Full text data of MTHFD1
MTHFD1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
F5H2F4
ID F5H2F4_HUMAN Unreviewed; 1020 AA.
AC F5H2F4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
read moreDT 22-JAN-2014, entry version 25.
DE SubName: Full=C-1-tetrahydrofolate synthase, cytoplasmic;
GN Name=MTHFD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA Quetier F., Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL122035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005267750.1; XM_005267693.1.
DR ProteinModelPortal; F5H2F4; -.
DR SMR; F5H2F4; 58-352, 372-963.
DR PRIDE; F5H2F4; -.
DR Ensembl; ENST00000545908; ENSP00000438588; ENSG00000100714.
DR GeneID; 4522; -.
DR UCSC; uc010aqf.3; human.
DR HGNC; HGNC:7432; MTHFD1.
DR OMA; GFHAYNI; -.
DR OrthoDB; EOG76T9QN; -.
DR ChiTaRS; MTHFD1; human.
DR NextBio; 35508415; -.
DR ArrayExpress; F5H2F4; -.
DR Bgee; F5H2F4; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:InterPro.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_01543; FTHFS; 1; -.
DR HAMAP; MF_01576; THF_DHG_CYH; 1; -.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR Pfam; PF01268; FTHFS; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
DR PROSITE; PS00766; THF_DHG_CYH_1; 1.
DR PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome.
SQ SEQUENCE 1020 AA; 110613 MW; C4B137C42AC01F89 CRC64;
MRHRVCRGRS GQGRRRSSVI PWPVPKHVGW VVLLGCGGSG TSILVVSIVG SGLIKAMAPA
EILNGKEISA QIRARLKNQV TQLKEQVPGF TPRLAILQVG NRDDSNLYIN VKLKAAEEIG
IKATHIKLPR TTTESEVMKY ITSLNEDSTV HGFLVQLPLD SENSINTEEV INAIAPEKDV
DGLTSINAGK LARGDLNDCF IPCTPKGCLE LIKETGVPIA GRHAVVVGRS KIVGAPMHDL
LLWNNATVTT CHSKTAHLDE EVNKGDILVV ATGQPEMVKG EWIKPGAIVI DCGINYVPDD
KKPNGRKVVG DVAYDEAKER ASFITPVPGG VGPMTVAMLM QSTVESAKRF LEKFKPGKWM
IQYNNLNLKT PVPSDIDISR SCKPKPIGKL AREIGLLSEE VELYGETKAK VLLSALERLK
HRPDGKYVVV TGITPTPLGE GKSTTTIGLV QALGAHLYQN VFACVRQPSQ GPTFGIKGGA
AGGGYSQVIP MEEFNLHLTG DIHAITAANN LVAAAIDARI FHELTQTDKA LFNRLVPSVN
GVRRFSDIQI RRLKRLGIEK TDPTTLTDEE INRFARLDID PETITWQRVL DTNDRFLRKI
TIGQAPTEKG HTRTAQFDIS VASEIMAVLA LTTSLEDMRE RLGKMVVASS KKGEPVSAED
LGVSGALTVL MKDAIKPNLM QTLEGTPVFV HAGPFANIAH GNSSIIADRI ALKLVGPEGF
VVTEAGFGAD IGMEKFFNIK CRYSGLCPHV VVLVATVRAL KMHGGGPTVT AGLPLPKAYI
QENLELVEKG FSNLKKQIEN ARMFGIPVVV AVNAFKTDTE SELDLISRLS REHGAFDAVK
CTHWAEGGKG ALALAQAVQR AAQAPSSFQL LYDLKLPVED KIRIIAQKIY GADDIELLPE
AQHKAEVYTK QGFGNLPICM AKTHLSLSHN PEQKGVPTGF ILPIRDIRAS VGAGFLYPLV
GTITIHLQEA TLKVWPVSIQ AHWELGSISK PREVSPCPED LKLIVGVSPE VIFSLNSHHV
//
ID F5H2F4_HUMAN Unreviewed; 1020 AA.
AC F5H2F4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
read moreDT 22-JAN-2014, entry version 25.
DE SubName: Full=C-1-tetrahydrofolate synthase, cytoplasmic;
GN Name=MTHFD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA Quetier F., Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL122035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005267750.1; XM_005267693.1.
DR ProteinModelPortal; F5H2F4; -.
DR SMR; F5H2F4; 58-352, 372-963.
DR PRIDE; F5H2F4; -.
DR Ensembl; ENST00000545908; ENSP00000438588; ENSG00000100714.
DR GeneID; 4522; -.
DR UCSC; uc010aqf.3; human.
DR HGNC; HGNC:7432; MTHFD1.
DR OMA; GFHAYNI; -.
DR OrthoDB; EOG76T9QN; -.
DR ChiTaRS; MTHFD1; human.
DR NextBio; 35508415; -.
DR ArrayExpress; F5H2F4; -.
DR Bgee; F5H2F4; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:InterPro.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_01543; FTHFS; 1; -.
DR HAMAP; MF_01576; THF_DHG_CYH; 1; -.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR Pfam; PF01268; FTHFS; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
DR PROSITE; PS00766; THF_DHG_CYH_1; 1.
DR PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome.
SQ SEQUENCE 1020 AA; 110613 MW; C4B137C42AC01F89 CRC64;
MRHRVCRGRS GQGRRRSSVI PWPVPKHVGW VVLLGCGGSG TSILVVSIVG SGLIKAMAPA
EILNGKEISA QIRARLKNQV TQLKEQVPGF TPRLAILQVG NRDDSNLYIN VKLKAAEEIG
IKATHIKLPR TTTESEVMKY ITSLNEDSTV HGFLVQLPLD SENSINTEEV INAIAPEKDV
DGLTSINAGK LARGDLNDCF IPCTPKGCLE LIKETGVPIA GRHAVVVGRS KIVGAPMHDL
LLWNNATVTT CHSKTAHLDE EVNKGDILVV ATGQPEMVKG EWIKPGAIVI DCGINYVPDD
KKPNGRKVVG DVAYDEAKER ASFITPVPGG VGPMTVAMLM QSTVESAKRF LEKFKPGKWM
IQYNNLNLKT PVPSDIDISR SCKPKPIGKL AREIGLLSEE VELYGETKAK VLLSALERLK
HRPDGKYVVV TGITPTPLGE GKSTTTIGLV QALGAHLYQN VFACVRQPSQ GPTFGIKGGA
AGGGYSQVIP MEEFNLHLTG DIHAITAANN LVAAAIDARI FHELTQTDKA LFNRLVPSVN
GVRRFSDIQI RRLKRLGIEK TDPTTLTDEE INRFARLDID PETITWQRVL DTNDRFLRKI
TIGQAPTEKG HTRTAQFDIS VASEIMAVLA LTTSLEDMRE RLGKMVVASS KKGEPVSAED
LGVSGALTVL MKDAIKPNLM QTLEGTPVFV HAGPFANIAH GNSSIIADRI ALKLVGPEGF
VVTEAGFGAD IGMEKFFNIK CRYSGLCPHV VVLVATVRAL KMHGGGPTVT AGLPLPKAYI
QENLELVEKG FSNLKKQIEN ARMFGIPVVV AVNAFKTDTE SELDLISRLS REHGAFDAVK
CTHWAEGGKG ALALAQAVQR AAQAPSSFQL LYDLKLPVED KIRIIAQKIY GADDIELLPE
AQHKAEVYTK QGFGNLPICM AKTHLSLSHN PEQKGVPTGF ILPIRDIRAS VGAGFLYPLV
GTITIHLQEA TLKVWPVSIQ AHWELGSISK PREVSPCPED LKLIVGVSPE VIFSLNSHHV
//