Full text data of FIBP
FIBP
[Confidence: low (only semi-automatic identification from reviews)]
Acidic fibroblast growth factor intracellular-binding protein; aFGF intracellular-binding protein (FGF-1 intracellular-binding protein)
Acidic fibroblast growth factor intracellular-binding protein; aFGF intracellular-binding protein (FGF-1 intracellular-binding protein)
UniProt
O43427
ID FIBP_HUMAN Reviewed; 364 AA.
AC O43427; A8K0J7; Q27Q85; Q6IBQ3; Q9HD65;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 27-APR-2001, sequence version 3.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Acidic fibroblast growth factor intracellular-binding protein;
DE Short=aFGF intracellular-binding protein;
DE AltName: Full=FGF-1 intracellular-binding protein;
GN Name=FIBP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC TISSUE=Mammary cancer;
RX PubMed=9806903;
RA Kolpakova E., Wiedlocha A., Stenmark H., Klingenberg O., Falnes P.O.,
RA Olsnes S.;
RT "Cloning of an intracellular protein that binds selectively to
RT mitogenic acidic fibroblast growth factor.";
RL Biochem. J. 336:213-222(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC TISSUE=Heart, Mammary cancer, and Umbilical vein endothelial cell;
RA Imamura T., Loupatov A.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM LONG).
RX PubMed=11104667; DOI=10.1042/0264-6021:3520629;
RA Kolpakova E., Frengen E., Stokke T., Olsnes S.;
RT "Organization, chromosomal localization and promoter analysis of the
RT gene encoding human acidic fibroblast growth factor intracellular
RT binding protein.";
RL Biochem. J. 352:629-635(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-351 AND ARG-359.
RG NIEHS SNPs program;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP INTERACTION WITH FGF1.
RX PubMed=11964394; DOI=10.1074/jbc.M112193200;
RA Skjerpen C.S., Wesche J., Olsnes S.;
RT "Identification of ribosome-binding protein p34 as an intracellular
RT protein that binds acidic fibroblast growth factor.";
RL J. Biol. Chem. 277:23864-23871(2002).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in mitogenic function of FGF1.
CC -!- SUBUNIT: Binds to internalized FGF1; this interaction is increased
CC in the presence of CSNKB, suggesting a possible cooperative
CC interaction between CSNKB and FIBP in binding to FGF1.
CC -!- SUBCELLULAR LOCATION: Nucleus. Endomembrane system; Peripheral
CC membrane protein. Note=Also associated with cytoplasmic membranes,
CC particularly of mitochondria.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=O43427-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=O43427-2; Sequence=VSP_004250;
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and
CC pancreas. Expressed at lower levels in brain. Also found in
CC placenta, liver and kidney.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/fibp/";
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF010187; AAC97140.2; -; mRNA.
DR EMBL; AF171944; AAD51694.1; -; mRNA.
DR EMBL; AF171945; AAD51695.1; -; mRNA.
DR EMBL; AF171946; AAD51696.1; -; mRNA.
DR EMBL; AF250391; AAG01396.1; -; mRNA.
DR EMBL; AF250392; AAG01397.1; -; Genomic_DNA.
DR EMBL; CR456749; CAG33030.1; -; mRNA.
DR EMBL; AK289562; BAF82251.1; -; mRNA.
DR EMBL; DQ388430; ABD48957.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW74465.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW74466.1; -; Genomic_DNA.
DR EMBL; BC014388; AAH14388.1; -; mRNA.
DR EMBL; BC017448; AAH17448.1; -; mRNA.
DR RefSeq; NP_004205.2; NM_004214.4.
DR RefSeq; NP_942600.1; NM_198897.1.
DR UniGene; Hs.7768; -.
DR ProteinModelPortal; O43427; -.
DR IntAct; O43427; 3.
DR MINT; MINT-1376383; -.
DR STRING; 9606.ENSP00000344572; -.
DR PhosphoSite; O43427; -.
DR PaxDb; O43427; -.
DR PRIDE; O43427; -.
DR DNASU; 9158; -.
DR Ensembl; ENST00000338369; ENSP00000344572; ENSG00000172500.
DR Ensembl; ENST00000357519; ENSP00000350124; ENSG00000172500.
DR GeneID; 9158; -.
DR KEGG; hsa:9158; -.
DR UCSC; uc001ogd.3; human.
DR CTD; 9158; -.
DR GeneCards; GC11M065651; -.
DR HGNC; HGNC:3705; FIBP.
DR HPA; HPA011729; -.
DR MIM; 608296; gene.
DR neXtProt; NX_O43427; -.
DR PharmGKB; PA28145; -.
DR eggNOG; NOG70779; -.
DR HOGENOM; HOG000234336; -.
DR HOVERGEN; HBG005728; -.
DR InParanoid; O43427; -.
DR OMA; QVDDMDV; -.
DR OrthoDB; EOG754HQB; -.
DR PhylomeDB; O43427; -.
DR SignaLink; O43427; -.
DR GeneWiki; FIBP; -.
DR GenomeRNAi; 9158; -.
DR NextBio; 34357; -.
DR PRO; PR:O43427; -.
DR ArrayExpress; O43427; -.
DR Bgee; O43427; -.
DR CleanEx; HS_FIBP; -.
DR Genevestigator; O43427; -.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005739; C:mitochondrion; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:ProtInc.
DR InterPro; IPR008614; FIBP.
DR PANTHER; PTHR13223; PTHR13223; 1.
DR Pfam; PF05427; FIBP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Membrane;
KW Nucleus; Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 364 Acidic fibroblast growth factor
FT intracellular-binding protein.
FT /FTId=PRO_0000087237.
FT MOD_RES 2 2 N-acetylthreonine.
FT VAR_SEQ 216 222 Missing (in isoform Short).
FT /FTId=VSP_004250.
FT VARIANT 152 152 R -> W (in dbSNP:rs11559154).
FT /FTId=VAR_050991.
FT VARIANT 351 351 M -> V (in dbSNP:rs2231893).
FT /FTId=VAR_050992.
FT VARIANT 359 359 L -> R (in dbSNP:rs36080962).
FT /FTId=VAR_060711.
SQ SEQUENCE 364 AA; 41878 MW; 7E9A05908760FF45 CRC64;
MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA VLQSDTMDHY
RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD EAFVREVLGK KLSKGTKKDL
DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA
NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD
LKELKVLVAD KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR
DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY MGTLRGCLLR
LYHD
//
ID FIBP_HUMAN Reviewed; 364 AA.
AC O43427; A8K0J7; Q27Q85; Q6IBQ3; Q9HD65;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 27-APR-2001, sequence version 3.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Acidic fibroblast growth factor intracellular-binding protein;
DE Short=aFGF intracellular-binding protein;
DE AltName: Full=FGF-1 intracellular-binding protein;
GN Name=FIBP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC TISSUE=Mammary cancer;
RX PubMed=9806903;
RA Kolpakova E., Wiedlocha A., Stenmark H., Klingenberg O., Falnes P.O.,
RA Olsnes S.;
RT "Cloning of an intracellular protein that binds selectively to
RT mitogenic acidic fibroblast growth factor.";
RL Biochem. J. 336:213-222(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC TISSUE=Heart, Mammary cancer, and Umbilical vein endothelial cell;
RA Imamura T., Loupatov A.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM LONG).
RX PubMed=11104667; DOI=10.1042/0264-6021:3520629;
RA Kolpakova E., Frengen E., Stokke T., Olsnes S.;
RT "Organization, chromosomal localization and promoter analysis of the
RT gene encoding human acidic fibroblast growth factor intracellular
RT binding protein.";
RL Biochem. J. 352:629-635(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-351 AND ARG-359.
RG NIEHS SNPs program;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP INTERACTION WITH FGF1.
RX PubMed=11964394; DOI=10.1074/jbc.M112193200;
RA Skjerpen C.S., Wesche J., Olsnes S.;
RT "Identification of ribosome-binding protein p34 as an intracellular
RT protein that binds acidic fibroblast growth factor.";
RL J. Biol. Chem. 277:23864-23871(2002).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in mitogenic function of FGF1.
CC -!- SUBUNIT: Binds to internalized FGF1; this interaction is increased
CC in the presence of CSNKB, suggesting a possible cooperative
CC interaction between CSNKB and FIBP in binding to FGF1.
CC -!- SUBCELLULAR LOCATION: Nucleus. Endomembrane system; Peripheral
CC membrane protein. Note=Also associated with cytoplasmic membranes,
CC particularly of mitochondria.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=O43427-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=O43427-2; Sequence=VSP_004250;
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and
CC pancreas. Expressed at lower levels in brain. Also found in
CC placenta, liver and kidney.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/fibp/";
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF010187; AAC97140.2; -; mRNA.
DR EMBL; AF171944; AAD51694.1; -; mRNA.
DR EMBL; AF171945; AAD51695.1; -; mRNA.
DR EMBL; AF171946; AAD51696.1; -; mRNA.
DR EMBL; AF250391; AAG01396.1; -; mRNA.
DR EMBL; AF250392; AAG01397.1; -; Genomic_DNA.
DR EMBL; CR456749; CAG33030.1; -; mRNA.
DR EMBL; AK289562; BAF82251.1; -; mRNA.
DR EMBL; DQ388430; ABD48957.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW74465.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW74466.1; -; Genomic_DNA.
DR EMBL; BC014388; AAH14388.1; -; mRNA.
DR EMBL; BC017448; AAH17448.1; -; mRNA.
DR RefSeq; NP_004205.2; NM_004214.4.
DR RefSeq; NP_942600.1; NM_198897.1.
DR UniGene; Hs.7768; -.
DR ProteinModelPortal; O43427; -.
DR IntAct; O43427; 3.
DR MINT; MINT-1376383; -.
DR STRING; 9606.ENSP00000344572; -.
DR PhosphoSite; O43427; -.
DR PaxDb; O43427; -.
DR PRIDE; O43427; -.
DR DNASU; 9158; -.
DR Ensembl; ENST00000338369; ENSP00000344572; ENSG00000172500.
DR Ensembl; ENST00000357519; ENSP00000350124; ENSG00000172500.
DR GeneID; 9158; -.
DR KEGG; hsa:9158; -.
DR UCSC; uc001ogd.3; human.
DR CTD; 9158; -.
DR GeneCards; GC11M065651; -.
DR HGNC; HGNC:3705; FIBP.
DR HPA; HPA011729; -.
DR MIM; 608296; gene.
DR neXtProt; NX_O43427; -.
DR PharmGKB; PA28145; -.
DR eggNOG; NOG70779; -.
DR HOGENOM; HOG000234336; -.
DR HOVERGEN; HBG005728; -.
DR InParanoid; O43427; -.
DR OMA; QVDDMDV; -.
DR OrthoDB; EOG754HQB; -.
DR PhylomeDB; O43427; -.
DR SignaLink; O43427; -.
DR GeneWiki; FIBP; -.
DR GenomeRNAi; 9158; -.
DR NextBio; 34357; -.
DR PRO; PR:O43427; -.
DR ArrayExpress; O43427; -.
DR Bgee; O43427; -.
DR CleanEx; HS_FIBP; -.
DR Genevestigator; O43427; -.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005739; C:mitochondrion; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:ProtInc.
DR InterPro; IPR008614; FIBP.
DR PANTHER; PTHR13223; PTHR13223; 1.
DR Pfam; PF05427; FIBP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome; Membrane;
KW Nucleus; Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 364 Acidic fibroblast growth factor
FT intracellular-binding protein.
FT /FTId=PRO_0000087237.
FT MOD_RES 2 2 N-acetylthreonine.
FT VAR_SEQ 216 222 Missing (in isoform Short).
FT /FTId=VSP_004250.
FT VARIANT 152 152 R -> W (in dbSNP:rs11559154).
FT /FTId=VAR_050991.
FT VARIANT 351 351 M -> V (in dbSNP:rs2231893).
FT /FTId=VAR_050992.
FT VARIANT 359 359 L -> R (in dbSNP:rs36080962).
FT /FTId=VAR_060711.
SQ SEQUENCE 364 AA; 41878 MW; 7E9A05908760FF45 CRC64;
MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA VLQSDTMDHY
RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD EAFVREVLGK KLSKGTKKDL
DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA
NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD
LKELKVLVAD KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR
DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY MGTLRGCLLR
LYHD
//
MIM
608296
*RECORD*
*FIELD* NO
608296
*FIELD* TI
*608296 FIBROBLAST GROWTH FACTOR, ACIDIC, INTRACELLULAR BINDING PROTEIN; FIBP
*FIELD* TX
read more
CLONING
Using the yeast 2-hybrid system, Kolpakova et al. (1998) identified a
HeLa cell cDNA, which the authors termed FIBP, that interacts with
acidic fibroblast growth factor (FGF1; 131220). The FIBP cDNA encodes a
deduced 372-amino acid protein with a predicted molecular mass of 42 kD.
The protein is mainly hydrophilic and has no N-terminal signal sequence.
Northern blot analysis demonstrated that FIBP and FGF1 have similar
expression patterns. FIBP is expressed ubiquitously as an approximately
1.4-kb transcript at highest levels in heart, skeletal muscle, and
pancreas, and at somewhat lower levels in brain. In vitro experiments
showed that FIBP readily attaches to microsomal membranes and is capable
of binding FGF1 with high affinity. Immunofluorescence studies
demonstrated that FIBP is mainly localized in the nucleus and to a
lesser extent in mitochondria and other cytoplasmic membranes. Western
blot analysis indicated the presence of 2 forms of FIBP.
By RT-PCR analysis, Kolpakova et al. (2000) identified a second FIBP
transcript caused by alternative splicing of exon 5 and resulting in a
protein with an additional 7 residues. They cloned and characterized the
mouse Fibp gene and, by database searching, identified a Drosophila
homolog. Human FIBP shares 97% and 46% sequence identity with the mouse
and Drosophila homologs, respectively.
GENE STRUCTURE
Kolpakova et al. (2000) determined that the FIBP gene contains 10 exons
and spans more than 5 kb. Sequence analysis of the region surrounding
the translation start revealed a CpG island. Functional studies of the
promoter region suggested strong transcriptional activity.
MAPPING
By FISH, Kolpakova et al. (2000) mapped the FIBP gene to chromosome
11q13.1.
*FIELD* RF
1. Kolpakova, E.; Frengen, E.; Stokke, T.; Olsnes, S.: Organization,
chromosomal localization and promoter analysis of the gene encoding
human acidic fibroblast growth factor intracellular binding protein. Biochem.
J. 352: 629-635, 2000.
2. Kolpakova, E.; Wiedlocha, A.; Stenmark, H.; Klingenberg, O.; Falnes,
P. O.; Olsnes, S.: Cloning of an intracellular protein that binds
selectively to mitogenic acidic fibroblast growth factor. Biochem.
J. 336: 213-222, 1998.
*FIELD* CD
Carol A. Bocchini: 12/1/2003
*FIELD* ED
tkritzer: 12/01/2003
carol: 12/1/2003
*RECORD*
*FIELD* NO
608296
*FIELD* TI
*608296 FIBROBLAST GROWTH FACTOR, ACIDIC, INTRACELLULAR BINDING PROTEIN; FIBP
*FIELD* TX
read more
CLONING
Using the yeast 2-hybrid system, Kolpakova et al. (1998) identified a
HeLa cell cDNA, which the authors termed FIBP, that interacts with
acidic fibroblast growth factor (FGF1; 131220). The FIBP cDNA encodes a
deduced 372-amino acid protein with a predicted molecular mass of 42 kD.
The protein is mainly hydrophilic and has no N-terminal signal sequence.
Northern blot analysis demonstrated that FIBP and FGF1 have similar
expression patterns. FIBP is expressed ubiquitously as an approximately
1.4-kb transcript at highest levels in heart, skeletal muscle, and
pancreas, and at somewhat lower levels in brain. In vitro experiments
showed that FIBP readily attaches to microsomal membranes and is capable
of binding FGF1 with high affinity. Immunofluorescence studies
demonstrated that FIBP is mainly localized in the nucleus and to a
lesser extent in mitochondria and other cytoplasmic membranes. Western
blot analysis indicated the presence of 2 forms of FIBP.
By RT-PCR analysis, Kolpakova et al. (2000) identified a second FIBP
transcript caused by alternative splicing of exon 5 and resulting in a
protein with an additional 7 residues. They cloned and characterized the
mouse Fibp gene and, by database searching, identified a Drosophila
homolog. Human FIBP shares 97% and 46% sequence identity with the mouse
and Drosophila homologs, respectively.
GENE STRUCTURE
Kolpakova et al. (2000) determined that the FIBP gene contains 10 exons
and spans more than 5 kb. Sequence analysis of the region surrounding
the translation start revealed a CpG island. Functional studies of the
promoter region suggested strong transcriptional activity.
MAPPING
By FISH, Kolpakova et al. (2000) mapped the FIBP gene to chromosome
11q13.1.
*FIELD* RF
1. Kolpakova, E.; Frengen, E.; Stokke, T.; Olsnes, S.: Organization,
chromosomal localization and promoter analysis of the gene encoding
human acidic fibroblast growth factor intracellular binding protein. Biochem.
J. 352: 629-635, 2000.
2. Kolpakova, E.; Wiedlocha, A.; Stenmark, H.; Klingenberg, O.; Falnes,
P. O.; Olsnes, S.: Cloning of an intracellular protein that binds
selectively to mitogenic acidic fibroblast growth factor. Biochem.
J. 336: 213-222, 1998.
*FIELD* CD
Carol A. Bocchini: 12/1/2003
*FIELD* ED
tkritzer: 12/01/2003
carol: 12/1/2003