Full text data of PDIA6
PDIA6
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
F8WA83
ID F8WA83_HUMAN Unreviewed; 445 AA.
AC F8WA83;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
read moreDT 22-JAN-2014, entry version 19.
DE SubName: Full=Protein disulfide-isomerase A6;
GN Name=PDIA6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC -!- SIMILARITY: Contains 2 thioredoxin domains.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC092687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001269635.1; NM_001282706.1.
DR ProteinModelPortal; F8WA83; -.
DR SMR; F8WA83; 32-285.
DR PRIDE; F8WA83; -.
DR Ensembl; ENST00000381611; ENSP00000371024; ENSG00000143870.
DR GeneID; 10130; -.
DR UCSC; uc010yjh.2; human.
DR HGNC; HGNC:30168; PDIA6.
DR ChiTaRS; PDIA6; human.
DR NextBio; 35513104; -.
DR ArrayExpress; F8WA83; -.
DR Bgee; F8WA83; -.
DR GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
DR Gene3D; 3.40.30.10; -; 2.
DR InterPro; IPR005788; Disulphide_isomerase.
DR InterPro; IPR005746; Thioredoxin.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 2.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; SSF52833; 3.
DR TIGRFAMs; TIGR01126; pdi_dom; 2.
DR PROSITE; PS00194; THIOREDOXIN_1; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 2.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome; Repeat.
SQ SEQUENCE 445 AA; 48646 MW; 1C9AE81DD2216FFD CRC64;
MYPSTTMANA PGLVSCTFFL AVNGLYSSSD DVIELTPSNF NREVIQSDSL WLVEFYAPWC
GHCQRLTPEW KKAATALKDV VKVGAVDADK HHSLGGQYGV QGFPTIKIFG SNKNRPEDYQ
GGRTGEAIVD AALSALRQLV KDRLGGRSGG YSSGKQGRSD SSSKKDVIEL TDDSFDKNVL
DSEDVWMVEF YAPWCGHCKN LEPEWAAAAS EVKEQTKGKV KLAAVDATVN QVLASRYGIR
GFPTIKIFQK GESPVDYDGG RTRSDIVSRA LDLFSDNAPP PELLEIINED IAKRTCEEHQ
LCVVAVLPHI LDTGAAGRNS YLEVLLKLAD KYKKKMWGWL WTEAGAQSEL ETALGIGGFG
YPAMAAINAR KMKFALLKGS FSEQGINEFL RELSFGRGST APVGGGAFPT IVEREPWDGR
DGELPVEDDI DLSDVELDDL GKDEL
//
ID F8WA83_HUMAN Unreviewed; 445 AA.
AC F8WA83;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
read moreDT 22-JAN-2014, entry version 19.
DE SubName: Full=Protein disulfide-isomerase A6;
GN Name=PDIA6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC -!- SIMILARITY: Contains 2 thioredoxin domains.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC092687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001269635.1; NM_001282706.1.
DR ProteinModelPortal; F8WA83; -.
DR SMR; F8WA83; 32-285.
DR PRIDE; F8WA83; -.
DR Ensembl; ENST00000381611; ENSP00000371024; ENSG00000143870.
DR GeneID; 10130; -.
DR UCSC; uc010yjh.2; human.
DR HGNC; HGNC:30168; PDIA6.
DR ChiTaRS; PDIA6; human.
DR NextBio; 35513104; -.
DR ArrayExpress; F8WA83; -.
DR Bgee; F8WA83; -.
DR GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
DR Gene3D; 3.40.30.10; -; 2.
DR InterPro; IPR005788; Disulphide_isomerase.
DR InterPro; IPR005746; Thioredoxin.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 2.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; SSF52833; 3.
DR TIGRFAMs; TIGR01126; pdi_dom; 2.
DR PROSITE; PS00194; THIOREDOXIN_1; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 2.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome; Repeat.
SQ SEQUENCE 445 AA; 48646 MW; 1C9AE81DD2216FFD CRC64;
MYPSTTMANA PGLVSCTFFL AVNGLYSSSD DVIELTPSNF NREVIQSDSL WLVEFYAPWC
GHCQRLTPEW KKAATALKDV VKVGAVDADK HHSLGGQYGV QGFPTIKIFG SNKNRPEDYQ
GGRTGEAIVD AALSALRQLV KDRLGGRSGG YSSGKQGRSD SSSKKDVIEL TDDSFDKNVL
DSEDVWMVEF YAPWCGHCKN LEPEWAAAAS EVKEQTKGKV KLAAVDATVN QVLASRYGIR
GFPTIKIFQK GESPVDYDGG RTRSDIVSRA LDLFSDNAPP PELLEIINED IAKRTCEEHQ
LCVVAVLPHI LDTGAAGRNS YLEVLLKLAD KYKKKMWGWL WTEAGAQSEL ETALGIGGFG
YPAMAAINAR KMKFALLKGS FSEQGINEFL RELSFGRGST APVGGGAFPT IVEREPWDGR
DGELPVEDDI DLSDVELDDL GKDEL
//