Full text data of GLIPR2
GLIPR2
(C9orf19, GAPR1)
[Confidence: high (present in two of the MS resources)]
Golgi-associated plant pathogenesis-related protein 1; GAPR-1; Golgi-associated PR-1 protein (Glioma pathogenesis-related protein 2; GliPR 2)
Golgi-associated plant pathogenesis-related protein 1; GAPR-1; Golgi-associated PR-1 protein (Glioma pathogenesis-related protein 2; GliPR 2)
hRBCD
IPI00007067
IPI00007067 chromosome 9 open reading frame 19 chromosome 9 open reading frame 19 membrane n/a 3 1 1 3 n/a 2 1 1 1 5 1 n/a 4 3 n/a 3 5 3 5 extracellular region n/a found at its expected molecular weight found at molecular weight
IPI00007067 chromosome 9 open reading frame 19 chromosome 9 open reading frame 19 membrane n/a 3 1 1 3 n/a 2 1 1 1 5 1 n/a 4 3 n/a 3 5 3 5 extracellular region n/a found at its expected molecular weight found at molecular weight
UniProt
Q9H4G4
ID GAPR1_HUMAN Reviewed; 154 AA.
AC Q9H4G4; Q5VZR1; Q8N2S6; Q8WWC9; Q8WX36;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=Golgi-associated plant pathogenesis-related protein 1;
DE Short=GAPR-1;
DE Short=Golgi-associated PR-1 protein;
DE AltName: Full=Glioma pathogenesis-related protein 2;
DE Short=GliPR 2;
GN Name=GLIPR2; Synonyms=C9orf19, GAPR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68,
RP SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, AND INTERACTION WITH
RP CAV1.
RC TISSUE=Brain;
RX PubMed=11865038;
RA Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D.,
RA Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.;
RT "Identification and characterization of a novel human plant
RT pathogenesis-related protein that localizes to lipid-enriched
RT microdomains in the Golgi complex.";
RL J. Cell Sci. 115:827-838(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=12137952; DOI=10.1016/S0378-1119(02)00703-5;
RA Eisenberg I., Barash M., Kahan T., Mitrani-Rosenbaum S.;
RT "Cloning and characterization of a human novel gene C9orf19 encoding a
RT conserved putative protein with an SCP-like extracellular protein
RT domain.";
RL Gene 293:141-148(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA Rogers J., Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-90.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), AND HOMODIMERIZATION.
RX PubMed=15123429; DOI=10.1016/j.jmb.2004.03.015;
RA Serrano R.L., Kuhn A., Hendricks A., Helms J.B., Sinning I.,
RA Groves M.R.;
RT "Structural analysis of the human Golgi-associated plant pathogenesis
RT related protein GAPR-1 implicates dimerization as a regulatory
RT mechanism.";
RL J. Mol. Biol. 339:173-183(2004).
CC -!- SUBUNIT: Homodimer. Interacts with CAV1.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
CC Note=Binds lipid-enriched microdomains of Golgi membranes not only
CC by ionic interactions but also through the myristate.
CC -!- TISSUE SPECIFICITY: Highest expression in lung and peripheral
CC leukocytes, and minor expression in liver and kidney.
CC -!- SIMILARITY: Belongs to the CRISP family.
CC -!- SIMILARITY: Contains 1 SCP domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ011129; CAC12812.1; -; mRNA.
DR EMBL; AY039756; AAK83460.1; -; mRNA.
DR EMBL; AK074488; BAC11019.1; -; mRNA.
DR EMBL; AK075091; BAC11395.1; -; mRNA.
DR EMBL; AL158830; CAH73678.1; -; Genomic_DNA.
DR EMBL; BC017918; AAH17918.1; -; mRNA.
DR RefSeq; NP_071738.1; NM_022343.2.
DR UniGene; Hs.493819; -.
DR PDB; 1SMB; X-ray; 1.55 A; A=1-154.
DR PDB; 4AIW; X-ray; 1.50 A; A=1-154.
DR PDBsum; 1SMB; -.
DR PDBsum; 4AIW; -.
DR ProteinModelPortal; Q9H4G4; -.
DR SMR; Q9H4G4; 4-154.
DR DIP; DIP-60127N; -.
DR IntAct; Q9H4G4; 1.
DR STRING; 9606.ENSP00000367196; -.
DR PhosphoSite; Q9H4G4; -.
DR DMDM; 46397431; -.
DR PaxDb; Q9H4G4; -.
DR PeptideAtlas; Q9H4G4; -.
DR PRIDE; Q9H4G4; -.
DR Ensembl; ENST00000377960; ENSP00000367196; ENSG00000122694.
DR GeneID; 152007; -.
DR KEGG; hsa:152007; -.
DR UCSC; uc003zyy.1; human.
DR CTD; 152007; -.
DR GeneCards; GC09P036127; -.
DR HGNC; HGNC:18007; GLIPR2.
DR HPA; HPA029478; -.
DR MIM; 607141; gene.
DR neXtProt; NX_Q9H4G4; -.
DR PharmGKB; PA164720283; -.
DR eggNOG; COG2340; -.
DR HOVERGEN; HBG051701; -.
DR OMA; DQSGKDV; -.
DR PhylomeDB; Q9H4G4; -.
DR ChiTaRS; GLIPR2; human.
DR EvolutionaryTrace; Q9H4G4; -.
DR GenomeRNAi; 152007; -.
DR NextBio; 86851; -.
DR PRO; PR:Q9H4G4; -.
DR ArrayExpress; Q9H4G4; -.
DR Bgee; Q9H4G4; -.
DR CleanEx; HS_GLIPR2; -.
DR Genevestigator; Q9H4G4; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR001283; Allrgn_V5/Tpx1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; FALSE_NEG.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Complete proteome;
KW Direct protein sequencing; Golgi apparatus; Lipoprotein; Membrane;
KW Myristate; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 154 Golgi-associated plant pathogenesis-
FT related protein 1.
FT /FTId=PRO_0000211524.
FT DOMAIN 14 132 SCP.
FT REGION 91 98 Interaction with CAV1.
FT COILED 30 53 Potential.
FT LIPID 2 2 N-myristoyl glycine.
FT CONFLICT 37 37 R -> Q (in Ref. 1; AA sequence).
FT CONFLICT 87 90 IKNY -> VHFM (in Ref. 5; AAH17918).
FT CONFLICT 101 154 TGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVN
FT EGFFEENVLPPKK -> IRFFFFNFLLFLSKPLLYFSYF
FT (in Ref. 3; BAC11019).
FT HELIX 5 23
FT HELIX 33 49
FT HELIX 56 59
FT STRAND 62 72
FT HELIX 76 84
FT HELIX 85 89
FT TURN 99 101
FT HELIX 102 108
FT STRAND 114 121
FT STRAND 127 135
FT HELIX 144 148
SQ SEQUENCE 154 AA; 17218 MW; 5AA9B26A21EF1039 CRC64;
MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR ILKHSPESSR
GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG TGHFTAMVWK NTKKMGVGKA
SASDGSSFVV ARYFPAGNVV NEGFFEENVL PPKK
//
ID GAPR1_HUMAN Reviewed; 154 AA.
AC Q9H4G4; Q5VZR1; Q8N2S6; Q8WWC9; Q8WX36;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=Golgi-associated plant pathogenesis-related protein 1;
DE Short=GAPR-1;
DE Short=Golgi-associated PR-1 protein;
DE AltName: Full=Glioma pathogenesis-related protein 2;
DE Short=GliPR 2;
GN Name=GLIPR2; Synonyms=C9orf19, GAPR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68,
RP SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, AND INTERACTION WITH
RP CAV1.
RC TISSUE=Brain;
RX PubMed=11865038;
RA Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D.,
RA Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.;
RT "Identification and characterization of a novel human plant
RT pathogenesis-related protein that localizes to lipid-enriched
RT microdomains in the Golgi complex.";
RL J. Cell Sci. 115:827-838(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=12137952; DOI=10.1016/S0378-1119(02)00703-5;
RA Eisenberg I., Barash M., Kahan T., Mitrani-Rosenbaum S.;
RT "Cloning and characterization of a human novel gene C9orf19 encoding a
RT conserved putative protein with an SCP-like extracellular protein
RT domain.";
RL Gene 293:141-148(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA Rogers J., Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-90.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), AND HOMODIMERIZATION.
RX PubMed=15123429; DOI=10.1016/j.jmb.2004.03.015;
RA Serrano R.L., Kuhn A., Hendricks A., Helms J.B., Sinning I.,
RA Groves M.R.;
RT "Structural analysis of the human Golgi-associated plant pathogenesis
RT related protein GAPR-1 implicates dimerization as a regulatory
RT mechanism.";
RL J. Mol. Biol. 339:173-183(2004).
CC -!- SUBUNIT: Homodimer. Interacts with CAV1.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
CC Note=Binds lipid-enriched microdomains of Golgi membranes not only
CC by ionic interactions but also through the myristate.
CC -!- TISSUE SPECIFICITY: Highest expression in lung and peripheral
CC leukocytes, and minor expression in liver and kidney.
CC -!- SIMILARITY: Belongs to the CRISP family.
CC -!- SIMILARITY: Contains 1 SCP domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ011129; CAC12812.1; -; mRNA.
DR EMBL; AY039756; AAK83460.1; -; mRNA.
DR EMBL; AK074488; BAC11019.1; -; mRNA.
DR EMBL; AK075091; BAC11395.1; -; mRNA.
DR EMBL; AL158830; CAH73678.1; -; Genomic_DNA.
DR EMBL; BC017918; AAH17918.1; -; mRNA.
DR RefSeq; NP_071738.1; NM_022343.2.
DR UniGene; Hs.493819; -.
DR PDB; 1SMB; X-ray; 1.55 A; A=1-154.
DR PDB; 4AIW; X-ray; 1.50 A; A=1-154.
DR PDBsum; 1SMB; -.
DR PDBsum; 4AIW; -.
DR ProteinModelPortal; Q9H4G4; -.
DR SMR; Q9H4G4; 4-154.
DR DIP; DIP-60127N; -.
DR IntAct; Q9H4G4; 1.
DR STRING; 9606.ENSP00000367196; -.
DR PhosphoSite; Q9H4G4; -.
DR DMDM; 46397431; -.
DR PaxDb; Q9H4G4; -.
DR PeptideAtlas; Q9H4G4; -.
DR PRIDE; Q9H4G4; -.
DR Ensembl; ENST00000377960; ENSP00000367196; ENSG00000122694.
DR GeneID; 152007; -.
DR KEGG; hsa:152007; -.
DR UCSC; uc003zyy.1; human.
DR CTD; 152007; -.
DR GeneCards; GC09P036127; -.
DR HGNC; HGNC:18007; GLIPR2.
DR HPA; HPA029478; -.
DR MIM; 607141; gene.
DR neXtProt; NX_Q9H4G4; -.
DR PharmGKB; PA164720283; -.
DR eggNOG; COG2340; -.
DR HOVERGEN; HBG051701; -.
DR OMA; DQSGKDV; -.
DR PhylomeDB; Q9H4G4; -.
DR ChiTaRS; GLIPR2; human.
DR EvolutionaryTrace; Q9H4G4; -.
DR GenomeRNAi; 152007; -.
DR NextBio; 86851; -.
DR PRO; PR:Q9H4G4; -.
DR ArrayExpress; Q9H4G4; -.
DR Bgee; Q9H4G4; -.
DR CleanEx; HS_GLIPR2; -.
DR Genevestigator; Q9H4G4; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR001283; Allrgn_V5/Tpx1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; FALSE_NEG.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Complete proteome;
KW Direct protein sequencing; Golgi apparatus; Lipoprotein; Membrane;
KW Myristate; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 154 Golgi-associated plant pathogenesis-
FT related protein 1.
FT /FTId=PRO_0000211524.
FT DOMAIN 14 132 SCP.
FT REGION 91 98 Interaction with CAV1.
FT COILED 30 53 Potential.
FT LIPID 2 2 N-myristoyl glycine.
FT CONFLICT 37 37 R -> Q (in Ref. 1; AA sequence).
FT CONFLICT 87 90 IKNY -> VHFM (in Ref. 5; AAH17918).
FT CONFLICT 101 154 TGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVN
FT EGFFEENVLPPKK -> IRFFFFNFLLFLSKPLLYFSYF
FT (in Ref. 3; BAC11019).
FT HELIX 5 23
FT HELIX 33 49
FT HELIX 56 59
FT STRAND 62 72
FT HELIX 76 84
FT HELIX 85 89
FT TURN 99 101
FT HELIX 102 108
FT STRAND 114 121
FT STRAND 127 135
FT HELIX 144 148
SQ SEQUENCE 154 AA; 17218 MW; 5AA9B26A21EF1039 CRC64;
MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR ILKHSPESSR
GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG TGHFTAMVWK NTKKMGVGKA
SASDGSSFVV ARYFPAGNVV NEGFFEENVL PPKK
//
MIM
607141
*RECORD*
*FIELD* NO
607141
*FIELD* TI
*607141 GLIOMA PATHOGENESIS-RELATED PROTEIN 2; GLIPR2
;;GOLGI-ASSOCIATED PR1 PROTEIN; GAPR1;;
read moreCHROMOSOME 9 OPEN READING FRAME 19; C9ORF19
*FIELD* TX
CLONING
Using a positional cloning strategy, Eisenberg et al. (2002) identified
a novel transcript in the critical region for IBM2 (600737) on
chromosome 9p13-p12. They cloned the full-length cDNA, designated
C9ORF19, from a human placenta cDNA library. C9ORF19 encodes a deduced
154-amino acid protein with a calculated molecular mass of 17.2 kD.
Northern blot analysis detected a 1.9-kb transcript in most adult
tissues tested, with highest expression in lung and peripheral
leukocytes and minor expression in liver and kidney.
GENE STRUCTURE
Eisenberg et al. (2002) determined that the GLIPR2 gene contains 5 exons
and spans more than 27 kb.
GENE FUNCTION
Shoji-Kawata et al. (2013) showed that a peptide, Tat-beclin-1, derived
from a region of the autophagy protein beclin-1 (604378), which binds
HIV-1 Nef, is a potent inducer of autophagy, and interacts with a
negative regulator of autophagy, GAPR1 (also called GLIPR2).
Tat-beclin-1 decreases the accumulation of polyglutamine expansion
protein aggregates and the replication of several pathogens, including
HIV-1, in vitro, and reduces mortality in mice infected with chikungunya
or West Nile virus. Shoji-Kawata et al. (2013) concluded that, through
the characterization of a domain of beclin-1 that interacts with HIV-1
Nef, they have developed an autophagy-inducing peptide that has
potential efficacy in the treatment of human diseases.
MAPPING
By sequence analysis, Eisenberg et al. (2002) mapped the GLIPR2 gene to
chromosome 9p13-p12.
MOLECULAR GENETICS
By mutation analysis in patients with IBM2, Eisenberg et al. (2002)
excluded C9ORF19 as the disease-causing gene.
*FIELD* RF
1. Eisenberg, I.; Barash, M.; Kahan, T.; Mitrani-Rosenbaum, S.: Cloning
and characterization of a human novel gene C9orf19 encoding a conserved
putative protein with an SCP-like extracellular protein domain. Gene 293:
1451-148, 2002.
2. Shoji-Kawata, S.; Sumpter, R., Jr.; Leveno, M.; Campbell, G. R.;
Zou, Z.; Kinch, L.; Wilkins, A. D.; Sun, Q.; Pallauf, K.; MacDuff,
D.; Huerta, C.; Virgin, H. W.; and 12 others: Identification of
a candidate therapeutic autophagy-inducing peptide. Nature 494:
201-206, 2013.
*FIELD* CN
Ada Hamosh - updated: 2/26/2013
*FIELD* CD
Carol A. Bocchini: 8/9/2002
*FIELD* ED
alopez: 03/04/2013
terry: 2/26/2013
mgross: 8/12/2002
carol: 8/9/2002
*RECORD*
*FIELD* NO
607141
*FIELD* TI
*607141 GLIOMA PATHOGENESIS-RELATED PROTEIN 2; GLIPR2
;;GOLGI-ASSOCIATED PR1 PROTEIN; GAPR1;;
read moreCHROMOSOME 9 OPEN READING FRAME 19; C9ORF19
*FIELD* TX
CLONING
Using a positional cloning strategy, Eisenberg et al. (2002) identified
a novel transcript in the critical region for IBM2 (600737) on
chromosome 9p13-p12. They cloned the full-length cDNA, designated
C9ORF19, from a human placenta cDNA library. C9ORF19 encodes a deduced
154-amino acid protein with a calculated molecular mass of 17.2 kD.
Northern blot analysis detected a 1.9-kb transcript in most adult
tissues tested, with highest expression in lung and peripheral
leukocytes and minor expression in liver and kidney.
GENE STRUCTURE
Eisenberg et al. (2002) determined that the GLIPR2 gene contains 5 exons
and spans more than 27 kb.
GENE FUNCTION
Shoji-Kawata et al. (2013) showed that a peptide, Tat-beclin-1, derived
from a region of the autophagy protein beclin-1 (604378), which binds
HIV-1 Nef, is a potent inducer of autophagy, and interacts with a
negative regulator of autophagy, GAPR1 (also called GLIPR2).
Tat-beclin-1 decreases the accumulation of polyglutamine expansion
protein aggregates and the replication of several pathogens, including
HIV-1, in vitro, and reduces mortality in mice infected with chikungunya
or West Nile virus. Shoji-Kawata et al. (2013) concluded that, through
the characterization of a domain of beclin-1 that interacts with HIV-1
Nef, they have developed an autophagy-inducing peptide that has
potential efficacy in the treatment of human diseases.
MAPPING
By sequence analysis, Eisenberg et al. (2002) mapped the GLIPR2 gene to
chromosome 9p13-p12.
MOLECULAR GENETICS
By mutation analysis in patients with IBM2, Eisenberg et al. (2002)
excluded C9ORF19 as the disease-causing gene.
*FIELD* RF
1. Eisenberg, I.; Barash, M.; Kahan, T.; Mitrani-Rosenbaum, S.: Cloning
and characterization of a human novel gene C9orf19 encoding a conserved
putative protein with an SCP-like extracellular protein domain. Gene 293:
1451-148, 2002.
2. Shoji-Kawata, S.; Sumpter, R., Jr.; Leveno, M.; Campbell, G. R.;
Zou, Z.; Kinch, L.; Wilkins, A. D.; Sun, Q.; Pallauf, K.; MacDuff,
D.; Huerta, C.; Virgin, H. W.; and 12 others: Identification of
a candidate therapeutic autophagy-inducing peptide. Nature 494:
201-206, 2013.
*FIELD* CN
Ada Hamosh - updated: 2/26/2013
*FIELD* CD
Carol A. Bocchini: 8/9/2002
*FIELD* ED
alopez: 03/04/2013
terry: 2/26/2013
mgross: 8/12/2002
carol: 8/9/2002