Full text data of FAM213A
FAM213A
(C10orf58, PAMM)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM)
Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM)
hRBCD
IPI00296190
IPI00296190 Conserved hypothetical protein Hypothetical protein FLJ90162, no information available soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00296190 Conserved hypothetical protein Hypothetical protein FLJ90162, no information available soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q9BRX8
ID F213A_HUMAN Reviewed; 229 AA.
AC Q9BRX8; B2RD81; Q6UW08; Q8N2K3; Q8NBK9; Q96JR0;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-NOV-2004, sequence version 3.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=Redox-regulatory protein FAM213A;
DE AltName: Full=Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes;
DE Short=Protein PAMM;
GN Name=FAM213A; Synonyms=C10orf58, PAMM;
GN ORFNames=PRO2290, PSEC0139, UNQ611/PRO1198;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo, and Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-229 (ISOFORMS 1/2).
RC TISSUE=Fetal liver;
RX PubMed=11483580; DOI=10.1101/gr.175501;
RA Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C.,
RA Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C.,
RA He F.;
RT "Gene expression profiling in human fetal liver and identification of
RT tissue- and developmental-stage-specific genes through compiled
RT expression profiles and efficient cloning of full-length cDNAs.";
RL Genome Res. 11:1392-1403(2001).
RN [7]
RP PROTEIN SEQUENCE OF 90-99; 156-164 AND 192-199, AND MASS SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP CYS-85 AND CYS-88.
RX PubMed=19951071; DOI=10.1089/ars.2009.2886;
RA Xu Y., Morse L.R., da Silva R.A., Odgren P.R., Sasaki H.,
RA Stashenko P., Battaglino R.A.;
RT "PAMM: a redox regulatory protein that modulates osteoclast
RT differentiation.";
RL Antioxid. Redox Signal. 13:27-37(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in redox regulation of the cell. Acts as an
CC antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and
CC osteoclast differentiation. May affect bone resorption and help to
CC maintain bone mass.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BRX8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRX8-2; Sequence=VSP_042229;
CC -!- TISSUE SPECIFICITY: Expressed in CSF1 and TNFSF11-stimulated
CC CD14(+) peripheral blood mononuclear cells (PBMCs).
CC -!- INDUCTION: By CSF1 in peripheral blood mononuclear cells (PBMCs).
CC This induction is reduced in the presence of TNFSF11.
CC -!- MISCELLANEOUS: The active site cysteines correspond to the redox-
CC active cysteines of peroxiredoxins.
CC -!- SIMILARITY: Belongs to the peroxiredoxin-like FAM213 family.
CC FAM213A subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK55527.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAG37828.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; AY359059; AAQ89418.1; -; mRNA.
DR EMBL; AK315440; BAG37828.1; ALT_INIT; mRNA.
DR EMBL; AK074643; BAC11108.1; -; mRNA.
DR EMBL; AK075447; BAC11627.1; -; mRNA.
DR EMBL; AC021028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005871; AAH05871.3; -; mRNA.
DR EMBL; AF305824; AAK55527.1; ALT_INIT; mRNA.
DR RefSeq; NP_001230707.1; NM_001243778.1.
DR RefSeq; NP_001230708.1; NM_001243779.1.
DR RefSeq; NP_001230709.1; NM_001243780.1.
DR RefSeq; NP_001230710.1; NM_001243781.1.
DR RefSeq; NP_001230711.1; NM_001243782.1.
DR RefSeq; NP_115709.3; NM_032333.4.
DR UniGene; Hs.500333; -.
DR UniGene; Hs.718589; -.
DR ProteinModelPortal; Q9BRX8; -.
DR PhosphoSite; Q9BRX8; -.
DR DMDM; 73620080; -.
DR PaxDb; Q9BRX8; -.
DR PRIDE; Q9BRX8; -.
DR Ensembl; ENST00000372181; ENSP00000361254; ENSG00000122378.
DR Ensembl; ENST00000372185; ENSP00000361259; ENSG00000122378.
DR Ensembl; ENST00000372187; ENSP00000361261; ENSG00000122378.
DR Ensembl; ENST00000372188; ENSP00000361262; ENSG00000122378.
DR GeneID; 84293; -.
DR KEGG; hsa:84293; -.
DR UCSC; uc001kcc.4; human.
DR CTD; 84293; -.
DR GeneCards; GC10P082167; -.
DR H-InvDB; HIX0008980; -.
DR H-InvDB; HIX0170428; -.
DR HGNC; HGNC:28651; FAM213A.
DR HPA; HPA009025; -.
DR HPA; HPA024565; -.
DR neXtProt; NX_Q9BRX8; -.
DR PharmGKB; PA134969403; -.
DR eggNOG; NOG254187; -.
DR HOGENOM; HOG000293175; -.
DR HOVERGEN; HBG060239; -.
DR InParanoid; Q9BRX8; -.
DR OMA; WYNFFRA; -.
DR OrthoDB; EOG7TQV22; -.
DR GeneWiki; C10orf58; -.
DR GenomeRNAi; 84293; -.
DR NextBio; 73936; -.
DR PRO; PR:Q9BRX8; -.
DR Bgee; Q9BRX8; -.
DR CleanEx; HS_C10orf58; -.
DR Genevestigator; Q9BRX8; -.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016209; F:antioxidant activity; IDA:UniProtKB.
DR GO; GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
DR GO; GO:0045670; P:regulation of osteoclast differentiation; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Alternative splicing; Antioxidant; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Redox-active center; Reference proteome.
FT CHAIN 1 229 Redox-regulatory protein FAM213A.
FT /FTId=PRO_0000019550.
FT REGION 14 112 Thioredoxin fold (By similarity).
FT ACT_SITE 85 85 Redox-active (By similarity).
FT ACT_SITE 88 88 Redox-active (By similarity).
FT VAR_SEQ 1 11 Missing (in isoform 2).
FT /FTId=VSP_042229.
FT MUTAGEN 85 85 C->G: Decrease of about 38% in
FT antioxidant activity in TNFSF11-
FT stimulated osteoclasts and reduced
FT inhibition of TNFSF11-induced osteoclast
FT formation.
FT MUTAGEN 88 88 C->G: Decrease of about 125% in
FT antioxidant activity in TNFSF11-
FT stimulated osteoclasts and reduced
FT inhibition of TNFSF11-induced osteoclast
FT formation.
FT CONFLICT 201 201 K -> N (in Ref. 2; BAC11108).
FT CONFLICT 206 206 K -> R (in Ref. 3; BAC11627).
SQ SEQUENCE 229 AA; 25764 MW; 9ECE72DEF6C338D7 CRC64;
MSFLQDPSFF TMGMWSIGAG ALGAAALALL LANTDVFLSK PQKAALEYLE DIDLKTLEKE
PRTFKAKELW EKNGAVIMAV RRPGCFLCRE EAADLSSLKS MLDQLGVPLY AVVKEHIRTE
VKDFQPYFKG EIFLDEKKKF YGPQRRKMMF MGFIRLGVWY NFFRAWNGGF SGNLEGEGFI
LGGVFVVGSG KQGILLEHRE KEFGDKVNLL SVLEAAKMIK PQTLASEKK
//
ID F213A_HUMAN Reviewed; 229 AA.
AC Q9BRX8; B2RD81; Q6UW08; Q8N2K3; Q8NBK9; Q96JR0;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-NOV-2004, sequence version 3.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=Redox-regulatory protein FAM213A;
DE AltName: Full=Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes;
DE Short=Protein PAMM;
GN Name=FAM213A; Synonyms=C10orf58, PAMM;
GN ORFNames=PRO2290, PSEC0139, UNQ611/PRO1198;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo, and Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-229 (ISOFORMS 1/2).
RC TISSUE=Fetal liver;
RX PubMed=11483580; DOI=10.1101/gr.175501;
RA Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C.,
RA Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C.,
RA He F.;
RT "Gene expression profiling in human fetal liver and identification of
RT tissue- and developmental-stage-specific genes through compiled
RT expression profiles and efficient cloning of full-length cDNAs.";
RL Genome Res. 11:1392-1403(2001).
RN [7]
RP PROTEIN SEQUENCE OF 90-99; 156-164 AND 192-199, AND MASS SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP CYS-85 AND CYS-88.
RX PubMed=19951071; DOI=10.1089/ars.2009.2886;
RA Xu Y., Morse L.R., da Silva R.A., Odgren P.R., Sasaki H.,
RA Stashenko P., Battaglino R.A.;
RT "PAMM: a redox regulatory protein that modulates osteoclast
RT differentiation.";
RL Antioxid. Redox Signal. 13:27-37(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in redox regulation of the cell. Acts as an
CC antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and
CC osteoclast differentiation. May affect bone resorption and help to
CC maintain bone mass.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BRX8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRX8-2; Sequence=VSP_042229;
CC -!- TISSUE SPECIFICITY: Expressed in CSF1 and TNFSF11-stimulated
CC CD14(+) peripheral blood mononuclear cells (PBMCs).
CC -!- INDUCTION: By CSF1 in peripheral blood mononuclear cells (PBMCs).
CC This induction is reduced in the presence of TNFSF11.
CC -!- MISCELLANEOUS: The active site cysteines correspond to the redox-
CC active cysteines of peroxiredoxins.
CC -!- SIMILARITY: Belongs to the peroxiredoxin-like FAM213 family.
CC FAM213A subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK55527.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAG37828.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; AY359059; AAQ89418.1; -; mRNA.
DR EMBL; AK315440; BAG37828.1; ALT_INIT; mRNA.
DR EMBL; AK074643; BAC11108.1; -; mRNA.
DR EMBL; AK075447; BAC11627.1; -; mRNA.
DR EMBL; AC021028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005871; AAH05871.3; -; mRNA.
DR EMBL; AF305824; AAK55527.1; ALT_INIT; mRNA.
DR RefSeq; NP_001230707.1; NM_001243778.1.
DR RefSeq; NP_001230708.1; NM_001243779.1.
DR RefSeq; NP_001230709.1; NM_001243780.1.
DR RefSeq; NP_001230710.1; NM_001243781.1.
DR RefSeq; NP_001230711.1; NM_001243782.1.
DR RefSeq; NP_115709.3; NM_032333.4.
DR UniGene; Hs.500333; -.
DR UniGene; Hs.718589; -.
DR ProteinModelPortal; Q9BRX8; -.
DR PhosphoSite; Q9BRX8; -.
DR DMDM; 73620080; -.
DR PaxDb; Q9BRX8; -.
DR PRIDE; Q9BRX8; -.
DR Ensembl; ENST00000372181; ENSP00000361254; ENSG00000122378.
DR Ensembl; ENST00000372185; ENSP00000361259; ENSG00000122378.
DR Ensembl; ENST00000372187; ENSP00000361261; ENSG00000122378.
DR Ensembl; ENST00000372188; ENSP00000361262; ENSG00000122378.
DR GeneID; 84293; -.
DR KEGG; hsa:84293; -.
DR UCSC; uc001kcc.4; human.
DR CTD; 84293; -.
DR GeneCards; GC10P082167; -.
DR H-InvDB; HIX0008980; -.
DR H-InvDB; HIX0170428; -.
DR HGNC; HGNC:28651; FAM213A.
DR HPA; HPA009025; -.
DR HPA; HPA024565; -.
DR neXtProt; NX_Q9BRX8; -.
DR PharmGKB; PA134969403; -.
DR eggNOG; NOG254187; -.
DR HOGENOM; HOG000293175; -.
DR HOVERGEN; HBG060239; -.
DR InParanoid; Q9BRX8; -.
DR OMA; WYNFFRA; -.
DR OrthoDB; EOG7TQV22; -.
DR GeneWiki; C10orf58; -.
DR GenomeRNAi; 84293; -.
DR NextBio; 73936; -.
DR PRO; PR:Q9BRX8; -.
DR Bgee; Q9BRX8; -.
DR CleanEx; HS_C10orf58; -.
DR Genevestigator; Q9BRX8; -.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016209; F:antioxidant activity; IDA:UniProtKB.
DR GO; GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
DR GO; GO:0045670; P:regulation of osteoclast differentiation; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Alternative splicing; Antioxidant; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Redox-active center; Reference proteome.
FT CHAIN 1 229 Redox-regulatory protein FAM213A.
FT /FTId=PRO_0000019550.
FT REGION 14 112 Thioredoxin fold (By similarity).
FT ACT_SITE 85 85 Redox-active (By similarity).
FT ACT_SITE 88 88 Redox-active (By similarity).
FT VAR_SEQ 1 11 Missing (in isoform 2).
FT /FTId=VSP_042229.
FT MUTAGEN 85 85 C->G: Decrease of about 38% in
FT antioxidant activity in TNFSF11-
FT stimulated osteoclasts and reduced
FT inhibition of TNFSF11-induced osteoclast
FT formation.
FT MUTAGEN 88 88 C->G: Decrease of about 125% in
FT antioxidant activity in TNFSF11-
FT stimulated osteoclasts and reduced
FT inhibition of TNFSF11-induced osteoclast
FT formation.
FT CONFLICT 201 201 K -> N (in Ref. 2; BAC11108).
FT CONFLICT 206 206 K -> R (in Ref. 3; BAC11627).
SQ SEQUENCE 229 AA; 25764 MW; 9ECE72DEF6C338D7 CRC64;
MSFLQDPSFF TMGMWSIGAG ALGAAALALL LANTDVFLSK PQKAALEYLE DIDLKTLEKE
PRTFKAKELW EKNGAVIMAV RRPGCFLCRE EAADLSSLKS MLDQLGVPLY AVVKEHIRTE
VKDFQPYFKG EIFLDEKKKF YGPQRRKMMF MGFIRLGVWY NFFRAWNGGF SGNLEGEGFI
LGGVFVVGSG KQGILLEHRE KEFGDKVNLL SVLEAAKMIK PQTLASEKK
//