Full text data of FAM184A
FAM184A
(C6orf60)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Protein FAM184A
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein FAM184A
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00413868
IPI00413868 Splice isoform 1 of Q8NB25 Hypothetical protein C6orf60 Splice isoform 1 of Q8NB25 Hypothetical protein C6orf60 membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a not mentioned ADFNKTNELLK (identified at least 3 times) found at its expected molecular weight found at molecular weight
IPI00413868 Splice isoform 1 of Q8NB25 Hypothetical protein C6orf60 Splice isoform 1 of Q8NB25 Hypothetical protein C6orf60 membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a not mentioned ADFNKTNELLK (identified at least 3 times) found at its expected molecular weight found at molecular weight
UniProt
Q8NB25
ID F184A_HUMAN Reviewed; 1140 AA.
AC Q8NB25; B9DI75; F8W8D6; Q5TBS9; Q7Z323; Q96GY8; Q9H0J8; Q9H851;
read moreDT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 22-JAN-2014, entry version 88.
DE RecName: Full=Protein FAM184A;
GN Name=FAM184A; Synonyms=C6orf60;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NB25-1; Sequence=Displayed;
CC Note=No experimental confirmation available;
CC Name=2;
CC IsoId=Q8NB25-2; Sequence=VSP_007446, VSP_007447;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q8NB25-3; Sequence=VSP_039102, VSP_039103;
CC Name=4;
CC IsoId=Q8NB25-4; Sequence=VSP_044520, VSP_007446;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the FAM184 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14769.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAC03719.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; BX538186; CAD98058.1; -; mRNA.
DR EMBL; AL137009; CAI20344.1; -; Genomic_DNA.
DR EMBL; AL132874; CAI20344.1; JOINED; Genomic_DNA.
DR EMBL; AL365275; CAI20344.1; JOINED; Genomic_DNA.
DR EMBL; AL365275; CAI40383.1; -; Genomic_DNA.
DR EMBL; AL132874; CAI40383.1; JOINED; Genomic_DNA.
DR EMBL; AL137009; CAI40383.1; JOINED; Genomic_DNA.
DR EMBL; AL132874; CAX30830.1; -; Genomic_DNA.
DR EMBL; AL137009; CAX30830.1; JOINED; Genomic_DNA.
DR EMBL; AL365275; CAX30830.1; JOINED; Genomic_DNA.
DR EMBL; CH471051; EAW48188.1; -; Genomic_DNA.
DR EMBL; AK024004; BAB14769.1; ALT_INIT; mRNA.
DR EMBL; AK091682; BAC03719.1; ALT_INIT; mRNA.
DR EMBL; BC009055; AAH09055.2; -; mRNA.
DR EMBL; AL136767; CAB66701.1; -; mRNA.
DR RefSeq; NP_001093881.1; NM_001100411.1.
DR RefSeq; NP_078857.5; NM_024581.4.
DR RefSeq; XP_005267200.1; XM_005267143.1.
DR UniGene; Hs.443789; -.
DR ProteinModelPortal; Q8NB25; -.
DR MINT; MINT-4712612; -.
DR PhosphoSite; Q8NB25; -.
DR DMDM; 209572754; -.
DR PaxDb; Q8NB25; -.
DR PRIDE; Q8NB25; -.
DR DNASU; 79632; -.
DR Ensembl; ENST00000338891; ENSP00000342604; ENSG00000111879.
DR Ensembl; ENST00000352896; ENSP00000326608; ENSG00000111879.
DR Ensembl; ENST00000521531; ENSP00000430442; ENSG00000111879.
DR GeneID; 79632; -.
DR KEGG; hsa:79632; -.
DR UCSC; uc003pyj.3; human.
DR CTD; 79632; -.
DR GeneCards; GC06M119280; -.
DR HGNC; HGNC:20991; FAM184A.
DR HPA; HPA034571; -.
DR neXtProt; NX_Q8NB25; -.
DR PharmGKB; PA164719768; -.
DR eggNOG; NOG138283; -.
DR HOGENOM; HOG000090031; -.
DR HOVERGEN; HBG050909; -.
DR InParanoid; Q8NB25; -.
DR OMA; RQQHEET; -.
DR OrthoDB; EOG7JQBMM; -.
DR ChiTaRS; FAM184A; human.
DR GenomeRNAi; 79632; -.
DR NextBio; 68735; -.
DR PRO; PR:Q8NB25; -.
DR ArrayExpress; Q8NB25; -.
DR Bgee; Q8NB25; -.
DR CleanEx; HS_FAM184A; -.
DR Genevestigator; Q8NB25; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 1140 Protein FAM184A.
FT /FTId=PRO_0000089512.
FT COILED 57 256 Potential.
FT COILED 296 800 Potential.
FT COILED 868 907 Potential.
FT VAR_SEQ 1 120 Missing (in isoform 4).
FT /FTId=VSP_044520.
FT VAR_SEQ 924 972 Missing (in isoform 2 and isoform 4).
FT /FTId=VSP_007446.
FT VAR_SEQ 1012 1046 Missing (in isoform 2).
FT /FTId=VSP_007447.
FT VAR_SEQ 1114 1116 SPA -> RYQ (in isoform 3).
FT /FTId=VSP_039102.
FT VAR_SEQ 1117 1140 Missing (in isoform 3).
FT /FTId=VSP_039103.
FT VARIANT 174 174 Q -> H (in dbSNP:rs34681930).
FT /FTId=VAR_054101.
FT VARIANT 177 177 V -> G (in dbSNP:rs34977570).
FT /FTId=VAR_054102.
FT VARIANT 599 599 D -> N (in dbSNP:rs17827619).
FT /FTId=VAR_054103.
FT CONFLICT 546 546 N -> D (in Ref. 1; CAD98058).
FT CONFLICT 620 620 Missing (in Ref. 4; BAC03719).
FT CONFLICT 739 739 Q -> R (in Ref. 4; BAC03719).
FT CONFLICT 795 795 F -> L (in Ref. 1; CAD98058).
FT CONFLICT 882 882 H -> R (in Ref. 1; CAD98058).
SQ SEQUENCE 1140 AA; 132965 MW; 6565FD0C349B37E1 CRC64;
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ LTKVIYALNT
KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE ELDLRRKIQV LESSLEDHIK
MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR IVTMSREVEE IRRKFEEKLR SFGQLQVQFE
KDKRLALEDL QAAHRREIQE LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE
RKKLIEDYEG KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG EMALLSKHKE
VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI KDLESEKSRV NERLSQLEEE
RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK RTQQEYYERE LKNLQSRLEE EVTQLNEAHS
KTLEELAWKH HMAIEAVHSN AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV
LEDKLNTANQ EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS KLREELRLQH
EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL KQNLEIQLSQ SQTSLQQLQA
QFTQERQRLT QELEELEEQH QQRHKSLKEA HVLAFQTMEE EKEKEQRALE NHLQQKHSAE
LQSLKDAHRE SMEGFRIEME QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH
HQELAAAKME LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI MRADFNKTNE
LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML TERDQIIKKL IEDNKFYQLE
LVNRETNFNK VFNSSPTVGV INPLAKQKKK NDKSPTNRFV SVPNLSALES GGVGNGHPNR
LDPIPNSPVH DIEFNSSKPL PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF
//
ID F184A_HUMAN Reviewed; 1140 AA.
AC Q8NB25; B9DI75; F8W8D6; Q5TBS9; Q7Z323; Q96GY8; Q9H0J8; Q9H851;
read moreDT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 22-JAN-2014, entry version 88.
DE RecName: Full=Protein FAM184A;
GN Name=FAM184A; Synonyms=C6orf60;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NB25-1; Sequence=Displayed;
CC Note=No experimental confirmation available;
CC Name=2;
CC IsoId=Q8NB25-2; Sequence=VSP_007446, VSP_007447;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q8NB25-3; Sequence=VSP_039102, VSP_039103;
CC Name=4;
CC IsoId=Q8NB25-4; Sequence=VSP_044520, VSP_007446;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the FAM184 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14769.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAC03719.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; BX538186; CAD98058.1; -; mRNA.
DR EMBL; AL137009; CAI20344.1; -; Genomic_DNA.
DR EMBL; AL132874; CAI20344.1; JOINED; Genomic_DNA.
DR EMBL; AL365275; CAI20344.1; JOINED; Genomic_DNA.
DR EMBL; AL365275; CAI40383.1; -; Genomic_DNA.
DR EMBL; AL132874; CAI40383.1; JOINED; Genomic_DNA.
DR EMBL; AL137009; CAI40383.1; JOINED; Genomic_DNA.
DR EMBL; AL132874; CAX30830.1; -; Genomic_DNA.
DR EMBL; AL137009; CAX30830.1; JOINED; Genomic_DNA.
DR EMBL; AL365275; CAX30830.1; JOINED; Genomic_DNA.
DR EMBL; CH471051; EAW48188.1; -; Genomic_DNA.
DR EMBL; AK024004; BAB14769.1; ALT_INIT; mRNA.
DR EMBL; AK091682; BAC03719.1; ALT_INIT; mRNA.
DR EMBL; BC009055; AAH09055.2; -; mRNA.
DR EMBL; AL136767; CAB66701.1; -; mRNA.
DR RefSeq; NP_001093881.1; NM_001100411.1.
DR RefSeq; NP_078857.5; NM_024581.4.
DR RefSeq; XP_005267200.1; XM_005267143.1.
DR UniGene; Hs.443789; -.
DR ProteinModelPortal; Q8NB25; -.
DR MINT; MINT-4712612; -.
DR PhosphoSite; Q8NB25; -.
DR DMDM; 209572754; -.
DR PaxDb; Q8NB25; -.
DR PRIDE; Q8NB25; -.
DR DNASU; 79632; -.
DR Ensembl; ENST00000338891; ENSP00000342604; ENSG00000111879.
DR Ensembl; ENST00000352896; ENSP00000326608; ENSG00000111879.
DR Ensembl; ENST00000521531; ENSP00000430442; ENSG00000111879.
DR GeneID; 79632; -.
DR KEGG; hsa:79632; -.
DR UCSC; uc003pyj.3; human.
DR CTD; 79632; -.
DR GeneCards; GC06M119280; -.
DR HGNC; HGNC:20991; FAM184A.
DR HPA; HPA034571; -.
DR neXtProt; NX_Q8NB25; -.
DR PharmGKB; PA164719768; -.
DR eggNOG; NOG138283; -.
DR HOGENOM; HOG000090031; -.
DR HOVERGEN; HBG050909; -.
DR InParanoid; Q8NB25; -.
DR OMA; RQQHEET; -.
DR OrthoDB; EOG7JQBMM; -.
DR ChiTaRS; FAM184A; human.
DR GenomeRNAi; 79632; -.
DR NextBio; 68735; -.
DR PRO; PR:Q8NB25; -.
DR ArrayExpress; Q8NB25; -.
DR Bgee; Q8NB25; -.
DR CleanEx; HS_FAM184A; -.
DR Genevestigator; Q8NB25; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 1140 Protein FAM184A.
FT /FTId=PRO_0000089512.
FT COILED 57 256 Potential.
FT COILED 296 800 Potential.
FT COILED 868 907 Potential.
FT VAR_SEQ 1 120 Missing (in isoform 4).
FT /FTId=VSP_044520.
FT VAR_SEQ 924 972 Missing (in isoform 2 and isoform 4).
FT /FTId=VSP_007446.
FT VAR_SEQ 1012 1046 Missing (in isoform 2).
FT /FTId=VSP_007447.
FT VAR_SEQ 1114 1116 SPA -> RYQ (in isoform 3).
FT /FTId=VSP_039102.
FT VAR_SEQ 1117 1140 Missing (in isoform 3).
FT /FTId=VSP_039103.
FT VARIANT 174 174 Q -> H (in dbSNP:rs34681930).
FT /FTId=VAR_054101.
FT VARIANT 177 177 V -> G (in dbSNP:rs34977570).
FT /FTId=VAR_054102.
FT VARIANT 599 599 D -> N (in dbSNP:rs17827619).
FT /FTId=VAR_054103.
FT CONFLICT 546 546 N -> D (in Ref. 1; CAD98058).
FT CONFLICT 620 620 Missing (in Ref. 4; BAC03719).
FT CONFLICT 739 739 Q -> R (in Ref. 4; BAC03719).
FT CONFLICT 795 795 F -> L (in Ref. 1; CAD98058).
FT CONFLICT 882 882 H -> R (in Ref. 1; CAD98058).
SQ SEQUENCE 1140 AA; 132965 MW; 6565FD0C349B37E1 CRC64;
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ LTKVIYALNT
KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE ELDLRRKIQV LESSLEDHIK
MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR IVTMSREVEE IRRKFEEKLR SFGQLQVQFE
KDKRLALEDL QAAHRREIQE LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE
RKKLIEDYEG KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG EMALLSKHKE
VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI KDLESEKSRV NERLSQLEEE
RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK RTQQEYYERE LKNLQSRLEE EVTQLNEAHS
KTLEELAWKH HMAIEAVHSN AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV
LEDKLNTANQ EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS KLREELRLQH
EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL KQNLEIQLSQ SQTSLQQLQA
QFTQERQRLT QELEELEEQH QQRHKSLKEA HVLAFQTMEE EKEKEQRALE NHLQQKHSAE
LQSLKDAHRE SMEGFRIEME QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH
HQELAAAKME LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI MRADFNKTNE
LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML TERDQIIKKL IEDNKFYQLE
LVNRETNFNK VFNSSPTVGV INPLAKQKKK NDKSPTNRFV SVPNLSALES GGVGNGHPNR
LDPIPNSPVH DIEFNSSKPL PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF
//