Full text data of FAM211A
FAM211A
(C17orf76)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Leucine-rich repeat-containing protein FAM211A
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Leucine-rich repeat-containing protein FAM211A
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8NAA5
ID F211A_HUMAN Reviewed; 344 AA.
AC Q8NAA5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-MAY-2007, sequence version 2.
DT 22-JAN-2014, entry version 74.
DE RecName: Full=Leucine-rich repeat-containing protein FAM211A;
GN Name=FAM211A; Synonyms=C17orf76;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-344 (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NAA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NAA5-2; Sequence=VSP_025134, VSP_025135;
CC -!- SIMILARITY: Belongs to the FAM211 family.
CC -!- SIMILARITY: Contains 2 LRR (leucine-rich) repeats.
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DR EMBL; AC127540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK093015; BAC04020.1; -; mRNA.
DR RefSeq; NP_001107039.1; NM_001113567.2.
DR RefSeq; NP_997270.2; NM_207387.3.
DR UniGene; Hs.25425; -.
DR ProteinModelPortal; Q8NAA5; -.
DR SMR; Q8NAA5; 203-278.
DR PhosphoSite; Q8NAA5; -.
DR DMDM; 147640319; -.
DR PaxDb; Q8NAA5; -.
DR PRIDE; Q8NAA5; -.
DR Ensembl; ENST00000409083; ENSP00000386504; ENSG00000181350.
DR Ensembl; ENST00000470794; ENSP00000419502; ENSG00000181350.
DR GeneID; 388341; -.
DR KEGG; hsa:388341; -.
DR UCSC; uc010cph.2; human.
DR CTD; 388341; -.
DR GeneCards; GC17M016344; -.
DR HGNC; HGNC:32403; FAM211A.
DR HPA; HPA028528; -.
DR neXtProt; NX_Q8NAA5; -.
DR PharmGKB; PA143485400; -.
DR eggNOG; NOG41786; -.
DR HOGENOM; HOG000111942; -.
DR HOVERGEN; HBG066484; -.
DR InParanoid; Q8NAA5; -.
DR OMA; KFPSVTW; -.
DR OrthoDB; EOG7RZ5RM; -.
DR GenomeRNAi; 388341; -.
DR NextBio; 101984; -.
DR PRO; PR:Q8NAA5; -.
DR Bgee; Q8NAA5; -.
DR CleanEx; HS_C17orf76; -.
DR Genevestigator; Q8NAA5; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Leucine-rich repeat;
KW Reference proteome; Repeat.
FT CHAIN 1 344 Leucine-rich repeat-containing protein
FT FAM211A.
FT /FTId=PRO_0000286624.
FT REPEAT 204 217 LRR 1.
FT REPEAT 229 242 LRR 2.
FT VAR_SEQ 126 212 EGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLK
FT AVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSV
FT ELGFT -> PQGCPGRKPPRQHSGPVGNPTDLPRPGAGDQL
FT PTALWGAGRQRGAGLHRPHGRHGPAAAASTQHPAPPHHTGT
FT QWQPVDPGRAARPH (in isoform 2).
FT /FTId=VSP_025134.
FT VAR_SEQ 213 344 Missing (in isoform 2).
FT /FTId=VSP_025135.
SQ SEQUENCE 344 AA; 37780 MW; E76D268A6D393A0C CRC64;
MGTRQTKGSL AERASPGAAP GPRRERPDFW ASLLLRAGDK AGRAGAGMPP YHRRVGMVQE
LLRMVRQGRR EEAGTLLQHL RQDLGMESTS LDDVLYRYAS FRNLVDPITH DLIISLARYI
HCPKPEGDAL GAMEKLCRQL TYHLSPHSQW RRHRGLVKRK PQACLKAVLA GSPPDNTVDL
SGIPLTSRDL ERVTSYLQRC GEQVDSVELG FTGLTDDMVL QLLPALSTLP RLTTLALNGN
RLTRAVLRDL TDILKDPSKF PNVTWIDLGN NVDIFSLPQP FLLSLRKRSP KQGHLPTILE
LGEGPGSGEE VREGTVGQED PGGGPVAPAE DHHEGKETVA AAQT
//
ID F211A_HUMAN Reviewed; 344 AA.
AC Q8NAA5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-MAY-2007, sequence version 2.
DT 22-JAN-2014, entry version 74.
DE RecName: Full=Leucine-rich repeat-containing protein FAM211A;
GN Name=FAM211A; Synonyms=C17orf76;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-344 (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NAA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NAA5-2; Sequence=VSP_025134, VSP_025135;
CC -!- SIMILARITY: Belongs to the FAM211 family.
CC -!- SIMILARITY: Contains 2 LRR (leucine-rich) repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC127540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK093015; BAC04020.1; -; mRNA.
DR RefSeq; NP_001107039.1; NM_001113567.2.
DR RefSeq; NP_997270.2; NM_207387.3.
DR UniGene; Hs.25425; -.
DR ProteinModelPortal; Q8NAA5; -.
DR SMR; Q8NAA5; 203-278.
DR PhosphoSite; Q8NAA5; -.
DR DMDM; 147640319; -.
DR PaxDb; Q8NAA5; -.
DR PRIDE; Q8NAA5; -.
DR Ensembl; ENST00000409083; ENSP00000386504; ENSG00000181350.
DR Ensembl; ENST00000470794; ENSP00000419502; ENSG00000181350.
DR GeneID; 388341; -.
DR KEGG; hsa:388341; -.
DR UCSC; uc010cph.2; human.
DR CTD; 388341; -.
DR GeneCards; GC17M016344; -.
DR HGNC; HGNC:32403; FAM211A.
DR HPA; HPA028528; -.
DR neXtProt; NX_Q8NAA5; -.
DR PharmGKB; PA143485400; -.
DR eggNOG; NOG41786; -.
DR HOGENOM; HOG000111942; -.
DR HOVERGEN; HBG066484; -.
DR InParanoid; Q8NAA5; -.
DR OMA; KFPSVTW; -.
DR OrthoDB; EOG7RZ5RM; -.
DR GenomeRNAi; 388341; -.
DR NextBio; 101984; -.
DR PRO; PR:Q8NAA5; -.
DR Bgee; Q8NAA5; -.
DR CleanEx; HS_C17orf76; -.
DR Genevestigator; Q8NAA5; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Leucine-rich repeat;
KW Reference proteome; Repeat.
FT CHAIN 1 344 Leucine-rich repeat-containing protein
FT FAM211A.
FT /FTId=PRO_0000286624.
FT REPEAT 204 217 LRR 1.
FT REPEAT 229 242 LRR 2.
FT VAR_SEQ 126 212 EGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLK
FT AVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSV
FT ELGFT -> PQGCPGRKPPRQHSGPVGNPTDLPRPGAGDQL
FT PTALWGAGRQRGAGLHRPHGRHGPAAAASTQHPAPPHHTGT
FT QWQPVDPGRAARPH (in isoform 2).
FT /FTId=VSP_025134.
FT VAR_SEQ 213 344 Missing (in isoform 2).
FT /FTId=VSP_025135.
SQ SEQUENCE 344 AA; 37780 MW; E76D268A6D393A0C CRC64;
MGTRQTKGSL AERASPGAAP GPRRERPDFW ASLLLRAGDK AGRAGAGMPP YHRRVGMVQE
LLRMVRQGRR EEAGTLLQHL RQDLGMESTS LDDVLYRYAS FRNLVDPITH DLIISLARYI
HCPKPEGDAL GAMEKLCRQL TYHLSPHSQW RRHRGLVKRK PQACLKAVLA GSPPDNTVDL
SGIPLTSRDL ERVTSYLQRC GEQVDSVELG FTGLTDDMVL QLLPALSTLP RLTTLALNGN
RLTRAVLRDL TDILKDPSKF PNVTWIDLGN NVDIFSLPQP FLLSLRKRSP KQGHLPTILE
LGEGPGSGEE VREGTVGQED PGGGPVAPAE DHHEGKETVA AAQT
//