Full text data of EEPD1
EEPD1
(KIAA1706)
[Confidence: low (only semi-automatic identification from reviews)]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q7L9B9
ID EEPD1_HUMAN Reviewed; 569 AA.
AC Q7L9B9; Q96K64; Q9C0F7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 2.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1;
GN Name=EEPD1; Synonyms=KIAA1706;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-343.
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-343.
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-343.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-343.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-343.
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP MYRISTOYLATION AT GLY-2.
RX PubMed=20213681; DOI=10.1002/pmic.200900783;
RA Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,
RA Tsunasawa S., Utsumi T.;
RT "Strategy for comprehensive identification of human N-myristoylated
RT proteins using an insect cell-free protein synthesis system.";
RL Proteomics 10:1780-1793(2010).
CC -!- SIMILARITY: Contains 1 HhH domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21797.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB051493; BAB21797.1; ALT_INIT; mRNA.
DR EMBL; AK027386; BAB55076.1; -; mRNA.
DR EMBL; AC007327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC078841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236951; EAL23976.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW94063.1; -; Genomic_DNA.
DR EMBL; BC065518; AAH65518.1; -; mRNA.
DR RefSeq; NP_085139.2; NM_030636.2.
DR UniGene; Hs.487994; -.
DR UniGene; Hs.670591; -.
DR ProteinModelPortal; Q7L9B9; -.
DR STRING; 9606.ENSP00000242108; -.
DR PhosphoSite; Q7L9B9; -.
DR DMDM; 296434489; -.
DR PaxDb; Q7L9B9; -.
DR PeptideAtlas; Q7L9B9; -.
DR PRIDE; Q7L9B9; -.
DR Ensembl; ENST00000242108; ENSP00000242108; ENSG00000122547.
DR Ensembl; ENST00000534978; ENSP00000442692; ENSG00000122547.
DR GeneID; 80820; -.
DR KEGG; hsa:80820; -.
DR UCSC; uc003tfa.3; human.
DR CTD; 80820; -.
DR GeneCards; GC07P036192; -.
DR H-InvDB; HIX0006600; -.
DR HGNC; HGNC:22223; EEPD1.
DR neXtProt; NX_Q7L9B9; -.
DR PharmGKB; PA162384303; -.
DR eggNOG; COG1555; -.
DR HOGENOM; HOG000112330; -.
DR HOVERGEN; HBG100313; -.
DR InParanoid; Q7L9B9; -.
DR OMA; KFCAELN; -.
DR OrthoDB; EOG779NXK; -.
DR GenomeRNAi; 80820; -.
DR NextBio; 71220; -.
DR PRO; PR:Q7L9B9; -.
DR Bgee; Q7L9B9; -.
DR CleanEx; HS_EEPD1; -.
DR Genevestigator; Q7L9B9; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR004509; Competence_ComEA_HhH.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF56219; SSF56219; 1.
DR TIGRFAMs; TIGR00426; TIGR00426; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Lipoprotein; Myristate; Phosphoprotein;
KW Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 569 Endonuclease/exonuclease/phosphatase
FT family domain-containing protein 1.
FT /FTId=PRO_0000317261.
FT DOMAIN 38 67 HhH.
FT MOD_RES 25 25 Phosphoserine (By similarity).
FT MOD_RES 106 106 Phosphoserine (By similarity).
FT MOD_RES 110 110 Phosphoserine (By similarity).
FT MOD_RES 173 173 Phosphoserine (By similarity).
FT LIPID 2 2 N-myristoyl glycine.
FT VARIANT 343 343 S -> N (in dbSNP:rs196586).
FT /FTId=VAR_060374.
FT VARIANT 358 358 A -> S (in dbSNP:rs3815682).
FT /FTId=VAR_056867.
FT VARIANT 416 416 P -> S (in dbSNP:rs196594).
FT /FTId=VAR_056868.
SQ SEQUENCE 569 AA; 62403 MW; 6A1C1D106583E670 CRC64;
MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL MTLPGVTRAV
ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV SSKGSSAQHS PSSLRRDLLA
EQQPHHLATA VPLTPRVNIN TATPAQLMSV RGLSEKMALS IVDFRREHGP FRSVEDLVRM
DGINAAFLDR IRHQVFAERS RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ
IISTRPSVEA FGGTRDGRPV LRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
ELLDREALEK FCTELNQPTL PNIRKWKGPR GCWKAVVAEK PSSQLQKGAG YAGFLWDAAA
GMELRDAGSQ ESSPSNGHGK LAGPSPYLGR FKVGSHDLTL VNLHLAALTL LGSENPSKNH
SDGHRLASFA QTLQETLKGE KDVIILGDFG QGPDSNDYDI LRKEKFHHLI PAHTFTNIST
KNPQGSKSLD NIWISKSLKK VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAEFYT
EKDWSKKDAP RNGSGVALER SEANIKHER
//
ID EEPD1_HUMAN Reviewed; 569 AA.
AC Q7L9B9; Q96K64; Q9C0F7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 2.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1;
GN Name=EEPD1; Synonyms=KIAA1706;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-343.
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-343.
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-343.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-343.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-343.
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP MYRISTOYLATION AT GLY-2.
RX PubMed=20213681; DOI=10.1002/pmic.200900783;
RA Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,
RA Tsunasawa S., Utsumi T.;
RT "Strategy for comprehensive identification of human N-myristoylated
RT proteins using an insect cell-free protein synthesis system.";
RL Proteomics 10:1780-1793(2010).
CC -!- SIMILARITY: Contains 1 HhH domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21797.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB051493; BAB21797.1; ALT_INIT; mRNA.
DR EMBL; AK027386; BAB55076.1; -; mRNA.
DR EMBL; AC007327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC078841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236951; EAL23976.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW94063.1; -; Genomic_DNA.
DR EMBL; BC065518; AAH65518.1; -; mRNA.
DR RefSeq; NP_085139.2; NM_030636.2.
DR UniGene; Hs.487994; -.
DR UniGene; Hs.670591; -.
DR ProteinModelPortal; Q7L9B9; -.
DR STRING; 9606.ENSP00000242108; -.
DR PhosphoSite; Q7L9B9; -.
DR DMDM; 296434489; -.
DR PaxDb; Q7L9B9; -.
DR PeptideAtlas; Q7L9B9; -.
DR PRIDE; Q7L9B9; -.
DR Ensembl; ENST00000242108; ENSP00000242108; ENSG00000122547.
DR Ensembl; ENST00000534978; ENSP00000442692; ENSG00000122547.
DR GeneID; 80820; -.
DR KEGG; hsa:80820; -.
DR UCSC; uc003tfa.3; human.
DR CTD; 80820; -.
DR GeneCards; GC07P036192; -.
DR H-InvDB; HIX0006600; -.
DR HGNC; HGNC:22223; EEPD1.
DR neXtProt; NX_Q7L9B9; -.
DR PharmGKB; PA162384303; -.
DR eggNOG; COG1555; -.
DR HOGENOM; HOG000112330; -.
DR HOVERGEN; HBG100313; -.
DR InParanoid; Q7L9B9; -.
DR OMA; KFCAELN; -.
DR OrthoDB; EOG779NXK; -.
DR GenomeRNAi; 80820; -.
DR NextBio; 71220; -.
DR PRO; PR:Q7L9B9; -.
DR Bgee; Q7L9B9; -.
DR CleanEx; HS_EEPD1; -.
DR Genevestigator; Q7L9B9; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR004509; Competence_ComEA_HhH.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF56219; SSF56219; 1.
DR TIGRFAMs; TIGR00426; TIGR00426; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Lipoprotein; Myristate; Phosphoprotein;
KW Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 569 Endonuclease/exonuclease/phosphatase
FT family domain-containing protein 1.
FT /FTId=PRO_0000317261.
FT DOMAIN 38 67 HhH.
FT MOD_RES 25 25 Phosphoserine (By similarity).
FT MOD_RES 106 106 Phosphoserine (By similarity).
FT MOD_RES 110 110 Phosphoserine (By similarity).
FT MOD_RES 173 173 Phosphoserine (By similarity).
FT LIPID 2 2 N-myristoyl glycine.
FT VARIANT 343 343 S -> N (in dbSNP:rs196586).
FT /FTId=VAR_060374.
FT VARIANT 358 358 A -> S (in dbSNP:rs3815682).
FT /FTId=VAR_056867.
FT VARIANT 416 416 P -> S (in dbSNP:rs196594).
FT /FTId=VAR_056868.
SQ SEQUENCE 569 AA; 62403 MW; 6A1C1D106583E670 CRC64;
MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL MTLPGVTRAV
ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV SSKGSSAQHS PSSLRRDLLA
EQQPHHLATA VPLTPRVNIN TATPAQLMSV RGLSEKMALS IVDFRREHGP FRSVEDLVRM
DGINAAFLDR IRHQVFAERS RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ
IISTRPSVEA FGGTRDGRPV LRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
ELLDREALEK FCTELNQPTL PNIRKWKGPR GCWKAVVAEK PSSQLQKGAG YAGFLWDAAA
GMELRDAGSQ ESSPSNGHGK LAGPSPYLGR FKVGSHDLTL VNLHLAALTL LGSENPSKNH
SDGHRLASFA QTLQETLKGE KDVIILGDFG QGPDSNDYDI LRKEKFHHLI PAHTFTNIST
KNPQGSKSLD NIWISKSLKK VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAEFYT
EKDWSKKDAP RNGSGVALER SEANIKHER
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