Full text data of FAM46C
FAM46C
[Confidence: low (only semi-automatic identification from reviews)]
Protein FAM46C
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein FAM46C
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q5VWP2
ID FA46C_HUMAN Reviewed; 391 AA.
AC Q5VWP2; A3KMG2; Q8NE25; Q9NXK0;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 30-AUG-2005, sequence version 1.
DT 22-JAN-2014, entry version 63.
DE RecName: Full=Protein FAM46C;
GN Name=FAM46C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=21478870; DOI=10.1038/nature09907;
RA Schoggins J.W., Wilson S.J., Panis M., Murphy M.Y., Jones C.T.,
RA Bieniasz P., Rice C.M.;
RT "A diverse range of gene products are effectors of the type I
RT interferon antiviral response.";
RL Nature 472:481-485(2011).
CC -!- FUNCTION: Seems to enhance replication of some viruses, including
CC yellow fever virus, in response to type I interferon.
CC -!- INDUCTION: By type I interferons.
CC -!- SIMILARITY: Belongs to the FAM46 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK000209; BAA91010.1; -; mRNA.
DR EMBL; AL365331; CAH73761.1; -; Genomic_DNA.
DR EMBL; BC036516; AAH36516.3; -; mRNA.
DR EMBL; BC131726; AAI31727.1; -; mRNA.
DR RefSeq; NP_060179.2; NM_017709.3.
DR RefSeq; XP_005271017.1; XM_005270960.1.
DR UniGene; Hs.356216; -.
DR ProteinModelPortal; Q5VWP2; -.
DR IntAct; Q5VWP2; 4.
DR MINT; MINT-1471126; -.
DR STRING; 9606.ENSP00000358458; -.
DR PhosphoSite; Q5VWP2; -.
DR DMDM; 117940143; -.
DR PaxDb; Q5VWP2; -.
DR PRIDE; Q5VWP2; -.
DR Ensembl; ENST00000369448; ENSP00000358458; ENSG00000183508.
DR GeneID; 54855; -.
DR KEGG; hsa:54855; -.
DR UCSC; uc001ehe.3; human.
DR CTD; 54855; -.
DR GeneCards; GC01P118148; -.
DR HGNC; HGNC:24712; FAM46C.
DR HPA; HPA054049; -.
DR MIM; 613952; gene.
DR neXtProt; NX_Q5VWP2; -.
DR PharmGKB; PA134955264; -.
DR eggNOG; NOG310777; -.
DR HOGENOM; HOG000234733; -.
DR HOVERGEN; HBG057969; -.
DR InParanoid; Q5VWP2; -.
DR OMA; FFYDCSS; -.
DR OrthoDB; EOG74R1QS; -.
DR PhylomeDB; Q5VWP2; -.
DR GenomeRNAi; 54855; -.
DR NextBio; 57718; -.
DR PRO; PR:Q5VWP2; -.
DR Bgee; Q5VWP2; -.
DR CleanEx; HS_FAM46C; -.
DR Genevestigator; Q5VWP2; -.
DR InterPro; IPR012937; DUF1693.
DR Pfam; PF07984; DUF1693; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Polymorphism; Reference proteome.
FT CHAIN 1 391 Protein FAM46C.
FT /FTId=PRO_0000259933.
FT VARIANT 67 67 H -> Q (in dbSNP:rs1630312).
FT /FTId=VAR_060132.
FT CONFLICT 150 150 D -> V (in Ref. 1; BAA91010).
SQ SEQUENCE 391 AA; 44944 MW; 1B73C6688284F8AC CRC64;
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE
EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL
PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGKNVELKFV DSIRRQFEFS
VDSFQIILDS LLFFYDCSNN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR
GGGLLKYSNL LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA
PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N
//
ID FA46C_HUMAN Reviewed; 391 AA.
AC Q5VWP2; A3KMG2; Q8NE25; Q9NXK0;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 30-AUG-2005, sequence version 1.
DT 22-JAN-2014, entry version 63.
DE RecName: Full=Protein FAM46C;
GN Name=FAM46C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=21478870; DOI=10.1038/nature09907;
RA Schoggins J.W., Wilson S.J., Panis M., Murphy M.Y., Jones C.T.,
RA Bieniasz P., Rice C.M.;
RT "A diverse range of gene products are effectors of the type I
RT interferon antiviral response.";
RL Nature 472:481-485(2011).
CC -!- FUNCTION: Seems to enhance replication of some viruses, including
CC yellow fever virus, in response to type I interferon.
CC -!- INDUCTION: By type I interferons.
CC -!- SIMILARITY: Belongs to the FAM46 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK000209; BAA91010.1; -; mRNA.
DR EMBL; AL365331; CAH73761.1; -; Genomic_DNA.
DR EMBL; BC036516; AAH36516.3; -; mRNA.
DR EMBL; BC131726; AAI31727.1; -; mRNA.
DR RefSeq; NP_060179.2; NM_017709.3.
DR RefSeq; XP_005271017.1; XM_005270960.1.
DR UniGene; Hs.356216; -.
DR ProteinModelPortal; Q5VWP2; -.
DR IntAct; Q5VWP2; 4.
DR MINT; MINT-1471126; -.
DR STRING; 9606.ENSP00000358458; -.
DR PhosphoSite; Q5VWP2; -.
DR DMDM; 117940143; -.
DR PaxDb; Q5VWP2; -.
DR PRIDE; Q5VWP2; -.
DR Ensembl; ENST00000369448; ENSP00000358458; ENSG00000183508.
DR GeneID; 54855; -.
DR KEGG; hsa:54855; -.
DR UCSC; uc001ehe.3; human.
DR CTD; 54855; -.
DR GeneCards; GC01P118148; -.
DR HGNC; HGNC:24712; FAM46C.
DR HPA; HPA054049; -.
DR MIM; 613952; gene.
DR neXtProt; NX_Q5VWP2; -.
DR PharmGKB; PA134955264; -.
DR eggNOG; NOG310777; -.
DR HOGENOM; HOG000234733; -.
DR HOVERGEN; HBG057969; -.
DR InParanoid; Q5VWP2; -.
DR OMA; FFYDCSS; -.
DR OrthoDB; EOG74R1QS; -.
DR PhylomeDB; Q5VWP2; -.
DR GenomeRNAi; 54855; -.
DR NextBio; 57718; -.
DR PRO; PR:Q5VWP2; -.
DR Bgee; Q5VWP2; -.
DR CleanEx; HS_FAM46C; -.
DR Genevestigator; Q5VWP2; -.
DR InterPro; IPR012937; DUF1693.
DR Pfam; PF07984; DUF1693; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Polymorphism; Reference proteome.
FT CHAIN 1 391 Protein FAM46C.
FT /FTId=PRO_0000259933.
FT VARIANT 67 67 H -> Q (in dbSNP:rs1630312).
FT /FTId=VAR_060132.
FT CONFLICT 150 150 D -> V (in Ref. 1; BAA91010).
SQ SEQUENCE 391 AA; 44944 MW; 1B73C6688284F8AC CRC64;
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE
EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL
PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGKNVELKFV DSIRRQFEFS
VDSFQIILDS LLFFYDCSNN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR
GGGLLKYSNL LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA
PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N
//
MIM
613952
*RECORD*
*FIELD* NO
613952
*FIELD* TI
*613952 FAMILY WITH SEQUENCE SIMILARITY 46, MEMBER C; FAM46C
*FIELD* TX
DESCRIPTION
read more
FAM46C is a type I interferon (e.g., IFNA1; 147660)-stimulated gene
(ISG) that encodes a protein that appears to enhance replication of
certain viruses (Schoggins et al., 2011).
GENE FUNCTION
Using an overexpression screening approach to test more than 380 ISGs,
including MB21D1, for their ability to inhibit replication of various
human and animal viruses, including hepatitis C virus (see 609532),
yellow fever virus (YFV), West Nile virus (see 610379), chikungunya
virus, Venezuelan equine encephalitis virus (VEEV), and human
immunodeficiency virus-1 (see 609423), Schoggins et al. (2011) found
that FAM46C enhanced replication of YFV and VEEV. FAM46C had little or
no effect on other viruses tested.
MAPPING
Gross (2011) mapped the FAM46C gene to chromosome 1p12 based on an
alignment of the FAM46C sequence (GenBank GENBANK BC036516) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Gross, M. B.: Personal Communication. Baltimore, Md. 5/13/2011.
2. Schoggins, J. W.; Wilson, S. J.; Panis, M.; Murphy, M. Y.; Jones,
C. T.; Bieniasz, P.; Rice, C. M.: A diverse range of gene products
are effectors of the type I interferon antiviral response. Nature 472:
481-485, 2011.
*FIELD* CN
Matthew B. Gross - updated: 05/13/2011
*FIELD* CD
Paul J. Converse: 5/3/2011
*FIELD* ED
mgross: 05/13/2011
carol: 5/13/2011
joanna: 5/10/2011
*RECORD*
*FIELD* NO
613952
*FIELD* TI
*613952 FAMILY WITH SEQUENCE SIMILARITY 46, MEMBER C; FAM46C
*FIELD* TX
DESCRIPTION
read more
FAM46C is a type I interferon (e.g., IFNA1; 147660)-stimulated gene
(ISG) that encodes a protein that appears to enhance replication of
certain viruses (Schoggins et al., 2011).
GENE FUNCTION
Using an overexpression screening approach to test more than 380 ISGs,
including MB21D1, for their ability to inhibit replication of various
human and animal viruses, including hepatitis C virus (see 609532),
yellow fever virus (YFV), West Nile virus (see 610379), chikungunya
virus, Venezuelan equine encephalitis virus (VEEV), and human
immunodeficiency virus-1 (see 609423), Schoggins et al. (2011) found
that FAM46C enhanced replication of YFV and VEEV. FAM46C had little or
no effect on other viruses tested.
MAPPING
Gross (2011) mapped the FAM46C gene to chromosome 1p12 based on an
alignment of the FAM46C sequence (GenBank GENBANK BC036516) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Gross, M. B.: Personal Communication. Baltimore, Md. 5/13/2011.
2. Schoggins, J. W.; Wilson, S. J.; Panis, M.; Murphy, M. Y.; Jones,
C. T.; Bieniasz, P.; Rice, C. M.: A diverse range of gene products
are effectors of the type I interferon antiviral response. Nature 472:
481-485, 2011.
*FIELD* CN
Matthew B. Gross - updated: 05/13/2011
*FIELD* CD
Paul J. Converse: 5/3/2011
*FIELD* ED
mgross: 05/13/2011
carol: 5/13/2011
joanna: 5/10/2011