Full text data of FKBP11
FKBP11
(FKBP19)
[Confidence: low (only semi-automatic identification from reviews)]
Peptidyl-prolyl cis-trans isomerase FKBP11; PPIase FKBP11; 5.2.1.8 (19 kDa FK506-binding protein; 19 kDa FKBP; FKBP-19; FK506-binding protein 11; FKBP-11; Rotamase; Flags: Precursor)
Peptidyl-prolyl cis-trans isomerase FKBP11; PPIase FKBP11; 5.2.1.8 (19 kDa FK506-binding protein; 19 kDa FKBP; FKBP-19; FK506-binding protein 11; FKBP-11; Rotamase; Flags: Precursor)
UniProt
Q9NYL4
ID FKB11_HUMAN Reviewed; 201 AA.
AC Q9NYL4; B4DWB7;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP11;
DE Short=PPIase FKBP11;
DE EC=5.2.1.8;
DE AltName: Full=19 kDa FK506-binding protein;
DE Short=19 kDa FKBP;
DE Short=FKBP-19;
DE AltName: Full=FK506-binding protein 11;
DE Short=FKBP-11;
DE AltName: Full=Rotamase;
DE Flags: Precursor;
GN Name=FKBP11; Synonyms=FKBP19; ORFNames=UNQ336/PRO535;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Rulten S., Kay J.E., Robinson C.;
RT "Identification of novel FKBP genes.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA Kucherlapati R., Weinstock G., Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: PPIases accelerate the folding of proteins during
CC protein synthesis.
CC -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC (omega=0).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NYL4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NYL4-2; Sequence=VSP_043037;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family.
CC -!- SIMILARITY: Contains 1 PPIase FKBP-type domain.
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DR EMBL; AF238079; AAF63478.1; -; mRNA.
DR EMBL; AY358998; AAQ89357.1; -; mRNA.
DR EMBL; AK301455; BAG62979.1; -; mRNA.
DR EMBL; AC073610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027973; AAH27973.1; -; mRNA.
DR RefSeq; NP_001137253.1; NM_001143781.1.
DR RefSeq; NP_001137254.1; NM_001143782.1.
DR RefSeq; NP_057678.1; NM_016594.2.
DR UniGene; Hs.655103; -.
DR ProteinModelPortal; Q9NYL4; -.
DR SMR; Q9NYL4; 26-145.
DR IntAct; Q9NYL4; 1.
DR STRING; 9606.ENSP00000256680; -.
DR PhosphoSite; Q9NYL4; -.
DR DMDM; 23396601; -.
DR PaxDb; Q9NYL4; -.
DR PRIDE; Q9NYL4; -.
DR DNASU; 51303; -.
DR Ensembl; ENST00000453172; ENSP00000396874; ENSG00000134285.
DR Ensembl; ENST00000550765; ENSP00000449751; ENSG00000134285.
DR GeneID; 51303; -.
DR KEGG; hsa:51303; -.
DR UCSC; uc001rsp.3; human.
DR CTD; 51303; -.
DR GeneCards; GC12M049315; -.
DR HGNC; HGNC:18624; FKBP11.
DR HPA; HPA041709; -.
DR MIM; 610571; gene.
DR neXtProt; NX_Q9NYL4; -.
DR PharmGKB; PA38607; -.
DR eggNOG; COG0545; -.
DR HOGENOM; HOG000154887; -.
DR HOVERGEN; HBG051623; -.
DR InParanoid; Q9NYL4; -.
DR KO; K09576; -.
DR OMA; SRPKVSK; -.
DR PhylomeDB; Q9NYL4; -.
DR ChiTaRS; FKBP11; human.
DR GenomeRNAi; 51303; -.
DR NextBio; 54609; -.
DR PRO; PR:Q9NYL4; -.
DR ArrayExpress; Q9NYL4; -.
DR Bgee; Q9NYL4; -.
DR CleanEx; HS_FKBP11; -.
DR Genevestigator; Q9NYL4; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:RefGenome.
DR GO; GO:0005528; F:FK506 binding; IBA:RefGenome.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW.
DR InterPro; IPR023566; PPIase_FKBP.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR PANTHER; PTHR10516; PTHR10516; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Isomerase; Membrane;
KW Reference proteome; Rotamase; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 27 Potential.
FT CHAIN 28 201 Peptidyl-prolyl cis-trans isomerase
FT FKBP11.
FT /FTId=PRO_0000025519.
FT TRANSMEM 156 176 Helical; (Potential).
FT DOMAIN 57 144 PPIase FKBP-type.
FT VAR_SEQ 130 201 ADAVVQYDVELIALIRANYWLKLVKGILPLVGMAMVPALLG
FT LIGYHLYRKANRPKVSKKKLKEEKRNKSKKK -> GTKDNL
FT MRPPGMTSSSQ (in isoform 2).
FT /FTId=VSP_043037.
SQ SEQUENCE 201 AA; 22180 MW; 586E430B9D2DC0A2 CRC64;
MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL
HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG
KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA
NRPKVSKKKL KEEKRNKSKK K
//
ID FKB11_HUMAN Reviewed; 201 AA.
AC Q9NYL4; B4DWB7;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP11;
DE Short=PPIase FKBP11;
DE EC=5.2.1.8;
DE AltName: Full=19 kDa FK506-binding protein;
DE Short=19 kDa FKBP;
DE Short=FKBP-19;
DE AltName: Full=FK506-binding protein 11;
DE Short=FKBP-11;
DE AltName: Full=Rotamase;
DE Flags: Precursor;
GN Name=FKBP11; Synonyms=FKBP19; ORFNames=UNQ336/PRO535;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Rulten S., Kay J.E., Robinson C.;
RT "Identification of novel FKBP genes.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA Kucherlapati R., Weinstock G., Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: PPIases accelerate the folding of proteins during
CC protein synthesis.
CC -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC (omega=0).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NYL4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NYL4-2; Sequence=VSP_043037;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family.
CC -!- SIMILARITY: Contains 1 PPIase FKBP-type domain.
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DR EMBL; AF238079; AAF63478.1; -; mRNA.
DR EMBL; AY358998; AAQ89357.1; -; mRNA.
DR EMBL; AK301455; BAG62979.1; -; mRNA.
DR EMBL; AC073610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027973; AAH27973.1; -; mRNA.
DR RefSeq; NP_001137253.1; NM_001143781.1.
DR RefSeq; NP_001137254.1; NM_001143782.1.
DR RefSeq; NP_057678.1; NM_016594.2.
DR UniGene; Hs.655103; -.
DR ProteinModelPortal; Q9NYL4; -.
DR SMR; Q9NYL4; 26-145.
DR IntAct; Q9NYL4; 1.
DR STRING; 9606.ENSP00000256680; -.
DR PhosphoSite; Q9NYL4; -.
DR DMDM; 23396601; -.
DR PaxDb; Q9NYL4; -.
DR PRIDE; Q9NYL4; -.
DR DNASU; 51303; -.
DR Ensembl; ENST00000453172; ENSP00000396874; ENSG00000134285.
DR Ensembl; ENST00000550765; ENSP00000449751; ENSG00000134285.
DR GeneID; 51303; -.
DR KEGG; hsa:51303; -.
DR UCSC; uc001rsp.3; human.
DR CTD; 51303; -.
DR GeneCards; GC12M049315; -.
DR HGNC; HGNC:18624; FKBP11.
DR HPA; HPA041709; -.
DR MIM; 610571; gene.
DR neXtProt; NX_Q9NYL4; -.
DR PharmGKB; PA38607; -.
DR eggNOG; COG0545; -.
DR HOGENOM; HOG000154887; -.
DR HOVERGEN; HBG051623; -.
DR InParanoid; Q9NYL4; -.
DR KO; K09576; -.
DR OMA; SRPKVSK; -.
DR PhylomeDB; Q9NYL4; -.
DR ChiTaRS; FKBP11; human.
DR GenomeRNAi; 51303; -.
DR NextBio; 54609; -.
DR PRO; PR:Q9NYL4; -.
DR ArrayExpress; Q9NYL4; -.
DR Bgee; Q9NYL4; -.
DR CleanEx; HS_FKBP11; -.
DR Genevestigator; Q9NYL4; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:RefGenome.
DR GO; GO:0005528; F:FK506 binding; IBA:RefGenome.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW.
DR InterPro; IPR023566; PPIase_FKBP.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR PANTHER; PTHR10516; PTHR10516; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Isomerase; Membrane;
KW Reference proteome; Rotamase; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 27 Potential.
FT CHAIN 28 201 Peptidyl-prolyl cis-trans isomerase
FT FKBP11.
FT /FTId=PRO_0000025519.
FT TRANSMEM 156 176 Helical; (Potential).
FT DOMAIN 57 144 PPIase FKBP-type.
FT VAR_SEQ 130 201 ADAVVQYDVELIALIRANYWLKLVKGILPLVGMAMVPALLG
FT LIGYHLYRKANRPKVSKKKLKEEKRNKSKKK -> GTKDNL
FT MRPPGMTSSSQ (in isoform 2).
FT /FTId=VSP_043037.
SQ SEQUENCE 201 AA; 22180 MW; 586E430B9D2DC0A2 CRC64;
MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL
HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG
KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA
NRPKVSKKKL KEEKRNKSKK K
//
MIM
610571
*RECORD*
*FIELD* NO
610571
*FIELD* TI
*610571 FK506-BINDING PROTEIN 11; FKBP11
;;FK506-BINDING PROTEIN, 19-KD; FKBP19
*FIELD* TX
read moreFor background information on FK506-binding proteins (FKBPs), see FKBP1A
(186945).
CLONING
By searching databases for putative FKBPs, Rulten et al. (2006) obtained
a full-length cDNA encoding FKBP11, which they called FKBP19. The
deduced 201-amino acid protein has a calculated molecular mass of 22 kD.
It has an N-terminal signal sequence, followed by a peptidyl-prolyl
isomerase domain, a transmembrane region, and a lysine-rich C-terminal
tail containing a variant of the dilysine motif found in endoplasmic
reticulum membrane proteins. Northern blot analysis detected high
expression of an 800-bp transcript in pancreas, with low levels in all
other tissues examined. RNA dot blot analysis revealed ubiquitous FKBP11
expression, with highest levels in pancreas and other secretory tissues,
such as stomach, pituitary, salivary gland, and lymph node.
GENE FUNCTION
Using an in vitro binding assay, Rulten et al. (2006) showed that FKBP11
bound FK506 weakly.
GENE STRUCTURE
Patterson et al. (2002) determined that the FKBP11 gene has 6 coding
exons. Rulten et al. (2006) identified 5 NKX2-5 (NKX2E; 600584)-binding
sites and 4 PAX4 (167413)-binding sites upstream of the FKBP11 coding
region.
MAPPING
Rulten et al. (2006) stated that the FKBP11 gene maps to chromosome
12q13.
*FIELD* RF
1. Patterson, C. E.; Gao, J.; Rooney, A. P.; Davis, E. C.: Genomic
organization of mouse and human 65 kDa FK506-binding protein genes
and evolution of the FKBP multigene family. Genomics 79: 881-889,
2002.
2. Rulten, S. L.; Kinloch, R. A.; Tateossian, H.; Robinson, C.; Gettins,
L.; Kay, J. E.: The human FK506-binding proteins: characterization
of human FKBP19. Mammalian Genome 17: 322-331, 2006.
*FIELD* CD
Patricia A. Hartz: 11/15/2006
*FIELD* ED
mgross: 03/03/2011
mgross: 11/15/2006
*RECORD*
*FIELD* NO
610571
*FIELD* TI
*610571 FK506-BINDING PROTEIN 11; FKBP11
;;FK506-BINDING PROTEIN, 19-KD; FKBP19
*FIELD* TX
read moreFor background information on FK506-binding proteins (FKBPs), see FKBP1A
(186945).
CLONING
By searching databases for putative FKBPs, Rulten et al. (2006) obtained
a full-length cDNA encoding FKBP11, which they called FKBP19. The
deduced 201-amino acid protein has a calculated molecular mass of 22 kD.
It has an N-terminal signal sequence, followed by a peptidyl-prolyl
isomerase domain, a transmembrane region, and a lysine-rich C-terminal
tail containing a variant of the dilysine motif found in endoplasmic
reticulum membrane proteins. Northern blot analysis detected high
expression of an 800-bp transcript in pancreas, with low levels in all
other tissues examined. RNA dot blot analysis revealed ubiquitous FKBP11
expression, with highest levels in pancreas and other secretory tissues,
such as stomach, pituitary, salivary gland, and lymph node.
GENE FUNCTION
Using an in vitro binding assay, Rulten et al. (2006) showed that FKBP11
bound FK506 weakly.
GENE STRUCTURE
Patterson et al. (2002) determined that the FKBP11 gene has 6 coding
exons. Rulten et al. (2006) identified 5 NKX2-5 (NKX2E; 600584)-binding
sites and 4 PAX4 (167413)-binding sites upstream of the FKBP11 coding
region.
MAPPING
Rulten et al. (2006) stated that the FKBP11 gene maps to chromosome
12q13.
*FIELD* RF
1. Patterson, C. E.; Gao, J.; Rooney, A. P.; Davis, E. C.: Genomic
organization of mouse and human 65 kDa FK506-binding protein genes
and evolution of the FKBP multigene family. Genomics 79: 881-889,
2002.
2. Rulten, S. L.; Kinloch, R. A.; Tateossian, H.; Robinson, C.; Gettins,
L.; Kay, J. E.: The human FK506-binding proteins: characterization
of human FKBP19. Mammalian Genome 17: 322-331, 2006.
*FIELD* CD
Patricia A. Hartz: 11/15/2006
*FIELD* ED
mgross: 03/03/2011
mgross: 11/15/2006