Full text data of FKBPL
FKBPL
(DIR1, NG7)
[Confidence: low (only semi-automatic identification from reviews)]
FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39; WISp39)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39; WISp39)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9UIM3
ID FKBPL_HUMAN Reviewed; 349 AA.
AC Q9UIM3; A8K5V3; B0UYX8; Q9H5G3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2000, sequence version 1.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=FK506-binding protein-like;
DE AltName: Full=WAF-1/CIP1 stabilizing protein 39;
DE Short=WISp39;
GN Name=FKBPL; Synonyms=DIR1, NG7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Lung;
RX PubMed=10521921;
RA Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E.,
RA Logan I., Jones H., McKeown S.R., Hirst D.G.;
RT "A novel human stress response-related gene with a potential role in
RT induced radioresistance.";
RL Radiat. Res. 152:451-461(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
RA Campbell R.D., Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-90.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-203.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-287 AND ARG-291, AND
RP INTERACTION WITH CDKN1A AND HSP90AB1.
RX PubMed=15664193; DOI=10.1016/j.molcel.2004.11.049;
RA Jascur T., Brickner H., Salles-Passador I., Barbier V.,
RA El Khissiin A., Smith B., Fotedar R., Fotedar A.;
RT "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR
RT protein.";
RL Mol. Cell 17:237-249(2005).
CC -!- FUNCTION: May be involved in response to X-ray. Regulates p21
CC protein stability by binding to Hsp90 and p21.
CC -!- SUBUNIT: Forms a ternary complex with CDKN1A/p21 and
CC HSP90AB1/Hsp90.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in
CC testis.
CC -!- SIMILARITY: Contains 3 TPR repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319;
CC Sequence=CAG33655.1; Type=Frameshift; Positions=201;
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DR EMBL; AF139374; AAF67785.1; -; Genomic_DNA.
DR EMBL; AK027119; BAB15663.1; ALT_FRAME; mRNA.
DR EMBL; AK291418; BAF84107.1; -; mRNA.
DR EMBL; U89337; AAF04864.1; -; Genomic_DNA.
DR EMBL; AL662828; CAI17420.1; -; Genomic_DNA.
DR EMBL; AL662884; CAI18338.1; -; Genomic_DNA.
DR EMBL; CR753803; CAQ09554.1; -; Genomic_DNA.
DR EMBL; CR925796; CAQ10265.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03586.1; -; Genomic_DNA.
DR EMBL; BC004168; AAH04168.1; -; mRNA.
DR EMBL; BC011966; AAH11966.1; -; mRNA.
DR EMBL; CR457374; CAG33655.1; ALT_FRAME; mRNA.
DR RefSeq; NP_071393.2; NM_022110.3.
DR UniGene; Hs.520042; -.
DR ProteinModelPortal; Q9UIM3; -.
DR SMR; Q9UIM3; 101-336.
DR IntAct; Q9UIM3; 1.
DR MINT; MINT-1373594; -.
DR STRING; 9606.ENSP00000397530; -.
DR PhosphoSite; Q9UIM3; -.
DR DMDM; 74762773; -.
DR PaxDb; Q9UIM3; -.
DR PRIDE; Q9UIM3; -.
DR DNASU; 63943; -.
DR Ensembl; ENST00000375156; ENSP00000364298; ENSG00000204315.
DR Ensembl; ENST00000425378; ENSP00000397530; ENSG00000230907.
DR Ensembl; ENST00000443350; ENSP00000398812; ENSG00000223666.
DR Ensembl; ENST00000456854; ENSP00000412439; ENSG00000224200.
DR GeneID; 63943; -.
DR KEGG; hsa:63943; -.
DR UCSC; uc003nzr.3; human.
DR CTD; 63943; -.
DR GeneCards; GC06M032099; -.
DR GeneCards; GC06Mj32044; -.
DR GeneCards; GC06Mk32072; -.
DR GeneCards; GC06Mm32172; -.
DR HGNC; HGNC:13949; FKBPL.
DR HPA; HPA043478; -.
DR neXtProt; NX_Q9UIM3; -.
DR PharmGKB; PA28167; -.
DR eggNOG; NOG307697; -.
DR HOGENOM; HOG000272638; -.
DR HOVERGEN; HBG099465; -.
DR InParanoid; Q9UIM3; -.
DR OMA; DSWELEA; -.
DR OrthoDB; EOG7HTHHD; -.
DR PhylomeDB; Q9UIM3; -.
DR ChiTaRS; FKBPL; human.
DR GeneWiki; FKBPL; -.
DR GenomeRNAi; 63943; -.
DR NextBio; 65716; -.
DR PRO; PR:Q9UIM3; -.
DR Bgee; Q9UIM3; -.
DR CleanEx; HS_FKBPL; -.
DR Genevestigator; Q9UIM3; -.
DR GO; GO:0016020; C:membrane; IBA:RefGenome.
DR GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR GO; GO:0005528; F:FK506 binding; IBA:RefGenome.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
DR GO; GO:0009314; P:response to radiation; NAS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR023566; PPIase_FKBP.
DR InterPro; IPR013026; TPR-contain_dom.
DR InterPro; IPR011990; TPR-like_helical.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10516; PTHR10516; 1.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 3.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Polymorphism; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1 349 FK506-binding protein-like.
FT /FTId=PRO_0000289878.
FT REPEAT 210 243 TPR 1.
FT REPEAT 252 285 TPR 2.
FT REPEAT 286 319 TPR 3.
FT VARIANT 90 90 A -> T (in dbSNP:rs28732176).
FT /FTId=VAR_061546.
FT MUTAGEN 287 287 K->A: Abolishes HSP90AB1 binding; when
FT associated with A-291.
FT MUTAGEN 291 291 R->A: Abolishes HSP90AB1 binding; when
FT associated with A-287.
FT CONFLICT 203 203 T -> I (in Ref. 7; CAG33655).
SQ SEQUENCE 349 AA; 38176 MW; 428EDD70FD9C807C CRC64;
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL
EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL
GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH
SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL
LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG
//
ID FKBPL_HUMAN Reviewed; 349 AA.
AC Q9UIM3; A8K5V3; B0UYX8; Q9H5G3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2000, sequence version 1.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=FK506-binding protein-like;
DE AltName: Full=WAF-1/CIP1 stabilizing protein 39;
DE Short=WISp39;
GN Name=FKBPL; Synonyms=DIR1, NG7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Lung;
RX PubMed=10521921;
RA Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E.,
RA Logan I., Jones H., McKeown S.R., Hirst D.G.;
RT "A novel human stress response-related gene with a potential role in
RT induced radioresistance.";
RL Radiat. Res. 152:451-461(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
RA Campbell R.D., Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-90.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-203.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-287 AND ARG-291, AND
RP INTERACTION WITH CDKN1A AND HSP90AB1.
RX PubMed=15664193; DOI=10.1016/j.molcel.2004.11.049;
RA Jascur T., Brickner H., Salles-Passador I., Barbier V.,
RA El Khissiin A., Smith B., Fotedar R., Fotedar A.;
RT "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR
RT protein.";
RL Mol. Cell 17:237-249(2005).
CC -!- FUNCTION: May be involved in response to X-ray. Regulates p21
CC protein stability by binding to Hsp90 and p21.
CC -!- SUBUNIT: Forms a ternary complex with CDKN1A/p21 and
CC HSP90AB1/Hsp90.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in
CC testis.
CC -!- SIMILARITY: Contains 3 TPR repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319;
CC Sequence=CAG33655.1; Type=Frameshift; Positions=201;
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DR EMBL; AF139374; AAF67785.1; -; Genomic_DNA.
DR EMBL; AK027119; BAB15663.1; ALT_FRAME; mRNA.
DR EMBL; AK291418; BAF84107.1; -; mRNA.
DR EMBL; U89337; AAF04864.1; -; Genomic_DNA.
DR EMBL; AL662828; CAI17420.1; -; Genomic_DNA.
DR EMBL; AL662884; CAI18338.1; -; Genomic_DNA.
DR EMBL; CR753803; CAQ09554.1; -; Genomic_DNA.
DR EMBL; CR925796; CAQ10265.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03586.1; -; Genomic_DNA.
DR EMBL; BC004168; AAH04168.1; -; mRNA.
DR EMBL; BC011966; AAH11966.1; -; mRNA.
DR EMBL; CR457374; CAG33655.1; ALT_FRAME; mRNA.
DR RefSeq; NP_071393.2; NM_022110.3.
DR UniGene; Hs.520042; -.
DR ProteinModelPortal; Q9UIM3; -.
DR SMR; Q9UIM3; 101-336.
DR IntAct; Q9UIM3; 1.
DR MINT; MINT-1373594; -.
DR STRING; 9606.ENSP00000397530; -.
DR PhosphoSite; Q9UIM3; -.
DR DMDM; 74762773; -.
DR PaxDb; Q9UIM3; -.
DR PRIDE; Q9UIM3; -.
DR DNASU; 63943; -.
DR Ensembl; ENST00000375156; ENSP00000364298; ENSG00000204315.
DR Ensembl; ENST00000425378; ENSP00000397530; ENSG00000230907.
DR Ensembl; ENST00000443350; ENSP00000398812; ENSG00000223666.
DR Ensembl; ENST00000456854; ENSP00000412439; ENSG00000224200.
DR GeneID; 63943; -.
DR KEGG; hsa:63943; -.
DR UCSC; uc003nzr.3; human.
DR CTD; 63943; -.
DR GeneCards; GC06M032099; -.
DR GeneCards; GC06Mj32044; -.
DR GeneCards; GC06Mk32072; -.
DR GeneCards; GC06Mm32172; -.
DR HGNC; HGNC:13949; FKBPL.
DR HPA; HPA043478; -.
DR neXtProt; NX_Q9UIM3; -.
DR PharmGKB; PA28167; -.
DR eggNOG; NOG307697; -.
DR HOGENOM; HOG000272638; -.
DR HOVERGEN; HBG099465; -.
DR InParanoid; Q9UIM3; -.
DR OMA; DSWELEA; -.
DR OrthoDB; EOG7HTHHD; -.
DR PhylomeDB; Q9UIM3; -.
DR ChiTaRS; FKBPL; human.
DR GeneWiki; FKBPL; -.
DR GenomeRNAi; 63943; -.
DR NextBio; 65716; -.
DR PRO; PR:Q9UIM3; -.
DR Bgee; Q9UIM3; -.
DR CleanEx; HS_FKBPL; -.
DR Genevestigator; Q9UIM3; -.
DR GO; GO:0016020; C:membrane; IBA:RefGenome.
DR GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR GO; GO:0005528; F:FK506 binding; IBA:RefGenome.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
DR GO; GO:0009314; P:response to radiation; NAS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR023566; PPIase_FKBP.
DR InterPro; IPR013026; TPR-contain_dom.
DR InterPro; IPR011990; TPR-like_helical.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10516; PTHR10516; 1.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 3.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Polymorphism; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1 349 FK506-binding protein-like.
FT /FTId=PRO_0000289878.
FT REPEAT 210 243 TPR 1.
FT REPEAT 252 285 TPR 2.
FT REPEAT 286 319 TPR 3.
FT VARIANT 90 90 A -> T (in dbSNP:rs28732176).
FT /FTId=VAR_061546.
FT MUTAGEN 287 287 K->A: Abolishes HSP90AB1 binding; when
FT associated with A-291.
FT MUTAGEN 291 291 R->A: Abolishes HSP90AB1 binding; when
FT associated with A-287.
FT CONFLICT 203 203 T -> I (in Ref. 7; CAG33655).
SQ SEQUENCE 349 AA; 38176 MW; 428EDD70FD9C807C CRC64;
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL
EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL
GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH
SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL
LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG
//