Full text data of FLG2
FLG2
(IFPS)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Filaggrin-2; FLG-2 (Intermediate filament-associated and psoriasis-susceptibility protein; Ifapsoriasin)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Filaggrin-2; FLG-2 (Intermediate filament-associated and psoriasis-susceptibility protein; Ifapsoriasin)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q5D862
ID FILA2_HUMAN Reviewed; 2391 AA.
AC Q5D862; Q9H4U1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 29-MAR-2005, sequence version 1.
DT 22-JAN-2014, entry version 81.
DE RecName: Full=Filaggrin-2;
DE Short=FLG-2;
DE AltName: Full=Intermediate filament-associated and psoriasis-susceptibility protein;
DE Short=Ifapsoriasin;
GN Name=FLG2; Synonyms=IFPS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Foreskin;
RA Wu Z.;
RT "The human intermediate filament-associated protein family.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Listwan P., Rothnagel J.A.;
RT "Identification and partial characterization of the human homolog of
RT mouse flg-2.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP PROTEIN SEQUENCE OF 7-17 AND 40-46, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RA Bienvenut W.V., Calvo F., Kolch W.;
RL Submitted (MAR-2008) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC -!- SIMILARITY: In the N-terminal section; belongs to the S-100
CC family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
CC -!- SIMILARITY: Contains 10 filaggrin repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY827490; AAX12417.1; -; mRNA.
DR EMBL; DQ118293; AAZ99029.1; -; Genomic_DNA.
DR EMBL; AL356504; CAC13173.2; -; Genomic_DNA.
DR RefSeq; NP_001014364.1; NM_001014342.2.
DR UniGene; Hs.156124; -.
DR ProteinModelPortal; Q5D862; -.
DR SMR; Q5D862; 11-97.
DR IntAct; Q5D862; 7.
DR MINT; MINT-6488800; -.
DR STRING; 9606.ENSP00000373370; -.
DR PhosphoSite; Q5D862; -.
DR DMDM; 74755309; -.
DR UCD-2DPAGE; Q5D862; -.
DR PaxDb; Q5D862; -.
DR PRIDE; Q5D862; -.
DR Ensembl; ENST00000388718; ENSP00000373370; ENSG00000143520.
DR GeneID; 388698; -.
DR KEGG; hsa:388698; -.
DR UCSC; uc001ezw.4; human.
DR CTD; 388698; -.
DR GeneCards; GC01M152321; -.
DR HGNC; HGNC:33276; FLG2.
DR HPA; HPA028699; -.
DR neXtProt; NX_Q5D862; -.
DR PharmGKB; PA162388694; -.
DR eggNOG; NOG12793; -.
DR HOGENOM; HOG000112590; -.
DR InParanoid; Q5D862; -.
DR KO; K10384; -.
DR OMA; GTTHAQS; -.
DR OrthoDB; EOG7BP821; -.
DR GenomeRNAi; 388698; -.
DR NextBio; 102296; -.
DR PRO; PR:Q5D862; -.
DR Bgee; Q5D862; -.
DR CleanEx; HS_FLG2; -.
DR Genevestigator; Q5D862; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003303; Filaggrin.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR PRINTS; PR00487; FILAGGRIN.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW Calcium; Complete proteome; Direct protein sequencing; Metal-binding;
KW Polymorphism; Reference proteome; Repeat.
FT CHAIN 1 2391 Filaggrin-2.
FT /FTId=PRO_0000331454.
FT DOMAIN 8 43 EF-hand 1.
FT DOMAIN 49 84 EF-hand 2.
FT REPEAT 245 289 Filaggrin 1.
FT REPEAT 421 466 Filaggrin 2.
FT REPEAT 1019 1051 Filaggrin 3.
FT REPEAT 1097 1141 Filaggrin 4.
FT REPEAT 1455 1510 Filaggrin 5.
FT REPEAT 1607 1662 Filaggrin 6.
FT REPEAT 1757 1812 Filaggrin 7.
FT REPEAT 1928 1964 Filaggrin 8.
FT REPEAT 1984 2039 Filaggrin 9.
FT REPEAT 2134 2189 Filaggrin 10.
FT CA_BIND 62 73 Potential.
FT REGION 1 81 S-100-like (By similarity).
FT COMPBIAS 132 1289 Ser-rich.
FT VARIANT 41 41 L -> F (in dbSNP:rs3818831).
FT /FTId=VAR_042868.
FT VARIANT 107 107 R -> Q (in dbSNP:rs2282304).
FT /FTId=VAR_042869.
FT VARIANT 137 137 G -> E (in dbSNP:rs6587667).
FT /FTId=VAR_042870.
FT VARIANT 276 276 R -> Q (in dbSNP:rs2282303).
FT /FTId=VAR_042871.
FT VARIANT 298 298 C -> S (in dbSNP:rs2282302).
FT /FTId=VAR_042872.
FT VARIANT 723 723 E -> K (in dbSNP:rs16842865).
FT /FTId=VAR_042873.
FT VARIANT 881 881 Y -> S (in dbSNP:rs12411129).
FT /FTId=VAR_042874.
FT VARIANT 958 958 S -> Y (in dbSNP:rs12411129).
FT /FTId=VAR_059173.
FT VARIANT 1249 1249 H -> R (in dbSNP:rs16833974).
FT /FTId=VAR_042875.
FT VARIANT 1992 1992 E -> D (in dbSNP:rs1858484).
FT /FTId=VAR_042876.
FT VARIANT 2239 2239 Q -> H (in dbSNP:rs12736606).
FT /FTId=VAR_042877.
SQ SEQUENCE 2391 AA; 248073 MW; 8BC74DE89E0DDC05 CRC64;
MTDLLRSVVT VIDVFYKYTK QDGECGTLSK GELKELLEKE LHPVLKNPDD PDTVDVIMHM
LDRDHDRRLD FTEFLLMIFK LTMACNKVLS KEYCKASGSK KHRRGHRHQE EESETEEDEE
DTPGHKSGYR HSSWSEGEEH GYSSGHSRGT VKCRHGSNSR RLGRQGNLSS SGNQEGSQKR
YHRSSCGHSW SGGKDRHGSS SVELRERINK SHISPSRESG EEYESGSGSN SWERKGHGGL
SCGLETSGHE SNSTQSRIRE QKLGSSCSGS GDSGRRSHAC GYSNSSGCGR PQNASSSCQS
HRFGGQGNQF SYIQSGCQSG IKGGQGHGCV SGGQPSGCGQ PESNPCSQSY SQRGYGAREN
GQPQNCGGQW RTGSSQSSCC GQYGSGGSQS CSNGQHEYGS CGRFSNSSSS NEFSKCDQYG
SGSSQSTSFE QHGTGLSQSS GFEQHVCGSG QTCGQHESTS SQSLGYDQHG SSSGKTSGFG
QHGSGSGQSS GFGQCGSGSG QSSGFGQHGS VSGQSSGFGQ HGSVSGQSSG FGQHESRSRQ
SSYGQHGSGS SQSSGYGQYG SRETSGFGQH GLGSGQSTGF GQYGSGSGQS SGFGQHGSGS
GQSSGFGQHE SRSGQSSYGQ HSSGSSQSSG YGQHGSRQTS GFGQHGSGSS QSTGFGQYGS
GSGQSSGFGQ HVSGSGQSSG FGQHESRSGH SSYGQHGFGS SQSSGYGQHG SSSGQTSGFG
QHELSSGQSS SFGQHGSGSG QSSGFGQHGS GSGQSSGFGQ HESRSGQSSY GQHSSGSSQS
SGYGQHGSRQ TSGFGQHGSG SSQSTGFGQY GSGSGQSAGF GQHGSGSGQS SGFGQHESRS
HQSSYGQHGS GSSQSSGYGQ HGSSSGQTSG FGQHRSSSGQ YSGFGQHGSG SGQSSGFGQH
GTGSGQYSGF GQHESRSHQS SYGQHGSGSS QSSGYGQHGS SSGQTFGFGQ HRSGSGQSSG
FGQHGSGSGQ SSGFGQHESG SGKSSGFGQH ESRSSQSNYG QHGSGSSQSS GYGQHGSSSG
QTTGFGQHRS SSGQYSGFGQ HGSGSDQSSG FGQHGTGSGQ SSGFGQYESR SRQSSYGQHG
SGSSQSSGYG QHGSNSGQTS GFGQHRPGSG QSSGFGQYGS GSGQSSGFGQ HGSGTGKSSG
FAQHEYRSGQ SSYGQHGTGS SQSSGCGQHE SGSGPTTSFG QHVSGSDNFS SSGQHISDSG
QSTGFGQYGS GSGQSTGLGQ GESQQVESGS TVHGRQETTH GQTINTTRHS QSGQGQSTQT
GSRVTRRRRS SQSENSDSEV HSKVSHRHSE HIHTQAGSHY PKSGSTVRRR QGTTHGQRGD
TTRHGHSGHG QSTQTGSRTS GRQRFSHSDA TDSEVHSGVS HRPHSQEQTH SQAGSQHGES
ESTVHERHET TYGQTGEATG HGHSGHGQST QRGSRTTGRR GSGHSESSDS EVHSGGSHRP
QSQEQTHGQA GSQHGESGST VHGRHGTTHG QTGDTTRHAH YHHGKSTQRG SSTTGRRGSG
HSESSDSEVH SGGSHTHSGH THGQSGSQHG ESESIIHDRH RITHGQTGDT TRHSYSGHEQ
TTQTGSRTTG RQRTSHSEST DSEVHSGGSH RPHSREHTYG QAGSQHEEPE FTVHERHGTT
HGQIGDTTGH SHSGHGQSTQ RGSRTTGRQR SSHSESSDSE VHSGVSHTHT GHTHGQAGSQ
HGQSESIVPE RHGTTHGQTG DTTRHAHYHH GLTTQTGSRT TGRRGSGHSE YSDSEGYSGV
SHTHSGHTHG QARSQHGESE SIVHERHGTI HGQTGDTTRH AHSGHGQSTQ TGSRTTGRRS
SGHSEYSDSE GHSGFSQRPH SRGHTHGQAG SQHGESESIV DERHGTTHGQ TGDTSGHSQS
GHGQSTQSGS STTGRRRSGH SESSDSEVHS GGSHTHSGHT HSQARSQHGE SESTVHKRHQ
TTHGQTGDTT EHGHPSHGQT IQTGSRTTGR RGSGHSEYSD SEGPSGVSHT HSGHTHGQAG
SHYPESGSSV HERHGTTHGQ TADTTRHGHS GHGQSTQRGS RTTGRRASGH SEYSDSEGHS
GVSHTHSGHA HGQAGSQHGE SGSSVHERHG TTHGQTGDTT RHAHSGHGQS TQRGSRTAGR
RGSGHSESSD SEVHSGVSHT HSGHTYGQAR SQHGESGSAI HGRQGTIHGQ TGDTTRHGQS
GHGQSTQTGS RTTGRQRSSH SESSDSEVHS EASPTHSGHT HSQAGSRHGQ SGSSGHGRQG
TTHGQTGDTT RHAHYGYGQS TQRGSRTTGR RGSGHSESSD SEVHSWGSHT HSGHIQGQAG
SQQRQPGSTV HGRLETTHGQ TGDTTRHGHS GYGQSTQTGS RSSRASHFQS HSSERQRHGS
SQVWKHGSYG PAEYDYGHTG YGPSGGSRKS ISNSHLSWST DSTANKQLSR H
//
ID FILA2_HUMAN Reviewed; 2391 AA.
AC Q5D862; Q9H4U1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 29-MAR-2005, sequence version 1.
DT 22-JAN-2014, entry version 81.
DE RecName: Full=Filaggrin-2;
DE Short=FLG-2;
DE AltName: Full=Intermediate filament-associated and psoriasis-susceptibility protein;
DE Short=Ifapsoriasin;
GN Name=FLG2; Synonyms=IFPS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Foreskin;
RA Wu Z.;
RT "The human intermediate filament-associated protein family.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Listwan P., Rothnagel J.A.;
RT "Identification and partial characterization of the human homolog of
RT mouse flg-2.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP PROTEIN SEQUENCE OF 7-17 AND 40-46, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RA Bienvenut W.V., Calvo F., Kolch W.;
RL Submitted (MAR-2008) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC -!- SIMILARITY: In the N-terminal section; belongs to the S-100
CC family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
CC -!- SIMILARITY: Contains 10 filaggrin repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY827490; AAX12417.1; -; mRNA.
DR EMBL; DQ118293; AAZ99029.1; -; Genomic_DNA.
DR EMBL; AL356504; CAC13173.2; -; Genomic_DNA.
DR RefSeq; NP_001014364.1; NM_001014342.2.
DR UniGene; Hs.156124; -.
DR ProteinModelPortal; Q5D862; -.
DR SMR; Q5D862; 11-97.
DR IntAct; Q5D862; 7.
DR MINT; MINT-6488800; -.
DR STRING; 9606.ENSP00000373370; -.
DR PhosphoSite; Q5D862; -.
DR DMDM; 74755309; -.
DR UCD-2DPAGE; Q5D862; -.
DR PaxDb; Q5D862; -.
DR PRIDE; Q5D862; -.
DR Ensembl; ENST00000388718; ENSP00000373370; ENSG00000143520.
DR GeneID; 388698; -.
DR KEGG; hsa:388698; -.
DR UCSC; uc001ezw.4; human.
DR CTD; 388698; -.
DR GeneCards; GC01M152321; -.
DR HGNC; HGNC:33276; FLG2.
DR HPA; HPA028699; -.
DR neXtProt; NX_Q5D862; -.
DR PharmGKB; PA162388694; -.
DR eggNOG; NOG12793; -.
DR HOGENOM; HOG000112590; -.
DR InParanoid; Q5D862; -.
DR KO; K10384; -.
DR OMA; GTTHAQS; -.
DR OrthoDB; EOG7BP821; -.
DR GenomeRNAi; 388698; -.
DR NextBio; 102296; -.
DR PRO; PR:Q5D862; -.
DR Bgee; Q5D862; -.
DR CleanEx; HS_FLG2; -.
DR Genevestigator; Q5D862; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003303; Filaggrin.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR PRINTS; PR00487; FILAGGRIN.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW Calcium; Complete proteome; Direct protein sequencing; Metal-binding;
KW Polymorphism; Reference proteome; Repeat.
FT CHAIN 1 2391 Filaggrin-2.
FT /FTId=PRO_0000331454.
FT DOMAIN 8 43 EF-hand 1.
FT DOMAIN 49 84 EF-hand 2.
FT REPEAT 245 289 Filaggrin 1.
FT REPEAT 421 466 Filaggrin 2.
FT REPEAT 1019 1051 Filaggrin 3.
FT REPEAT 1097 1141 Filaggrin 4.
FT REPEAT 1455 1510 Filaggrin 5.
FT REPEAT 1607 1662 Filaggrin 6.
FT REPEAT 1757 1812 Filaggrin 7.
FT REPEAT 1928 1964 Filaggrin 8.
FT REPEAT 1984 2039 Filaggrin 9.
FT REPEAT 2134 2189 Filaggrin 10.
FT CA_BIND 62 73 Potential.
FT REGION 1 81 S-100-like (By similarity).
FT COMPBIAS 132 1289 Ser-rich.
FT VARIANT 41 41 L -> F (in dbSNP:rs3818831).
FT /FTId=VAR_042868.
FT VARIANT 107 107 R -> Q (in dbSNP:rs2282304).
FT /FTId=VAR_042869.
FT VARIANT 137 137 G -> E (in dbSNP:rs6587667).
FT /FTId=VAR_042870.
FT VARIANT 276 276 R -> Q (in dbSNP:rs2282303).
FT /FTId=VAR_042871.
FT VARIANT 298 298 C -> S (in dbSNP:rs2282302).
FT /FTId=VAR_042872.
FT VARIANT 723 723 E -> K (in dbSNP:rs16842865).
FT /FTId=VAR_042873.
FT VARIANT 881 881 Y -> S (in dbSNP:rs12411129).
FT /FTId=VAR_042874.
FT VARIANT 958 958 S -> Y (in dbSNP:rs12411129).
FT /FTId=VAR_059173.
FT VARIANT 1249 1249 H -> R (in dbSNP:rs16833974).
FT /FTId=VAR_042875.
FT VARIANT 1992 1992 E -> D (in dbSNP:rs1858484).
FT /FTId=VAR_042876.
FT VARIANT 2239 2239 Q -> H (in dbSNP:rs12736606).
FT /FTId=VAR_042877.
SQ SEQUENCE 2391 AA; 248073 MW; 8BC74DE89E0DDC05 CRC64;
MTDLLRSVVT VIDVFYKYTK QDGECGTLSK GELKELLEKE LHPVLKNPDD PDTVDVIMHM
LDRDHDRRLD FTEFLLMIFK LTMACNKVLS KEYCKASGSK KHRRGHRHQE EESETEEDEE
DTPGHKSGYR HSSWSEGEEH GYSSGHSRGT VKCRHGSNSR RLGRQGNLSS SGNQEGSQKR
YHRSSCGHSW SGGKDRHGSS SVELRERINK SHISPSRESG EEYESGSGSN SWERKGHGGL
SCGLETSGHE SNSTQSRIRE QKLGSSCSGS GDSGRRSHAC GYSNSSGCGR PQNASSSCQS
HRFGGQGNQF SYIQSGCQSG IKGGQGHGCV SGGQPSGCGQ PESNPCSQSY SQRGYGAREN
GQPQNCGGQW RTGSSQSSCC GQYGSGGSQS CSNGQHEYGS CGRFSNSSSS NEFSKCDQYG
SGSSQSTSFE QHGTGLSQSS GFEQHVCGSG QTCGQHESTS SQSLGYDQHG SSSGKTSGFG
QHGSGSGQSS GFGQCGSGSG QSSGFGQHGS VSGQSSGFGQ HGSVSGQSSG FGQHESRSRQ
SSYGQHGSGS SQSSGYGQYG SRETSGFGQH GLGSGQSTGF GQYGSGSGQS SGFGQHGSGS
GQSSGFGQHE SRSGQSSYGQ HSSGSSQSSG YGQHGSRQTS GFGQHGSGSS QSTGFGQYGS
GSGQSSGFGQ HVSGSGQSSG FGQHESRSGH SSYGQHGFGS SQSSGYGQHG SSSGQTSGFG
QHELSSGQSS SFGQHGSGSG QSSGFGQHGS GSGQSSGFGQ HESRSGQSSY GQHSSGSSQS
SGYGQHGSRQ TSGFGQHGSG SSQSTGFGQY GSGSGQSAGF GQHGSGSGQS SGFGQHESRS
HQSSYGQHGS GSSQSSGYGQ HGSSSGQTSG FGQHRSSSGQ YSGFGQHGSG SGQSSGFGQH
GTGSGQYSGF GQHESRSHQS SYGQHGSGSS QSSGYGQHGS SSGQTFGFGQ HRSGSGQSSG
FGQHGSGSGQ SSGFGQHESG SGKSSGFGQH ESRSSQSNYG QHGSGSSQSS GYGQHGSSSG
QTTGFGQHRS SSGQYSGFGQ HGSGSDQSSG FGQHGTGSGQ SSGFGQYESR SRQSSYGQHG
SGSSQSSGYG QHGSNSGQTS GFGQHRPGSG QSSGFGQYGS GSGQSSGFGQ HGSGTGKSSG
FAQHEYRSGQ SSYGQHGTGS SQSSGCGQHE SGSGPTTSFG QHVSGSDNFS SSGQHISDSG
QSTGFGQYGS GSGQSTGLGQ GESQQVESGS TVHGRQETTH GQTINTTRHS QSGQGQSTQT
GSRVTRRRRS SQSENSDSEV HSKVSHRHSE HIHTQAGSHY PKSGSTVRRR QGTTHGQRGD
TTRHGHSGHG QSTQTGSRTS GRQRFSHSDA TDSEVHSGVS HRPHSQEQTH SQAGSQHGES
ESTVHERHET TYGQTGEATG HGHSGHGQST QRGSRTTGRR GSGHSESSDS EVHSGGSHRP
QSQEQTHGQA GSQHGESGST VHGRHGTTHG QTGDTTRHAH YHHGKSTQRG SSTTGRRGSG
HSESSDSEVH SGGSHTHSGH THGQSGSQHG ESESIIHDRH RITHGQTGDT TRHSYSGHEQ
TTQTGSRTTG RQRTSHSEST DSEVHSGGSH RPHSREHTYG QAGSQHEEPE FTVHERHGTT
HGQIGDTTGH SHSGHGQSTQ RGSRTTGRQR SSHSESSDSE VHSGVSHTHT GHTHGQAGSQ
HGQSESIVPE RHGTTHGQTG DTTRHAHYHH GLTTQTGSRT TGRRGSGHSE YSDSEGYSGV
SHTHSGHTHG QARSQHGESE SIVHERHGTI HGQTGDTTRH AHSGHGQSTQ TGSRTTGRRS
SGHSEYSDSE GHSGFSQRPH SRGHTHGQAG SQHGESESIV DERHGTTHGQ TGDTSGHSQS
GHGQSTQSGS STTGRRRSGH SESSDSEVHS GGSHTHSGHT HSQARSQHGE SESTVHKRHQ
TTHGQTGDTT EHGHPSHGQT IQTGSRTTGR RGSGHSEYSD SEGPSGVSHT HSGHTHGQAG
SHYPESGSSV HERHGTTHGQ TADTTRHGHS GHGQSTQRGS RTTGRRASGH SEYSDSEGHS
GVSHTHSGHA HGQAGSQHGE SGSSVHERHG TTHGQTGDTT RHAHSGHGQS TQRGSRTAGR
RGSGHSESSD SEVHSGVSHT HSGHTYGQAR SQHGESGSAI HGRQGTIHGQ TGDTTRHGQS
GHGQSTQTGS RTTGRQRSSH SESSDSEVHS EASPTHSGHT HSQAGSRHGQ SGSSGHGRQG
TTHGQTGDTT RHAHYGYGQS TQRGSRTTGR RGSGHSESSD SEVHSWGSHT HSGHIQGQAG
SQQRQPGSTV HGRLETTHGQ TGDTTRHGHS GYGQSTQTGS RSSRASHFQS HSSERQRHGS
SQVWKHGSYG PAEYDYGHTG YGPSGGSRKS ISNSHLSWST DSTANKQLSR H
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