CRC64;
MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA
TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG
AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS
MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI
HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
RTLAPGLFFS LMASRARKER KSKNS
//
ID DRS7B_HUMAN Reviewed; 325 AA.
AC Q6IAN0; B5MEF4; Q6UX59; Q9BTF9; Q9UFM6; Q9Y3A1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 04-DEC-2007, sequence version 2.
DT 22-JAN-2014, entry version 81.
DE RecName: Full=Dehydrogenase/reductase SDR family member 7B;
DE EC=1.1.-.-;
GN Name=DHRS7B; ORFNames=CGI-93, UNQ212/PRO238;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-325.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Putative oxidoreductase (Potential).
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass type II
CC membrane protein (Potential).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266;
CC Sequence=AAQ88862.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151851; AAD34088.1; ALT_FRAME; mRNA.
DR EMBL; AL117567; CAB55997.1; -; mRNA.
DR EMBL; CR457124; CAG33405.1; -; mRNA.
DR EMBL; AC087393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471210; EAX02596.1; -; Genomic_DNA.
DR EMBL; BC004126; AAH04126.1; -; mRNA.
DR EMBL; BC009679; AAH09679.1; -; mRNA.
DR EMBL; AY358498; AAQ88862.1; ALT_INIT; mRNA.
DR PIR; T17307; T17307.
DR RefSeq; NP_056325.2; NM_015510.4.
DR RefSeq; XP_005256653.1; XM_005256596.1.
DR UniGene; Hs.386989; -.
DR ProteinModelPortal; Q6IAN0; -.
DR SMR; Q6IAN0; 50-265.
DR IntAct; Q6IAN0; 4.
DR MINT; MINT-4901734; -.
DR STRING; 9606.ENSP00000378887; -.
DR PhosphoSite; Q6IAN0; -.
DR DMDM; 162416270; -.
DR PaxDb; Q6IAN0; -.
DR PRIDE; Q6IAN0; -.
DR Ensembl; ENST00000395511; ENSP00000378887; ENSG00000109016.
DR Ensembl; ENST00000579303; ENSP00000468585; ENSG00000109016.
DR GeneID; 25979; -.
DR KEGG; hsa:25979; -.
DR UCSC; uc002gyo.3; human.
DR CTD; 25979; -.
DR GeneCards; GC17P021531; -.
DR H-InvDB; HIX0013628; -.
DR HGNC; HGNC:24547; DHRS7B.
DR HPA; HPA012132; -.
DR HPA; HPA016873; -.
DR neXtProt; NX_Q6IAN0; -.
DR PharmGKB; PA142671976; -.
DR eggNOG; COG1028; -.
DR HOVERGEN; HBG107825; -.
DR InParanoid; Q6IAN0; -.
DR KO; K11166; -.
DR OMA; VQTHKPH; -.
DR PhylomeDB; Q6IAN0; -.
DR ChiTaRS; DHRS7B; human.
DR GeneWiki; DHRS7B; -.
DR GenomeRNAi; 25979; -.
DR NextBio; 47634; -.
DR PRO; PR:Q6IAN0; -.
DR ArrayExpress; Q6IAN0; -.
DR Bgee; Q6IAN0; -.
DR CleanEx; HS_DHRS7B; -.
DR Genevestigator; Q6IAN0; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR002347; Glc/ribitol_DH.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR Pfam; PF00106; adh_short; 1.
DR PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; NAD; NADP; Oxidoreductase; Peroxisome;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 325 Dehydrogenase/reductase SDR family member
FT 7B.
FT /FTId=PRO_0000312105.
FT TOPO_DOM 1 17 Cytoplasmic (Potential).
FT TRANSMEM 18 38 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 39 325 Peroxisomal (Potential).
FT NP_BIND 56 80 NAD or NADP (By similarity).
FT ACT_SITE 207 207 Proton acceptor (By similarity).
FT BINDING 194 194 Substrate (Potential).
FT CONFLICT 210 210 S -> P (in Ref. 2; CAB55997).
FT CONFLICT 256 256 Y -> C (in Ref. 2; CAB55997).
FT CONFLICT 312 312 M -> T (in Ref. 3; CAG33405).
SQ SEQUENCE 325 AA; 35119 MW; 18F4A4C40D3B95CE CRC64;
MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA
TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG
AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS
MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI
HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
RTLAPGLFFS LMASRARKER KSKNS
//