Full text data of FUK
FUK
[Confidence: low (only semi-automatic identification from reviews)]
L-fucose kinase; Fucokinase; 2.7.1.52
Note: presumably soluble (membrane word is not in UniProt keywords or features)
L-fucose kinase; Fucokinase; 2.7.1.52
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8N0W3
ID FUK_HUMAN Reviewed; 1084 AA.
AC Q8N0W3; Q5PSM3; Q5XKL6; Q6ZRA0; Q96MT9;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 30-AUG-2005, sequence version 2.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=L-fucose kinase;
DE Short=Fucokinase;
DE EC=2.7.1.52;
GN Name=FUK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12056818; DOI=10.1016/S0006-291X(02)00541-7;
RA Hinderlich S., Berger M., Blume A., Chen H., Ghaderi D., Bauer C.;
RT "Identification of human L-fucose kinase amino acid sequence.";
RL Biochem. Biophys. Res. Commun. 294:650-654(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Neuron, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-146; THR-521;
RP HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
RG SeattleSNPs variation discovery resource;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Takes part in the salvage pathway for reutilization of
CC fucose from the degradation of oligosaccharides.
CC -!- CATALYTIC ACTIVITY: ATP + L-fucose = ADP + beta-L-fucose 1-
CC phosphate.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N0W3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N0W3-2; Sequence=VSP_015422, VSP_015423;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the GHMP kinase family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71190.1; Type=Frameshift; Positions=19;
CC Sequence=CAD29647.1; Type=Frameshift; Positions=19;
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/fuk/";
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ441184; CAD29647.1; ALT_FRAME; mRNA.
DR EMBL; AK056456; BAB71190.1; ALT_FRAME; mRNA.
DR EMBL; AK128387; BAC87413.1; -; mRNA.
DR EMBL; AY829643; AAV67949.1; -; Genomic_DNA.
DR EMBL; BC013735; AAH13735.1; -; mRNA.
DR EMBL; BC032542; AAH32542.2; -; mRNA.
DR PIR; JC7878; JC7878.
DR RefSeq; NP_659496.2; NM_145059.2.
DR RefSeq; XP_005255889.1; XM_005255832.1.
DR UniGene; Hs.7907; -.
DR ProteinModelPortal; Q8N0W3; -.
DR STRING; 9606.ENSP00000288078; -.
DR PhosphoSite; Q8N0W3; -.
DR DMDM; 73915340; -.
DR PaxDb; Q8N0W3; -.
DR PRIDE; Q8N0W3; -.
DR DNASU; 197258; -.
DR Ensembl; ENST00000288078; ENSP00000288078; ENSG00000157353.
DR Ensembl; ENST00000378912; ENSP00000368192; ENSG00000157353.
DR GeneID; 197258; -.
DR KEGG; hsa:197258; -.
DR UCSC; uc002eyy.3; human.
DR CTD; 197258; -.
DR GeneCards; GC16P070488; -.
DR H-InvDB; HIX0013200; -.
DR HGNC; HGNC:29500; FUK.
DR HPA; HPA041971; -.
DR MIM; 608675; gene.
DR neXtProt; NX_Q8N0W3; -.
DR PharmGKB; PA134863646; -.
DR eggNOG; COG2605; -.
DR HOGENOM; HOG000294126; -.
DR HOVERGEN; HBG021773; -.
DR KO; K05305; -.
DR OMA; WRLSWEQ; -.
DR OrthoDB; EOG7X3QQC; -.
DR ChiTaRS; FUK; human.
DR GenomeRNAi; 197258; -.
DR NextBio; 89626; -.
DR PRO; PR:Q8N0W3; -.
DR ArrayExpress; Q8N0W3; -.
DR Bgee; Q8N0W3; -.
DR CleanEx; HS_FUK; -.
DR Genevestigator; Q8N0W3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050201; F:fucokinase activity; NAS:UniProtKB.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR012887; Fucokinase.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR Pfam; PF07959; Fucokinase; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF54211; SSF54211; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Polymorphism; Reference proteome; Transferase.
FT CHAIN 1 1084 L-fucose kinase.
FT /FTId=PRO_0000156672.
FT NP_BIND 834 845 ATP (Potential).
FT VAR_SEQ 78 78 T -> TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ
FT (in isoform 2).
FT /FTId=VSP_015422.
FT VAR_SEQ 816 841 Missing (in isoform 2).
FT /FTId=VSP_015423.
FT VARIANT 146 146 V -> M (in dbSNP:rs17881323).
FT /FTId=VAR_021327.
FT VARIANT 521 521 A -> T (in dbSNP:rs17881069).
FT /FTId=VAR_021328.
FT VARIANT 571 571 R -> H (in dbSNP:rs17886171).
FT /FTId=VAR_021329.
FT VARIANT 701 701 P -> L (in dbSNP:rs17883716).
FT /FTId=VAR_021330.
FT VARIANT 858 858 A -> T (in dbSNP:rs17884050).
FT /FTId=VAR_021331.
FT VARIANT 861 861 V -> M (in dbSNP:rs17878599).
FT /FTId=VAR_021332.
FT VARIANT 901 901 R -> W (in dbSNP:rs17881635).
FT /FTId=VAR_021333.
FT VARIANT 939 939 R -> Q (in dbSNP:rs17886060).
FT /FTId=VAR_021334.
FT VARIANT 939 939 R -> W (in dbSNP:rs17883248).
FT /FTId=VAR_021335.
FT CONFLICT 400 400 L -> S (in Ref. 2; BAB71190).
FT CONFLICT 609 609 C -> R (in Ref. 2; BAB71190).
SQ SEQUENCE 1084 AA; 117623 MW; 153F91882F4B143C CRC64;
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT
LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV
EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP
AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH
VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL
QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL
LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL
VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP
AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA
ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP
GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW
LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG
WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL
ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL
GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS
RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA
HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS
LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC
CPFP
//
ID FUK_HUMAN Reviewed; 1084 AA.
AC Q8N0W3; Q5PSM3; Q5XKL6; Q6ZRA0; Q96MT9;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 30-AUG-2005, sequence version 2.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=L-fucose kinase;
DE Short=Fucokinase;
DE EC=2.7.1.52;
GN Name=FUK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12056818; DOI=10.1016/S0006-291X(02)00541-7;
RA Hinderlich S., Berger M., Blume A., Chen H., Ghaderi D., Bauer C.;
RT "Identification of human L-fucose kinase amino acid sequence.";
RL Biochem. Biophys. Res. Commun. 294:650-654(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Neuron, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-146; THR-521;
RP HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
RG SeattleSNPs variation discovery resource;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Takes part in the salvage pathway for reutilization of
CC fucose from the degradation of oligosaccharides.
CC -!- CATALYTIC ACTIVITY: ATP + L-fucose = ADP + beta-L-fucose 1-
CC phosphate.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N0W3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N0W3-2; Sequence=VSP_015422, VSP_015423;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the GHMP kinase family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71190.1; Type=Frameshift; Positions=19;
CC Sequence=CAD29647.1; Type=Frameshift; Positions=19;
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/fuk/";
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ441184; CAD29647.1; ALT_FRAME; mRNA.
DR EMBL; AK056456; BAB71190.1; ALT_FRAME; mRNA.
DR EMBL; AK128387; BAC87413.1; -; mRNA.
DR EMBL; AY829643; AAV67949.1; -; Genomic_DNA.
DR EMBL; BC013735; AAH13735.1; -; mRNA.
DR EMBL; BC032542; AAH32542.2; -; mRNA.
DR PIR; JC7878; JC7878.
DR RefSeq; NP_659496.2; NM_145059.2.
DR RefSeq; XP_005255889.1; XM_005255832.1.
DR UniGene; Hs.7907; -.
DR ProteinModelPortal; Q8N0W3; -.
DR STRING; 9606.ENSP00000288078; -.
DR PhosphoSite; Q8N0W3; -.
DR DMDM; 73915340; -.
DR PaxDb; Q8N0W3; -.
DR PRIDE; Q8N0W3; -.
DR DNASU; 197258; -.
DR Ensembl; ENST00000288078; ENSP00000288078; ENSG00000157353.
DR Ensembl; ENST00000378912; ENSP00000368192; ENSG00000157353.
DR GeneID; 197258; -.
DR KEGG; hsa:197258; -.
DR UCSC; uc002eyy.3; human.
DR CTD; 197258; -.
DR GeneCards; GC16P070488; -.
DR H-InvDB; HIX0013200; -.
DR HGNC; HGNC:29500; FUK.
DR HPA; HPA041971; -.
DR MIM; 608675; gene.
DR neXtProt; NX_Q8N0W3; -.
DR PharmGKB; PA134863646; -.
DR eggNOG; COG2605; -.
DR HOGENOM; HOG000294126; -.
DR HOVERGEN; HBG021773; -.
DR KO; K05305; -.
DR OMA; WRLSWEQ; -.
DR OrthoDB; EOG7X3QQC; -.
DR ChiTaRS; FUK; human.
DR GenomeRNAi; 197258; -.
DR NextBio; 89626; -.
DR PRO; PR:Q8N0W3; -.
DR ArrayExpress; Q8N0W3; -.
DR Bgee; Q8N0W3; -.
DR CleanEx; HS_FUK; -.
DR Genevestigator; Q8N0W3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050201; F:fucokinase activity; NAS:UniProtKB.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR012887; Fucokinase.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR Pfam; PF07959; Fucokinase; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF54211; SSF54211; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Polymorphism; Reference proteome; Transferase.
FT CHAIN 1 1084 L-fucose kinase.
FT /FTId=PRO_0000156672.
FT NP_BIND 834 845 ATP (Potential).
FT VAR_SEQ 78 78 T -> TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ
FT (in isoform 2).
FT /FTId=VSP_015422.
FT VAR_SEQ 816 841 Missing (in isoform 2).
FT /FTId=VSP_015423.
FT VARIANT 146 146 V -> M (in dbSNP:rs17881323).
FT /FTId=VAR_021327.
FT VARIANT 521 521 A -> T (in dbSNP:rs17881069).
FT /FTId=VAR_021328.
FT VARIANT 571 571 R -> H (in dbSNP:rs17886171).
FT /FTId=VAR_021329.
FT VARIANT 701 701 P -> L (in dbSNP:rs17883716).
FT /FTId=VAR_021330.
FT VARIANT 858 858 A -> T (in dbSNP:rs17884050).
FT /FTId=VAR_021331.
FT VARIANT 861 861 V -> M (in dbSNP:rs17878599).
FT /FTId=VAR_021332.
FT VARIANT 901 901 R -> W (in dbSNP:rs17881635).
FT /FTId=VAR_021333.
FT VARIANT 939 939 R -> Q (in dbSNP:rs17886060).
FT /FTId=VAR_021334.
FT VARIANT 939 939 R -> W (in dbSNP:rs17883248).
FT /FTId=VAR_021335.
FT CONFLICT 400 400 L -> S (in Ref. 2; BAB71190).
FT CONFLICT 609 609 C -> R (in Ref. 2; BAB71190).
SQ SEQUENCE 1084 AA; 117623 MW; 153F91882F4B143C CRC64;
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT
LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV
EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP
AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH
VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL
QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL
LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL
VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP
AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA
ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP
GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW
LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG
WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL
ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL
GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS
RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA
HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS
LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC
CPFP
//
MIM
608675
*RECORD*
*FIELD* NO
608675
*FIELD* TI
*608675 FUCOKINASE; FUK
;;L-FUCOSE KINASE
*FIELD* TX
DESCRIPTION
The sugar fucose is present in glycoproteins and glycolipids and is
read moreinvolved in blood group antigen recognition, inflammation, and
metastasis. Fucokinase participates in a salvage pathway for
reutilization of fucose from oligosaccharide degradation (Hinderlich et
al., 2002).
CLONING
By searching sequence databases using peptides from pig fucokinase as
probes, Hinderlich et al. (2002) identified 2 full-length cDNAs encoding
human FUK. The deduced 990-amino acid FUK protein has a predicted
molecular mass of 107 kD. It contains 5 C-terminal motifs characteristic
of the ATP-binding sites of hexokinases, as well as 31 potential
phosphorylation sites evenly distributed throughout its sequence.
GENE FUNCTION
Using in vitro assays, Hinderlich et al. (2002) showed that recombinant
FUK had fucokinase activity, with the active site located at the C
terminus.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the FUK
gene to chromosome 16 (TMAP RH44544).
*FIELD* RF
1. Hinderlich, S.; Berger, M.; Blume, A.; Chen, H.; Ghaderi, D.; Bauer,
C.: Identification of human L-fucose kinase amino acid sequence. Biochem.
Biophys. Res. Commun. 294: 650-654, 2002.
*FIELD* CD
Laura L. Baxter: 5/20/2004
*FIELD* ED
mgross: 05/20/2004
*RECORD*
*FIELD* NO
608675
*FIELD* TI
*608675 FUCOKINASE; FUK
;;L-FUCOSE KINASE
*FIELD* TX
DESCRIPTION
The sugar fucose is present in glycoproteins and glycolipids and is
read moreinvolved in blood group antigen recognition, inflammation, and
metastasis. Fucokinase participates in a salvage pathway for
reutilization of fucose from oligosaccharide degradation (Hinderlich et
al., 2002).
CLONING
By searching sequence databases using peptides from pig fucokinase as
probes, Hinderlich et al. (2002) identified 2 full-length cDNAs encoding
human FUK. The deduced 990-amino acid FUK protein has a predicted
molecular mass of 107 kD. It contains 5 C-terminal motifs characteristic
of the ATP-binding sites of hexokinases, as well as 31 potential
phosphorylation sites evenly distributed throughout its sequence.
GENE FUNCTION
Using in vitro assays, Hinderlich et al. (2002) showed that recombinant
FUK had fucokinase activity, with the active site located at the C
terminus.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the FUK
gene to chromosome 16 (TMAP RH44544).
*FIELD* RF
1. Hinderlich, S.; Berger, M.; Blume, A.; Chen, H.; Ghaderi, D.; Bauer,
C.: Identification of human L-fucose kinase amino acid sequence. Biochem.
Biophys. Res. Commun. 294: 650-654, 2002.
*FIELD* CD
Laura L. Baxter: 5/20/2004
*FIELD* ED
mgross: 05/20/2004